Cited by 334Genetics, Aging, and Longevity in Model OrganismsInflammatory Biomarkers in Disease PrognosisFrailty in Older Adults

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Elevated levels of tumor necrosis factor alpha and mortality in centenarians

Bruunsgaard, Helle, Andersen-Ranberg, Karen, Hjelmborg, Jacob v.B, Pedersen, Bente Klarlund, Jeune, Bernard·2003·The American Journal of Medicine

DOI 10.1016/s0002-9343(03)00329-2

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Abstract

Background Aging is accompanied by low-grade inflammation. Tumor necrosis factor (TNF) alpha initiates the cytokine cascade, and high levels are associated with dementia and atherosclerosis in persons aged 100 years. We hypothesized that TNF-alpha was also a prognostic marker for all-cause mortality in these persons.Methods We enrolled 126 subjects at or around the time of their 100th birthday. Plasma levels of TNF-alpha, interleukin (IL)-6, IL-8, and C-reactive protein were measured at baseline, and we determined the associations between the markers of inflammation and mortality during the subsequent 5 years.Results Only 9 subjects were alive after 5 years. Elevated levels of TNF-alpha were associated with mortality in both men and women (hazard ratio = 1.34 per SD of 2.81 pg/mL; 95% confidence interval: 1.12 to 1.60, P = 0.001). Levels of IL-6 and IL-8 did not affect survival; levels of C-reactive protein were not associated with mortality when levels of TNF-alpha were included in the analysis. Dementia and cardiovascular diseases represented the major causes of comorbid conditions at baseline. TNF-alpha was still associated with mortality in multivariate models that included these parameters as confounders.Conclusion TNF-alpha was an independent prognostic marker for mortality in persons aged 100 years, suggesting that it has specific biological effects and is a marker of frailty in the very elderly.

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Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Information Theory and an Extension of the Maximum Likelihood Principle
Akaike, H. (1998) · Springer series in statistics · doi:10.1007/978-1-4612-1694-0_15 · Cited by 18,591
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Modelling for Survival Data in Medical Research
(1995) · Technometrics · doi:10.1080/00401706.1995.10485920 · Cited by 2,159
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.
Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X.-F., & Achong, M. K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1368 · Cited by 1,578
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488
Relationship of Interleukin-6 and Tumor Necrosis Factor- With Muscle Mass and Muscle Strength in Elderly Men and Women: The Health ABC Study
Visser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., Nevitt, M., & Harris, T. B. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.5.m326 · Cited by 1,294
Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.
Tilg, H., Trehu, E., Atkins, M., Dinarello, C., & Mier, J. (1994) · Blood · doi:10.1182/blood.v83.1.113.113 · Cited by 817
Biodemographic Trajectories of Longevity
Vaupel, J. W., Carey, J. R., Christensen, K., Johnson, T. E., Yashin, A. I., Holm, N. V., Iachine, I. A., Kannisto, V., Khazaeli, A. A., Liedo, P., et al. (1998) · Science · doi:10.1126/science.280.5365.855 · Cited by 803

Show all 36 references

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Bruunsgaard, 2000, Ageing, TNF-alpha and atherosclerosis, Clin Exp Immunol, 21, 255

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Tesar, B. M., Walker, W. E., Unternaehrer, J., Joshi, N. S., Chandele, A., Haynes, L., Kaech, S. M., & Goldstein, D. R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00245.x · Cited by 93
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Dirks, A. J., & Leeuwenburgh, C. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.11.002 · Cited by 95
Immunosenescence in monocytes, macrophages, and dendritic cells: Lessons learned from the lung and heart
Linton, P., & Thoman, M. L. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.017 · Cited by 87
Inflamm-ageing: How cytokines and nutrition shape the trajectory of ageing
Coperchini, F., Greco, A., Teliti, M., Croce, L., Chytiris, S., Magri, F., Gaetano, C., & Rotondi, M. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.08.004 · Cited by 94
Aging and the pathogenic response to burn.
Rani, M., & Schwacha, M. G. (2012) · Europe PMC (PubMed Central) · Cited by 87
Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction
Halade, G. V., Kain, V., Black, L. M., Prabhu, S. D., & Ingle, K. A. (2016) · Aging · doi:10.18632/aging.101077 · Cited by 83
Aging and Inflammation: Etiological Culprits of Cancer
Ahmad, A., Banerjee, S., Wang, Z. P., Kong, D., Majumdar, A. P. N., & Sarkar, F. H. (2009) · Current Aging Science · doi:10.2174/1874609810902030174 · Cited by 83
Host Resistance and Immune Aging
Bandaranayake, T., & Shaw, A. C. (2016) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2016.02.007 · Cited by 88
Complexity of Anti‐immunosenescence Strategies in Humans
Capri, M., Monti, D., Salvioli, S., Lescai, F., Pierini, M., Altilia, S., Sevini, F., Valensin, S., Ostan, R., Bucci, L., et al. (2006) · Artificial Organs · doi:10.1111/j.1525-1594.2006.00295.x · Cited by 81
A gut‐centric view of aging: Do intestinal epithelial cells contribute to age‐associated microbiota changes, inflammaging, and immunosenescence?
Hohman, L. S., & Osborne, L. C. (2022) · Aging Cell · doi:10.1111/acel.13700 · Cited by 86
Nutrient–gene interaction in ageing and successful ageing
Mocchegiani, E., Costarelli, L., Giacconi, R., Cipriano, C., Muti, E., Tesei, S., & Malavolta, M. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.010 · Cited by 80
Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging
Brosh, R. M., Bellani, M. A., Liu, Y., & Seidman, M. M. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.005 · Cited by 84
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Kirkland, J. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025908 · Cited by 78
Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice
Sayed, R. K. A., de Leonardis, E. C., Guerrero-Martinez, J. A., Rahim, I., Mokhtar, D. M., Saleh, A. M., Abdalla, K. E. H., Pozo, M. J., Escames, G., López, L. C., et al. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.07.007 · Cited by 81
An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition
Nomellini, V., Faunce, D. E., Gómez, C. R., & Kovacs, E. J. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1007672 · Cited by 78
A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
Gupta, S., Agrawal, A., Agrawal, S., Su, H., & Gollapudi, S. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-5 · Cited by 77
The ocular surface immune system through the eyes of aging
Galletti, J. G., & de Paiva, C. S. (2021) · The Ocular Surface · doi:10.1016/j.jtos.2021.02.007 · Cited by 78
Cardiovascular risk factors in centenarians
Galioto, A., Dominguez, L. J., Pineo, A., Ferlisi, A., Putignano, E., Belvedere, M., Costanza, G., & Barbagallo, M. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.009 · Cited by 74
Tumor necrosis factor-α promotes the accumulation of neutrophils and macrophages in skeletal muscle
Peterson, J. M., Feeback, K. D., Baas, J. H., & Pizza, F. X. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01453.2005 · Cited by 74
Aging, traumatic injury, and estrogen treatment
Kovacs, E. J. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.009 · Cited by 76
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Biochemical Markers of Aging for Longitudinal Studies in Humans
Engelfriet, P. M., Jansen, E. H. J. M., Picavet, H. S. J., & Dollé, M. E. T. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs011 · Cited by 75
Innate immune perturbations, accumulating DAMPs and inflammasome dysregulation: A ticking time bomb in ageing
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Systems approaches to investigate the role of NF-κB signaling in aging
Haga, M., & Okada, M. (2022) · Biochemical Journal · doi:10.1042/bcj20210547 · Cited by 67
Antibody Quality in Old Age
Howard, W. A., Gibson, K. L., & Dunn‐Walters, D. K. (2006) · Rejuvenation Research · doi:10.1089/rej.2006.9.117 · Cited by 68
Biochemical Markers and Risk Factors of Alzheimers Disease
Flirski, M., & Sobów, T. (2005) · Current Alzheimer Research · doi:10.2174/1567205052772704 · Cited by 67

Authors: Bruunsgaard, H., Andersen-Ranberg, K., Hjelmborg, J. V. B., Pedersen, B. K., & Jeune, B.
Affiliations: University of Southern Denmark (DK)
University of Copenhagen (DK)
ORCID: Hjelmborg, Jacob v.B
Pedersen, Bente Klarlund
Venue: The American Journal of Medicine
Publisher: Elsevier BV
Published: 2003-09
Volume: 115
Issue: 4
Pages: 278-283
ISSN: 0002-9343 (ISSN-L)
DOI: 10.1016/s0002-9343(03)00329-2
OpenAlex: W2000119824
Cited by: 325
References: 36
Citations by year: 2026: 7 · 2025: 19 · 2024: 16 · 2023: 16 · 2022: 17 · 2021: 23 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 12 · 2016: 15 · 2015: 14 · 2014: 13 · 2013: 13 · 2012: 11
FWCI: 3.89
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The American Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords: TNF-α, centenarians, all-cause mortality, low-grade inflammation, prognostic factors, interleukin-6, interleukin-8, C-reactive protein, frailty, oldest old, dementia, cardiovascular disease
MeSH terms: Aged, Aged, 80 and over, C-Reactive Protein, Cardiovascular Diseases, Dementia, Denmark, Female, Follow-Up Studies, Humans, Male, Respiratory Tract Infections, Severity of Illness Index, Statistics as Topic, Biomarkers, Interleukin-6, Multivariate Analysis, Survival Analysis, Interleukin-8

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Elevated levels of tumor necrosis factor alpha and mortality in centenarians

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