Oxytocin reduces amygdala responses during threat approach
Open accessAbstract
Oxytocin reduces amygdala responses to threatening social stimuli in males and has been suggested to facilitate approach-related processing by either decreasing anxiety or intensifying salience. The current administration study tested whether oxytocin either reduces or enhances amygdala responses during threat approach in a placebo-controlled randomized, double-blind, between-subjects design with 52 healthy males undergoing fMRI during a social approach-avoidance task. Oxytocin decreased amygdala activation during threat approach and not during threat avoidance. This neural effect supports oxytocin's social anxiolytic effects and provides a neuroendocrine mechanism promoting social approach. The findings may yield clinical implications for individuals suffering from dysregulations of social approach such as patients with anxiety disorders.
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Radke et al. (2017) found a significant increase in avoidance reaction times with a moderate effect size (ES = -0.56, 95% CI [-1.11, -0.002], total N = 52).
“Conversely, Radke et al. (2017) found that oxytocin led to a non-significant increase in approach reaction times towards social threat with a moderate effect size (ES = -0.51,95% [-1.07, 0.04], total N = 52), and a significant increase in avoidance reaction times with a moderate effect size (ES = -0.56,95% CI [-1.11, -0.002], total N = 52).”
From Meta-analytic review of the effects of a single dose of intranasal oxytocin on threat processing in humans (2018) · cites this paper as Radke et al. (2017)
Radke et al. (2017) found that oxytocin led to a non-significant increase in approach reaction times towards social threat with a moderate effect size (ES = -0.51, 95% [-1.07, 0.04], total N = 52).
“Conversely, Radke et al. (2017) found that oxytocin led to a non-significant increase in approach reaction times towards social threat with a moderate effect size (ES = -0.51,95% [-1.07, 0.04], total N = 52), and a significant increase in avoidance reaction times with a moderate effect size (ES = -0.56,95% CI [-1.11, -0.002], total N = 52).”
From Meta-analytic review of the effects of a single dose of intranasal oxytocin on threat processing in humans (2018) · cites this paper as Radke et al. (2017)
Neural substrates mediating oxytocin's effects on approach-avoidance behavior remain unclear, with initial evidence showing decreased amygdala activity only when approaching angry faces.
“Moreover, the neural substrates mediating OT’s effects on AA behavior also remain unclear, with initial evidence showing decreased amygdala activity only when approaching angry faces (Radke et al., 2017).”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Radke et al., 2017
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- Authors
- Radke, S., Volman, I., Kokal, I., Roelofs, K., de Bruijn, E. R. A., & Toni, I.
- Affiliations
- Radboud University Nijmegen (NL)
- Corresponding author
- Radke, Sina
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 79
- Pages
- 160-166
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2594360226
- Semantic Scholar
- 18b94b448e8d51aa97c19a98be043f55174cbcac
- Cited by
- 67
- References
- 62
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 12 · 2019: 9 · 2018: 10 · 2017: 6
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Commission (660397, HORIZON2020)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (453-12-001, 452-12-005)
- Horizon 2020 Framework Programme (MSCA-IF-2014)
- FP7 Ideas: European Research Council (313749)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, amygdala, threat avoidance, anxiety, social salience, social anxiety disorder
- MeSH terms
- Administration, Intranasal, Adolescent, Adult, Amygdala, Double-Blind Method, Emotions, Facial Expression, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxytocin, Social Behavior, Young Adult
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