Depression symptoms and cognitive control of emotion cues: a functional magnetic resonance imaging study
Open accessAbstract
Few studies have examined associations between depressive symptoms and alterations in neural systems that subserve cognitive control. Cognitive control was assessed with an exogenous cueing task using happy, sad, and neutral facial expressions as cues among women with mild to moderate symptoms of depression and a non-depressed control group while functional magnetic resonance imaging (fMRI) measured brain activity. Amygdala and medial/orbital prefrontal cortex (PFC) response to valid emotion cues did not differ as a function of depression symptoms. However, significant depression group differences were observed when task demands required cognitive control. Participants with elevated depression symptoms showed weaker activation in right and left lateral PFC and parietal regions when shifting attentional focus away from invalid emotion cues. No depression group differences were observed for invalid non-emotional cues. Findings suggest that mild to moderate depression symptoms are associated with altered function in brain regions that mediate cognitive control of emotional information.
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This deficit in inhibitory regulation by the anterior cingulate and prefrontal results in an overactive amygdala as well as biases in memory towards negative stimuli and away from positive stimuli.
“This deficit in inhibitory regulation by the anterior cingulate and prefrontal results in an overactive amygdala as well as biases in memory towards negative stimuli and away from positive stimuli [57–60].”
From Association between time perspective and metacognition among Lebanese adults: the mediating role of mindfulness (2023) · cites this paper as [60]
The Abstract and Discussion (page unavailable) report weaker lateral prefrontal activation during cognitive control of emotional cues in women with mild to moderate depressive symptoms. They do not establish an anterior cingulate deficit or a bias in memory toward negative and away from positive stimuli. The study found no depression-group difference in amygdala activity, so it does not support the claimed resulting overactive amygdala. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn depressed individuals, processing of negative information is associated with stronger and longer-lasting amygdala activation.
“Among individuals with depression, processing of negative information is associated with stronger and longer lasting activation of the amygdala (Beevers et al., 2010; Drevets, 2001; Fu et al., 2004; Siegle et al., 2002; Stuhrmann et al., 2013), a region responsible for interpreting the emotional quality and salience of a given stimulus (Fu et al., 2004).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Beevers et al., 2010
Past studies have found impairments in cognitive control in individuals with depression when they are confronted with emotional information.
“Past studies have found impairments in cognitive control in individuals with depression when confronted with emotional information (Beevers et al. 2010; Ditcher et al. 2009; Fales et al. 2008).”
From Executive Function Deficits in Daily Life Prospectively Predict Increases in Depressive Symptoms (2014) · cites this paper as Beevers et al. 2010
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Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
The attention system of the human brain
Posner, M. I., & Petersen, S. E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000325 · Cited by 8,070 · see citing works
MacDonald, A. W., Cohen, J. D., Stenger, V. A., & Carter, C. S. (2000) · Science · doi:10.1126/science.288.5472.1835 · Cited by 3,666 · see citing works
The NimStim set of facial expressions: Judgments from untrained research participants.
Tottenham, N., Tanaka, J. W., Leon, A. C., McCarry, T., Nurse, M., Hare, T. A., Marcus, D. J., Westerlund, A., Casey, B., & Nelson, C. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.05.006 · Cited by 3,454 · see citing works
Prefrontal-Subcortical Pathways Mediating Successful Emotion Regulation
Wager, T. D., Davidson, M. L., Hughes, B. L., Lindquist, M. A., & Ochsner, K. N. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.006 · Cited by 1,761 · see citing works
Attentional biases for negative interpersonal stimuli in clinical depression
Gotlib, I. H., Krasnoperova, E., Yue, D. N., & Joormann, J. (2004) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.113.1.121 · Cited by 911 · see citing works
Siegle, G. J., Thompson, W., Carter, C. S., Steinhauer, S. R., & Thase, M. E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.048 · Cited by 857 · see citing works
Interference resolution: Insights from a meta-analysis of neuroimaging tasks
NEE, D. E., WAGER, T. D., & JONIDES, J. (2007) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.7.1.1 · Cited by 798 · see citing works
Aron, A. R., & Poldrack, R. A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.026 · Cited by 602 · see citing works
Adolescent psychopathology: II. Psychosocial risk factors for depression.
Lewinsohn, P. M., ROBERTS, R. E., Seeley, J. R., Rohde, P., Gotlib, I. H., & Hops, H. (1994) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.103.2.302 · Cited by 565 · see citing works
Shortening the CES-D to improve its ability to detect cases of depression.
Santor, D. A., & Coyne, J. C. (1997) · Psychological Assessment · doi:10.1037/1040-3590.9.3.233 · Cited by 422 · see citing works
Adolescent psychopathology: II. Psychosocial risk factors for depression.
Lewinsohn, P. M., ROBERTS, R. E., Seeley, J. R., et al. (1994) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.103.2.302 · Cited by 414 · see citing works
Koster, E. H. W., De Raedt, R., Goeleven, E., Franck, E., & Crombez, G. (2005) · Emotion · doi:10.1037/1528-3542.5.4.446 · Cited by 397 · see citing works
Neural Substrates of Increased Memory Sensitivity for Negative Stimuli in Major Depression
Hamilton, J. P., & Gotlib, I. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.12.015 · Cited by 345 · see citing works
Liotti, M., Mayberg, H. S., McGinnis, S., Brannan, S. L., & Jerabek, P. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1830 · Cited by 331 · see citing works
Wang, L., LaBar, K. S., Smoski, M., Rosenthal, M. Z., Dolcos, F., Lynch, T. R., Krishnan, R. R., & McCarthy, G. (2008) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.10.004 · Cited by 210 · see citing works
Dozois, D., & Dobson, K. (2001) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.110.2.236 · Cited by 192 · see citing works
Dozois, D. J. A., & Dobson, K. S. (2001) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.110.2.236 · Cited by 180 · see citing works
The inventory to diagnose depression, lifetime version
Zimmerman, M. B., & Coryell, W. H. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb02824.x · Cited by 162 · see citing works
Affective context interferes with cognitive control in unipolar depression: an fMRI investigation
Dichter, G. S., Felder, J. N., & Smoski, M. J. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.06.027 · Cited by 99 · see citing works
Screening for Depression Prevention: Identifying Adolescent Girls at High Risk for Future Depression
Seeley, J., Stice, E., & Rohde, P. (2009) · Journal of Abnormal Psychology · doi:10.1037/a0014741 · Cited by 88 · see citing works
Self-citationEmslie (1998) · doi:10.1002/(sici)1520-6394(1998)7:1
Flagged first, then by citations
Cited by
Sorted by citations
Neural mechanisms of the cognitive model of depression.
Disner, S. G., Beevers, C. G., Haigh, E. A. P., & Beck, A. T. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3027 · Cited by 1,718 · see citing works
Self-citationMillan, M. J., Agid, Y., Brüne, M., Bullmore, E. T., Carter, C. S., Clayton, N. S., Connor, R., Davis, S., Deakin, B., DeRubeis, R. J., et al. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3628 · Cited by 1,292 · see citing works
Cognitive theory and therapy of anxiety and depression: Convergence with neurobiological findings
Clark, D. A., & Beck, A. T. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.06.007 · Cited by 619 · see citing works
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works
Beevers, C. G., Clasen, P. C., Enock, P. M., & Schnyer, D. M. (2015) · Journal of Abnormal Psychology · doi:10.1037/abn0000049 · Cited by 192 · see citing works
Self-citationDooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176 · see citing works
Lei, Y., Wang, J., Wang, D., Li, C., Liu, B., Fang, X., You, J., Guo, M., & Lu, X.-Y. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0352-1 · Cited by 131 · see citing works
Cognitive Control in Depression: Toward Clinical Models Informed by Cognitive Neuroscience
Grahek, I., Everaert, J., Krebs, R. M., & Koster, E. H. W. (2018) · Clinical Psychological Science · doi:10.1177/2167702618758969 · Cited by 101 · see citing works
Roberts-Wolfe, D., Sacchet, M., Hastings, E., Roth, H., & Britton, W. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00015 · Cited by 79 · see citing works
“, 2004) and biases in attention and memory away from positive stimuli and toward negative stimuli (Fales et al., 2008; Beevers et al., 2010; Koster et al., 2010).”
BackgroundRzepa, E., Fisk, J., & McCabe, C. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881116681416 · Cited by 68 · see citing works
Almeida, J. R. C. D., Kronhaus, D. M., Sibille, E. L., Langenecker, S. A., Versace, A., LaBarbara, E. J., & Phillips, M. L. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00069 · Cited by 64 · see citing works
Executive Function Deficits in Daily Life Prospectively Predict Increases in Depressive Symptoms
Letkiewicz, A. M., Miller, G. A., Crocker, L. D., Warren, S. L., Infantolino, Z. P., Mimnaugh, K. J., & Heller, W. (2014) · Cognitive Therapy and Research · doi:10.1007/s10608-014-9629-5 · Cited by 63 · see citing works
Cognitive behavioural therapy for depression: systematic review of imaging studies
Franklin, G., Carson, A. J., & Welch, K. A. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.41 · Cited by 63 · see citing works
Li, H., Wei, D., Browning, M., Du, X., Zhang, Q., & Qiu, J. (2016) · Psychological Medicine · doi:10.1017/s003329171500238x · Cited by 59 · see citing works
Imaging the neural effects of cognitive bias modification training
Wiers, C. E., & Wiers, R. W. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.07.041 · Cited by 52 · see citing works
Chahine, A., El Zouki, C.-J., Mhanna, M., Hallit, S., & Obeid, S. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-05356-w · Cited by 4 · see citing works
- Authors
- Beevers, C. G., Clasen, P., Stice, E., & Schnyer, D.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Beevers, C.G.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 167
- Issue
- 1
- Pages
- 97-103
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC2840066
- OpenAlex
- W2125072783
- Cited by
- 108
- References
- 23
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 6 · 2019: 12 · 2018: 9 · 2017: 11 · 2016: 9 · 2015: 11 · 2014: 12 · 2013: 4 · 2012: 5
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH076897)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, cognitive control, emotion cues, facial expressions, cue validity, attentional shift, amygdala, medial prefrontal cortex, lateral prefrontal cortex, parietal cortex, emotional processing, women
- MeSH terms
- Adolescent, Adult, Amygdala, Brain Mapping, Cognition, Cues, Depression, Emotions, Facial Expression, Female, Humans, Magnetic Resonance Imaging, Neural Pathways, Neuropsychological Tests, Parietal Lobe, Visual Perception, Prefrontal Cortex, Young Adult
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