CoChat
Sign Up
Cited by 137

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Keeping Your Brain in Balance: Homeostatic Regulation of Network Function

Wen, Wei, Turrigiano, Gina G.·2024·Annual Review of Neuroscience
DOI 10.1146/annurev-neuro-092523-110001
Open this paper in CoChat — free account

Abstract

To perform computations with the efficiency necessary for animal survival, neocortical microcircuits must be capable of reconfiguring in response to experience, while carefully regulating excitatory and inhibitory connectivity to maintain stable function. This dynamic fine-tuning is accomplished through a rich array of cellular homeostatic plasticity mechanisms that stabilize important cellular and network features such as firing rates, information flow, and sensory tuning properties. Further, these functional network properties can be stabilized by different forms of homeostatic plasticity, including mechanisms that target excitatory or inhibitory synapses, or that regulate intrinsic neuronal excitability. Here we discuss which aspects of neocortical circuit function are under homeostatic control, how this homeostasis is realized on the cellular and molecular levels, and the pathological consequences when circuit homeostasis is impaired. A remaining challenge is to elucidate how these diverse homeostatic mechanisms cooperate within complex circuits to enable them to be both flexible and stable.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1146/annurev-neuro-092523-110001

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 25 references

Research works printed but not linked: 164

  1. 2000, Synaptic plasticity: taming the beast, Nat. Neurosci., 3, 1178
  2. 2019, Increased excitation-inhibition ratio stabilizes synapse and circuit excitability in four autism mouse models, Neuron, 101, 648, 10.1016/j.neuron.2018.12.026 · DOI · Paper page
  3. 2022, Homeostatic regulation of extracellular signal-regulated kinase 1/2 activity and axonal Kv7.3 expression by prolonged blockade of hippocampal neuronal activity, Front. Cell. Neurosci., 16, 838419, 10.3389/fncel.2022.838419 · DOI
  4. 2017, Deprivation-induced homeostatic spine scaling in vivo is localized to dendritic branches that have undergone recent spine loss, Neuron, 96, 871, 10.1016/j.neuron.2017.09.052 · DOI
  5. 2015, Subnetwork-specific homeostatic plasticity in mouse visual cortex in vivo, Neuron, 86, 1290, 10.1016/j.neuron.2015.05.010 · DOI
  6. 2018, Activity-dependent inhibitory synapse scaling is determined by gephyrin phosphorylation and subsequent regulation of GABAA receptor diffusion, eNeuro, 5, ENEURO.0203
  7. 2004, Neuronal avalanches are diverse and precise activity patterns that are stable for many hours in cortical slice cultures, J. Neurosci., 24, 5216, 10.1523/JNEUROSCI.0540-04.2004 · DOI
  8. 2021, The complex formed by group I metabotropic glutamate receptor (mGluR) and Homer1a plays a central role in metaplasticity and homeostatic synaptic scaling, J. Neurosci., 41, 5567, 10.1523/JNEUROSCI.0026-21.2021 · DOI
  9. 2020, Input-output relationship of CA1 pyramidal neurons reveals intact homeostatic mechanisms in a mouse model of fragile X syndrome, Cell Rep, 32, 107988, 10.1016/j.celrep.2020.107988 · DOI
  10. 2023, Basal forebrain cholinergic activity is necessary for upward firing rate homeostasis in the rodent visual cortex, PNAS, 121, e2317987121
  11. 2018, Two distinct mechanisms for experience-dependent homeostasis, Nat. Neurosci., 21, 843, 10.1038/s41593-018-0150-0 · DOI
  12. 2014, The log-dynamic brain: how skewed distributions affect network operations, Nat. Rev. Neurosci., 15, 264, 10.1038/nrn3687 · DOI
  13. 2008, Downregulation of dendritic I h in CA1 pyramidal neurons after LTP, J. Neurosci., 28, 8635, 10.1523/JNEUROSCI.1411-08.2008 · DOI
  14. 2016, Synaptic and intrinsic homeostasis cooperate to optimize single neuron response properties and tune integrator circuits, J. Neurophysiol., 116, 2004, 10.1152/jn.00253.2016 · DOI
  15. 2017, Stable control of firing rate mean and variance by dual homeostatic mechanisms, J. Math. Neurosci., 7, 1, 10.1186/s13408-017-0043-7 · DOI
  16. 2010, Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons, Nat. Neurosci., 13, 1090, 10.1038/nn.2621 · DOI · Paper page
  17. 2021, My Neighbour Hetero—deconstructing the mechanisms underlying heterosynaptic plasticity, Curr. Opin. Neurobiol., 67, 106, 10.1016/j.conb.2020.10.007 · DOI
  18. 2013, Highly specific structural plasticity of inhibitory circuits in the adult neocortex, Neuroscientist, 19, 384, 10.1177/1073858413479824 · DOI
  19. 2022, Homeostatic plasticity and excitation-inhibition balance: the good, the bad, and the ugly, Curr. Opin. Neurobiol., 75, 102553, 10.1016/j.conb.2022.102553 · DOI
  20. 2014, Role of small conductance Ca2+-activated K+ channels in controlling CA1 pyramidal cell excitability, J. Neurosci., 34, 8219, 10.1523/JNEUROSCI.0936-14.2014 · DOI
  21. 2022, NMDAR-dependent presynaptic homeostasis in adult hippocampus: synapse growth and cross-modal inhibitory plasticity, Neuron, 110, 3302, 10.1016/j.neuron.2022.08.014 · DOI
  22. 2019, Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity, Nat. Rev. Neurosci., 20, 272, 10.1038/s41583-019-0141-5 · DOI
  23. 2018, Input-specific NMDAR-dependent potentiation of dendritic GABAergic inhibition, Neuron, 97, 368, 10.1016/j.neuron.2017.12.032 · DOI
  24. 2018, Homeostatic synaptic scaling: molecular regulators of synaptic AMPA-type glutamate receptors, F1000Research, 7, 234, 10.12688/f1000research.13561.1 · DOI
  25. 2017, Criticality in the brain: a synthesis of neurobiology, models and cognition, Prog. Neurobiol., 158, 132, 10.1016/j.pneurobio.2017.07.002 · DOI
  26. 2023, Chandelier cells shine a light on the formation of GABAergic synapses, Curr. Opin. Neurobiol., 80, 102697, 10.1016/j.conb.2023.102697 · DOI
  27. 2010, Spike-time precision and network synchrony are controlled by the homeostatic regulation of the D-type potassium current, J. Neurosci., 30, 12885, 10.1523/JNEUROSCI.0740-10.2010 · DOI · Paper page
  28. 2003, Long-term plasticity of intrinsic excitability: learning rules and mechanisms, Learn. Mem., 10, 456, 10.1101/lm.64103 · DOI
  29. 2015, Homeostatic control of presynaptic neurotransmitter release, Annu. Rev. Physiol., 77, 251, 10.1146/annurev-physiol-021014-071740 · DOI · Paper page
  30. 2005, Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuits, J. Neurosci., 25, 7121, 10.1523/JNEUROSCI.5221-04.2005 · DOI · Paper page
  31. 1999, Plasticity in the intrinsic excitability of cortical pyramidal neurons, Nat. Neurosci., 2, 515, 10.1038/9165 · DOI · Paper page
  32. 2021, Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling, Cell Rep, 36, 109583, 10.1016/j.celrep.2021.109583 · DOI
  33. 2020, Proteome dynamics during homeostatic scaling in cultured neurons, eLife, 9, e52939, 10.7554/eLife.52939 · DOI
  34. 2013, Pumilio-2 regulates translation of Nav1.6 to mediate homeostasis of membrane excitability, J. Neurosci., 33, 9644, 10.1523/JNEUROSCI.0921-13.2013 · DOI
  35. 2022, miR-124-dependent tagging of synapses by synaptopodin enables input-specific homeostatic plasticity, EMBO. J., 41, e109012, 10.15252/embj.2021109012 · DOI
  36. 2007, Homeostatic plasticity studied using in vivo hippocampal activity-blockade: synaptic scaling, intrinsic plasticity and age-dependence, PLOS ONE, 2, e700, 10.1371/journal.pone.0000700 · DOI · Paper page
  37. 2018, Locally coordinated synaptic plasticity of visual cortex neurons in vivo, Science, 360, 1349, 10.1126/science.aao0862 · DOI
  38. 2021, Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice, Mol. Psychiatry, 26, 3614, 10.1038/s41380-021-01070-9 · DOI
  39. 2016, Mechanisms of homeostatic plasticity in the excitatory synapse, J. Neurochem., 139, 973, 10.1111/jnc.13687 · DOI
  40. 2015, Upward synaptic scaling is dependent on neurotransmission rather than spiking, Nat. Commun., 6, 6339, 10.1038/ncomms7339 · DOI
  41. 2020, Homeostatic control of Drosophila neuromuscular junction function, Synapse, 74, e22133, 10.1002/syn.22133 · DOI
  42. 2018, Rapid disinhibition by adjustment of PV intrinsic excitability during whisker map plasticity in mouse S1, J. Neurosci., 38, 4749, 10.1523/JNEUROSCI.3628-17.2018 · DOI
  43. 2017, Multiple shared mechanisms for homeostatic plasticity in rodent somatosensory and visual cortex, Philos. Trans. R. Soc. B, 372, 20160157, 10.1098/rstb.2016.0157 · DOI · Paper page
  44. 2015, Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade, PNAS, 112, E3590
  45. 2018, Clptm1 limits forward trafficking of GABAA receptors to scale inhibitory synaptic strength, Neuron, 97, 596, 10.1016/j.neuron.2017.12.038 · DOI
  46. 2017, Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling, eLife, 6, e25480, 10.7554/eLife.25480 · DOI
  47. 2021, Synaptic homeostats: latent plasticity revealed at the Drosophila neuromuscular junction, Cell. Mol. Life Sci., 78, 3159, 10.1007/s00018-020-03732-3 · DOI
  48. 2006, Spontaneous network activity in the embryonic spinal cord regulates AMPAergic and GABAergic synaptic strength, Neuron, 49, 563, 10.1016/j.neuron.2006.01.017 · DOI · Paper page
  49. 2010, Single-cell optogenetic excitation drives homeostatic synaptic depression, Neuron, 68, 512, 10.1016/j.neuron.2010.09.020 · DOI · Paper page
  50. 2015, Hebbian and homeostatic plasticity mechanisms in regular spiking and intrinsic bursting cells of cortical layer 5, Neuron, 88, 539, 10.1016/j.neuron.2015.09.025 · DOI
  51. 2010, Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability, Nature, 465, 1070, 10.1038/nature09160 · DOI
  52. 2013, Obligatory role for the immediate early gene NARP in critical period plasticity, Neuron, 79, 335, 10.1016/j.neuron.2013.05.016 · DOI
  53. 2006, Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition, J. Neurosci., 26, 4535, 10.1523/JNEUROSCI.5297-05.2006 · DOI · Paper page
  54. 2020, Divergent synaptic scaling of miniature EPSCs following activity blockade in dissociated neuronal cultures, J. Neurosci., 40, 4090, 10.1523/JNEUROSCI.1393-19.2020 · DOI
  55. 2005, Synapse-specific regulation of AMPA receptor subunit composition by activity, J. Neurosci., 25, 6379, 10.1523/JNEUROSCI.0302-05.2005 · DOI
  56. 2006, Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons, Nat. Neurosci., 9, 642, 10.1038/nn1677 · DOI · Paper page
  57. 2008, Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling, PLOS ONE, 3, e2979, 10.1371/journal.pone.0002979 · DOI
  58. 2013, Firing rate homeostasis in visual cortex of freely behaving rodents, Neuron, 80, 335, 10.1016/j.neuron.2013.08.038 · DOI
  59. 2016, Neuronal firing rate homeostasis is inhibited by sleep and promoted by wake, Cell, 165, 180, 10.1016/j.cell.2016.01.046 · DOI
  60. 2023, A role for KCNQ channels on cell type-specific plasticity in mouse auditory cortex after peripheral damage, J. Neurosci., 43, 2277, 10.1523/JNEUROSCI.1070-22.2023 · DOI
  61. 2011, Parallel regulation of feedforward inhibition and excitation during whisker map plasticity, Neuron, 72, 819, 10.1016/j.neuron.2011.09.008 · DOI
  62. 2020, Whole-neuron synaptic mapping reveals spatially precise excitatory/inhibitory balance limiting dendritic and somatic spiking, Neuron, 106, 566, 10.1016/j.neuron.2020.02.015 · DOI
  63. 2008, Rapid synaptic scaling induced by changes in postsynaptic firing, Neuron, 57, 819, 10.1016/j.neuron.2008.02.031 · DOI · Paper page
  64. 2011, How inhibition shapes cortical activity, Neuron, 72, 231, 10.1016/j.neuron.2011.09.027 · DOI · Paper page
  65. 1993, GABAergic neurons and their role in cortical plasticity in primates, Cereb. Cortex, 3, 361, 10.1093/cercor/3.5.361-a · DOI
  66. 2008, Tumor necrosis factor-α mediates one component of competitive, experience-dependent plasticity in developing visual cortex, Neuron, 58, 673, 10.1016/j.neuron.2008.04.023 · DOI · Paper page
  67. 2006, Different forms of homeostatic plasticity are engaged with distinct temporal profiles, Eur. J. Neurosci., 23, 1575, 10.1111/j.1460-9568.2006.04692.x · DOI
  68. 2023, Rapid homeostatic plasticity and neuropsychiatric therapeutics, Neuropsychopharmacology, 48, 54, 10.1038/s41386-022-01411-4 · DOI
  69. 2013, Synaptic scaling and homeostatic plasticity in the mouse visual cortex in vivo, Neuron, 80, 327, 10.1016/j.neuron.2013.08.018 · DOI
  70. 2017b, Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions, Philos. Trans. R. Soc. B, 372, 20160158, 10.1098/rstb.2016.0158 · DOI
  71. 2002, Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABAA receptors clustered at neocortical synapses, J. Neurosci., 22, 1328, 10.1523/JNEUROSCI.22-04-01328.2002 · DOI · Paper page
  72. 2008, Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation, Neuron, 58, 925, 10.1016/j.neuron.2008.05.009 · DOI · Paper page
  73. 2005, Hearing loss raises excitability in the auditory cortex, J. Neurosci., 25, 3908, 10.1523/JNEUROSCI.5169-04.2005 · DOI
  74. 2022, Juvenile Shank3 KO mice adopt distinct hunting strategies during prey capture learning, eNeuro, 9, ENEURO.0230
  75. 2013, Synaptic and intrinsic homeostatic mechanisms cooperate to increase L2/3 pyramidal neuron excitability during a late phase of critical period plasticity, J. Neurosci., 33, 8810, 10.1523/JNEUROSCI.4502-12.2013 · DOI
  76. 2015, N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity, Mol. Brain., 8, 4, 10.1186/s13041-015-0094-1 · DOI
  77. 2013, Long-term inhibitory plasticity in visual cortical layer 4 switches sign at the opening of the critical period, PNAS, 110, E4540
  78. 2019, Differential role of pre- and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites, PLOS Biol, 17, e2006223, 10.1371/journal.pbio.2006223 · DOI
  79. 2020a, Neuronal inactivity co-opts LTP machinery to drive potassium channel splicing and homeostatic spike widening, Cell, 181, 1547, 10.1016/j.cell.2020.05.013 · DOI
  80. 2020b, Defective memory engram reactivation underlies impaired fear memory recall in fragile X syndrome, eLife, 9, e61882, 10.7554/eLife.61882 · DOI
  81. 2014, Rapid homeostasis by disinhibition during whisker map plasticity, PNAS, 111, 1616, 10.1073/pnas.1312455111 · DOI
  82. 2015, Inferring learning rules from distributions of firing rates in cortical neurons, Nat. Neurosci., 18, 1804, 10.1038/nn.4158 · DOI
  83. 2018, Rapid activity-dependent modulation of the intrinsic excitability through up-regulation of KCNQ/Kv7 channel function in neonatal spinal motoneurons, PLOS ONE, 13, e0193948, 10.1371/journal.pone.0193948 · DOI
  84. 2019, Cortical circuit dynamics are homeostatically tuned to criticality in vivo, Neuron, 104, 655, 10.1016/j.neuron.2019.08.031 · DOI
  85. 2006, Variability, compensation and homeostasis in neuron and network function, Nat. Rev. Neurosci., 7, 563, 10.1038/nrn1949 · DOI · Paper page
  86. 2002, Modeling stability in neuron and network function: the role of activity in homeostasis, BioEssays, 24, 1145, 10.1002/bies.10185 · DOI
  87. 2023, The plasticitome of cortical interneurons, Nat. Rev. Neurosci., 24, 80, 10.1038/s41583-022-00663-9 · DOI
  88. 2002, Dark rearing alters the development of GABAergic transmission in visual cortex, J. Neurosci., 22, 8084, 10.1523/JNEUROSCI.22-18-08084.2002 · DOI · Paper page
  89. 2019, Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo, eLife, 8, e49915, 10.7554/eLife.49915 · DOI
  90. 2007, Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity, Neuron, 54, 961, 10.1016/j.neuron.2007.05.028 · DOI · Paper page
  91. 2021, Distinct molecular pathways govern presynaptic homeostatic plasticity, Cell Rep, 37, 110105, 10.1016/j.celrep.2021.110105 · DOI
  92. 2015, Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders, Neuron, 87, 684, 10.1016/j.neuron.2015.07.033 · DOI · Paper page
  93. 2015, Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons, Cell Rep, 10, 162, 10.1016/j.celrep.2014.12.016 · DOI
  94. 2010, Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization, J. Physiol., 588, 157, 10.1113/jphysiol.2009.181024 · DOI
  95. 2014, Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model, Neuron, 82, 809, 10.1016/j.neuron.2014.04.002 · DOI
  96. 2020, Activity-dependent plasticity of axo-axonic synapses at the axon initial segment, Neuron, 106, 265, 10.1016/j.neuron.2020.01.037 · DOI
  97. 2021, FMRP interacts with RARα in synaptic retinoic acid signaling and homeostatic synaptic plasticity, Int. J. Mol. Sci., 22, 6579, 10.3390/ijms22126579 · DOI
  98. 2022, The uniform and nonuniform nature of slow and rapid scaling in embryonic motoneurons, J. Neurosci., 42, 1224, 10.1523/JNEUROSCI.0899-21.2021 · DOI
  99. 2010, Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling, J. Neurosci., 30, 16220, 10.1523/JNEUROSCI.3085-10.2010 · DOI
  100. 2003, Pyramidal neuron as two-layer neural network, Neuron, 37, 989, 10.1016/S0896-6273(03)00149-1 · DOI
  101. 2010, Unraveling mechanisms of homeostatic synaptic plasticity, Neuron, 66, 337, 10.1016/j.neuron.2010.04.028 · DOI · Paper page
  102. 2011, Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling, Nat. Neurosci., 14, 1112, 10.1038/nn.2893 · DOI
  103. 2014, Dystroglycan mediates homeostatic synaptic plasticity at GABAergic synapses, PNAS, 111, 6810, 10.1073/pnas.1321774111 · DOI
  104. 2006, The interplay between homeostatic synaptic plasticity and functional dendritic compartments, J. Neurophysiol., 96, 276, 10.1152/jn.00074.2006 · DOI
  105. 2023, Age-related dysregulation of homeostatic control in neuronal microcircuits, Nat. Neurosci., 26, 2158, 10.1038/s41593-023-01451-z · DOI
  106. 2011, Homeostatic strengthening of inhibitory synapses is mediated by the accumulation of GABAA receptors, J. Neurosci., 31, 17701, 10.1523/JNEUROSCI.4476-11.2011 · DOI
  107. 2012, Homeostatic plasticity mechanisms are required for juvenile, but not adult, ocular dominance plasticity, PNAS, 109, 1311, 10.1073/pnas.1112204109 · DOI
  108. 2015, Spontaneous neurotransmission signals through store-driven Ca2+ transients to maintain synaptic homeostasis, eLife, 4, e09262, 10.7554/eLife.09262 · DOI
  109. 2014, BDNF contributes to both rapid and homeostatic alterations in AMPA receptor surface expression in nucleus accumbens medium spiny neurons, Eur. J. Neurosci., 39, 1159, 10.1111/ejn.12422 · DOI
  110. 2020, Stability in the face of change: lifelong experience-dependent plasticity in the sensory cortex, Front. Cell. Neurosci., 14, 76, 10.3389/fncel.2020.00076 · DOI
  111. 2019, Disruption of NMDAR function prevents normal experience-dependent homeostatic synaptic plasticity in mouse primary visual cortex, J. Neurosci., 39, 7664, 10.1523/JNEUROSCI.2117-18.2019 · DOI
  112. 2016, Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex, Science, 352, 1319, 10.1126/science.aad3358 · DOI
  113. 2021, Mitochondria: new players in homeostatic regulation of firing rate set points, Trends Neurosci, 44, 605, 10.1016/j.tins.2021.03.002 · DOI
  114. 2022, Self-healing codes: how stable neural populations can track continually reconfiguring neural representations, PNAS, 119, e2106692119, 10.1073/pnas.2106692119 · DOI
  115. 1997, Brain-derived neurotrophic factor mediates the activity-dependent regulation of inhibition in neocortical cultures, J. Neurosci., 17, 4527, 10.1523/JNEUROSCI.17-12-04527.1997 · DOI · Paper page
  116. 1998, BDNF has opposite effects on the quantal amplitude of pyramidal neuron and interneuron excitatory synapses, Neuron, 21, 521, 10.1016/S0896-6273(00)80563-2 · DOI · Paper page
  117. 2007, Activity-dependent ubiquitination of GABAA receptors regulates their accumulation at synaptic sites, J. Neurosci., 27, 13341, 10.1523/JNEUROSCI.3277-07.2007 · DOI
  118. 2011, Developmental plasticity of auditory cortical inhibitory synapses, Hear. Res., 279, 140
  119. 2018, Time- and polarity-dependent proteomic changes associated with homeostatic scaling at central synapses, eLife, 7, e33322, 10.7554/eLife.33322 · DOI
  120. 2016, Nascent proteome remodeling following homeostatic scaling at hippocampal synapses, Neuron, 92, 358, 10.1016/j.neuron.2016.09.058 · DOI
  121. 2017, An intrinsic transcriptional program underlying synaptic scaling during activity suppression, Cell Rep., 18, 1512, 10.1016/j.celrep.2017.01.033 · DOI
  122. 2013, Learning to learn—intrinsic plasticity as a metaplasticity mechanism for memory formation, Neurobiol. Learn. Mem., 105, 186, 10.1016/j.nlm.2013.07.008 · DOI
  123. 2015, Adaptation to sensory input tunes visual cortex to criticality, Nat. Phys., 11, 659, 10.1038/nphys3370 · DOI
  124. 2013, The functional benefits of criticality in the cortex, Neuroscientist, 19, 88, 10.1177/1073858412445487 · DOI · Paper page
  125. 2015, Interplay between population firing stability and single neuron dynamics in hippocampal networks, eLife, 4, e04378, 10.7554/eLife.04378 · DOI
  126. 2019, Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders, Mol. Psychiatry, 24, 1248, 10.1038/s41380-019-0426-0 · DOI · Paper page
  127. 2016, Upregulation of μ3A drives homeostatic plasticity by rerouting AMPAR into the recycling endosomal pathway, Cell Rep, 16, 2711, 10.1016/j.celrep.2016.08.009 · DOI
  128. 2010, Tumor necrosis factor-α signaling maintains the ability of cortical synapses to express synaptic scaling, J. Neurosci., 30, 14685, 10.1523/JNEUROSCI.2210-10.2010 · DOI · Paper page
  129. 2019, Mitochondrial regulation of the hippocampal firing rate set point and seizure susceptibility, Neuron, 102, 1009, 10.1016/j.neuron.2019.03.045 · DOI
  130. 2006, Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis, Cell, 125, 785, 10.1016/j.cell.2006.03.040 · DOI · Paper page
  131. 2007, Postsynaptic decoding of neural activity: eEF2 as a biochemical sensor coupling miniature synaptic transmission to local protein synthesis, Neuron, 55, 648, 10.1016/j.neuron.2007.07.030 · DOI · Paper page
  132. 2021, Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action, Cell Rep, 37, 109918, 10.1016/j.celrep.2021.109918 · DOI · Paper page
  133. 2006, Activity-dependent scaling of GABAergic synapse strength is regulated by brain-derived neurotrophic factor, Mol. Cell. Neurosci., 31, 481, 10.1016/j.mcn.2005.11.002 · DOI
  134. 2016, Dynamic DNA methylation controls glutamate receptor trafficking and synaptic scaling, J. Neurochem., 137, 312, 10.1111/jnc.13564 · DOI
  135. 2011, Age-dependent effect of hearing loss on cortical inhibitory synapse function, J. Neurophysiol., 107, 937
  136. 2015, GRIP1 is required for homeostatic regulation of AMPAR trafficking, PNAS, 112, 10026, 10.1073/pnas.1512786112 · DOI · Paper page
  137. 2005, Activity-dependent matching of excitatory and inhibitory inputs during refinement of visual receptive fields, Neuron, 45, 829, 10.1016/j.neuron.2005.01.046 · DOI
  138. 2020, Autism-associated Shank3 is essential for homeostatic compensation in rodent V1, Neuron, 106, 769, 10.1016/j.neuron.2020.02.033 · DOI
  139. 2017, Homeostatic plasticity and synaptic scaling in the adult mouse auditory cortex, Sci. Rep., 7, 17423, 10.1038/s41598-017-17711-5 · DOI
  140. 2014, Cell adhesion and homeostatic synaptic plasticity, Neuropharmacology, 78, 23, 10.1016/j.neuropharm.2013.03.015 · DOI
  141. 2018, Homeostatic plasticity in neural development, Neural Dev, 13, 9, 10.1186/s13064-018-0105-x · DOI
  142. 2021, Sleep promotes downward firing rate homeostasis, Neuron, 109, 530, 10.1016/j.neuron.2020.11.001 · DOI
  143. 2019, Rapid and active stabilization of visual cortical firing rates across light-dark transitions, PNAS, 116, 18068, 10.1073/pnas.1906595116 · DOI
  144. 2021, Activity labeling in vivo using CaMPARI2 reveals intrinsic and synaptic differences between neurons with high and low firing rate set points, Neuron, 109, 663, 10.1016/j.neuron.2020.11.027 · DOI
  145. 2021, CaMKIV signaling is not essential for the maintenance of intrinsic or synaptic properties in mouse visual cortex, eNeuro, 8, ENEURO.0135
  146. 2008, The self-tuning neuron: synaptic scaling of excitatory synapses, Cell, 135, 422, 10.1016/j.cell.2008.10.008 · DOI · Paper page
  147. 2011, Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement, Annu. Rev. Neurosci., 34, 89, 10.1146/annurev-neuro-060909-153238 · DOI · Paper page
  148. 2017, The dialectic of Hebb and homeostasis, Philos. Trans. R. Soc. B, 372, 20160258, 10.1098/rstb.2016.0258 · DOI
  149. 1994, Activity-dependent changes in the intrinsic properties of cultured neurons, Science, 264, 974, 10.1126/science.8178157 · DOI
  150. 2004, Homeostatic plasticity in the developing nervous system, Nat. Rev. Neurosci., 5, 97, 10.1038/nrn1327 · DOI · Paper page
  151. 2023, A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex, eLife, 12, e74899, 10.7554/eLife.74899 · DOI
  152. 2004, Homeostatic scaling of neuronal excitability by synaptic modulation of somatic hyperpolarization-activated I h channels, PNAS, 101, 5123, 10.1073/pnas.0307711101 · DOI
  153. 2016, Homeostatic plasticity of subcellular neuronal structures: from inputs to outputs, Trends Neurosci., 39, 656, 10.1016/j.tins.2016.08.004 · DOI
  154. 2021, Developmental regulation of homeostatic plasticity in mouse primary visual cortex, J. Neurosci., 41, 9891, 10.1523/JNEUROSCI.1200-21.2021 · DOI
  155. 2014, Homeostatic synaptic plasticity in developing spinal networks driven by excitatory GABAergic currents, Neuropharmacology, 78, 55, 10.1016/j.neuropharm.2013.04.058 · DOI
  156. 2023, Dendrites help mitigate the plasticity-stability dilemma, Sci. Rep., 13, 6543, 10.1038/s41598-023-32410-0 · DOI
  157. 2021, Homeostatic synaptic scaling establishes the specificity of an associative memory, Curr. Biol., 31, 2274, 10.1016/j.cub.2021.03.024 · DOI
  158. 2022, A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling, eLife, 11, e74277, 10.7554/eLife.74277 · DOI
  159. 2008, Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity, J. Neurophysiol., 100, 1897, 10.1152/jn.90346.2008 · DOI
  160. 2020, Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics, PNAS, 117, 24514, 10.1073/pnas.1918368117 · DOI · Paper page
  161. 2011, Homeostatic plasticity drives tinnitus perception in an animal model, PNAS, 108, 14974, 10.1073/pnas.1107998108 · DOI
  162. 2021, Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit, PNAS, 118, e2110601118, 10.1073/pnas.2110601118 · DOI
  163. 2003, The other side of the engram: experience-driven changes in neuronal intrinsic excitability, Nat. Rev. Neurosci., 4, 885, 10.1038/nrn1248 · DOI
  164. 2022, Inactivity and Ca2+ signaling regulate synaptic compensation in motoneurons following hibernation in American bullfrogs, Sci. Rep., 12, 11610, 10.1038/s41598-022-15525-8 · DOI

Cited by

Sorted by citations

See all 137

Metadata

Authors
Wen, W., & Turrigiano, G. G.
Affiliations
Department of Biology, Brandeis University, Waltham, Massachusetts, USA; email: turrigiano@brandeis.edu
Venue
Annual Review of Neuroscience
Publisher
Annual Reviews
Published
2024-08-08
Volume
47
Issue
1
Pages
41-61
ISSN
  • 0147-006X
  • 1545-4126
DOI
10.1146/annurev-neuro-092523-110001
Cited by
137
References
25
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review