Cited by 137Cancer Immunotherapy and BiomarkersLung Cancer Treatments and MutationsFerroptosis and cancer prognosis

Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms

Huang, Mu-Yang, Jiang, Xiao-Ming, Wang, Bing-Lin, Sun, Yang, Lu, Jin-Jian·2021·Pharmacology & Therapeutics

Abstract

Programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade has been approved as the standard-of-care for the treatment of non-small cell lung cancer (NSCLC). Yet, the population of patients who benefit from the treatment remains modest, some of whom would get relapsed and progressed eventually. Combination therapy has emerged as an effective way to broaden beneficiaries from PD-1/PD-L1 immunotherapy and overcome or delay the resistance. In this review, we discuss the PD-1/PD-L1 blockade in combination with conventional chemotherapy, targeted therapy or immunotherapy. Meanwhile, we illustrate their underlying mechanisms in regulating the process of the cancer-immunity cycle, providing the rationale for the PD-1/PD-L1 blockade-based combination therapy. The challenges of combination regimens are also addressed.

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Crossref · 10.1016/j.pharmthera.2020.107694

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Authors
Huang, M.-Y., Jiang, X.-M., Wang, B.-L., Sun, Y., & Lu, J.-J.
Affiliations
  • University of Macau (MO)
  • State Key Laboratory of Pharmaceutical Biotechnology (CN)
Corresponding author
Lu, Jin-Jian
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2021-03
Volume
219
Pages
107694
ISSN
0163-7258 (ISSN-L)
OpenAlex
W3089009365
Cited by
136
References
142
Citations by year
2026: 14 · 2025: 14 · 2024: 24 · 2023: 40 · 2022: 28 · 2021: 14 · 2020: 1
FWCI
2.23
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Universidade de Macau
  • National Natural Science Foundation of China
Topics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
Keywords
PD-1/PD-L1 blockade, non-small cell lung cancer, combination therapy, cancer immunotherapy, combination chemotherapy, combination targeted therapy, immunotherapy resistance, cancer-immunity cycle, immune checkpoint inhibitors
MeSH terms
Carcinoma, Non-Small-Cell Lung, Humans, Immunotherapy, Lung Neoplasms, B7-H1 Antigen, Programmed Cell Death 1 Receptor

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