Neural representation of reward in recovered depressed patients
Open accessAbstract
INTRODUCTION: Anhedonia, a loss of interest and pleasure in normally rewarding stimuli, is a key diagnostic criterion for major depression. It has been suggested that deficits in the processing of reward-relevant stimuli could represent an endophenotype for depression. We hypothesized that people at risk of depression by virtue of a personal history of the illness would show impaired neural responses to a primary rewarding stimulus. MATERIALS AND METHODS: Using functional magnetic resonance imaging, we measured the neural response to the sight and flavor of chocolate, and their combination, in 13 unmedicated recovered patients with a history of major depression and 14 healthy controls matched for age and gender. We also examined a control aversive condition consisting of the sight of moldy strawberries and a corresponding unpleasant taste. Participants simultaneously recorded subjective ratings of "pleasantness," "intensity," and "wanting." RESULTS AND DISCUSSION: Despite no differences between the groups in stimulus ratings, patients showed decreased neural responses to the pleasant stimulus in the ventral striatum and increases in the caudate nucleus to the aversive stimulus. Furthermore, patients had a diminished neural supralinearity response (the potentiation produced by simultaneous presentation of the sight and flavor of the stimuli) in the prefrontal cortex for both aversive and pleasant conditions. Patients recovered from depression appear to have deficits in the neural basis of reward and may also have impairments in the cross-modal integration of sensory stimuli. CONCLUSION: These findings support the view that abnormal neural responses to reward may be an endophenotype for depression and a potential target for intervention and prevention strategies.
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Loss of interest and pleasure is part of the endophenotype of depression.
“Loss of interest and pleasure is known to be part of the endophenotype of depression (McCabe et al., 2009)”
From Emotional blunting with antidepressant treatments: A survey among depressed patients (2017) · cites this paper as McCabe et al., 2009
The Introduction defines anhedonia as loss of interest and pleasure and says it has been suggested as a potential endophenotypic marker of depression. The Discussion likewise says deficient reward processes could be part of an endophenotype, but notes that the findings cannot establish whether the impairment preceded illness. The claim overstates this tentative proposal as something known. (LLM, conf=0.88)
Experimental — accuracy not yet measuredEuthymic individuals with a history of depression show decreased ventral striatal activation during reward outcome in response to the sight and flavor of chocolate.
“McCabe et al. [235] found decreased ventral striatal activation during reward outcome in response to the sight and flavor of chocolate in euthymic individuals with a history of depression”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [235]
A decrease in nucleus accumbens activation is also seen in remitted MDD patients for pleasurable foods.
“A decrease in nucleus accumbens activation is also seen in remitted MDD patients for pleasurable foods, a finding pertinent to anhedonic symptoms (132).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [132]
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- Authors
- McCabe, C., Cowen, P. J., & Harmer, C. J.
- Affiliations
- Warneford Hospital (GB)
- Corresponding author
- McCabe, Ciara
- Venue
- Psychopharmacology
- Published
- 2009-06-16
- Volume
- 205
- Issue
- 4
- Pages
- 667-677
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC2718193
- OpenAlex
- W2106916957
- Cited by
- 248
- References
- 44
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 10 · 2019: 15 · 2018: 16 · 2017: 15 · 2016: 21 · 2015: 36 · 2014: 23 · 2013: 23 · 2012: 13
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Psychopharmacology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- anhedonia, major depressive disorder, endophenotypes, reward processing, recovered depression, ventral striatum, caudate nucleus, prefrontal cortex, cross-modal integration, sensory integration, aversive stimuli, chocolate
- MeSH terms
- Adult, Basal Ganglia, Caudate Nucleus, Depression, Female, Humans, Magnetic Resonance Imaging, Male, Reward, Case-Control Studies, Prefrontal Cortex
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