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Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin
Open accessAbstract
SUMMARY Colony-forming units – fibroblast (CFU-Fs), analogous to those giving rise to bone marrow (BM) mesenchymal stem cells (MSCs), are present in many organs, although the relationship between BM and organ-specific CFU-Fs in homeostasis and tissue repair is unknown. Here we describe a population of adult cardiac-resident CFU-Fs (cCFU-Fs) that occupy a perivascular, adventitial niche and show broad trans-germ layer potency in vitro and in vivo. CRE lineage tracing and embryo analysis demonstrated a proepicardial origin for cCFU-Fs. Furthermore, in BM transplantation chimeras, we found no interchange between BM and cCFU-Fs after aging, myocardial infarction, or BM stem cell mobilization. BM and cardiac and aortic CFU-Fs had distinct CRE lineage signatures, indicating that they arise from different progenitor beds during development. These diverse origins for CFU-Fs suggest an underlying basis for differentiation biases seen in different CFU-F populations, and could also influence their capacity for participating in tissue repair.
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Metadata
- Authors
- Chong, J. J. H., Chandrakanthan, V., Xaymardan, M., Asli, N. S., Li, J., Ahmed, I., Heffernan, C., Menon, M. K., Scarlett, C. J., Rashidianfar, A., Biben, C., Zoellner, H., Colvin, E. K., Pimanda, J. E., Biankin, A. V., Zhou, B., Pu, W. T., Prall, O. W. J., & Harvey, R. P.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 9
- Issue
- 6
- Pages
- 527-540
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2165160576
- Cited by
- 389
- References
- 52
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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