Cited by 231Toxic Organic Pollutants ImpactIon channel regulation and functionCardiac electrophysiology and arrhythmias

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Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity

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Pessah, Isaac N., Cherednichenko, Gennady, Lein, Pamela J.·2010·Pharmacology & Therapeutics

DOI 10.1016/j.pharmthera.2009.10.009PMC PMC2823855

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Abstract

Chronic low-level polychlorinated biphenyl (PCB) exposures remain a significant public health concern since results from epidemiological studies indicate that PCB burden is associated with immune system dysfunction, cardiovascular disease, and impairment of the developing nervous system. Of these various adverse health effects, developmental neurotoxicity has emerged as a particularly vulnerable endpoint in PCB toxicity. Arguably the most pervasive biological effects of PCBs could be mediated by their ability to alter the spatial and temporal fidelity of Ca2+ signals through one or more receptor-mediated processes. This review will focus on our current knowledge of the structure and function of ryanodine receptors (RyRs) in muscle and nerve cells and how PCBs and related non-coplanar structures alter these functions. The molecular and cellular mechanisms by which non-coplanar PCBs and related structures alter local and global Ca2+ signaling properties and the possible short and long-term consequences of these perturbations on neurodevelopment and neurodegeneration are reviewed.

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Authors: Pessah, I. N., Cherednichenko, G., & Lein, P. J.
Affiliations: University of California, Davis (US)
Corresponding author: Pessah, Isaac N.
ORCID: Pessah, Isaac N.
Lein, Pamela J.
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2010-02
Volume: 125
Issue: 2
Pages: 260-285
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/j.pharmthera.2009.10.009
PMC: PMC2823855
OpenAlex: W2171969201
Cited by: 231
References: 452
Citations by year: 2026: 2 · 2025: 8 · 2024: 4 · 2023: 12 · 2022: 12 · 2021: 9 · 2020: 18 · 2019: 15 · 2018: 19 · 2017: 22 · 2016: 14 · 2015: 15 · 2014: 19 · 2013: 15 · 2012: 27
FWCI: 1.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Environmental Health Sciences (1 P01-ES11269, P42-ES-04699, P42ES004699, P01ES011269, R01ES014901)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: polychlorinated biphenyls, ryanodine receptor, calcium signaling, developmental neurotoxicity, neurodegeneration, intracellular calcium stores, immune dysfunction, cardiovascular disease
MeSH terms: Calcium, Environmental Pollutants, Humans, Polychlorinated Biphenyls, Structure-Activity Relationship, Ryanodine Receptor Calcium Release Channel

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Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity

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