Role of advanced glycation end products in cellular signaling

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Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

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Chemical Composition of Hazelnut Skin Food Waste and Protective Role against Advanced Glycation End-Products (AGEs) Damage in THP-1-Derived Macrophages

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Oxidative stress and glyoxalase I activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen resistant derivative

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Advanced Glycation End Products Induce Proliferation and Migration of Human Aortic Smooth Muscle Cells through PI3K/AKT Pathway

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Lipopolysaccharides induce a RAGE-mediated sensitization of sensory neurons and fluid hypersecretion in the upper airways

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A prospective study of soluble receptor for advanced glycation end-products and colorectal cancer risk in postmenopausal women

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The Role of Advanced Glycation End-Products in the Pathophysiology and Pharmacotherapy of Cardiovascular Disease

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Amelioration of neuropilin-1 and RAGE/matrix metalloproteinase-2 pathway-induced renal injury in diabetic rats by rosuvastatin

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Effect of dietary advanced glycation end-products restriction on type 2 diabetes mellitus control: a systematic review

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Exposure of Caenorhabditis elegans to Dietary Nε-Carboxymethyllysine Emphasizes Endocytosis as a New Route for Intestinal Absorption of Advanced Glycation End Products

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All-Trans Retinoic Acid supplementation prevents cardiac fibrosis and cytokines induced by Methylglyoxal

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Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls

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The downregulation of thioredoxin accelerated Neuro2a cell apoptosis induced by advanced glycation end product via activating several pathways

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Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for diseases involving carbonyl stress

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The protective effects of exenatide against AGEs-induced articular matrix degradation in human primary chondrocytes.

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Acute Methylglyoxal-Induced Damage in Blood–Brain Barrier and Hippocampal Tissue

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The Effect of the Restrictive Ketogenic Diet on the Body Composition, Haematological and Biochemical Parameters, Oxidative Stress and Advanced Glycation End-Products in Young Wistar Rats with Diet-Induced Obesity

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Repurposing alagebrium for diabetic foot ulcer healing: Impact on AGEs/NFκB/NOX1 signaling

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Advanced glycation end products and insulin resistance in diabetic nephropathy

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Apigenin and baicalein ameliorate thoracic aortic structural deterioration and cognitive deficit via inhibiting AGEs/RAGE/NF-κB pathway in D-galactose-induced aging rats

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Natural polysaccharides: The potential biomacromolecules for treating diabetes and its complications via AGEs-RAGE-oxidative stress axis

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Migratory, metabolic and functional alterations of fibrocytes in type 2 diabetes

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Porphyromonas gingivalis lipopolysaccharide and glycated serum albumin increase the production of several pro-inflammatory molecules in human gingival fibroblasts via NFκB

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Blood protein profiles related to preterm birth and retinopathy of prematurity

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RAGE controls leukocyte adhesion in preterm and term infants

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N-Acetyl Cysteine Attenuated the Deleterious Effects of Advanced Glycation End-Products on the Kidney of Non-Diabetic Rats

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Glycation stimulates cutaneous monocyte differentiation in reconstructed skin in vitro

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ADAM 10 modulates calcitriol‐regulated RAGE in cardiomyocytes

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Glycation of Wild‐Type Apomyoglobin Induces Formation of Highly Cytotoxic Oligomeric Species

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Exploring the Role of GLP ‐1 Agents in Managing Diabetic Foot Ulcers: A Narrative and Systematic Review

Gruzmark, F. S., Beraja, G. E., Jozic, I., & Lev‐Tov, H. A. (2025) · Wound Repair and Regeneration · doi:10.1111/wrr.70085 · Cited by 17

Immunological mechanisms underlying sterile inflammation in the pathogenesis of atherosclerosis: potential sites for intervention

Truong, R., Thankam, F. G., & Agrawal, D. K. (2020) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2020.1860757 · Cited by 18

Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems

Wouters, K., Cento, A. S., Gaens, K. H. J., Teunissen, M., Scheijen, J. L. J. M., Barutta, F., Chiazza, F., Collotta, D., Aragno, M., Gruden, G., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-96859-7 · Cited by 15

Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer

Enríquez‐Flores, S., Flores-López, L. A., la Mora, I. D. L. M.-D., García‐Torres, I., Gracia‐Mora, I., Gutiérrez‐Castrellón, P., Fernández‐Lainez, C., Martínez-Pérez, Y., Olaya‐Vargas, A., de Vos, P., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-08051-0 · Cited by 15

Long Noncoding RNAs and Mitochondrial Homeostasis in the Development of Diabetic Retinopathy

Kowluru, R. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.915031 · Cited by 17

Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation

Hyun, M. K., Kim, D. H., Park, C. H., Noh, S. G., Choi, S., Lee, J. Y., Choi, J. H., 박두현, Choi, Y. J., & Chung, H. Y. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02243-x · Cited by 15

Diagnosis of Fibrotic Hypersensitivity Pneumonitis: Is There a Role for Biomarkers?

Pereira, J. O., Fernandes, V., Alfaro, T. M., Freitas, S., & Cordeiro, C. R. (2023) · Life · doi:10.3390/life13020565 · Cited by 16

Non-apoptotic programmed cell deaths in diabetic pulmonary dysfunction: the new side of advanced glycation end products

Dai, Y., Zhou, S., Lin, Q., Zhao, P., Zhao, J., Xu, D., Wu, C., Li, M., Zeng, X., & Wang, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1126661 · Cited by 16

Fructose-mediated AGE-RAGE axis: approaches for mild modulation

Semchyshyn, H. M. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1500375 · Cited by 15

The effect of advanced glycation end products on cellular signaling molecules in skeletal muscle

Egawa, T., Ohno, Y., Yokoyama, S., Goto, A., Ito, R., Hayashi, T., & Goto, K. (2018) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.7.229 · Cited by 15

Matrine suppresses advanced glycation end products-induced human coronary smooth muscle cells phenotype conversion by regulating endoplasmic reticulum stress-dependent Notch signaling

Zhao, L., Cai, H., Tang, Z., Cui, Q., Liu, Z., & Lu, S. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173257 · Cited by 15

Opening eyes to therapeutic perspectives of bioactive polyphenols and their nanoformulations against diabetic neuropathy and related complications

Khursheed, R., Singh, S. K., Wadhwa, S., Gulati, M., Kapoor, B., Awasthi, A., Ramanunny, A. K., Kumar, R., Pottoo, F. H., Kumar, V., et al. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1846517 · Cited by 15

Biological Anti‐TNF‐α Therapy and Markers of Oxidative and Carbonyl Stress in Patients with Rheumatoid Arthritis

Šteňová, E., Bakošová, M., Lauková, L., Celec, P., & Vlková, B. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5575479 · Cited by 15

Distinctive effects of different types of advanced glycation end-products (AGEs) on liver glucose metabolism

Fan, L., Yu, W., Zhang, B., Cao, B., Wang, M., & Hu, X. (2022) · Food & Function · doi:10.1039/d2fo01974d · Cited by 15

Nutrition Alters the Stiffness of Adipose Tissue and Cell Signaling

Naftaly, A., Kislev, N., Izgilov, R., Adler, R., Silber, M., Shalgi, R., & Benayahu, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315237 · Cited by 14

Advanced Glycation Endproducts Interfere with Adhesion and Neurite Outgrowth

Bennmann, D., Horstkorte, R., Hofmann, B., Jacobs, K. E., Santos, A. N., Simm, A., Bork, K., & Gnanapragassam, V. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112115 · Cited by 15

Reprint of “Accumulation of modified proteins and aggregate formation in aging”

Nowotny, K., Jung, T., Grune, T., & Höhn, A. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.10.001 · Cited by 15

The receptor for advanced glycation end products RAGE is involved in corneal healing

Naß, N., Trau, S., Paulsen, F. P., Kaiser, D., Kalinski, T., & Sel, S. (2017) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2017.01.003 · Cited by 15

A single high-fat meal alters human soluble RAGE profiles and PBMC RAGE expression with no effect of prior aerobic exercise

Fuller, K. N. Z., Valentine, R. J., Miranda, E. R., Kumar, P., Prabhakar, B. S., & Haus, J. M. (2018) · Physiological Reports · doi:10.14814/phy2.13811 · Cited by 16

High mobility group protein B1 (HMGB1) interacts with receptor for advanced glycation end products (RAGE) to promote airway smooth muscle cell proliferation through ERK and NF-κB pathways.

Qu, D., Ling, Z., Tan, X., Chen, Y., Huang, Q., Li, M., Liu, T., Hou, C., & Chen, Y. (2019) · PubMed Central · Cited by 15

Dietary advanced glycation end products (AGEs): A modifiable risk factor in the prevention of chronic diseases associated with aging?

Ávila, F., Cruz, N., González, M. A., Eduardo Fuentes, Q., Wehinger, S., & Mariane Lutz, R. (2025) · Biochimie · doi:10.1016/j.biochi.2025.06.001 · Cited by 15

Protective effects of dietary carnosine during in‐vitro digestion of pork differing in fat content and cooking conditions

Li, Y. Y., Yaylayan, V. A., Palin, M., Sullivan, B., Fortin, F., Cliché, S., Sabik, H., & Gariépy, C. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13624 · Cited by 14

Methylglyoxal reduces molecular responsiveness to 4 weeks of endurance exercise in mouse plantaris muscle

Egawa, T., Ogawa, T., Yokokawa, T., Kido, K., Goto, K., & Hayashi, T. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00539.2021 · Cited by 14

Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology

Nedić, O., Rattan, S. I. S., Grune, T., & Trougakos, I. P. (2013) · Free Radical Research · doi:10.3109/10715762.2013.806798 · Cited by 162

AGEsによる炎症関連疾患の増悪化と制御

森, 秀., 豊村, 隆., Mori, S., & Toyomura, T. (2015) · Institutional Repositories DataBase (IRDB)

The dynamic roles of advanced glycation end products

Khalid, M., & Adem, A. (2024) · Vitamins and hormones · doi:10.1016/bs.vh.2024.02.008 · Cited by 11

Advanced Glycation End Products— Physiology and Pathological Activity: A Literature Review

Ali, S. H., & Mhaibes, S. H. (2026) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v10i1.2593

Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation

Ramasamy, R., Vannucci, S. J., Yan, S. S. D., Herold, K., Yan, S. F., & Schmidt, A. M. (2005) · Glycobiology · doi:10.1093/glycob/cwi053 · Cited by 834