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Preliminary evidence suggesting caution in the use of psychiatric self-report measures with adolescents with high-functioning autism spectrum disorders

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Mazefsky, C.A., Kao, J., Oswald, D.P.·2011·Research in Autism Spectrum Disorders

DOI 10.1016/j.rasd.2010.03.006PMC PMC3762501

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Abstract

This study investigated the utility of self-report measures to screen for psychiatric comorbidities in autism spectrum disorders (ASDs). Thirty-eight 10-17 year olds with an ASD and without mental retardation completed: the Children's Depression Inventory-Short version (CDI-S), Revised Children's Manifest Anxiety Scale (RCMAS), Conners-Wells Adolescent Self-report Scale-Short edition (CASS-S), and Short Leyton Obsessional Inventory-Child Version (SLOI-CV). Their parents were interviewed with the Autism Comorbidity Interview-Present and Lifetime (ACI-PL) to establish psychiatric diagnoses. Sensitivity, specificity, positive and negative predictive values, and reliability coefficients were calculated for each self-report and compared to values from literature. The CDI-S and CASS-S yielded a high number of false negatives, with lower sensitivities and specificities in the sample than the literature. There was a nearly significant difference in total mean RCMAS scores between participants with and without anxiety, though again the means for both groups were below the threshold of concern. The SLOI-CV yielded a high false positive rate. All four instruments had reliability coefficients comparable to literature values. Results must be considered preliminary due to sample size. However, the findings suggest that although self-report instruments may provide useful information in the diagnosis of psychiatric comorbidities in ASD, caution must be exercised in their interpretation.

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Authors: Mazefsky, C. A., Kao, J., & Oswald, D. P.
Affiliations: University of Pittsburgh (US)
Virginia Commonwealth University (US)
Corresponding author: Mazefsky, C.A.
ORCID: Mazefsky, C.A.
Oswald, D.P.
Venue: Research in Autism Spectrum Disorders
Publisher: Elsevier BV
Published: 2011-01
Volume: 5
Issue: 1
Pages: 164-174
ISSN: 1878-0237 (ISSN-L)
1750-9467
DOI: 10.1016/j.rasd.2010.03.006
PMC: PMC3762501
OpenAlex: W2077644735
Cited by: 325
References: 41
Citations by year: 2026: 10 · 2025: 19 · 2024: 30 · 2023: 11 · 2022: 24 · 2021: 28 · 2020: 30 · 2019: 20 · 2018: 17 · 2017: 26 · 2016: 14 · 2015: 25 · 2014: 23 · 2013: 23 · 2012: 10
FWCI: 9.28
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Research in Autism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Organization for Autism Research
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD060601, L40 HD051318)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords: autism spectrum disorder, high-functioning autism, adolescents, psychiatric comorbidity, self-report measures, depression screening, anxiety screening, obsessive-compulsive symptoms, Revised Children's Manifest Anxiety Scale, screening sensitivity and specificity, false positives and false negatives

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Preliminary evidence suggesting caution in the use of psychiatric self-report measures with adolescents with high-functioning autism spectrum disorders

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