Cited by 309Effects and risks of endocrine disrupting chemicalsEpigenetics and DNA MethylationEstrogen and related hormone effects

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The role of Bisphenol A in shaping the brain, epigenome and behavior

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Wolstenholme, Jennifer T., Rissman, Emilie F., Connelly, Jessica J.·2011·Hormones and Behavior

DOI 10.1016/j.yhbeh.2010.10.001PMC PMC3725332

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Abstract

Bisphenol A (BPA) is a xenoestrogen that was first synthesized in 1891. Its estrogenic properties were discovered in 1930, and shortly after that chemists identified its usefulness in the production of epoxy resins. Since the 1950s BPA has been used as a synthetic monomer in the manufacturing of polycarbonate plastic, polystyrene resins, and dental sealants. Roughly 6.5 billion pounds of BPA are produced each year and it is the major estrogenic compound that leaches into nearby water and food supplies (vom Saal et al., 2007). BPA has been detected in 95% of human urine samples, which indicates that environmental exposure is widespread (Calafat et al., 2005). Moreover, BPA affects reproductive tissues and the brain. Thus many studies have focused on the effects of BPA during embryonic development. The most recent FDA update (Administration January 2010) points to "some concern about the potential effects of Bisphenol A on the brain, behavior, and prostate gland in fetuses, infants, and young children." In light of this concern, we present an updated review of BPA's action on the brain and behavior. We begin with a discussion of BPA's role as both an endocrine active compound and an agent that alters DNA methylation. Next, we review publications that have reported effects of BPA on brain and behavior. We end with our interpretation of these data and suggestions for future research directions.

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See all 309

Authors: Wolstenholme, J. T., Rissman, E. F., & Connelly, J. J.
Affiliations: University of Virginia (US)
Corresponding author: Connelly, Jessica J.
ORCID: Wolstenholme, Jennifer T.
Rissman, Emilie F.
Connelly, Jessica J.
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2011-03
Volume: 59
Issue: 3
Pages: 296-305
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2010.10.001
PMC: PMC3725332
OpenAlex: W2044819518
Cited by: 309
References: 98
Citations by year: 2026: 6 · 2025: 11 · 2024: 14 · 2023: 16 · 2022: 18 · 2021: 12 · 2020: 21 · 2019: 25 · 2018: 36 · 2017: 15 · 2016: 32 · 2015: 24 · 2014: 18 · 2013: 27 · 2012: 22
FWCI: 1.94
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH086711)
National Institute of Environmental Health Sciences (F32ES019404)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: bisphenol A, xenoestrogens, endocrine disruptors, brain development, behavior, DNA methylation, epigenetics, embryonic development, prenatal exposure, polycarbonate plastics, estrogenic activity
MeSH terms: Bisphenol A Compounds, Animals, Behavior, Animal, Benzhydryl Compounds, Brain, Estrogens, Non-Steroidal, Female, Humans, Learning, Maternal Behavior, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Sex Characteristics, Epigenesis, Genetic

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The role of Bisphenol A in shaping the brain, epigenome and behavior

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