Parvalbumin-Expressing Inhibitory Interneurons in Auditory Cortex Are Well-Tuned for Frequency
Open accessAbstract
In the auditory cortex, synaptic inhibition is known to be involved in shaping receptive fields, enhancing temporal precision, and regulating gain. Cortical inhibition is provided by local GABAergic interneurons, which comprise 10–20% of the cortical population and can be separated into numerous subclasses. The morphological and physiological diversity of interneurons suggests that these different subclasses have unique roles in sound processing; however, these roles are yet unknown. Understanding the receptive field properties of distinct inhibitory cell types will be critical to elucidating their computational function in cortical circuits. Here we characterized the tuning and response properties of parvalbumin-positive (PV+) interneurons, the largest inhibitory subclass. We used channelrhodopsin-2 (ChR2) as an optogenetic tag to identify PV+ and PV− neurons in vivo in transgenic mice. In contrast to PV+ neurons in mouse visual cortex, which are broadly tuned for orientation, we found that auditory cortical PV+ neurons were well tuned for frequency, although very tightly tuned PV+ cells were uncommon. This suggests that PV+ neurons play a minor role in shaping frequency tuning, and is consistent with the idea that PV+ neurons nonselectively pool input from the local network. PV+ interneurons had shallower response gain and were less intensity-tuned than PV− neurons, suggesting that PV+ neurons provide dynamic gain control and shape intensity tuning in auditory cortex. PV+ neurons also had markedly faster response latencies than PV− neurons, consistent with a computational role in enhancing the temporal precision of cortical responses.
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PV-positive neurons in auditory cortex are tuned to sound frequency to a similar degree as nearby PV-negative neurons.
“PV-positive neurons in auditory cortex are tuned to sound frequency to a similar degree as nearby PV-negative neurons (Moore and Wehr, 2013).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Moore and Wehr, 2013
GABAergic signaling is involved in shaping frequency selectivity, spontaneous activity levels and spectrotemporal selectivity, with fast-spiking PV cells shaping both spectral and temporal selectivity.
“GABAergic signaling is involved in shaping these properties, with fast-spiking PV cells shaping both spectral and temporal selectivity (Moore and Wehr, 2012).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Moore and Wehr, 2012
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Cites
Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954 · see citing works
Highly nonrandom features of synaptic connectivity in local cortical circuits
Song, S., Sjöström, P. J., Reigl, M., Nelson, S., & Chklovskii, D. B. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030068 · Cited by 1,512 · see citing works
DeFelipe, J. (1997) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(97)10013-8 · Cited by 550 · see citing works
Xu, X., Roby, K. D., & Callaway, E. M. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22229 · Cited by 429 · see citing works
Classification of fusiform neocortical interneurons based on unsupervised clustering
Cauli, B., Porter, J. T., Tsuzuki, K., Lambolez, B., Rossier, J., Quenet, B., & Audinat, E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6144 · Cited by 316 · see citing works
Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A
Meyer, H. S., Schwarz, D., Wimmer, V. C., Schmitt, A. C., Kerr, J. N. D., Sakmann, B., & Helmstaedter, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113648108 · Cited by 254 · see citing works
Runyan, C. A., Schummers, J., Van Wart, A., Kuhlman, S. J., Wilson, N. R., Huang, Z. J., & Sur, M. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.006 · Cited by 244 · see citing works
Stimulus feature selectivity in excitatory and inhibitory neurons in primary visual cortex
Cardin, J. A., Palmer, L. A., & Contreras, D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1692-07.2007 · Cited by 185 · see citing works
Functionally distinct inhibitory neurons at the first stage of visual cortical processing
Hirsch, J. A., Martinez, L. M., Pillai, C., Alonso, J.-M., Wang, Q., & Sommer, F. T. (2003) · Nature Neuroscience · doi:10.1038/nn1152 · Cited by 176 · see citing works
Anderson, L. A., Christianson, G. B., & Linden, J. F. (2009) · Brain Research · doi:10.1016/j.brainres.2008.11.037 · Cited by 71 · see citing works
Flagged first, then by citations
Research works printed but not linked: 62
- Atallah BV, Bruns W, Carandini M, Scanziani M (2012) Parvalbumin- expressing interneurons linearly transform cortical responses to visual stimuli. Neuron 73:159 -170. CrossRef Medline · DOI · Paper page
- Atencio CA, Schreiner CE (2008) Spectrotemporal processing differences between auditory cortical fast-spiking and regular-spiking neurons. J Neurosci 28:3897-3910. CrossRef Medline · DOI
- Bandyopadhyay S, Shamma SA, Kanold PO (2010) Dichotomy of func- tional organization in the mouse auditory cortex. Nat Neurosci 13:361- 368. CrossRef Medline · DOI
- Barbour DL, Callaway EM (2008) Excitatory local connections of superficial neurons in rat auditory cortex. J Neurosci 28:11174 -11185. CrossRef Medline · DOI
- Chang EF, Bao S, Imaizumi K, Schreiner CE, Merzenich MM (2005) Devel- opment of spectral and temporal response selectivity in the auditory cor- tex. Proc Natl Acad Sci U S A 102:16460 -16465. CrossRef Medline · DOI
- Chen QC, Jen PH (2000) Bicuculline application affects discharge patterns, rate-intensity functions, and frequency tuning characteristics of bat audi- tory cortical neurons. Hear Res 150:161-174. CrossRef Medline · DOI
- Cruikshank SJ, Killackey HP, Metherate R (2001) Parvalbumin and calbin- din are differentially distributed within primary and secondary subre- gions of the mouse auditory forebrain. Neuroscience 105:553-569. CrossRef Medline · DOI
- de la Rocha J, Marchetti C, Schiff M, Reyes AD (2008) Linking the response properties of cells in auditory cortex with network architecture: cotuning versus lateral inhibition. J Neurosci 28:9151-9163. CrossRef Medline · DOI
- Fino E, Packer AM, Yuste R (2013) The logic of inhibitory connectivity in the neocortex. Neuroscientist 19:228 -237. CrossRef Medline · DOI
- Gold C, Henze DA, Koch C, Buza ´aki G (2006) On the origin of the extracel- lular action potential waveform: a modeling study. J Neurophysiol 95: 3113-3128. CrossRef Medline · DOI
- Gonza ´lez-Burgos G, Krimer LS, Povysheva NV, Barrionuevo G, Lewis DA (2005) Functional properties of fast spiking interneurons and their syn- aptic connections with pyramidal cells in primate dorsolateral prefrontal cortex. J Neurophysiol 93:942-953. CrossRef Medline · DOI
- Gray CM, McCormick DA (1996) Chattering cells: superficial pyramidal neurons contributing to the generation of synchronous oscillations in the visual cortex. Science 274:109 -113. CrossRef Medline · DOI
- Guo W, Chambers AR, Darrow KN, Hancock KE, Shinn-Cunningham BG, Polley DB (2012) Robustness of cortical topography across fields, lami- nae, anesthetic states, and neurophysiological signal types. J Neurosci 32:9159 -9172. CrossRef Medline · DOI
- Hama H, Kurokawa H, Kawano H, Ando R, Shimogori T, Noda H, Fukami K, Sakaue-Sawano A, Miyawaki A (2011) Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain. Nat Neurosci 14:1481-1488. CrossRef Medline · DOI
- Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle DR, Arber S (2005) A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol 3:e159. CrossRef Medline · DOI
- Hofer SB, Ko H, Pichler B, Vogelstein J, Ros H, Zeng H, Lein E, Lesica NA, Mrsic-Flogel TD (2011) Differential connectivity and response dynam- ics of excitatory and inhibitory neurons in visual cortex. Nat Neurosci 14:1045-1052. CrossRef Medline · DOI · Paper page
- Hroma ´dka T, Deweese MR, Zador AM (2008) Sparse representation of sounds in the unanesthetized auditory cortex. PLoS Biol 6:e16. CrossRef Medline · DOI
- Isaacson JS, Scanziani M (2011) How inhibition shapes cortical activity. Neuron 72:231-243. CrossRef Medline · DOI · Paper page
- Ison JR, Allen PD, O'Neill WE (2007) Age-related hearing loss in C57BL/6J mice has both frequency-specific and nonfrequency-specific components that produce a hyperacusis-like exaggeration of the acoustic startle reflex. J Assoc Res Otolaryngol 8:539 -550. CrossRef Medline · DOI
- Kawaguchi Y, Kubota Y (1997) GABAergic cell subtypes and their synaptic connections in rat frontal cortex. Cereb Cortex 7:476 -486. CrossRef Medline · DOI · Paper page
- Kerlin AM, Andermann ML, Berezovskii VK, Reid RC (2010) Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex. Neuron 67:858 -871. CrossRef Medline · DOI · Paper page
- Kuhlman SJ, Huang ZJ (2008) High-resolution labeling and functional ma- nipulation of specific neuron types in mouse brain by Cre-activated viral gene expression. PLoS One 3:e2005. CrossRef Medline · DOI
- Kuhlman SJ, Tring E, Trachtenberg JT (2011) Fast-spiking interneurons have an initial orientation bias that is lost with vision. Nat Neurosci 14: 1121-1123. CrossRef Medline · DOI
- Kurt S, Crook JM, Ohl FW, Scheich H, Schulze H (2006) Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuc- ulline and gabazine in sensory cortex. Hear Res 212:224 -235. CrossRef Medline · DOI
- Levy RB, Reyes AD (2011) Coexistence of lateral and co-tuned inhibitory con- figurations in cortical networks. PLoS Comput Biol 7:e1002161. CrossRef Medline · DOI
- Levy RB, Reyes AD (2012) Spatial profile of excitatory and inhibitory syn- aptic connectivity in mouse primary auditory cortex. J Neurosci 32:5609 - 5619. CrossRef Medline · DOI
- Lima SQ, Hroma ´dka T, Znamenskiy P, Zador AM (2009) PINP: a new method of tagging neuronal populations for identification during in vivo electrophysiological recording. PLoS One 4:e6099. CrossRef Medline · DOI
- Liu BH, Li P, Li YT, Sun YJ, Yanagawa Y, Obata K, Zhang LI, Tao HW (2009) Visual receptive field structure of cortical inhibitory neurons revealed by two-photon imaging guided recording. J Neurosci 29:10520 -10532. CrossRef Medline · DOI
- Ma WP, Liu BH, Li YT, Huang ZJ, Zhang LI, Tao HW (2010) Visual repre- sentations by cortical somatostatin inhibitory neurons: selective but with weak and delayed responses. J Neurosci 30:14371-14379. CrossRef Medline · DOI
- Madisen L et al. (2012) A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci 15:793-802. CrossRef Medline · DOI · Paper page
- Madisen L, Zwingman TA, Sunkin SM, Oh SW, Zariwala HA, Gu H, Ng LL, Palmiter RD, Hawrylycz MJ, Jones AR, Lein ES, Zeng H (2010) A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13:133-140. CrossRef Medline · DOI · Paper page
- Niell CM, Stryker MP (2008) Highly selective receptive fields in mouse vi- sual cortex. J Neurosci 28:7520 -7536. CrossRef Medline · DOI · Paper page
- Nowak LG, Azouz R, Sanchez-Vives MV, Gray CM, McCormick DA (2003) Electrophysiological classes of cat primary visual cortical neurons in vivo as revealed by quantitative analyses. J Neurophysiol 89:1541-1566. CrossRef Medline · DOI
- Nowak LG, Sanchez-Vives MV, McCormick DA (2008) Lack of orientation and direction selectivity in a subgroup of fast-spiking inhibitory interneu- rons: cellular and synaptic mechanisms and comparison with other elec- trophysiological cell types. Cereb Cortex 18:1058 -1078. CrossRef Medline · DOI
- Oswald AM, Reyes AD (2008) Maturation of intrinsic and synaptic proper- ties of layer 2/3 pyramidal neurons in mouse auditory cortex. J Neuro- physiol 99:2998 -3008. CrossRef Medline · DOI
- Oswald AM, Schiff ML, Reyes AD (2006) Synaptic mechanisms underlying auditory processing. Curr Opin Neurobiol 16:371-376. CrossRef Medline · DOI
- Phillips DP, Orman SS, Musicant AD, Wilson GF (1985) Neurons in the cat's primary auditory cortex distinguished by their responses to tones and wide-spectrum noise. Hear Res 18:73-86. CrossRef Medline · DOI
- Polley DB, Heiser MA, Blake DT, Schreiner CE, Merzenich MM (2004) As- sociative learning shapes the neural code for stimulus magnitude in pri- mary auditory cortex. Proc Natl Acad Sci U S A 101:16351-16356. CrossRef Medline · DOI
- Polley DB, Steinberg EE, Merzenich MM (2006) Perceptual learning directs auditory cortical map reorganization through top-down influences. J Neurosci 26:4970 -4982. CrossRef Medline · DOI
- Rabinowitz NC, Willmore BD, Schnupp JW, King AJ (2011) Contrast gain control in auditory cortex. Neuron 70:1178 -1191. CrossRef Medline · DOI
- Rothschild G, Nelken I, Mizrahi A (2010) Functional organization and pop- ulation dynamics in the mouse primary auditory cortex. Nat Neurosci 13:353-360. CrossRef Medline · DOI
- Scholl B, Gao X, Wehr M (2008) Level dependence of contextual modula- tion in auditory cortex. J Neurophysiol 99:1616 -1627. CrossRef Medline · DOI
- Sutter ML, Loftus WC (2003) Excitatory and inhibitory intensity tuning in auditory cortex: evidence for multiple inhibitory mechanisms. J Neuro- physiol 90:2629 -2647. CrossRef Medline · DOI
- Swadlow HA (2003) Fast-spike interneurons and feed-forward inhibition in sensory neocortex. Cereb Cortex 13:25-32. CrossRef Medline · DOI
- Tan AY, Wehr M (2009) Balanced tone-evoked synaptic excitation and in- hibition in mouse auditory cortex. Neuroscience 163:1302-1315. CrossRef Medline · DOI
- Tan AY, Zhang LI, Merzenich MM, Schreiner CE (2004) Tone-evoked ex- citatory and inhibitory synaptic conductances of primary auditory cortex neurons. J Neurophysiol 92:630 -643. CrossRef Medline · DOI
- Tan AY, Atencio CA, Polley DB, Merzenich MM, Schreiner CE (2007) Un- balanced synaptic inhibition can create intensity-tuned auditory cortex neurons. Neuroscience 146:449 -462. CrossRef Medline · DOI
- Tanahira C, Higo S, Watanabe K, Tomioka R, Ebihara S, Kaneko T, Tama- maki N (2009) Parvalbumin neurons in the forebrain as revealed by parvalbumin-cre transgenic mice. Neurosci Res 63:213-223. CrossRef Medline · DOI
- Thomson AM, Lamy C (2007) Functional maps of neocortical local cir- cuitry. Front Neurosci 1:19 -42. CrossRef Medline · DOI · Paper page
- Wang J, Caspary D, Salvi RJ (2000) GABA-A antagonist causes dramatic expan- sion of tuning in primary auditory cortex. Neuroreport 11:1137-1140. CrossRef Medline · DOI · Paper page
- Wang Y, Gupta A, Toledo-Rodriguez M, Wu CZ, Markram H (2002a) An- atomical, physiological, molecular and circuit properties of nest basket cells in the developing somatosensory cortex. Cereb Cortex 12:395-410. CrossRef Medline · DOI
- Wang J, McFadden SL, Caspary D, Salvi R (2002b) Gamma-aminobutyric acid circuits shape response properties of auditory cortex neurons. Brain Res 944:219 -231. CrossRef Medline · DOI
- Watkins PV, Barbour DL (2011) Rate-level responses in awake marmoset auditory cortex. Hear Res 275:30 -42. CrossRef Medline · DOI
- Wehr M, Zador AM (2003) Balanced inhibition underlies tuning and sharp- ens spike timing in auditory cortex. Nature 426:442-446. CrossRef Medline · DOI
- Wilson NR, Runyan CA, Wang FL, Sur M (2012) Division and subtraction by distinct cortical inhibitory networks in vivo. Nature 488:343-348. CrossRef Medline · DOI · Paper page
- Wu GK, Li P, Tao HW, Zhang LI (2006) Nonmonotonic synaptic excitation and imbalanced inhibition underlying cortical intensity tuning. Neuron 52:705-715. CrossRef Medline · DOI
- Wu GK, Arbuckle R, Liu BH, Tao HW, Zhang LI (2008) Lateral sharpening of cortical frequency tuning by approximately balanced inhibition. Neu- ron 58:132-143. CrossRef Medline · DOI
- Yang Y, DeWeese MR, Otazu GH, Zador AM (2008) Millisecond-scale dif- ferences in neural activity in auditory cortex can drive decisions. Nat Neurosci 11:1262-1263. CrossRef Medline · DOI
- Yoshimura Y, Dantzker JL, Callaway EM (2005) Excitatory cortical neurons form fine-scale functional networks. Nature 433:868 -873. CrossRef Medline · DOI
- Zariwala HA, Madisen L, Ahrens KF, Bernard A, Lein ES, Jones AR, Zeng H (2011) Visual tuning properties of genetically identified layer 2/3 neuro- nal types in the primary visual cortex of cre-transgenic mice. Front Syst Neurosci 4:162. CrossRef Medline · DOI
- Zhang LI, Tan AY, Schreiner CE, Merzenich MM (2003) Topography and synaptic shaping of direction selectivity in primary auditory cortex. Na- ture 424:201-205. CrossRef Medline · DOI
- 13723a • J. Neurosci., August 21, 2013 • 33(34):13713-13723 Moore and Wehr • PV Neurons in Auditory Cortex
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- Authors
- Moore, A. K., & Wehr, M.
- Affiliations
- University of Oregon (US)
- ORCID
- Wehr, Michael
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-08-21
- Volume
- 33
- Issue
- 34
- Pages
- 13713-13723
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3755717
- OpenAlex
- W2065355492
- Cited by
- 225
- References
- 10
- Citations by year
- 2026: 4 · 2025: 20 · 2024: 22 · 2023: 20 · 2022: 16 · 2021: 11 · 2020: 26 · 2019: 15 · 2018: 18 · 2017: 18 · 2016: 20 · 2015: 16 · 2014: 19
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Whitehall Foundation
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders (R01DC011379)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- parvalbumin interneurons, auditory cortex, frequency tuning, GABAergic interneurons, cortical inhibition, receptive fields, gain control, response latency, temporal precision, channelrhodopsin-2
- MeSH terms
- Channelrhodopsins, Acoustic Stimulation, Action Potentials, Animals, Auditory Cortex, Auditory Perception, Female, Interneurons, Male, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Parvalbumins, Photic Stimulation, Reaction Time, Patch-Clamp Techniques, Statistics, Nonparametric, Green Fluorescent Proteins, Mice, Optogenetics
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