Role of advanced glycation end products in cellular signaling

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz

(2013) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/103.1437-1588 · Cited by 11,769

Pathways towards and Away from Alzheimer’s Disease

Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052

Broken Limits to Life Expectancy

Oeppen, J., & Vaupel, J. W. (2002) · Science · doi:10.1126/science.1069675 · Cited by 2,819

Advanced glycation end-products: A review

Singh, R., Barden, A., Mori, T., & Beilin, L. (2001) · Diabetologia · doi:10.1007/s001250051591 · Cited by 2,597

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

Goldstein, J. L., Ho, Y. K., Basu, S. K., & Brown, M. S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.333 · Cited by 2,447

Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury

Goldin, A., Beckman, J. A., Schmidt, A. M., & Creager, M. A. (2006) · Circulation · doi:10.1161/circulationaha.106.621854 · Cited by 2,261

Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

Acton, S., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., & Krieger, M. (1996) · Science · doi:10.1126/science.271.5248.518 · Cited by 2,026

Understanding the odd science of aging

Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984

RAGE Mediates a Novel Proinflammatory Axis

Hofmann, M. A., Drury, S., Fu, C., Qu, W., Taguchi, A., Lu, Y., Avila, C., Kambham, N., Bierhaus, A., Nawroth, P., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80801-6 · Cited by 1,864

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

Steinbrecher, U. P., Parthasarathy, S., Leake, D. S., Witztum, J. L., & Steinberg, D. I. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3883 · Cited by 1,626

Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus

Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095

Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications

Kang, Q., & Yang, C. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101799 · Cited by 1,134

Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives

Khalid, M., Petroianu, G. A., & Adem, A. (2022) · Biomolecules · doi:10.3390/biom12040542 · Cited by 972

Redox regulation of FoxO transcription factors

Klotz, L.-O., Sánchez-Ramos, C., Prieto-Arroyo, I., Urbánek, P., Steinbrenner, H., & Monsalve, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.019 · Cited by 747

Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs

Twarda‐Clapa, A., Olczak, A., Białkowska, A. M., & Koziołkiewicz, M. (2022) · Cells · doi:10.3390/cells11081312 · Cited by 829

Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Li, Y., Liu, Y., Liu, S., Gao, M., Wang, W., Chen, K., Huang, L., & Liu, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01400-z · Cited by 799

Endothelial Cell Metabolism in Normal and Diseased Vasculature

Eelen, G., de Zeeuw, P., Simons, M., & Carmeliet, P. (2015) · Circulation Research · doi:10.1161/circresaha.116.302855 · Cited by 637

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Daryabor, G., Atashzar, M. R., Kabelitz, D., Meri, S., & Kalantar, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01582 · Cited by 617

Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept

Chung, H. Y., Kim, D. H., Lee, E. K., Chung, K. W., Chung, S., Lee, B., Seo, A. Y., Chung, J. H., Jung, Y. S., Im, E., et al. (2018) · Aging and Disease · doi:10.14336/ad.2018.0324 · Cited by 512

Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects

Perrone, A., Giovino, A., Benny, J., & Martinelli, F. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3818196 · Cited by 459

Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411

Pathobiology of Modic changes

Dudli, S., Fields, A. J., Samartzis, D., Karppinen, J. I., & Lotz, J. C. (2016) · European Spine Journal · doi:10.1007/s00586-016-4459-7 · Cited by 388

Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases

Byun, K., Yoo, Y., Son, M., Lee, J., Jeong, G.-B., Park, Y. M., Salekdeh, G. H., & Lee, B. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.030 · Cited by 357

Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health

Kehrer, J. P., & Klotz, L. (2015) · Critical Reviews in Toxicology · doi:10.3109/10408444.2015.1074159 · Cited by 359

Oxidative stress, mitochondrial damage and diabetic retinopathy

Kowluru, R. A., & Mishra, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.001 · Cited by 345

Alzheimer's disease as type 3 diabetes: common pathophysiological mechanisms between Alzheimer's disease and type 2 diabetes

Michailidis, M., Moraitou, D., Tata, D. A., Kalinderi, K., Papamitsou, T., & Papaliagkas, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052687 · Cited by 330

The role of advanced glycation end-products in the development of coronary artery disease in patients with and without diabetes mellitus: a review

Fishman, S. L., Sonmez, H., Basman, C., Singh, V., & Poretsky, L. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0060-3 · Cited by 330

Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: The potential contribution to diabetes complications and cardiovascular disease

Bonnet, F., & Scheen, A. J. (2018) · Diabetes & Metabolism · doi:10.1016/j.diabet.2018.09.005 · Cited by 322

The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases

Shen, C., Lu, C., Wu, C.-H., Li, K., Kuo, Y., Hsieh, S., & Yu, C. (2020) · Molecules · doi:10.3390/molecules25235591 · Cited by 316

Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging

Fournet, M., Bonté, F., & Desmoulière, A. (2018) · Aging and Disease · doi:10.14336/ad.2017.1121 · Cited by 312

Immunology of Osteoporosis: A Mini-Review

Pietschmann, P., Mechtcheriakova, D., Meshcheryakova, A., Föger‐Samwald, U., & Ellinger, I. (2015) · Gerontology · doi:10.1159/000431091 · Cited by 291

Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

Wu, X., Xu, M., Geng, M., Chen, S., Little, P. J., Xu, S., & Weng, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01439-y · Cited by 295

Insulin Resistance and Oxidative Stress in the Brain: What’s New?

Maciejczyk, M., Żebrowska, E., & Chabowski, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040874 · Cited by 293

Obesity May Accelerate the Aging Process

Salvestrini, V., Sell, C., & Lorenzini, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00266 · Cited by 260

Novel advances in inhibiting advanced glycation end product formation using natural compounds

Song, Q., Liu, J., Dong, L., Wang, X., & Zhang, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111750 · Cited by 259

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

Ma, J., Li, Y., Yang, X., Liu, K., Zhang, X., Zuo, X., Ye, R., Wang, Z., Shi, R., Meng, Q., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01430-7 · Cited by 265

Uremic Toxicity of Advanced Glycation End Products in CKD

Stinghen, A. E. M., Massy, Z. A., Vlassara, H., Striker, G. E., & Boullier, A. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014101047 · Cited by 243

Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: a perspective review

Ramasubbu, K., & Rajeswari, V. D. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04587-x · Cited by 256

AGE/RAGE in diabetic kidney disease and ageing kidney

Wu, X., Zhang, D., Wang, Y., Tan, Y.-Q., Yu, X.-Y., & Zhao, Y. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.025 · Cited by 241

Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health

Gill, V., Kumar, V., Singh, K., Kumar, A., & Kim, J.-J. (2019) · Biomolecules · doi:10.3390/biom9120888 · Cited by 232

Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology

Snelson, M., & Coughlan, M. (2019) · Nutrients · doi:10.3390/nu11020215 · Cited by 230

Advanced Glycation End Products (AGEs), Receptor for AGEs, Diabetes, and Bone: Review of the Literature

Asadipooya, K., & Uy, E. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00160 · Cited by 210

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

Zhang, Q., Wang, Y., & Fu, L. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12593 · Cited by 239

Oxidative Stress and Microvascular Alterations in Diabetic Retinopathy: Future Therapies

Rodríguez, M. L., Pérez, S., Mena, S., Desco, C., & Ortega, Á. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4940825 · Cited by 234

Salivary markers of oxidative stress in oral diseases

Tóthová, Ľ., Kamodyová, N., Červenka, T., & Celec, P. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00073 · Cited by 222

Damage-associated molecular patterns in trauma

Relja, B., & Land, W. G. (2019) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-019-01235-w · Cited by 225

Food Processing: The Influence of the Maillard Reaction on Immunogenicity and Allergenicity of Food Proteins

Teodorowicz, M., van Neerven, R. J. J., & Savelkoul, H. F. J. (2017) · Nutrients · doi:10.3390/nu9080835 · Cited by 224

Endogenous advanced glycation end products in the pathogenesis of chronic diabetic complications

Mengstie, M. A., Abebe, E. C., Teklemariam, A. B., Mulu, A. T., Agidew, M. M., Azezew, M. T., Zewde, E. A., & Teshome, A. A. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1002710 · Cited by 232

Redox Signaling and Advanced Glycation Endproducts (AGEs) in Diet-Related Diseases

Cepas, V., Collino, M., Mayo, J. C., & Sainz, R. M. (2020) · Antioxidants · doi:10.3390/antiox9020142 · Cited by 216

AGEs, RAGEs and s-RAGE; friend or foe for cancer

Ahmad, S., Khan, H., Siddiqui, Z., Khan, M. Y., Rehman, S., Shahab, U., Godovikova, T. S., Silnikov, V. N., & Moinuddin, M. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.07.001 · Cited by 196

The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction

Sergi, D., Boulestin, H., Campbell, F. M., & Williams, L. M. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900934 · Cited by 194

Understanding the Connection Between Common Stroke Comorbidities, Their Associated Inflammation, and the Course of the Cerebral Ischemia/Reperfusion Cascade

Przykaza, Ł. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.782569 · Cited by 177

Diabetes and aortic aneurysm: current state of the art

Raffort, J., Lareyre, F., Clément, M., Hassen‐Khodja, R., Chinetti, G., & Mallat, Z. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy174 · Cited by 182

Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism

Chen, X., Luo, Y., Zhu, Q., Zhang, J., Huang, H., Kan, Y., Li, D., Xu, M., Liu, S., Li, J., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00612-4 · Cited by 174

Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway

Jin, X., Yao, T., Zhou, Z., Zhu, J., Zhang, S., Hu, W., & Shen, C. (2015) · BioMed Research International · doi:10.1155/2015/732450 · Cited by 173

The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder

Maurya, P. K., Noto, C. D. S., Rizzo, L. B., Rios, A. C., Nunes, S. O. V., Barbosa, D. S., Sethi, S., Zeni‐Graiff, M., Mansur, R. B., Maes, M. H. J., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.016 · Cited by 174

Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing

Chen, S., Zhu, Y., Xu, Q., Jiang, Q., Chen, D., Chen, T., Xu, X., Jin, Z., & He, Q. (2022) · Nature Communications · doi:10.1038/s41467-022-33475-7 · Cited by 170

Age-induced oxidative stress: how does it influence skeletal muscle quantity and quality?

Baumann, C. W., Kwak, D., Liu, H. M., & Thompson, L. V. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00321.2016 · Cited by 169

RAGE and Its Ligands: Molecular Interplay Between Glycation, Inflammation, and Hallmarks of Cancer—a Review

Palanissami, G., & Paul, S. F. D. (2018) · Hormones and Cancer · doi:10.1007/s12672-018-0342-9 · Cited by 174

Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies

Chen, J., Lin, X., Bu, C., & Zhang, X. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0306-7 · Cited by 178

Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis

Cremonini, E., Daveri, E., Mastaloudis, A., Adamo, A. M., Mills, D. A., Kalanetra, K. M., Hester, S. N., Wood, S. M., Fraga, C. G., & Oteiza, P. I. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101269 · Cited by 170

Advanced glycation end products mediated cellular and molecular events in the pathology of diabetic nephropathy

Kumar Pasupulati, A., Chitra, P. S., & Reddy, G. B. (2016) · Biomolecular Concepts · doi:10.1515/bmc-2016-0021 · Cited by 163

Diabetic nephropathy: Focusing on pathological signals, clinical treatment, and dietary regulation

Hu, Q., Chen, Y., Deng, X., Li, Y., Ma, X., Zeng, J., & Zhao, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114252 · Cited by 165

Metabolic memory: mechanisms and diseases

Dong, H., Sun, Y., Nie, L., Cui, A., Zhao, P., Leung, W. K., & Wang, Q. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01755-x · Cited by 186

The cell biology of Parkinson’s disease

Panicker, N., Ge, P., Dawson, V. L., & Dawson, T. M. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202012095 · Cited by 179

The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures?

Deponte, M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7123 · Cited by 154

Advanced Glycation End Products in the Skin: Molecular Mechanisms, Methods of Measurement, and Inhibitory Pathways

Chen, C., Zhang, J., Li, L., Guo, M., He, Y., Dong, Y., Meng, H., & Yi, F. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.837222 · Cited by 175

A Role for Advanced Glycation End Products in Molecular Ageing

Zgutka, K., Tkacz, M., Tomasiak, P., & Tarnowski, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129881 · Cited by 158

Advanced Glycation End Products in Health and Disease

Reddy, V. P., Aryal, P., & Darkwah, E. K. (2022) · Microorganisms · doi:10.3390/microorganisms10091848 · Cited by 155

Natural antioxidant polyphenols on inflammation management: Anti-glycation activity vs metalloproteinases inhibition

Crascì, L., Lauro, M. R., Puglisi, G., & Panico, A. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1229657 · Cited by 148

Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline

Little, K., Llorián‐Salvador, M., Scullion, S., Hernández, C., Simó‐Servat, O., del Marco, À., Bosma, E. K., Vargas-Soria, M., Carranza-Naval, M. J., Bergen, T. V., et al. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.10.008 · Cited by 142

AGE-RAGE synergy influences programmed cell death signaling to promote cancer

Waghela, B. N., Vaidya, F. U., Ranjan, K., Chhipa, A. S., Tiwari, B. S., & Pathak, C. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03928-y · Cited by 135

Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation

Kold-Christensen, R., & Johannsen, M. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.10.003 · Cited by 133

Role of advanced glycation end products in carcinogenesis and their therapeutic implications

Schröter, D., & Höhn, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190130145549 · Cited by 126

The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes

Erusalimsky, J. D. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101958 · Cited by 131

Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression

Zhou, Z., Tang, Y. M., Jin, X., Chen, C., Lu, Y., Liu, L., & Shen, C. (2016) · Journal of Diabetes Research · doi:10.1155/2016/4847812 · Cited by 127

Implications and Future Perspectives of AGEs in PCOS Pathophysiology

Merhi, Z. O., Kandaraki, E., & Diamanti‐Kandarakis, E. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.01.005 · Cited by 126

Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications

Song, B.-J., Akbar, M., Abdelmegeed, M. A., Byun, K., Lee, B., Yoon, S. K., & Hardwick, J. P. (2014) · Redox Biology · doi:10.1016/j.redox.2014.10.004 · Cited by 123

The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise

Kim, C., Park, S., & Kim, J. (2017) · Physical Activity and Nutrition · doi:10.20463/jenb.2017.0027 · Cited by 123

Cells producing their own nemesis: Understanding methylglyoxal metabolism

Chakraborty, S., Karmakar, K., & Chakravortty, D. (2014) · IUBMB Life · doi:10.1002/iub.1324 · Cited by 121

A Review of Traditional Chinese Medicine on Treatment of Diabetic Nephropathy and the Involved Mechanisms

Liu, X., Hu, X., Yang, H., Gui, L.-M., Cai, Z.-X., Qi, M.-S., & Dai, C. (2022) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x22500744 · Cited by 124

Apigenin and its methylglyoxal-adduct inhibit advanced glycation end products-induced oxidative stress and inflammation in endothelial cells

Zhou, Q., Cheng, K., Gong, J., Li, E. T. S., & Wang, M. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.05.027 · Cited by 121

Proinflammatory Proteins S100A8/S100A9 Activate NK Cells via Interaction with RAGE

Narumi, K., Miyakawa, R., Ueda, R., Hashimoto, H., Yamamoto, Y., Yoshida, T., & Aoki, K. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402301 · Cited by 123

Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats.

Jayanthy, G., & Pillai, S. S. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2374-6 · Cited by 115

Chrysin, a PPAR-γ agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation

Rani, N., Bharti, S., Bhatia, J., Nag, T. C., Ray, R., & Arya, D. S. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.03.015 · Cited by 115

Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway

Tu, Y., Song, E., Wang, Z., Ji, N., Zhu, L., Wang, K., Sun, H., Zhang, Y., Zhu, Q., Liu, X., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111274 · Cited by 114

Advanced glycation end products and their receptors in serum of patients with type 2 diabetes

Indyk, D., Bronowicka-Szydełko, A., Gamian, A., & Kuzan, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-92630-0 · Cited by 120

Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer’s Disease: A Hypothesis

Sonawane, S. K., & Chinnathambi, S. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1111-5 · Cited by 115

Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant‐Derived Antioxidants: A Single‐Blind Case‐Control Clinical Study

Luca, C. D., Mikhalchik, E. V., Suprun, M. V., Papacharalambous, M., Truhanov, A. I., & Korkina, L. G. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4389410 · Cited by 112

Advanced glycation end products and reactive oxygen species: uncovering the potential role of ferroptosis in diabetic complications

Chen, Y., Meng, Z., Li, Y., Liu, S., Hu, P. L., & Luo, E. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00905-9 · Cited by 132

Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential contributions to disease

Reynaert, N. L., Gopal, P., Rutten, E. P. A., Wouters, E. F. �., & Schalkwijk, C. G. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.06.016 · Cited by 113

Redox Balance, Antioxidant Defense, and Oxidative Damage in the Hypothalamus and Cerebral Cortex of Rats with High Fat Diet‐Induced Insulin Resistance

Maciejczyk, M., Żebrowska, E., Zalewska, A., & Chabowski, A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6940515 · Cited by 112

Metformin as a geroprotector: experimental and clinical evidence

Piskovatska, V., Stefanyshyn, N., Storey, K. B., Vaiserman, A. M., & Lushchak, O. V. (2018) · Biogerontology · doi:10.1007/s10522-018-9773-5 · Cited by 111

Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans

Brunt, V. E., Casso, A. G., Gioscia‐Ryan, R. A., Sapinsley, Z. J., Ziemba, B. P., Clayton, Z. S., Bazzoni, A. E., VanDongen, N. S., Richey, J. J., Hutton, D. A., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16895 · Cited by 111

Comparison of Free and Bound Advanced Glycation End Products in Food: A Review on the Possible Influence on Human Health

Zhao, D., Sheng, B., Wu, Y., Li, H., Xu, D., Nian, Y., Mao, S., Li, C., Xu, X., & Zhou, G. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b05891 · Cited by 107

Small dense low-density lipoprotein-cholesterol (sdLDL-C): Analysis, effects on cardiovascular endpoints and dietary strategies

Santos, H. O., Earnest, C. P., Tinsley, G. M., Izidoro, L. F. M., & Macedo, R. C. O. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.04.009 · Cited by 107

Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond

Daiber, A., Hahad, O., Andreadou, I., Steven, S., Daub, S., & Münzel, T. F. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101875 · Cited by 110

On the antioxidant, neuroprotective and anti-inflammatory properties of S-allyl cysteine: An update

Colín-González, A. L., Ali, S. F., Túnez, I., & Santamarı́a, A. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.06.011 · Cited by 107

Protein Carbonylation and Glycation in Legume Nodules

Matamoros, M. A., Kim, A., Peñuelas, M., Ihling, C. H., Griesser, E., Hoffmann, R., Fedorova, M., Frolov, A., & Becana, M. (2018) · PLANT PHYSIOLOGY · doi:10.1104/pp.18.00533 · Cited by 105

Clinical/Translational Aspects of Advanced Glycation End-Products

Zeng, C., Li, Y., Ma, J., Niu, L., & Tay, F. R. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.08.005 · Cited by 107

RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage

Piras, S., Furfaro, A. L., Domenicotti, C., Traverso, N., Marinari, U. M., Pronzato, M. A., & Nitti, M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9348651 · Cited by 108

Alterations in intervertebral disc composition, matrix homeostasis and biomechanical behavior in the UCD‐T2DM rat model of type 2 diabetes

Fields, A. J., Berg‐Johansen, B., Metz, L. N., Miller, S., La, B., Liebenberg, E. C., Coughlin, D., Graham, J. L., Stanhope, K. L., Havel, P. J., et al. (2015) · Journal of Orthopaedic Research® · doi:10.1002/jor.22807 · Cited by 103

Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies

Xu, J., Zhou, L., & Liu, Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.601325 · Cited by 113

Dietary AGEs as Exogenous Boosters of Inflammation

Garay‐Sevilla, M. E., Armando Rojas, R., Portero‐Otín, M., & Uribarri, J. (2021) · Nutrients · doi:10.3390/nu13082802 · Cited by 106

Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H2O2 and entailing Glyoxalase 1-dependent MG-H1 accumulation leading to TG2-mediated NF-kB desensitization: Implication for smokers-related osteoporosis

Marinucci, L., Balloni, S., Fettucciari, K., Bodo, M., Talesa, V. N., & Antognelli, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.017 · Cited by 101

Oxidative stress biomarkers in the serum and plasma of patients with non-alcoholic fatty liver disease (NAFLD). Can plasma AGE be a marker of NAFLD? Oxidative stress biomarkers in NAFLD patients

Świderska, M., Maciejczyk, M., Zalewska, A., Pogorzelska, J., Flisiak, R., & Chabowski, A. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1635691 · Cited by 107

Global proteomic analysis of advanced glycation end products in the Arabidopsis proteome provides evidence for age-related glycation hot spots

Bilova, T. E., Paudel, G., Shilyaev, N., Schmidt, R., Brauch, D., Tarakhovskaya, E., Milrud, S., Николаевна, С. Г., Tissier, A. F., Vogt, T., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.794537 · Cited by 98

Diabetic Wound Repair: From Mechanism to Therapeutic Opportunities

Wang, R., Gu, S., Kim, Y. H., Lee, A., Lin, H., & Jiang, D. (2025) · MedComm · doi:10.1002/mco2.70406 · Cited by 118

Impact of obesity and overweight on DNA stability: Few facts and many hypotheses

Setayesh, T., Nersesyan, A., Mišík, M., Ferk, F., Langie, S., Andrade, V. M., Haslberger, A., & Knasmüller, S. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.07.001 · Cited by 98

Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology

Nedić, O., Rattan, S. I. S., Grune, T., & Trougakos, I. P. (2013) · Free Radical Research · doi:10.3109/10715762.2013.806798 · Cited by 162

AGEsによる炎症関連疾患の増悪化と制御

森, 秀., 豊村, 隆., Mori, S., & Toyomura, T. (2015) · Institutional Repositories DataBase (IRDB)

The dynamic roles of advanced glycation end products

Khalid, M., & Adem, A. (2024) · Vitamins and hormones · doi:10.1016/bs.vh.2024.02.008 · Cited by 11

Advanced Glycation End Products— Physiology and Pathological Activity: A Literature Review

Ali, S. H., & Mhaibes, S. H. (2026) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v10i1.2593

Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation

Ramasamy, R., Vannucci, S. J., Yan, S. S. D., Herold, K., Yan, S. F., & Schmidt, A. M. (2005) · Glycobiology · doi:10.1093/glycob/cwi053 · Cited by 834