Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms
Abstract
Programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade has been approved as the standard-of-care for the treatment of non-small cell lung cancer (NSCLC). Yet, the population of patients who benefit from the treatment remains modest, some of whom would get relapsed and progressed eventually. Combination therapy has emerged as an effective way to broaden beneficiaries from PD-1/PD-L1 immunotherapy and overcome or delay the resistance. In this review, we discuss the PD-1/PD-L1 blockade in combination with conventional chemotherapy, targeted therapy or immunotherapy. Meanwhile, we illustrate their underlying mechanisms in regulating the process of the cancer-immunity cycle, providing the rationale for the PD-1/PD-L1 blockade-based combination therapy. The challenges of combination regimens are also addressed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The timing and sequence of combination therapy also influence treatment toxicity.
“Additionally, the timing and sequence of combination therapy also influence treatment toxicity, which should be further validated in clinical studies [186, 207].”
From Combination strategies with PD-1/PD-L1 blockade: current advances and future directions (2022) · cites this paper as [186]
The modest efficacy of α-PD-1/PD-L1 in EGFR-mutated patients might be attributed to lack of concurrent TIL and PD-L1 expression, low tumor mutation burden, or increased Tregs in the TME.
“which might be attributed to the lack of concurrent TIL and PD-L1 expression, low tumor mutation burden, or increased Tregs in the TME [186].”
From Combination strategies with PD-1/PD-L1 blockade: current advances and future directions (2022) · cites this paper as [186]
Cites
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109 · see citing works
Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer
Reck, M., Rodríguez-Abreu, D., Robinson, A. G., Hui, R., Csőszi, T., Fülöp, A., Gottfried, M., Peled, N., Tafreshi, A., Cuffe, S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1606774 · Cited by 10,089 · see citing works
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer
Brahmer, J., Reckamp, K. L., Baas, P., Crinò, L., Eberhardt, W. E. E., Poddubskaya, E., Antonia, S., Pluzanski, A., Vokes, E. E., Holgado, E., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504627 · Cited by 8,447 · see citing works
Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994 · see citing works
Oncology meets immunology: the cancer-immunity cycle.
Chen, D. S., & Mellman, I. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.012 · Cited by 6,929 · see citing works
Cancer immunotherapy using checkpoint blockade
Ribas, A., & Wolchok, J. D. (2018) · Science · doi:10.1126/science.aar4060 · Cited by 6,791 · see citing works
Pembrolizumab plus chemotherapy in metastatic non–small-cell lung cancer
Gandhi, L., Rodríguez-Abreu, D., Gadgeel, S., Esteban, E., Felip, E., De Angelis, F., Domine, M., Clingan, P., Hochmair, M. J., Powell, S. F., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1801005 · Cited by 6,607 · see citing works
Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer
Garon, E. B., Rizvi, N. A., Hui, R., Leighl, N., Balmanoukian, A. S., Eder, J. P., Patnaik, A., Aggarwal, C., Gubens, M., Horn, L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1501824 · Cited by 6,198 · see citing works
Understanding the tumor immune microenvironment (TIME) for effective therapy
Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0014-x · Cited by 6,145 · see citing works
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400 · see citing works
The biology and management of non-small cell lung cancer
Herbst, R. S., Morgensztern, D., & Boshoff, C. (2018) · Nature · doi:10.1038/nature25183 · Cited by 4,891 · see citing works
Rittmeyer, A., Barlési, F., Waterkamp, D., Park, K., Ciardiello, F., von Pawel, J., Gadgeel, S. M., Hida, T., Kowalski, D. M., Cobo, M., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)32517-x · Cited by 4,684 · see citing works
Innate and adaptive immune cells in the tumor microenvironment
Gajewski, T. F., Schreiber, H., & Fu, Y.-X. (2013) · Nature Immunology · doi:10.1038/ni.2703 · Cited by 4,148 · see citing works
Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC
Socinski, M. A., Jotte, R. M., Cappuzzo, F., Orlandi, F., Stroyakovskiy, D., Nogami, N., Rodríguez-Abreu, D., Moro-Sibilot, D., Thomas, C. A., Barlesi, F., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1716948 · Cited by 3,733 · see citing works
Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer
Paz-Ares, L., Luft, A., Vicente, D., Tafreshi, A., Gümüş, M., Mazières, J., Hermes, B., Çay Şenler, F., Csőszi, T., Fülöp, A., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1810865 · Cited by 3,617 · see citing works
Mok, T. S. K., Wu, Y.-L. L. C., Kudaba, I., Kowalski, D. M., Cho, B. C., Turna, H. Z., de Castro, G., Srimuninnimit, V., Лактионов, К. К., Bondarenko, I., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32409-7 · Cited by 3,319 · see citing works
Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden
Hellmann, M. D., Ciuleanu, T.-E., Pluzanski, A., Lee, J. S., Otterson, G. A., Audigier-Valette, C., Minenza, E., Linardou, H., Burgers, S., Salman, P., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1801946 · Cited by 3,063 · see citing works
Nivolumab plus ipilimumab in advanced non-small-cell lung cancer
Hellmann, M. D., Paz-Ares, L., Bernabe Caro, R., Zurawski, B., Kim, S.-W., Carcereny Costa, E., Park, K., Alexandru, A., Lupinacci, L., de la Mora Jimenez, E., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1910231 · Cited by 2,823 · see citing works
Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC
Antonia, S. J., Villegas, A., Daniel, D., Vicente, D., Murakami, S., Hui, R., Kurata, T., Chiappori, A., Lee, K. H., de Wit, M., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1809697 · Cited by 2,798 · see citing works
Marabelle, A., Fakih, M., Lopez, J., Shah, M., Shapira-Frommer, R., Nakagawa, K., Chung, H. C., Kindler, H. L., Lopez-Martin, J. A., Miller, W. H., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30445-9 · Cited by 2,552 · see citing works
The Clinical KRAS(G12C) Inhibitor AMG 510 Drives Anti-Tumour Immunity
Canon, J., Rex, K., Saiki, A. Y., Mohr, C., Cooke, K., Bagal, D., Gaida, K., Holt, T., Knutson, C. G., Koppada, N., et al. (2019) · Nature · doi:10.1038/s41586-019-1694-1 · Cited by 2,277 · see citing works
Regulation and Function of the PD-L1 Checkpoint
Sun, C., Mezzadra, R., & Schumacher, T. N. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.014 · Cited by 2,187 · see citing works
Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation
Anderson, A. C., Joller, N., & Kuchroo, V. K. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.001 · Cited by 2,096 · see citing works
Natural Innate and Adaptive Immunity to Cancer
Vesely, M. D., Kershaw, M. H., Schreiber, R. D., & Smyth, M. J. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101324 · Cited by 2,095 · see citing works
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges
Fukumura, D., Kloepper, J., Amoozgar, Z., Duda, D. G., & Jain, R. K. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2018.29 · Cited by 2,027 · see citing works
Non-small-cell lung cancers: a heterogeneous set of diseases
Chen, Z., Brainson, C. F., Hammerman, P. S., Kim, C. F., & Wong, K. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3775 · Cited by 1,936 · see citing works
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
Tauriello, D. V. F., Palomo-Ponce, S., Stork, D., Berenguer-Llergo, A., Badia-Ramentol, J., Iglesias, M., Sevillano, M., Ibiza, S., Cañellas, A., Hernando-Momblona, X., et al. (2018) · Nature · doi:10.1038/nature25492 · Cited by 1,851 · see citing works
Single-cell RNA sequencing to explore immune cell heterogeneity
Papalexi, E., & Satija, R. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.76 · Cited by 1,806 · see citing works
Cancer immunoediting and resistance to T cell-based immunotherapy
O’Donnell, J. S., Teng, M. W. L., & Smyth, M. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0142-8 · Cited by 1,759 · see citing works
West, H., McCleod, M., Hussein, M., Morabito, A., Rittmeyer, A., Conter, H. J., Kopp, H.-G., Daniel, D., McCune, S., Mekhail, T., et al. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30167-6 · Cited by 1,662 · see citing works
Woo, S.-R., Turnis, M. E., Goldberg, M. V., Bankoti, J., Selby, M., Nirschl, C. J., Bettini, M. L., Gravano, D. M., Vogel, P., Liu, C. L., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-1620 · Cited by 1,647 · see citing works
<i>STK11/LKB1</i> Mutations and PD-1 Inhibitor Resistance in <i>KRAS</i> -Mutant Lung Adenocarcinoma
Skoulidis, F., Goldberg, M. E., Greenawalt, D. M., Hellmann, M. D., Awad, M. M., Gainor, J. F., Schrock, A. B., Hartmaier, R. J., Trabucco, S. E., Gay, L., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0099 · Cited by 1,641 · see citing works
Koyama, S., Akbay, E. A., Li, Y. Y., Herter-Sprie, G. S., Buczkowski, K. A., Richards, W. G., Gandhi, L., Redig, A. J., Rodig, S. J., Asahina, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms10501 · Cited by 1,580 · see citing works
Mazières, J., Drilon, A. E. D. C., Lusque, A., Mhanna, L., Cortot, A. B., Mezquita, L., Thai, A. A., Mascaux, C., Couraud, S., Veillon, R., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz167 · Cited by 1,356 · see citing works
Combination cancer immunotherapy and new immunomodulatory targets
Mahoney, K. M., Rennert, P. D., & Freeman, G. J. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4591 · Cited by 1,294 · see citing works
Gainor, J. F., Shaw, A. T., Sequist, L. V. D., Fu, X., Azzoli, C. G., Piotrowska, Z., Huynh, T. G., Zhao, L., Fulton, L. E., Schultz, K. R., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-3101 · Cited by 1,256 · see citing works
CTLA-4: a moving target in immunotherapy
Rowshanravan, B., Halliday, N., & Sansom, D. M. (2018) · Blood · doi:10.1182/blood-2017-06-741033 · Cited by 1,233 · see citing works
Cytokines in clinical cancer immunotherapy
Berraondo, P., Sanmamed, M. F., Ochoa, M. C., Etxeberría, I., Aznar, M. A., Perez‐Gracia, J. L., Rodriguez-Ruiz, M. E., Ponz‐Sarvisé, M., Álvarez, E. C., & Melero, I. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0328-y · Cited by 1,190 · see citing works
Targeting KRAS mutant cancers with a covalent G12C-specific inhibitor
Janes, M. R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S. J., Darjania, L., et al. (2018) · Cell · doi:10.1016/j.cell.2018.01.006 · Cited by 1,172 · see citing works
Gadgeel, S. M., Rodríguez‐Abreu, D., Speranza, G., Esteban, E., Felip, E., Dómine, M., Hui, R., Hochmair, M. J., Clingan, P. R., Powell, S. F., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.19.03136 · Cited by 1,114 · see citing works
Reck, M., Mok, T. S. K., Nishio, M., Jotte, R. M., Cappuzzo, F., Orlandi, F., Stroyakovskiy, D., Nogami, N., Rodríguez‐Abreu, D., Moro‐Sibilot, D., et al. (2019) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(19)30084-0 · Cited by 953 · see citing works
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
Melero, I., Shuford, W. W., Newby, S. A., Aruffo, A. A., Ledbetter, J. A., Hellström, K. E., Mittler, R. S., & Chen, L. (1997) · Nature Medicine · doi:10.1038/nm0697-682 · Cited by 899 · see citing works
LAG3 (CD223) as a Cancer Immunotherapy Target
Andrews, L. P., Marciscano, A., Drake, C., & Vignali, D. A. A. (2017) · Immunological Reviews · doi:10.1111/imr.12519 · Cited by 881 · see citing works
Kamphorst, A. O., Pillai, R. N., Yang, S., Nasti, T. H., Akondy, R. S., Wieland, A., Sica, G. L., Yu, K., Koenig, L., Patel, N. T., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705327114 · Cited by 854 · see citing works
Checkpoint inhibitors in metastatic EGFR-mutated non–small cell lung cancer-a meta-analysis
Lee, C. K., Man, J., Lord, S., Links, M., Gebski, V., Mok, T., & Yang, J. C.-H. (2017) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.10.007 · Cited by 839 · see citing works
The Interplay of Immunotherapy and Chemotherapy: Harnessing Potential Synergies
Emens, L. A., & Middleton, G. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0064 · Cited by 830 · see citing works
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
Li, X., Wenes, M., Romero, P. J., Huang, S. C., Fendt, S., & Ho, P. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0203-7 · Cited by 745 · see citing works
Ebert, P. J. R., Cheung, J., Yang, Y., McNamara, E., Hong, R., Moskalenko, M., Gould, S. E., Maecker, H., Irving, B. A., Kim, J. M., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.024 · Cited by 713 · see citing works
Ma, Y., Adjemian, S., Mattarollo, S. R., Yamazaki, T., Aymeric, L., Yang, H., Catani, J. P. P., Hannani, D., Duret, H., Steegh, K., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.003 · Cited by 698 · see citing works
Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa
Khan, K. A., & Kerbel, R. S. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2018.9 · Cited by 661 · see citing works
Jotte, R. M., Cappuzzo, F., Vynnychenko, I. O., Stroyakovskiy, D., Rodríguez‐Abreu, D., Hussein, M., Soo, R. A., Conter, H. J., Kozuki, T., Huang, K.-C., et al. (2020) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.03.028 · Cited by 603 · see citing works
Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape
Wellenstein, M. D., & de Visser, K. E. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.004 · Cited by 581 · see citing works
Lisberg, A., Cummings, A., Goldman, J. W., Bornazyan, K., Reese, N., Wang, T., Coluzzi, P., Ledezma, B., Mendenhall, M., Hunt, J., et al. (2018) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.03.035 · Cited by 580 · see citing works
PARP inhibition elicits STING-dependent antitumor immunity in brca1-deficient ovarian cancer
Ding, L., Kim, H.-J., Wang, Q., Kearns, M., Jiang, T., Ohlson, C. E., Li, B. B., Xie, S., Liu, J. F., Stover, E. H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.054 · Cited by 572 · see citing works
Discovery of IDO1 Inhibitors: From Bench to Bedside
Prendergast, G. C., Malachowski, W. P., DuHadaway, J. B., & Muller, A. J. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-2285 · Cited by 563 · see citing works
Improving immune–vascular crosstalk for cancer immunotherapy
Huang, Y., Kim, B. Y. S., Chan, C. K., Hahn, S. M., Weissman, I. L., & Jiang, W. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.145 · Cited by 563 · see citing works
Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer
Kitajima, S., Ivanova, E., Guo, S., Yoshida, R., Campisi, M., Sundararaman, S. K., Tange, S., Mitsuishi, Y., Thai, T. C., Masuda, S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0689 · Cited by 526 · see citing works
Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
Allard, B., Pommey, S., Smyth, M. J., & Stagg, J. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0545 · Cited by 459 · see citing works
Inflammation-driven carcinogenesis is mediated through STING
Ahn, J., Xia, T., Konno, H., Konno, K., Ruiz, P., & Barber, G. N. (2014) · Nature Communications · doi:10.1038/ncomms6166 · Cited by 446 · see citing works
Oxnard, G. R., Yang, J. C.-H., Yu, H., Kim, S.-W., Saka, H., Horn, L., Goto, K., Ohe, Y., Mann, H., Thress, K. S., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.01.013 · Cited by 438 · see citing works
Severe immune-related adverse events are common with sequential PD-(L)1 blockade and osimertinib
Schoenfeld, A. J., Arbour, K. C., Rizvi, H., Iqbal, A. N., Gadgeel, S. M., Girshman, J., Kris, M. G., Riely, G. J., Yu, H. A., & Hellmann, M. D. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz077 · Cited by 406 · see citing works
The promise and challenges of immune agonist antibody development in cancer
Mayes, P. A., Hance, K. W., & Hoos, A. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.75 · Cited by 355 · see citing works
Cisplatin-Induced Antitumor Immunomodulation: A Review of Preclinical and Clinical Evidence
de Biasi, A. R., Villena-Vargas, J., & Adusumilli, P. S. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1298 · Cited by 342 · see citing works
Beavis, P. A., Milenkovski, N., Henderson, M. A., John, L. B., Allard, B., Loi, S., Kershaw, M. H., Stagg, J., & Darcy, P. K. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0211 · Cited by 331 · see citing works
Making the first move in EGFR-driven or ALK-driven NSCLC: first-generation or next-generation TKI?
Recondo, G., Facchinetti, F., Olaussen, K. A., Besse, B., & Friboulet, L. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0081-4 · Cited by 321 · see citing works
Zhao, S., Ren, S., Jiang, T., Zhu, B., Li, X., Zhao, C., Jia, Y., Shi, J., Zhang, L., Liu, X., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0640 · Cited by 320 · see citing works
Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40
Messenheimer, D. J., Jensen, S. M., Afentoulis, M. E., Wegmann, K. W., Feng, Z., Friedman, D. J., Gough, M. J., Urba, W. J., & Fox, B. A. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2677 · Cited by 319 · see citing works
Oshima, Y., Tanimoto, T., Yuji, K., & Tojo, A. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2017.4526 · Cited by 313 · see citing works
Targeting metabolism to regulate immune responses in autoimmunity and cancer
Patel, C. H., Leone, R. D., Horton, M. R., & Powell, J. D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0032-5 · Cited by 307 · see citing works
The therapeutic potential of targeting tryptophan catabolism in cancer
Opitz, C. A., Somarribas Patterson, L. F., Mohapatra, S. R., Dewi, D. L., Sadik, A., Platten, M., & Trump, S. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0664-6 · Cited by 300 · see citing works
Sugiyama, E., Togashi, Y., Takeuchi, Y., Shinya, S., Tada, Y., Kataoka, K., Tane, K., Sato, E., Ishii, G., Goto, K., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aav3937 · Cited by 290 · see citing works
Hyperprogressive disease during PD-1/PD-L1 blockade in patients with non-small-cell lung cancer
Kim, C. G., Kim, K. H., Pyo, K., Xin, C.-F., Hong, M. H., Ahn, B., Kim, Y., Choi, S. J., Yoon, H. I., Lee, J. G., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz123 · Cited by 282 · see citing works
Herbst, R. S., Garon, E. B., Kim, D., Cho, B. C., Perez‐Gracia, J. L., Han, J., Arvis, C. D., Majem, M., Forster, M. D., Monnet, I., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.19.02446 · Cited by 282 · see citing works
Targeted Therapy and Checkpoint Immunotherapy Combinations for the Treatment of Cancer
Hughes, P. E., Caenepeel, S. R., & Wu, L. C. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.04.010 · Cited by 280 · see citing works
He, Y., Yu, H., Rozeboom, L. M., Rivard, C. J., Ellison, K. E., Dziadziuszko, R., Suda, K., Ren, S., Wu, C., Hou, L., et al. (2017) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2017.01.019 · Cited by 269 · see citing works
Herbst, R. S., Arkenau, H., Santana-Dávila, R., Calvo, E., Paz-Ares, L. G., Cassier, P. A., Bendell, J. C., Penel, N., Krebs, M., Martín-Liberal, J., et al. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30458-9 · Cited by 268 · see citing works
Immunogenic cell death in anticancer chemotherapy and its impact on clinical studies
Wang, Q., Ju, X., Wang, J., Fan, Y. J., Ren, M., & Zhang, H. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.08.028 · Cited by 265 · see citing works
STING activation in cancer immunotherapy
Su, T., Zhang, Y. L., Valerie, K. C., Wang, X., Lin, S., & Zhu, G. (2019) · Theranostics · doi:10.7150/thno.37574 · Cited by 258 · see citing works
Fournel, L., Wu, Z., Stadler, N., Damotte, D., Lococo, F., Boulle, G., Ségal-Bendirdjian, E., Bobbio, A., Icard, P., Trédaniel, J., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.08.005 · Cited by 249 · see citing works
Lind, H., Gameiro, S. R., Jochems, C., Donahue, R. N., Strauss, J., Gulley, J. L., Palena, C., & Schlom, J. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000433 · Cited by 247 · see citing works
Rossi, A., & Maïo, M. D. (2016) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2016.1170596 · Cited by 246 · see citing works
Predictive Markers for the Efficacy of Anti–PD-1/PD-L1 Antibodies in Lung Cancer
Shukuya, T., & Carbone, D. P. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.02.015 · Cited by 245 · see citing works
Rodríguez‐Abreu, D., Johnson, M. L., Hussein, M., Cobo, M., Patel, A. J., Sečen, N., Lee, K. H., Massutí, B., Hiret, S., Yang, J. C.-H., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.2020.38.15_suppl.9503 · Cited by 244 · see citing works
Manegold, C., Dingemans, A. C., Gray, J. E., Nakagawa, K., Nicolson, M. C., Peters, S., Reck, M., Wu, Y.-L. L. C., Brustugun, O. T., Crinò, L., et al. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.10.003 · Cited by 239 · see citing works
Humanized Mouse Xenograft Models: Narrowing the Tumor–Microenvironment Gap
Morton, J. J., Bird, G. A., Refaeli, Y., & Jimeno, A. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1260 · Cited by 238 · see citing works
Diab, A., Tannir, N. M., Bentebibel, S.-E., Hwu, P., Papadimitrakopoulou, V., Haymaker, C., Kluger, H. M., Gettinger, S. N., Sznol, M., Tykodi, S. S., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1510 · Cited by 237 · see citing works
Bancroft, C. C., Chen, Z., Yeh, J., Sunwoo, J. B., Yeh, N. T., Jackson, S., Jackson, C. R., & Waes, C. V. (2002) · International Journal of Cancer · doi:10.1002/ijc.10398 · Cited by 230 · see citing works
Garassino, M. C., Gadgeel, S. M., Esteban, E., Felip, E., Speranza, G., Dómine, M., Hochmair, M. J., Powell, S. F., Cheng, S. Y.-S., Bischoff, H. G., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30801-0 · Cited by 215 · see citing works
CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment
Neo, S., Yang, Y., Record, J., Ma, R., Chen, X., Chen, Z., Tobin, N. P., Blake, E., Seitz, C., Thomas, R., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128895 · Cited by 205 · see citing works
Paz-Ares, L. G., Kim, T. M., Vicente, D., Felip, E., Lee, D. H., Lee, K. H., Lin, C., Flor, M. J., Nicola, M. D., Alvarez, R. M., et al. (2020) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.03.003 · Cited by 205 · see citing works
Leonetti, A., Wever, B. M. M., Mazzaschi, G., Assaraf, Y. G., Rolfo, C. D., Quaini, F., Tiseo, M., & Giovannetti, E. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100644 · Cited by 201 · see citing works
Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes
Wong, D. Y. Q., Ong, W. W. F., & Ang, W. H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201500934 · Cited by 186 · see citing works
David, J. M., Dominguez, C., McCampbell, K. K., Gulley, J. L., Schlom, J., & Palena, C. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1349589 · Cited by 180 · see citing works
Nivolumab Plus Erlotinib in Patients With EGFR-Mutant Advanced NSCLC
Gettinger, S. N., Hellmann, M. D., Chow, L. Q. M., Borghaei, H., Antonia, S. J., Brahmer, J. R., Goldman, J. W., Gerber, D. E., Juergens, R. A., Shepherd, F. A., et al. (2018) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.05.015 · Cited by 180 · see citing works
STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype
Corte, C. M. D., Sen, T., Gay, C. M., Ramkumar, K., Diao, L., Cardnell, R. J., Rodriguez, B. L., Stewart, C. A., Papadimitrakopoulou, V. A., Gibson, L., et al. (2020) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.01.009 · Cited by 180 · see citing works
Jia, Y., Li, X., Jiang, T., Zhao, S., Zhao, C., Zhang, L., Liu, X., Shi, J., Qiao, M., Luo, J., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32191 · Cited by 164 · see citing works
Shrimali, R. K., Ahmad, S., Verma, V., Zeng, P., Ananth, S., Gaur, P., Gittelman, R. M., Yusko, E. C., Sanders, C. M., Robins, H. S., et al. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0292 · Cited by 161 · see citing works
Targeting the CD73-adenosine axis in immuno-oncology
Allard, D., Chrobák, P., Allard, B., Messaoudi, N., & Stagg, J. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.05.001 · Cited by 161 · see citing works
Spigel, D. R., de Marinis, F., Giaccone, G., Reinmuth, N., Vergnenégre, A., Barrios, C. H., Morise, M., Felip, E., Andric, Z. G., Geater, S. L., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz293 · Cited by 146 · see citing works
Combining chemotherapy with PD-1 blockade in NSCLC
Mathew, M., Enzler, T., Shu, C. A., & Rizvi, N. A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.003 · Cited by 145 · see citing works
CD73–Adenosine: A Next-Generation Target in Immuno-Oncology
Allard, D., Allard, B., Gaudreau, P.-O., Chrobák, P., & Stagg, J. (2016) · Immunotherapy · doi:10.2217/imt.15.106 · Cited by 140 · see citing works
Lin, J. J., Chin, E., Yeap, B. Y., Ferris, L. A., Kamesan, V., Lennes, I. T., Sequist, L. V., Heist, R. S., Mino-Kenudson, M., Gainor, J. F., et al. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.09.001 · Cited by 140 · see citing works
Hong, S., Chen, N., Fang, W., Zhan, J., Liu, Q., Kang, S., He, X., Liu, L., Zhou, T., Huang, J., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1094598 · Cited by 136 · see citing works
Gettinger, S. N., Wurtz, A., Goldberg, S. B., Rimm, D. L., Schalper, K. A., Kaech, S. M., Kavathas, P., Chiang, A. C., Lilenbaum, R., Zelterman, D. A., et al. (2018) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.03.008 · Cited by 135 · see citing works
The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy
Schaer, D. A., Geeganage, S., Amaladas, N., Lu, Z. H., Rasmussen, E. R., Sonyi, A., Chin, D., Capen, A., Li, Y., Meyer, C. M., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0433 · Cited by 132 · see citing works
The Macrophage ‘Do not eat me’ signal, CD47, is a clinically validated cancer immunotherapy target
Takimoto, C. H. M., Chao, M. P., Gibbs, C., Mccamish, M. A., Liu, J., Chen, J. Y., Majeti, R., & Weissman, I. L. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz006 · Cited by 128 · see citing works
Heist, R. S., Duda, D. G., Sahani, D. V., Ancukiewicz, M., Fidias, P., Sequist, L. V., Temel, J. S., Shaw, A. T., Pennell, N. A., Neal, J. W., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424024112 · Cited by 126 · see citing works
KRAS as a druggable target in NSCLC: Rising like a phoenix after decades of development failures
Friedlaender, A., Drilon, A., Weiss, G. J., Banna, G. L., & Addeo, A. (2020) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.101978 · Cited by 118 · see citing works
Pharmacological Modulation of the STING Pathway for Cancer Immunotherapy
Berger, G., Marloye, M., & Lawler, S. E. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.02.007 · Cited by 116 · see citing works
Immune Marker Profiling and Programmed Death Ligand 1 Expression Across NSCLC Mutations
Toki, M. I., Mani, N. L., Smithy, J. W., Liu, Y., Altan, M., Wasserman, B. E., Tuktamyshov, R., Schalper, K. A., Syrigos, K. N., & Rimm, D. L. (2018) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.09.012 · Cited by 111 · see citing works
Alshaker, H. A., & Matalka, K. Z. (2011) · Cancer Cell International · doi:10.1186/1475-2867-11-33 · Cited by 106 · see citing works
Gabryšová, L., Christensen, J. R., Wu, X., Kissenpfennig, A., MALISSEN, B., & O’Garra, A. (2011) · European Journal of Immunology · doi:10.1002/eji.201041073 · Cited by 94 · see citing works
Mazières, J., Kowalski, D. M., Luft, A. V., Vicente, D., Tafreshi, A., Gümüş, M., Лактионов, К. К., Hermes, B., Çiçin, İ., Rodríguez‐Cid, J. R., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.19.01348 · Cited by 90 · see citing works
Liu, S.-Y., Dong, Z.-Y., Wu, S.-P., Xie, Z., Yan, L.-X., Li, Y.-F., Yan, H.-H., Su, J., Yang, J.-J., Zhou, Q., et al. (2018) · Lung Cancer · doi:10.1016/j.lungcan.2018.09.010 · Cited by 85 · see citing works
Co-Stimulatory Receptors in Cancers and Their Implications for Cancer Immunotherapy
Jeong, S., & Park, S. (2020) · Immune Network · doi:10.4110/in.2020.20.e3 · Cited by 75 · see citing works
Progress in targeting RAS with small molecule drugs
McCormick, F. P. (2019) · Biochemical Journal · doi:10.1042/bcj20170441 · Cited by 63 · see citing works
Azpilikueta, A., Agorreta, J., Labiano, S., Perez‐Gracia, J. L., Sánchez-Paulete, A. R., Aznar, M. A., Ajona, D., Bazo, I. G., Larráyoz, M., Teijeira, Á., et al. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.01.013 · Cited by 61 · see citing works
Ghosh, S., Sharma, G., Travers, J., Kumar, S., Choi, J., Jun, H. T., Kehry, M. R., Ramaswamy, S., & Jenkins, D. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0836 · Cited by 61 · see citing works
Efficacy of a Cancer Vaccine against ALK -Rearranged Lung Tumors
Voena, C., Menotti, M., Mastini, C., Giacomo, F. D., Longo, D. L., Castella, B., Merlo, M. E. B., Ambrogio, C., Wang, Q., Minero, V. G., et al. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0089 · Cited by 60 · see citing works
Shaw, A. T., Lee, S., Ramalingam, S. S., Bauer, T. M., Boyer, M. J., Carcereny, E., Felip, E., Han, J., Hida, T., Hughes, B. G. M., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.36.15_suppl.9008 · Cited by 60 · see citing works
Kim, D., Gadgeel, S. M., Gettinger, S. N., Riely, G. J., Oxnard, G. R., Mekhail, T. M., Schmid, P., Dowlati, A., Heist, R. S., Wozniak, A. J., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.36.15_suppl.9009 · Cited by 48 · see citing works
Tao, L., Huang, G., Shi, S., & Chen, L. (2013) · Medical Oncology · doi:10.1007/s12032-013-0777-3 · Cited by 45 · see citing works
Liu, Z., Han, C., Dong, C., Shen, A., Hsu, E. J., Ren, Z., Lu, C., Liu, L., Zhang, A., Timmerman, C., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav6473 · Cited by 41 · see citing works
Hellmann, M. D., Gettinger, S. N., Chow, L. Q. M., Gordon, M. S., Awad, M. M., Cha, E., Gong, X., Zhou, G., Walker, C., Leopold, L. H., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.32951 · Cited by 39 · see citing works
Felip, E., de Braud, F., Maur, M., Loong, H. H.-F., Shaw, A. T., Vansteenkiste, J., John, T., Liu, G., Lolkema, M. P., Scott, J. W., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.35.15_suppl.2502 · Cited by 37 · see citing works
Perdrizet, K., & Leighl, N. B. (2019) · Current Treatment Options in Oncology · doi:10.1007/s11864-019-0617-6 · Cited by 35 · see citing works
Patel, S. P., Pakkala, S., Pennell, N. A., Reckamp, K. L., Lanzalone, S., Polli, A., Tarazi, J., & Robert-Vizcarrondo, F. (2020) · The Oncologist · doi:10.1634/theoncologist.2020-0034 · Cited by 34 · see citing works
Mutant KRAS at the heart of tumor immune evasion
van Maldegem, F., & Downward, J. (2020) · Immunity · doi:10.1016/j.immuni.2019.12.013 · Cited by 32 · see citing works
Jia, Y., Zhao, S., Jiang, T., Li, X., Zhao, C., Liu, Y., Han, R., Qiao, M., Liu, S., Su, C., et al. (2019) · Lung Cancer · doi:10.1016/j.lungcan.2019.09.016 · Cited by 27 · see citing works
Thress, K. S., Jacobs, V. N., Angell, H. K., Yang, J. C., Sequist, L. V. D., Blackhall, F. H., Su, W., Schüler, M., Wolf, J., Gold, K. A., et al. (2017) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2017.07.011 · Cited by 25 · see citing works
Zhou, C., Gao, G., Wu, F., Chen, X., Li, W., Xiong, A., Su, C., Cai, W., Ren, S., Jiang, T., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.36.15_suppl.e21017 · Cited by 15 · see citing works
Rudin, C., Cervantes, A., Dowlati, A., Besse, B., Ma, B., Costa, D., Schmid, P., Heist, R., Villaflor, V., Sarkar, I., et al. (2017) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.11.1841 · Cited by 14 · see citing works
Herbst, R. S., Martín-Liberal, J., Calvo, E., Isambert, N., Bendell, J. C., Cassier, P. A., Jin, J., Mi, G., Rege, J. M., & Paz-Ares, L. G. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx091.010 · Cited by 13 · see citing works
IMpower150: Analysis of efficacy in patients (pts) with liver metastases (mets).
Socinski, M. A., Jotte, R. M., Cappuzzo, F., Mok, T. S. K., West, H., Nishio, M., Papadimitrakopoulou, V. A., Orlandi, F., Stroyakovskiy, D., Thomas, C. A., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.2019.37.15_suppl.9012 · Cited by 9 · see citing works
Cho, B. C., Kim, T. M., Vicente, D., Felip, E., Lee, D. H., Lee, K. H., Lin, C., Flor, M. J., Nicola, M. A. D., Alvarez, R. M., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.2020.38.15_suppl.9558 · Cited by 9 · see citing works
Yoo, C., Oh, D., Choi, H. J., Kudo, M., Ueno, M., Kondo, S., Chen, L., Osada, M., Helwig, C., Dussault, I., et al. (2019) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn.2019.ab053 · Cited by 7 · see citing works
Yoo, C., Oh, D., Choi, H. J., Kudo, M., Ueno, M., Kondo, S., Chen, L.-T., Osada, M., Helwig, C., Dussault, I., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy432.005 · Cited by 4 · see citing works
Yap, T. A., Gainor, J. F., Callahan, M. K., Falchook, G. S., Pachynski, R. K., LoRusso, P. M., Kummar, S., Gibney, G. T., Burris, H. A., Tykodi, S. S., et al. (2019) · Cancer Research · doi:10.1158/1538-7445.am2019-ct189 · Cited by 2 · see citing works
Ouwens, M., Darilay, A. T., Zhang, Y., Mukhopadhyay, P., Mann, H., Ryan, J., & Dennis, P. A. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz067 · Cited by 1 · see citing works
Flagged first, then by citations
3 of the 142 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Combination strategies with PD-1/PD-L1 blockade: current advances and future directions
Yi, M., Zheng, X., Niu, M., Zhu, S., Ge, H., & Wu, K. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01489-2 · Cited by 1,445 · see citing works
Co-inhibition of TIGIT and PD-1/PD-L1 in Cancer Immunotherapy: Mechanisms and Clinical Trials
Chu, X., Tian, W., Wang, Z., Zhang, J., & Zhou, R. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01800-3 · Cited by 222 · see citing works
Ashrafi, A., Akter, Z., Modareszadeh, P., Modareszadeh, P., Berisha, E., Alemi, P. S., Castro, M. D. C. C., Deese, A. R., & Li, Z. (2022) · Cancers · doi:10.3390/cancers14194562 · Cited by 193 · see citing works
Li, Y., Mao, T., Wang, J., Zheng, H., Hu, Z., Cao, P., Yang, S., Zhu, L., Guo, S., Zhao, X., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01082-8 · Cited by 116 · see citing works
Jiang, T., Wang, P., Zhang, J., Zhao, Y., Zhou, J., Fan, Y., Shu, Y., Liu, X., Zhang, H., He, J., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00751-9 · Cited by 92 · see citing works
Cancer-associated fibroblasts in non-small cell lung cancer: Recent advances and future perspectives
Zhang, H., Jiang, H., Zhu, L., Li, J., & Ma, S. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.009 · Cited by 84 · see citing works
Huang, M., Chen, Y., Lyu, W.-Y., He, X., Ye, Z.-H., Huang, C.-Y., He, X., Chen, X., Chen, X., Zhang, B., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106988 · Cited by 70 · see citing works
Self-citationTaurine enhances the antitumor efficacy of PD-1 antibody by boosting CD8+ T cell function
Yü, P., Shan, J., Liu, Y., Liu, F., Wang, L., Liu, Z., Li, J., Yue, D., Wang, L., Chen, X., et al. (2022) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-022-03308-z · Cited by 59 · see citing works
Zhang, Y., Hu, J., Ji, K., Jiang, S., Dong, Y., Sun, L., Wang, J., Hu, G., Chen, D., Chen, K., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101151 · Cited by 61 · see citing works
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Chen, M., Bie, L., & Ying, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115514 · Cited by 59 · see citing works
Yang, Z., Wu, G., Zhang, X., Gao, J., Meng, C., Liu, Y., Wei, Q., Sun, L., Wei, P., Bai, Z., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1001444 · Cited by 56 · see citing works
Zheng, J., Huang, J., Zhang, L., Wang, M., Xu, L., Dou, X., Leng, X., Fang, M., Sun, Y., & Wang, Z. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00350-5 · Cited by 54 · see citing works
Self-citationMyricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells
Chen, Y., He, X., Lu, Q., Shi, W., Yuan, L., Huang, M., Xu, Y., Chen, X., Gu, L., Zhang, L., et al. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114940 · Cited by 48 · see citing works
Self-citationSun, Z., Mai, H., Xue, C., Fan, Z., Li, J., Chen, H., Huo, N., Kang, X., Tang, C., Fang, L., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-007415 · Cited by 48 · see citing works
Lu, Y., Zhong, W., Liu, Y., chen, W., zhang, J., Zeng, Z., Huang, H., qiao, Y., Wan, X., Meng, X., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108504 · Cited by 48 · see citing works
Radiological artificial intelligence - predicting personalized immunotherapy outcomes in lung cancer
Roisman, L. C., Kian, W., Anoze, A., Fuchs, V., Spector, M., Steiner, R., Kassel, L., Rechnitzer, G., Fried, I., Peled, N., et al. (2023) · npj Precision Oncology · doi:10.1038/s41698-023-00473-x · Cited by 43 · see citing works
Jiang, A., Wang, J., Liu, N., Zheng, X., Li, Y., Ma, Y., Zheng, H., Chen, X., Fan, C., Zhang, R., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.833797 · Cited by 42 · see citing works
Ye, Z.-H., Yu, W., Huang, M., Chen, J., & Lu, J. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.12.016 · Cited by 40 · see citing works
Self-citationGong, C., Ruiz-Martínez, Á., Kimko, H. H. C., & Popel, A. S. (2021) · Cancers · doi:10.3390/cancers13153751 · Cited by 39 · see citing works
Bie, F., Tian, H., Sun, N., Zang, R., Zhang, M., Song, P., Liu, L., Peng, Y., Bai, G., Zhou, B., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.769124 · Cited by 39 · see citing works
Wu, Y., Hao, X., Wei, H., Sun, R., Chen, Y., & Tian, Z. (2022) · Hepatology · doi:10.1002/hep.32715 · Cited by 35 · see citing works
Modern therapies of nonsmall cell lung cancer
Jachowski, A., Marcinkowski, M., Szydłowski, J., Grabarczyk, O., Nogaj, Z., Marcin, L. P., Pławski, A., Jagodziński, P. P., & Słowikowski, B. K. (2023) · Journal of Applied Genetics · doi:10.1007/s13353-023-00786-4 · Cited by 35 · see citing works
Yu, D., Yang, P., Lu, X., Huang, S., Liu, L., & Fan, X. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01184-3 · Cited by 30 · see citing works
Huang, Z., Zeng, L., Ruan, Z., Zeng, Q., Yan, H., Jiang, W., Yi, X., Zhou, C., Yang, H., Liu, L. K., et al. (2026) · Nature Medicine · doi:10.1038/s41591-025-04181-w · Cited by 30 · see citing works
RetractedResearch Progress on Nanoparticles-Based CRISPR/Cas9 System for Targeted Therapy of Tumors
Nie, D., Guo, T., Yue, M., Li, W., Zong, X., Zhu, Y., Huang, J., & Lin, M. (2022) · Biomolecules · doi:10.3390/biom12091239 · Cited by 32 · see citing works
Godiyal, Y., Maheshwari, D., Taniguchi, H., Zinzuwadia, S. S., Díaz, Y. M., Tewari, D., & Bishayee, A. (2024) · Military Medical Research · doi:10.1186/s40779-024-00586-9 · Cited by 31 · see citing works
Immunology and immunotherapy in gastric cancer
Xu, X., Chen, J., Li, W., Feng, C., Liu, Q., Gao, W., & He, M. S. (2023) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-01104-2 · Cited by 28 · see citing works
Lin, A., Zhang, H., Meng, H., Deng, Z., Gu, T., Luo, P., & Zhang, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.667875 · Cited by 27 · see citing works
Sex Difference of Colon Adenoma Pathway and Colorectal Carcinogenesis
Choi, Y., & Kim, N. (2023) · The World Journal of Men s Health · doi:10.5534/wjmh.230085 · Cited by 30 · see citing works
A target map of clinical combination therapies in oncology: an analysis of clinicaltrials.gov
Yang, J., Kang, H., Lyu, L., Xiong, W., & Yuanjia, H. (2023) · Discover Oncology · doi:10.1007/s12672-023-00758-4 · Cited by 25 · see citing works
Cheng, Y., Song, Z., Chen, J., Tang, Z., & Wang, B. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25895 · Cited by 25 · see citing works
Self-citationPD ‐1: A critical player and target for immune normalization
Liu, X., Zhao, A., Xiao, S., Li, H., Li, M., Guo, W., & Han, Q. (2024) · Immunology · doi:10.1111/imm.13755 · Cited by 26 · see citing works
Ni, J., Zhou, Y., Wu, L., Ai, X., Dong, X., Chu, Q., Han, C., Wang, X., & Zhu, Z. (2021) · Radiation Oncology · doi:10.1186/s13014-021-01905-3 · Cited by 24 · see citing works
Ouyang, X., Zhu, R., Lin, L., Wang, X., Zhuang, Q., & Hu, D. (2023) · Metabolites · doi:10.3390/metabo13020142 · Cited by 24 · see citing works
Bai, X., Li, Q., Peng, X., Li, X., Qiao, C., Tang, Y., & Zhao, R. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09928-z · Cited by 24 · see citing works
Song, L., Wang, X., Wang, C., Wu, Y. M., Liu, M., Liu, R., Zhang, S., Hong, X., Liu, H., Tai, X., et al. (2021) · BMC Pulmonary Medicine · doi:10.1186/s12890-021-01796-w · Cited by 23 · see citing works
Deng, Y., Zhao, L., Huang, X., Zeng, Y., Xiong, Z., & Zuo, M. (2022) · Nutrition · doi:10.1016/j.nut.2022.111829 · Cited by 23 · see citing works
New prospects of cancer therapy based on pyroptosis and pyroptosis inducers
Chen, Q., Sun, Y., Wang, S., & Xu, J. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01906-5 · Cited by 23 · see citing works
Self-citationAliaga, P. T., Spitaleri, G., Attili, I., Corvaja, C., Battaiotto, E., Angelopoulos, P. A., Signore, E. D., Passaro, A., & de Marinis, F. (2025) · Molecules · doi:10.3390/molecules30122645 · Cited by 22 · see citing works
Zhao, J., Yu, X., Huang, D., Ma, Z., Gao, B., Cui, J., Chu, Q., Zhou, Q. H., Sun, M., Day, D., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006055 · Cited by 22 · see citing works
Ailia, M. J., Heo, J., & Yoo, S. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076495 · Cited by 22 · see citing works
Jia, L., Chen, N., Chen, X., Niu, C. S., Liu, Z., Ma, K., Wang, N., Yang, L., Zhao, Y., Song, W., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1074906 · Cited by 21 · see citing works
Self-citationGuo, Q., Liu, X., Liu, H.-S., Luo, X., Yuan, Y., Ji, Y., Liu, T., Guo, J., & Zhang, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4022896 · Cited by 20 · see citing works
RetractedLi, Y., Guo, R., Bie, Z., Li, B., & Li, X. (2021) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2021.08.019 · Cited by 20 · see citing works
Chu, X., Qiang, H., Xie, M., Li, X., Zhao, J., Wu, Y., Zhou, J., Ye, J., Zhao, C., Han, C., et al. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-021-03100-5 · Cited by 19 · see citing works
LIU, L. (2023) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2023.028227 · Cited by 19 · see citing works
Cheng, Y., Han, X., Lai, X., & Wei, X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156093 · Cited by 18 · see citing works
Preliminary anticancer evaluation of new Pd(II) complexes bearing NNO donor ligands
Hussain, S., Hussain, S., Zafar, M. N., Hussain, I., Khan, F., Mughal, E. U., & Tahir, M. N. (2023) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2023.101915 · Cited by 18 · see citing works
Cui, X., Li, C., Ding, J., Yao, Z., Zhao, T., Guo, J., Wang, Y., & Li, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054513 · Cited by 17 · see citing works
Dou, X.-J., Ma, R.-Y., Ren, D.-W., Liu, Q., & Yan, P. (2024) · Lung Cancer Targets and Therapy · doi:10.2147/lctt.s444884 · Cited by 17 · see citing works
Effect of JAK/STAT signaling on anti-PD-L1 immunotherapy efficacy in lung cancer
Yao, Y., Tao, G., Xie, D., Xu, Y., & Liang, L. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104861 · Cited by 16 · see citing works
Pan, S., Meng, H., Fan, T. T., Hao, B., Song, C., Li, D., Li, N., & Geng, Q. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.900159 · Cited by 16 · see citing works
Zhang, L., Zhang, K., Liu, S., Zhang, R., Yang, Y., Wang, Q., Zhao, S., Li, Y., Zhang, Y., & Wang, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.629941 · Cited by 15 · see citing works
Liang, X., Yuan, D., Zhao, S., Zhou, J., Wang, K., Liu, X., Liu, Y., Li, H., Hao, M., Huang, W., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08064-3 · Cited by 14 · see citing works
Liu, Z., Cheng, X., Pang, B., Wang, S., Liu, B., Chen, C., Qian, R., Liang, W., Zhu, Y., Li, P., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108399 · Cited by 14 · see citing works
Ma, N., Qiao, H., Tao, H., Gan, X., Shan, Z., Chen, X., & Zhou, X. (2022) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2022.101962 · Cited by 14 · see citing works
METTL14 regulates CD8+T-cell activation and immune responses to anti‐PD‐1 therapy in lung cancer
Sun, C., Wang, J., Li, H., Liu, L., Lin, Y., Zhang, L., Zu, X., Zhu, Y., Shu, Y., Shen, D., et al. (2024) · World Journal of Surgical Oncology · doi:10.1186/s12957-024-03402-9 · Cited by 13 · see citing works
Wang, H., Li, Z., Ou, S., Song, Y., Luo, K., Guan, Z., Zhao, L., Huang, R., & Yu, S. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.884839 · Cited by 13 · see citing works
Application of Nanoparticles in Tumour Targeted Drug Delivery and Vaccine
Tu, Y., Yao, Z., Yang, W., Tao, S., Li, B., Wang, Y., Su, Z., & Li, S. (2022) · Frontiers in Nanotechnology · doi:10.3389/fnano.2022.948705 · Cited by 12 · see citing works
Villaruz, L. C., Blumenschein, G. R., Otterson, G. A., & Leal, T. A. B. (2023) · Cancer · doi:10.1002/cncr.34683 · Cited by 12 · see citing works
Mao, Z., Jiang, P., Zhang, Y., Li, Y., Jia, X., Wang, Q., Jiao, M., Jiang, L., Shen, Y. L., & Guo, H. (2021) · Cancer Medicine · doi:10.1002/cam4.4405 · Cited by 11 · see citing works
A Novel PD-L1-Containing MSLN Targeting Vaccine for Lung Cancer Immunotherapy
Zeng, W., Pan, J., Fang, Z., Jia, J., Zhang, R., He, M., Zhong, H., He, J., Yang, X., Shi, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.925217 · Cited by 11 · see citing works
Self-citationXiang, Y., Tang, L. C., Pang, H., Han, X., He, Y., Feng, Y., Ju, L., Zhang, L., & Wang, D. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s464830 · Cited by 11 · see citing works
Lin, Y., Wang, Y., Xue, Q., Zheng, Q., Chen, L., Yan, J., Huang, Z., & Li, Y. (2024) · Translational Lung Cancer Research · doi:10.21037/tlcr-23-739 · Cited by 10 · see citing works
Interfacial Peptides as Affinity Modulating Agents of Protein-Protein Interactions
Ershov, P. V., Mezentsev, Y. V., & Ivanov, A. S. (2022) · Biomolecules · doi:10.3390/biom12010106 · Cited by 10 · see citing works
Zou, W., Luo, X., Gao, M., Chang, Y., Wan, X., Yu, S., Wu, Y., Wang, A., Fenical, W., Wei, Z., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16054 · Cited by 10 · see citing works
Siglec 15 as a biomarker or a druggable molecule for non-small cell lung cancer
Moreira, R. S., da Silva, M. M., Vasconcelos, C. F. D. M., da Silva, T. D., Cordeiro, G. G., Mattos, L. A. R., Pitta, M. G. D. R., Rêgo, M. J. B. D. M., & Pereira, M. C. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05437-z · Cited by 9 · see citing works
Liu, J., Mao, Y., Mao, C., Wang, D., Dong, L., & Zhu, W. (2024) · Journal of Immunology Research · doi:10.1155/2024/3604935 · Cited by 9 · see citing works
Zhen, S., Wang, W., Qin, G., Lu, T., Li, Y., & Zhang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1316778 · Cited by 8 · see citing works
β-elemene inhibits tumor-promoting in small cell lung cancer by affecting M2 macrophages and TGF-β
Huang, W., Fu, B., & Xu, H. (2025) · BMC Pulmonary Medicine · doi:10.1186/s12890-025-03533-z · Cited by 8 · see citing works
Li, F., Liao, B.-C., Wang, T., Qi, T., & Wang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.918709 · Cited by 8 · see citing works
Pourali, G., Zafari, N., Velayati, M., Mehrabadi, S., Maftooh, M., Hassanian, S. M., Mobarhan, M. G., Ferns, G. A., Avan, A., & Khazaei, M. (2023) · Current Drug Targets · doi:10.2174/0113894501264450231129042256 · Cited by 8 · see citing works
Zhang, Y., Chen, X., Hu, B., Zou, B., & Xu, Y. (2024) · Nanomedicine · doi:10.1080/17435889.2024.2374230 · Cited by 8 · see citing works
Zhao, Y., Zhang, D., Meng, L., Shan, S., Zhang, C., Deng, Z., Han, C., & Kong, L. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.10.030 · Cited by 7 · see citing works
Stensgaard, S., Thomsen, A., Helstrup, S., Meldgaard, P., & Sørensen, B. S. (2023) · Cancers · doi:10.3390/cancers15235628 · Cited by 6 · see citing works
Luo, Y., Zhang, S., Xie, H., Su, Q., He, S., & Lei, Z. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.14.9 · Cited by 6 · see citing works
Akbar, W., Ehsan, S., Siddique, S. A., Sarfraz, M., Shaheen, F., Shafqat, A., Shahnaz, Siddique, M. B. A., Saeed, A., Al‐Salahi, R. A., et al. (2024) · ACS Omega · doi:10.1021/acsomega.4c01980 · Cited by 6 · see citing works
Development of a Novel Pyroptosis-Associated lncRNA Biomarker Signature in Lung Adenocarcinoma
Wang, P., Wang, Z., Lin, Y., Castellano, L., Stebbing, J., Zhu, L., & Peng, L. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00757-4 · Cited by 6 · see citing works
Sae-Lim, S., Ngiwsara, L., Lirdprapamongkol, K., Puttamuk, T., Maneeanakekul, S., Thangsan, P., Sangsuwan, W., Svasti, J., & Chuawong, P. (2023) · Fitoterapia · doi:10.1016/j.fitote.2023.105781 · Cited by 6 · see citing works
Fu, J., Chen, Y. S., Li, J., Tan, M., Lin, R., Wang, J., Wu, G., Rao, Y., Wu, F., Gao, Y., et al. (2024) · Discover Oncology · doi:10.1007/s12672-024-01233-4 · Cited by 5 · see citing works
Cai, W., Jiang, B., Yin, Y., Ma, L., Li, T., & Chen, J. (2024) · Molecular Diversity · doi:10.1007/s11030-024-11067-5 · Cited by 5 · see citing works
Liu, X., Sui, X.-Y., Xu, Y., Yang, F., Wu, S., Zhu, X.-Z., Zuo, K., Cao, S.-W., Jin, X., Chen, L., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02505-5 · Cited by 4 · see citing works
Zhu, J., Yang, J., Chen, X., Wang, Y., Wang, X., Zhao, M., Li, G., Wang, Y., Zhu, Y., Yan, F., et al. (2024) · Journal of Cancer · doi:10.7150/jca.90768 · Cited by 4 · see citing works
The anticancer mechanisms of Toxoplasma gondii rhoptry protein 16 on lung adenocarcinoma cells
Li, G., Li, Q., Tong, Y., Zeng, J., Dang, T., Yang, N., Zhou, Y., Ma, L., Ge, Q. Y., & Zhao, Z. (2024) · Cancer Biology & Therapy · doi:10.1080/15384047.2024.2392902 · Cited by 4 · see citing works
Zhou, Z., Zheng, Y., Mo, S., Li, S., Zheng, X., Wei, R., Fan, T. T., Chen, T., Xiao, C., Li, C., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.71385 · Cited by 4 · see citing works
Yang, W., Wu, W., Wang, L., Zhang, S., Zhao, J.-J., & Qiang, Y. (2023) · Comput. Biol. Medicine · doi:10.1016/j.compbiomed.2023.107371 · Cited by 4 · see citing works
Dihydrotanshinone I inhibits PHGDH to suppress serine synthesis and remodel TME in NSCLC
Qian, C., Han, H., Wan, L., Huang, Y., Luo, Y., Wang, Z., Peng, C., Gao, M., Fan, W., Lu, Y., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158366 · Cited by 3 · see citing works
Dual blockade of GSTK1 and CD47 improves macrophage-mediated phagocytosis on cancer cells
Yu, W., Ye, Z.-H., Shi, J.-J., Deng, W.-Q., Chen, J., & Lu, J. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116898 · Cited by 3 · see citing works
Self-citationWang, R.-H., Chang, C., Chen, C., Liu, K., & Chao, J. (2023) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520623666230223111217 · Cited by 3 · see citing works
Guo, Y., Chang, G., Wan, R., Zhang, X., Ma, Z., Bai, H., & Wang, J. (2024) · Journal of Cancer · doi:10.7150/jca.93975 · Cited by 4 · see citing works
Research progress of anti-tumor active ingredients in Dandelion
Xie, J., Huang, Y., & Wang, Q. (2020) · Journal of Oncology Research · doi:10.30564/jor.v2i2.2472 · Cited by 3 · see citing works
A computational chemistry-based approach to optimizing PD-1/PD-L1 inhibitors
Zhai, M., Ji, S., Hu, H., Wu, Y., Shi, Y., Zhu, R., Jiang, Y., & Yang, Y. (2025) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1533541 · Cited by 2 · see citing works
Usama, M., Raza, B., Wu, M., & Ji, S. (1970) · Current Drug Targets · doi:10.2174/0113894501414090250903070446 · Cited by 2 · see citing works
Liu, X., Xu, Q., Wang, Y., Wang, C., Liang, W., Huang, L., Lü, L., Lv, J., Gao, J., Yu, B., et al. (2026) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2026.118706 · Cited by 2 · see citing works
Duan, X., Du, H., Qi, R., Yuan, M., & Shi, J. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.11915 · Cited by 2 · see citing works
Firoozi, M., Sadeghi‐Mohammadi, S., Asadi, M., Shekari, N., Nejad, F. S., Alizade‐Harakiyan, M., Soleimani, Z., & Zarredar, H. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3919 · Cited by 2 · see citing works
Zhao, Z., & Yua, Y. (2024) · Technology and Health Care · doi:10.3233/thc-240660 · Cited by 2 · see citing works
Zhao, L., Tang, C., Jin, X. S., Wang, H., Xu, K., Liu, X., Liu, Y., Zhao, W., Zhang, W., Ye, L., et al. (2025) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2025.02.004 · Cited by 2 · see citing works
Liu, M., Zhang, J., Zhao, Y., & Zhang, X. (2024) · Medicine · doi:10.1097/md.0000000000039300 · Cited by 1 · see citing works
Huang, J., & Tian, G. (2026) · Journal of Oncology Pharmacy Practice · doi:10.1177/10781552251414845 · Cited by 1 · see citing works
- Authors
- Huang, M.-Y., Jiang, X.-M., Wang, B.-L., Sun, Y., & Lu, J.-J.
- Affiliations
- University of Macau (MO)
- State Key Laboratory of Pharmaceutical Biotechnology (CN)
- Corresponding author
- Lu, Jin-Jian
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 219
- Pages
- 107694
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W3089009365
- Cited by
- 136
- References
- 142
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 24 · 2023: 40 · 2022: 28 · 2021: 14 · 2020: 1
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universidade de Macau
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Keywords
- PD-1/PD-L1 blockade, non-small cell lung cancer, combination therapy, cancer immunotherapy, combination chemotherapy, combination targeted therapy, immunotherapy resistance, cancer-immunity cycle, immune checkpoint inhibitors
- MeSH terms
- Carcinoma, Non-Small-Cell Lung, Humans, Immunotherapy, Lung Neoplasms, B7-H1 Antigen, Programmed Cell Death 1 Receptor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review