Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

RHO GTPASES: Biochemistry and Biology

Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009

Mechanisms of endocytosis

Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075

Routes and mechanisms of extracellular vesicle uptake

Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832

Regulation of Small GTPases by GEFs, GAPs, and GDIs

Cherfils, J., & Zeghouf, M. (2013) · Physiological Reviews · doi:10.1152/physrev.00003.2012 · Cited by 1,245

ADF/Cofilin: a functional node in cell biology

Bernstein, B. W., & Bamburg, J. R. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.01.001 · Cited by 704

Mechanoreciprocity in cell migration

van Helvert, S., Storm, C., & Friedl, P. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0012-0 · Cited by 587

Coordinated protein sorting, targeting and distribution in polarized cells

Mellman, I., & Nelson, W. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2525 · Cited by 521

Tumour-associated mutant p53 drives the Warburg effect

Zhang, C., Liu, J., Liang, Y., Wu, R., Zhao, Y., Hong, X., Lin, M., Yu, H., Liu, L., Levine, A. J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3935 · Cited by 434

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP

Shibasaki, T., Takahashi, H., Miki, T., Sunaga, Y., Matsumura, K., Yamanaka, M., Zhang, C., Tamamoto, A., Satoh, T., Miyazaki, J.-I., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707054104 · Cited by 425

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification

Roberts, P. J., Mitin, N., Keller, P. J., Chenette, E. J., Madigan, J. P., Currin, R. O., Cox, A. D., Wilson, O., Kirschmeier, P., & Der, C. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800882200 · Cited by 362

Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis

Hotulainen, P., Llano, O., Smirnov, S., Tanhuanpää, K., Faix, J., Rivera, C., & Lappalainen, P. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200809046 · Cited by 360

Rac1 GTPase: A “Rac” of All Trades

Bosco, E. E., Mulloy, J. C., & Zheng, Y. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8552-x · Cited by 350

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases

Shutes, A., Onesto, C., Picard, V., Leblond, B., Schweighoffer, F., & Der, C. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703571200 · Cited by 336

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

Duffney, L. J., Zhong, P., Wei, J., Matas, E., Cheng, J., Qin, L., Ma, K., Dietz, D. M., Kajiwara, Y., Buxbaum, J. D., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.064 · Cited by 281

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

Saci, A., Cantley, L. C., & Carpenter, C. L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.017 · Cited by 275

Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase

Montalvo-Ortiz, B. L., Castillo-Pichardo, L., Hernández, E., Humphries-Bickley, T., De La Mota-Peynado, A., Cubano, L. A., Vlaar, C. P., & Dharmawardhane, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.334524 · Cited by 213

Mapping of signaling networks through synthetic genetic interaction analysis by RNAi

Horn, T., Sandmann, T., Fischer, B., Axelsson, E., Huber, W., & Boutros, M. (2011) · Nature Methods · doi:10.1038/nmeth.1581 · Cited by 193

Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier

Li, J., Zheng, M., Shimoni, O., Banks, W. A., Bush, A. I., Gamble, J. R., & Shi, B. (2021) · Advanced Science · doi:10.1002/advs.202101090 · Cited by 202

ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65

Bisel, B., Wang, Y., Wei, J.-H., Xiang, Y., Tang, D., Miron-Mendoza, M., Yoshimura, S.-I., Nakamura, N., & Seemann, J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200805045 · Cited by 184

Focal adhesion kinase: from biological functions to therapeutic strategies

Tan, X., Yan, Y., Song, B., Zhu, S., Mei, Q., & Wu, K. (2023) · Experimental Hematology & Oncology · doi:10.1186/s40164-023-00446-7 · Cited by 158

Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells

Tkachenko, E., Sabouri-Ghomi, M., Pertz, O., Kim, C., Gutierrez, E., Machacek, M., Groisman, A., Danuser, G., & Ginsberg, M. H. (2011) · Nature Cell Biology · doi:10.1038/ncb2231 · Cited by 149

Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism

Duffney, L. J., Wei, J., Cheng, J., Liu, W., Smith, K. R., Kittler, J. T., & Yan, Z. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1175-13.2013 · Cited by 115

Deciphering the Molecular and Functional Basis of Dbl Family Proteins

Jaiswal, M., Dvorsky, R., & Ahmadian, M. R. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.429746 · Cited by 108

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation

Leemhuis, J., Bouché, E., Frotscher, M., Henle, F., Hein, L., Herz, J., Meyer, D. K., Pichler, M., Roth, G., Schwan, C., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4036-10.2010 · Cited by 80

Insights into the Origin of Metazoan Filopodia and Microvilli

Sebé-Pedrós, A., Burkhardt, P., Sánchez-Pons, N., Fairclough, S. R., Lang, B. F., King, N., & Ruiz-Trillo, I. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst110 · Cited by 84

Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2

Bunney, T. D., Opaleye, O., Roe, S. M., Vatter, P., Baxendale, R. W., Walliser, C., Everett, K. L., Josephs, M. B., Christow, C., Rodrigues-Lima, F., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.023 · Cited by 72

Rac GTPases play critical roles in early T-cell development

Dumont, C., Corsoni-Tadrzak, A., Ruf, S., de Boer, J., Williams, A., Turner, M., Kioussis, D., & Tybulewicz, V. L. J. (2009) · Blood · doi:10.1182/blood-2008-09-181180 · Cited by 66

Regulation of alveolar epithelial function by hypoxia

Zhou, G., Dada, L. A., & Sznajder, J. I. (2008) · European Respiratory Journal · doi:10.1183/09031936.00155507 · Cited by 57

Genomic architecture of haddock (Melanogrammus aeglefinus) shows expansions of innate immune genes and short tandem repeats

Tørresen, O. K., Brieuc, M. S. O., Solbakken, M. H., Sørhus, E., Nederbragt, A. J., Jakobsen, K. S., Meier, S., Edvardsen, R. B., & Jentoft, S. (2018) · BMC Genomics · doi:10.1186/s12864-018-4616-y · Cited by 46

Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts

Chaudhry, S. I., Hooper, S., Nye, E., Williamson, P., Harrington, K., & Sahai, E. (2013) · Oncogene · doi:10.1038/onc.2012.91 · Cited by 43

The neuronal protein Neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for synaptic vesicle clustering

Rui, M., Qian, J., Liu, L., Cai, Y., Lv, H., Han, J., Jia, Z., & Xie, W. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.794040 · Cited by 37

Regulation of the endothelial barrier function: a filum granum of cellular forces, Rho-GTPase signaling and microenvironment

Amado-Azevedo, J., Valent, E. T., & Van Nieuw Amerongen, G. P. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1828-6 · Cited by 36

Hypoxia suppresses myofibroblast differentiation by changing RhoA activity

Leinhos, L., Peters, J., Krull, S., Helbig, L., Vogler, M., Levay, M., van Belle, G. J., Ridley, A. J., Lutz, S., Katschinski, D. M., et al. (2019) · Journal of Cell Science · doi:10.1242/jcs.223230 · Cited by 30

The Role of RhoH in TCR Signalling and Its Involvement in Diseases

Ahmad Mokhtar, A. M., Hashim, I. F., Mohd Zaini Makhtar, M., Salikin, N. H., & Amin-Nordin, S. (2021) · Cells · doi:10.3390/cells10040950 · Cited by 25

RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry

Patnaik, S. R., Zhang, X., Biswas, L., Akhtar, S., Zhou, X., Kusuluri, D. K., Reilly, J., May-Simera, H., Chalmers, S., McCarron, J. G., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25259 · Cited by 17

RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation

Doye, A., Chaintreuil, P., Lagresle-Peyrou, C., Batistic, L., Marion, V., Munro, P., Loubatier, C., Chirara, R., Sorel, N., Bessot, B., et al. (2024) · Journal of Experimental Medicine · doi:10.1084/jem.20231562 · Cited by 12

Genetic variants linked to neurodevelopmental disorders within the β3-β4 loop of the TRIO PH2 domain release autoinhibition of GEF2 activity

Carrizales, M. G., Boulton, A. D., & Koleske, A. J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110429 · Cited by 2