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Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum

Wahlsten, Douglas, Metten, Pamela, Crabbe, John C.·2003·Brain Research

DOI 10.1016/s0006-8993(03)02354-0

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Abstract

A morphometric survey of brain size and forebrain commissures of 21 inbred mouse strains from the Jackson Laboratory was done with animals tested in two laboratories as part of the Mouse Phenome Project. Strain BTBR T/+ tf/tf was found to have 100% total absence of the corpus callosum as well as severe reduction of the hippocampal commissure in almost every animal, the most severe commissure defect observed to date in any commercially available mouse strain. The strain 129S1/SvImJ had a milder defect with incomplete penetrance. Crosses of BTBR mice with inbred strains BALB/cWah1, 129P1/ReJ, and the recombinant strain 9XCA/Wah having a severe commissure defect supported a two-locus model of the genetic defect in these strains. Brain size varied greatly among strains but for any one strain was almost identical in mice housed for 5 weeks in the two laboratories. Sex differences in brain weight and forebrain commissure sizes were not statistically significant.

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Retracted
Fractone-associated N-sulfated heparan sulfate shows reduced quantity in BTBR T+tf/J mice: A strong model of autism
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Meningeal/vascular alterations and loss of extracellular matrix in the neurogenic zone of adult BTBR T+ tf/J mice, animal model for autism
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Genetic Variations Strongly Influence Phenotypic Outcome in the Mouse Retina
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The role of neuroglia in autism spectrum disorders
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Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders
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Thirty Mouse Strain Survey of Voluntary Physical Activity and Energy Expenditure: Influence of Strain, Sex and Day–Night Variation
König, C., Plank, A.-C., Kapp, A., Timotius, I. K., von Hörsten, S., & Zimmermann, K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00531 · Cited by 26
The Behavioral Consequence of Phenylketonuria in Mice Depends on the Genetic Background
Bruinenberg, V. M., van der Goot, E., van Vliet, D., de Groot, M. J., Mazzola, P. N., Heiner-Fokkema, M. R., van Faassen, M. H. J. R., van Spronsen, F. J., & van der Zee, E. A. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00233 · Cited by 27

Authors: Wahlsten, D., Metten, P., & Crabbe, J. C.
Affiliations: Oregon Health & Science University (US)
ORCID: Metten, Pamela
Crabbe, John C.
Venue: Brain Research
Publisher: Elsevier BV
Published: 2003-05
Volume: 971
Issue: 1
Pages: 47-54
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/s0006-8993(03)02354-0
OpenAlex: W2052072017
Cited by: 206
References: 26
Citations by year: 2026: 4 · 2025: 6 · 2024: 8 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 16 · 2019: 6 · 2018: 7 · 2017: 11 · 2016: 9 · 2015: 8 · 2014: 13 · 2013: 15 · 2012: 14
FWCI: 7.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro) (submittedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R01AA12714, AA 10760, R01AA012714, P60AA010760)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: hippocampal commissure, corpus callosum, brain size, inbred mouse strains
MeSH terms: Congenital Abnormalities, Animals, Behavior, Animal, Crosses, Genetic, Female, Genotype, Hippocampus, Male, Mice, Inbred Strains, Mice, Neurologic Mutants, Sex Factors, Mice, Agenesis of Corpus Callosum

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Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum

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