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Cited by 82Attention Deficit Hyperactivity DisorderNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

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ADHD related behaviors are associated with brain activation in the reward system

Stark, R., Bauer, E., Merz, C.J., Zimmermann, M., Reuter, M., Plichta, M.M., Kirsch, P., Lesch, K.P., Fallgatter, A.J., Vaitl, D., Herrmann, M.J.·2011·Neuropsychologia
DOI 10.1016/j.neuropsychologia.2010.12.012
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Abstract

Neuroimaging studies on attention-deficit/hyperactivity disorder (ADHD) suggest dysfunctional reward processing, with hypo-responsiveness during reward anticipation in the reward system including the nucleus accumbens (NAcc). In this study, we investigated the association between ADHD related behaviors and the reward system using functional magnetic resonance imaging in a non-clinical sample. Participants were 31 healthy, female undergraduate students with varying levels of self-reported ADHD related behaviors measured by the adult ADHD self-report scale. The anticipation of different types of reward was investigated: monetary reward, punishment avoidance, and verbal feedback. All three reward anticipation conditions were found to be associated with increased brain activation in the reward system, with the highest activation in the monetary reward anticipation condition, followed by the punishment avoidance anticipation condition, and the lowest activation in the verbal feedback anticipation condition. Most interestingly, in all three conditions, NAcc activation was negatively correlated with ADHD related behaviors. In conclusion, our results from a non-clinical sample are in accordance with reported deficits in the reward system in ADHD patients: the higher the number and severity of ADHD related behaviors, the lower the neural responses in the dopaminergic driven reward anticipation task. Thus, our data support current aetiological models of ADHD which assume that deficits in the reward system might be responsible for many of the ADHD related behaviors.

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Metadata

Authors
Stark, R., Bauer, E., Merz, C. J., Zimmermann, M., Reuter, M., Plichta, M. M., Kirsch, P., Lesch, K. P., Fallgatter, A. J., Vaitl, D., & Herrmann, M. J.
Affiliations
  • Justus-Liebig-Universität Gießen (DE)
  • University of Bonn (DE)
  • University of Würzburg (DE)
  • Central Institute of Mental Health (DE)
  • University of Tübingen (DE)
Corresponding author
Stark, R.
ORCID
Venue
Neuropsychologia
Publisher
Elsevier BV
Published
2011-02
Volume
49
Issue
3
Pages
426-434
ISSN
0028-3932 (ISSN-L)
DOI
10.1016/j.neuropsychologia.2010.12.012
OpenAlex
W2006397164
Cited by
82
References
65
Citations by year
2026: 9 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 8 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 14
FWCI
5.01
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropsychologia (publishedVersion)
  • PubMed (publishedVersion)
Funders
German Research Foundation
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
attention deficit hyperactivity disorder, reward processing, reward anticipation, nucleus accumbens, brain activation, monetary rewards, punishment avoidance, verbal feedback, dopaminergic reward system, non-clinical sample, female undergraduates
MeSH terms
Attention Deficit Disorder with Hyperactivity, Behavior, Brain, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Motivation, Neuropsychological Tests, Nucleus Accumbens, Psychomotor Performance, Reaction Time, Reinforcement, Psychology, Reward, Feedback, Psychological, Diagnostic and Statistical Manual of Mental Disorders, Young Adult

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