Dissociable correlates of recollection and familiarity within the medial temporal lobes
Abstract
Regions in the medial temporal lobes (MTL) have long been implicated in the formation of new memories for events, however, it is unclear whether different MTL subregions support different memory processes. Here, we used event-related functional magnetic resonance imaging (fMRI) to examine the degree to which two recognition memory processes-recollection and familiarity-were supported by different MTL subregions. Results showed that encoding activity in the rhinal cortex selectively predicted familiarity-based recognition, whereas, activity in the hippocampus and posterior parahippocampal cortex selectively predicted recollection. Collectively, these results support the view that different subregions within the MTL memory system implement unique encoding processes that differentially support familiarity and recollection.
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The prior literature is most consistent with a role for the PRC in item processing.
“the prior literature is most consistent with a role for the PRC in item processing”
From Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval (2015) · cites this paper as Ranganath et al., 2003
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- Authors
- Ranganath, C., Yonelinas, A. P., Cohen, M. X., Dy, C. J., Tom, S. M., & D’Esposito, M.
- Affiliations
- University of California, Davis (US)
- University of California, Berkeley (US)
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 42
- Issue
- 1
- Pages
- 2-13
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2103235389
- Cited by
- 689
- References
- 74
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 11 · 2023: 9 · 2022: 19 · 2021: 12 · 2020: 21 · 2019: 29 · 2018: 27 · 2017: 36 · 2016: 19 · 2015: 35 · 2014: 31 · 2013: 32 · 2012: 47
- FWCI
- 16.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- National Institute on Aging (R01AG015793, AG 15793, F32AG005863, AG05863)
- National Institute of Mental Health (MH 59352, R01MH063901, MH 63901, R01MH059352)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- recollection, familiarity, recognition memory, medial temporal lobe, rhinal cortex, hippocampus, parahippocampal cortex, memory encoding, event memory
- MeSH terms
- Adolescent, Adult, Cognition, Humans, Magnetic Resonance Imaging, Male, Memory, Oxygen, Psychomotor Performance, Mental Recall, Temporal Lobe, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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