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Cited by 288Fatty Acid Research and HealthNutritional Studies and DietInflammatory mediators and NSAID effects

Dietary α-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients

Rallidis, Loukianos S., Paschos, Georgios, Liakos, Georgios K., Velissaridou, Aggeliki H., Anastasiadis, Georgios, Zampelas, Antonis·2003·Atherosclerosis
DOI 10.1016/s0021-9150(02)00427-6
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Abstract

Background Inflammation plays an important role in the pathogenesis of coronary artery disease. We examined whether dietary supplementation with alpha-linolenic acid (ALA, 18:3n-3) affects the levels of inflammatory markers in dyslipidaemic patients.Methods We recruited 76 male dyslipidaemic patients (mean age=51+/-8 years) following a typical Greek diet. They were randomly assigned either to 15 ml of linseed oil (rich in ALA) per day (n=50) or to 15 ml of safflower oil (rich in linoleic acid (LA, 18:2n-6)) per day (n=26). The ratio of n-6:n-3 in linseed oil supplemented group was 1.3:1 and in safflower oil supplemented group 13.2:1. Dietary intervention lasted for 3 months. Blood lipids and C-reactive protein (CRP), serum amyloid A (SAA), and interleukin-6 (IL-6) levels were determined prior and after intervention. CRP and SAA were measured by nephelometry and IL-6 by immunoassay.Results Dietary supplementation with ALA decreased significantly CRP, SAA and IL-6 levels. The median decrease of CRP was 38% (1.24 vs. 0.93 mg/l, P=0.0008), of SAA 23.1% (3.24 vs. 2.39 mg/l, P=0.0001) and of IL-6 10.5% (2.18 vs. 1.7 pg/ml, P=0.01). The decrease of inflammatory markers was independent of lipid changes. Dietary supplementation with LA did not affect significantly CRP, SAA and IL-6 concentrations but decreased cholesterol levels.Conclusions Dietary supplementation with ALA for 3 months decreases significantly CRP, SAA and IL-6 levels in dyslipidaemic patients. This anti-inflammatory effect may provide a possible additional mechanism for the beneficial effect of plant n-3 polyunsaturated fatty acids in primary and secondary prevention of coronary artery disease.

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  • The findings for ALA are mechanistically supported by effects of ALA on thrombosis, inflammation, arrhythmia, and endothelial function.

    “Mechanistically, these findings are supported by effects of ALA on thrombosis, inflammation, arrhythmia, and endothelial function.43–47”

    From ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies (2016) · cites this paper as [44]

  • In diabetic or glucose-intolerant patients, adipose-produced mediators such as CCL5, IL-1b, IL-8 and oxidative stress markers are increased, and insulin therapy reduces their circulating concentrations.

    “Several inflammatory mediators produced by adipose tissue, such as CCL5, IL-1b and IL-8, as well as markers of oxidative stress, are increased in diabetic or glucose-intolerant patients, and the amelioration of hyperglycaemia by insulin therapy reduces circulating concentrations of these molecules (104,105) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [104]

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Authors
Rallidis, L. S., Paschos, G., Liakos, G. K., Velissaridou, A. H., Anastasiadis, G., & Zampelas, A.
Affiliations
  • Harokopio University of Athens (GR)
  • General Hospital of Nikea (GR)
  • Laiko General Hospital of Athens (GR)
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2003-04
Volume
167
Issue
2
Pages
237-242
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/s0021-9150(02)00427-6
OpenAlex
W2098287260
Cited by
288
References
39
Citations by year
2026: 4 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 4 · 2021: 10 · 2020: 14 · 2019: 11 · 2018: 13 · 2017: 9 · 2016: 9 · 2015: 14 · 2014: 11 · 2013: 13 · 2012: 12
FWCI
16.89
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
alpha-linolenic acid, linseed oil, safflower oil, linoleic acid, dyslipidemia, C-reactive protein, serum amyloid A, interleukin-6, inflammation, n-6/n-3 ratio, polyunsaturated fatty acids, coronary artery disease, cholesterol, Greek diet
MeSH terms
Serum Amyloid A Protein, C-Reactive Protein, Humans, Hyperlipidemias, Linoleic Acids, Cholesterol, HDL, Cholesterol, LDL, Male, Probability, Radioimmunoassay, Sensitivity and Specificity, Cohort Studies, Interleukin-6, alpha-Linolenic Acid, Statistics, Nonparametric, Dietary Supplements

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