The DOI matches its Crossref record; 150 of the 166 references it cites were found in a registry or an index.
Phytoecdysteroids: biological aspects
Abstract
Phytoecdysteroids are a family of about 200 plant steroids related in structure to the invertebrate steroid hormone 20-hydroxyecdysone. Typically, they are C27, C28 or C29 compounds possessing a 14alpha-hydroxy-7-en-6-one chromophore and A/B-cis ring fusion (5beta-H). In the present review, the distribution, biosynthesis, biological significance and potential applications of phytoecdysteroids are summarised.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“research results suggest that only around 6% of plant species contain detectable levels of PEs [6,8,9,10].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [8]
In the citing paper
“However, variations exist regarding the levels of 20HE in spinach, with some reporting lower amounts, such as 50 μg/g dry mass, 10.3 and 16.8 μg/g in different spinach accessions, and 0.44 mg% dry weight [8,156,160].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [8]
In the citing paper
“The biosynthetic pathway(s) in plants, just like that in arthropods, has not yet been fully elucidated, but the biosynthesis appears to differ mechanistically from that in animals (Figure 7), and maybe also differ within types of plant (e.g., between angiosperms and ferns; [3,35])”
From Ecdysteroids (2021) · cites this paper as [35]
In the citing paper
“The huge diversity of phytoecdysteroid molecular structures indicates that biosynthesis in plants occurs as a combinatorial system of a network of enzymes without strong substrate specificity, which could result in over 1000 possible permutations of structure from a small number of early intermediates (14α-hydroxy-6-oxo-7-ene C 27/28/29sterols [35]).”
From Ecdysteroids (2021) · cites this paper as [35]
In the citing paper
“It has been shown in several ecdysteroid-accumulating species that ecdysteroid levels are additionally influenced by environmental factors (e.g., temperature, nutritional factors, invertebrate predation [35]).”
From Ecdysteroids (2021) · cites this paper as [35]
In the citing paper
“Both E and 20E exist in plants to play roles in the plants or participate in the defense of plants against insects [73].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [73]
In the citing paper
“A series of evidence suggests that PEs do not accumulate in the majority of plant species as the expression of the biosynthetic pathways in plants is downregulated6.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [6]
In the citing paper
“a survey indicates that only ∼6% of all plants contain detectable levels of ecdysteroids6.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [6]
In the citing paper
“PEs have several beneficial effects on mammals: they play roles in anabolic, adaptogenic, antidiabetic, anti-inflammatory, antioxidant, antitumor, antimicrobial, and anti-arthritic activity. They also act as hepatoprotectors and immunomodulators [3,8,12,15,155].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [3]
In the citing paper
“PE treatment negatively affects invertebrate growth, development, and reproduction, but PEs do not exhibit toxicity in mammals [3].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [3]
In the citing paper
“Ecdysteroids exhibit interesting pharmacological effects on mammals, such as the stimulation of protein synthesis, antidiabetic activity, and antirheumatic activity [5,6,7].”
In the citing paper
“Ecdysteroids are a,b-unsaturated 6-ketosteroids that occur in a wide range of plant species; as analogs of the insect molting hormone ecdysone, these compounds possess several biological functions in the flora and the fauna [11,12].”
From Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam (2018) · cites this paper as [11]
Citations
Cites
Comprehensive insect physiology, biochemistry and pharmacology
(1985) · Journal of Insect Physiology · doi:10.1016/0022-1910(85)90117-9 · Cited by 4,819
Progress in the Chemistry of Organic Natural Products 109
(2019) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-030-12858-6 · Cited by 2,052
Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
Yao, T., FORMAN, B. M., Jiang, Z., Cherbas, L., Chen, J.-D., McKeown, M., Cherbas, P. T., & Evans, R. M. (1993) · Nature · doi:10.1038/366476a0 · Cited by 947
New insecticides with ecdysteroidal and juvenile hormone activity
Dhadialla, T. S., Carlson, G. R., & Le, D. P. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.545 · Cited by 912
National Research Council (1969) · National Academies Press eBooks · doi:10.17226/20506 · Cited by 721
Naturally Occurring Insecticides
Jacobson, M., Crosby, D. G., & FORGASH, A. J. (1972) · Soil Science · doi:10.1097/00010694-197205000-00015 · Cited by 543
Ecdysone : from chemistry to mode of action
Koolman, J., Becker, J., & Karlson, P. (1989) · Medical Entomology and Zoology · Cited by 490
Miller, J. R., & Miller, T. A. (1986) · Springer series in experimental entomology · doi:10.1007/978-1-4612-4910-8 · Cited by 448
Über die Isolierung eines Metamorphose-Hormons der Insekten in kristallisierter Form
Butenandt, A., & Karlson, P. (1954) · Zeitschrift für Naturforschung B · doi:10.1515/znb-1954-0601 · Cited by 367
Ecological Chemistry and Biochemistry of Plant Terpenoids.
Meurer‐Grimes, B., Harborne, J. B., & Tomás-Barberán, F. A. (1992) · Brittonia · doi:10.2307/2806846 · Cited by 338
Research works printed but not linked: 20
- Anufrieva, 1998, The content and composition of ecdysteroids in plants and tissue cultures of Serratula coronata, Russian Journal of Plant Physiology, 45, 326
- Baltayev, 1992, Phytoecdysteroids of Rhaponticum carthamoides. III. Rapisterone C, Khimiya Prirodnykh Soedinenii, 231
- Delbecque, 1995, In vitro incorporation of radiolabelled cholesterol and mevalonic acid into ecdysteroids by hairy root cultures of a plant, Serratula tinctoria, European Journal of Entomology, 92, 301
- Dinan, 1995, A strategy for the identification of ecdysteroid receptor agonists and antagonists from plants, European Journal of Entomology, 92, 271
- Dinan, 1998, A strategy towards the elucidation of the contribution made by phytoecdysteroids to the deterrence of invertebrate predators on plants, Russian Journal of Plant Physiology, 45, 296
- Dinan, 1999, Phytoecdysteroids in seeds and plants of Rhagodia baccata (Labill.) Moq. (Chenopodiaceae), Archives of Insect Biochemistry and Physiology, 41, 18, 10.1002/(SICI)1520-6327(1999)41:1<18::AID-ARCH4>3.0.CO;2-T · DOI
- Koudela, 1995, Stimulation of growth and development in Japanese quails after oral administration of ecdysteroid-containing diet, European Journal of Entomology, 92, 349
- Lafont, 1997, Ecdysteroids and related molecules in animals and plants, Archives of Insect Biochemistry and Physiology, 35, 3, 10.1002/(SICI)1520-6327(1997)35:1/2<3::AID-ARCH2>3.0.CO;2-X · DOI
- Lafont, 1998, Phytoecdysteroids in the world flora, Russian Journal of Plant Physiology, 45, 276
- Lev, 1990, Ecdysteroids from tissue and cell cultures of Ajuga turkestanica, Khimiya Prirodnykh Soedinenii, 51
- Mirzaev, 1992, Effect of phytoecdysteroids on the sexual activity of male rats, Doklady Academii Nauk Respublinki Uzbekistan, 3, 47
- Mondy, 1997, Effects of the ingestion of Serratula tinctoria extracts, a plant containing phytoecdysteroids, on the development of the vineyard pest Lobesia botrana (Lepidoptera. Tortricidae), Archives of Insect Biochemistry and Physiology, 35, 227, 10.1002/(SICI)1520-6327(1997)35:1/2<227::AID-ARCH21>3.0.CO;2-C · DOI
- Prakash, 1979, Phytoecdysones, Journal of Scientific and Industrial Research (India), 38, 632
- Prymak, 1996, Effects of the phytoecdysteroid composition BTK-8L on fractionated intact rat liver chromatin, Ukrainskii Biokhimichnii Zhurnal, 68, 84
- Rees, 1995, Ecdysteroid biosynthesis and inactivation in relation to function, European Journal of Entomology, 92, 9
- Sláma, 1995, Insect hormones — ecdysteroids, European Journal of Entomology, 92, 355
- Spindler-Barth, 1997, Biological effects of muristerone A and turkesterone on the epithelial cell line from Chironomus tentans (Diptera, European Journal of Entomology, 94, 161
- Syrov, 1984, Mechanism of anabolic action of phytoecdysteroids in mammals, Biol. Nauki (Moscow), 11, 16
- Trenin, 1999, 20-Hydroxyecdysone as a human lymphocyte and neutrophil modulator, Archives of Insect Biochemistry and Physiology, 41, 156, 10.1002/(SICI)1520-6327(1999)41:3<156::AID-ARCH7>3.0.CO;2-Q · DOI
- Zibareva, 1997, The prognosis of the presence of ecdysteroids among the species Silene L. and Chenopodium L. to their contents in the seeds, Rastitelny Resursy, 33, 89
Cited by
Sorted by citations
Items 201–300 of 393
Park, M. N., Choi, J., Fahim, M. M. H., Asevedo, E. A., Nurkolis, F., Ribeiro, R. I. M. D. A., Kang, H. N., Kang, S., Syahputra, R. A., & Kim, B. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1504618 · Cited by 14
Zhao, X. (2020) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(19)62860-1 · Cited by 14
Nawrot, J., Budzianowski, J., Nowak, G., Micek, I., Budzianowska, A., & Gornowicz‐Porowska, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094428 · Cited by 14
“Nowadays, natural steroids are often chosen for skin change treatment, replacing synthetic steroids [8,26].”
BackgroundSazonalidade na produção de raízes e teor de β-ecdisona em acessos de fáfia
Júnior, C. C., Ming, L. C., & Cortez, D. A. G. (2008) · Horticultura Brasileira · doi:10.1590/s0102-05362008000300020 · Cited by 13
Ecdysteroids in Ferns: Distribution, Diversity, Biosynthesis, and Functions
Lafont, R., Ho, R., Raharivelomanana, P., & Dinan, L. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7162-3_22 · Cited by 13
“Ecdysteroids may contribute to phytophagous insect control, as shown with the same molecules isolated from various plant species ( Dinan 2001 ).”
BackgroundPlant Adaptogens: Natural Medicaments for 21 st Century?
Özdemir, Z., Bildziukevich, U., Wimmerová, M., Macůrková, A., Lovecká, P., & Wimmer, Z. (2018) · ChemistrySelect · doi:10.1002/slct.201702682 · Cited by 17
Steroidal compounds in Paris polyphylla:structure, biological activities, and biosynthesis
Hua, X., Kou, C., Wang, F., Zhang, J., Yuan, J., & Xue, Z. (2025) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2025.102695 · Cited by 12
Ecdysteroid content and distribution in plants of genus Potamogeton
Ivan, C., Volodin, V. V., Whiting, P., Shirshova, T. I., Kolegova, N. A., & Dinan, L. N. (2003) · Biochemical Systematics and Ecology · doi:10.1016/s0305-1978(02)00172-2 · Cited by 12
Ogura, T., Nakagawa, Y., Swevers, L., Smagghe, G. J., & Miyagawa, H. (2012) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2012.06.009 · Cited by 12
“There are various ecdysone agonists, and some of them have insecticidal activity by interfering with the function of 20E [6–9].”
BackgroundGuillén, P. O., Calabro, K., Jaramillo, K. B., Domínguez-Borbor, C., Genta‐Jouve, G., Rodríguez, J. A., & Thomas, O. (2018) · Marine Drugs · doi:10.3390/md16020058 · Cited by 12
“Ecdysteroids are known to be a widespread family of natural products produced by plants and arthropods, where they are known to play the role of molting hormones for arthropods, for example [33,34].”
BackgroundFujimoto, Y., Maeda, I., Ohyama, K., Hikiba, J., & Kataoka, H. (2015) · Phytochemistry · doi:10.1016/j.phytochem.2014.12.019 · Cited by 12
Jurenka, R. A., Russell, K., & O’Neal, M. E. (2016) · Pest Management Science · doi:10.1002/ps.4500 · Cited by 12
Dinan, L. N., Mamadalieva, N. Z., & Lafont, R. (2019) · Springer eBooks · doi:10.1007/978-981-13-1745-3_35-1 · Cited by 16
Gustatory perception of phytoecdysteroids in Plodia interpunctella larvae
Rharrabe, K., Sayah, F., & Marion‐Poll, F. (2010) · Entomologia Experimentalis et Applicata · doi:10.1111/j.1570-7458.2010.01068.x · Cited by 12
“The compounds used in this work are among the most common phytoecdysteroids present in plants (Dinan, 2001).”
BackgroundArbutin in Serratula quinquefolia M.B. (Asteraceae)
Nowak, G., Nawrot, J., & Latowski, K. (2011) · Acta Societatis Botanicorum Poloniae · doi:10.5586/asbp.2009.018 · Cited by 12
Davis, M. B., SanGil, I., Berry, G., Olayokun, R., & Neves, L. H. (2011) · BMC Developmental Biology · doi:10.1186/1471-213x-11-66 · Cited by 12
“Indeed, steroid signaling is an integral part of development in all animals and even in plant morphogenesis, phytoecdysteroids play important roles [74].”
BackgroundPhytoecdysteroids Do Not Have Anabolic Effects in Skeletal Muscle in Sedentary Aging Mice
Lawrence, M. M., Zwetsloot, K. A., Arthur, S. T., Sherman, C. A., Huot, J. R., Badmaev, V., Grace, M., Lila, M. A., Nieman, D. C., & Shanely, R. A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020370 · Cited by 11
“Phytoecdysteroids are plant-produced analogues of ecdysteroids, insect molting hormones that control cell proliferation, growth, and development [17].”
BackgroundEcdysteroids as defensive chemicals
(2022) · Advances in Insect Physiology · doi:10.1016/bs.aiip.2022.09.001 · Cited by 11
Ecdysteroids from Cyanotis longifolia Benth. (Commelinaceae)
Crouzet, S., Maria, A., Dinan, L., Lafont, R., & Girault, J. (2009) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.20329 · Cited by 25
Nawrot, J., Gornowicz‐Porowska, J., & Nowak, G. (2020) · Molecules · doi:10.3390/molecules25225329 · Cited by 11
“SD is a chronic dermatitis characterized by erythema and skin flaking, which occur most often on the face, scalp, ears, chest and body folds—in other words, places with a high concentration of sebaceous glands [64].”
BackgroundInsect Growth Regulatory Activity of Blechnum chilense
Carlos, A. H. L., Monsalve, Z. I., Parada, K., Lamilla, C., Alarcón, J., Céspedes, C. L., & Seigler, D. S. (2011) · Natural Product Communications · doi:10.1177/1934578x1100600808 · Cited by 11
Phytoecdysteroids: Isolation and Biological Applications
Naggar, Y. A. (2017) · American Journal of Life Sciences · doi:10.11648/j.ajls.20170501.12 · Cited by 11
“Phytoecdysteroid levels in plants are usually found to be 0.1% or less of their dry weight and have been isolated from all parts of plants in much higher amounts than those present in arthropods (Dinan 2001).”
BackgroundInfluentialBatista, D. S., Moreira, V. S., Felipe, S. H. S., Fortini, E. A., Silva, T. D., Chagas, K., Louback, E., Romanel, E. A. D. C., Costa, M. G. C., & Otoni, W. C. (2019) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-019-01606-6 · Cited by 11
“Those found in plants are called phytoecdysteroids, they are usually found in low levels and their production is extremely dependent on environmental factors, both biotic and abiotic (Dinan 2001, Thiem et al.”
BackgroundLomovsky, O. I., Королев, К. Г., & Kwon, Y. S. (2003) · Cited by 11
Novel Ecdysteroids fromSerratula wolffii
Ványolós, A., Béni, Z., Dékány, M., Simon, A., & Báthori, M. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/651275 · Cited by 11
“They are also present in large amounts and widely distributed in many plant species (from the Asteraceae, Lamiaceae, Caryophyllaceae, and Polypodiaceae families), where they display a certain potential in defense of plants against insects and nematodes [1].”
BackgroundExtraction and Monitoring of Phytoecdysteroids Through HPLC
Ghosh, D., & Laddha, K. S. (2006) · Journal of Chromatographic Science · doi:10.1093/chromsci/44.1.22 · Cited by 11
Burlini, N., Iriti, M., Daghetti, A., Faoro, F., Ruggiero, A., & Bernasconi, S. (2011) · Plant Cell Reports · doi:10.1007/s00299-011-1119-6 · Cited by 11
“Cell metabolism of 7-dehydrocholesterol is quite complex being the precursor of another class of steroid hormones, the phytoecdysteroids (Dinan 2001) (Fig.”
BackgroundValoy, M., Reguilón, C., & Podazza, G. (2015) · Wiley eBooks · doi:10.1002/9781118628041.ch5 · Cited by 11
NPC Natural Product Communications
Khana, S. I., Hester, J. P., Tekwania, B. L., Midiwob, J. O., Muhammada, I., Jaina, S. K., Jacoba, M. R., Walkera, L. A., Rahmana, A. A., & Samoylenkoa, V. (2011) · Cited by 11
Ecdysterone: Possible sources of origin in urine
Kwiatkowska, D., Grucza, K., Chajewska, K., Konarski, P., Wojtkowiak, K., Drapała, A., & Wicka, M. (2024) · Drug Testing and Analysis · doi:10.1002/dta.3420 · Cited by 10
Holá, D., Kočová, M., Rothová, O., Tůmová, L., Kamlar, M., & Macek, T. (2013) · Acta Physiologiae Plantarum · doi:10.1007/s11738-013-1379-6 · Cited by 10
Phytoecdysteroid and Clerodane Content in Three Wild Ajuga Species in Israel
Taha-Salaime, L., Davidovich-Rikanati, R., Sadeh, A., Abu-Nassar, J., Marzouk-Kheredin, S., Yahyaa, Y., Ibdah, M., Ghanim, M., Lewinsohn, E., Inbar, M., et al. (2019) · ACS Omega · doi:10.1021/acsomega.8b03029 · Cited by 10
Dinan, L. N., Lafont, F., & Lafont, R. (2023) · Plants · doi:10.3390/plants12040776 · Cited by 9
“The ecdysteroid profile of a plant can vary from simple, where one or two analogues are present, to more complex, where major ecdysteroids are accompanied by some minor analogues to form a complex cocktail made up of many different analogues [17,18].”
BackgroundEcdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities
Lu, M., Wang, P., Zhou, S., Flickinger, B., Malhotra, D. K., Ge, Y., Tatar, M., Dworkin, L. D., Liu, Z., & Gong, R. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493499 · Cited by 11
In Silico Identification of Chemicals Capable of Binding to the Ecdysone Receptor
Mellor, C. L., Tollefsen, K. E., LaLone, C. A., Cronin, M., & Firman, J. W. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4733 · Cited by 10
“Many steroidal ecdysteroids described in the literature have their origins in selected plant species, in which they are speculated to play a role in defence against herbivore grazing (Dinan 2001).”
BackgroundActivity of Ajuga iva Extracts Against the African Cotton Leafworm Spodoptera littoralis
Taha-Salaime, L., Lebedev, G., Abo-Nassar, J., Marzouk, S., Inbar, M., Ghanim, M., & Aly, R. (2020) · Insects · doi:10.3390/insects11110726 · Cited by 9
“Phytoecdysteroids are plant-produced steroids that are analogs of the steroid hormones that control molting and metamorphosis in arthropods (Dinan 2001).”
BackgroundInfluentialSzypuła, W. J., & Pietrosiuk, A. (2021) · Sustainable development and biodiversity · doi:10.1007/978-3-030-74779-4_19 · Cited by 10
A MONOGRAPHIC REVISION OF THE GENUS PODOCARPUS (PODOCARPACEAE): I. HISTORICAL REVIEW
Mill, R. R. (2014) · Edinburgh Journal of Botany · doi:10.1017/s0960428614000146 · Cited by 10
Kamimura, M., Shimura, S., & Kiuchi, M. (2003) · Journal of insect biotechnology and sericology · doi:10.11416/jibs.72.197 · Cited by 10
Gorelick-Feldman, J. (2009) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3wq041h · Cited by 10
“Their occurrence is distributed throughout the plant kingdom, with approximately 6% of all plants surveyed containing detectable levels of ecdysteroids (Dinan 2001).”
BackgroundAn overview of plant secondary metabolites, their biochemistry and generic applications
Rami, E., Singh, A., & Favzulazim, S. (2021) · The Journal of Phytopharmacology · doi:10.31254/phyto.2021.10523 · Cited by 9
Scanlan, J. L., & Robin, C. (2024) · Genome Biology and Evolution · doi:10.1093/gbe/evae019 · Cited by 8
Vasconcelos, J. M., Saldanha, C. W., Dias, L. L. C., Maldaner, J., do Rêgo, M. M., da Silva, L. C., & Otoni, W. C. (2014) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-014-9651-z · Cited by 9
“Phytoecdysteroids are plant secondary metabolites that mimic insect hormones responsible for the regulation of the molting process (Dinan 2001; Festucci-Buselli et al. 2008a).”
BackgroundMethodInfluentialThree phytoecdysteroids from Sagina japonica and potential biotransforming pathways of japonicone
Jia, A., Li, Y., Zhou, J., & Gao, J. (2010) · Chemistry of Natural Compounds · doi:10.1007/s10600-010-9729-8 · Cited by 9
Macchia, M., Montoro, P., Ceccarini, L., Molfetta, I., & Pìzza, C. (2009) · CINECA IRIS Institutial research information system (University of Pisa) · doi:10.5897/ajmr.9000024 · Cited by 9
Mechanochemically Assisted Extraction
Lomovsky, O. I., & Lomovsky, I. O. (2011) · Contemporary food engineering · doi:10.1201/b11241-14 · Cited by 9
Orie, N. N., Raees, A., Al-Jaber, M., Mohamed-Ali, N., Bensmail, H., Hamza, M. M., Al-Ansari, N., Beotra, A., Mohamed‐Ali, V., & Al‐Maadheed, M. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100078 · Cited by 9
Wu, J., Cheng, K., Wang, H., Ye, W., Li, E. T. S., & Wang, M. (2008) · Phytochemical Analysis · doi:10.1002/pca.1097 · Cited by 9
Isnansetyo, A., Trijoko, Setyowati, E. P., & Anshory, H. H. (2009) · Journal of Biological Sciences · doi:10.3923/jbs.2009.224.230 · Cited by 9
Ecdysteroids are present in the blood of wild passerine birds
Hornok, S., Csorba, A., Kováts, D., Csörgő, T., & Hunyadi, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-53090-9 · Cited by 7
Analysis of ecdysteroids by micellar electrokinetic chromatography with on-line preconcentration
Santagati, N. A., Tropea, S., & Ronsisvalle, G. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.05.004 · Cited by 9
Neves, C. S., Gomes, S. S. L., dos Santos, T. R., de Almeida, M. M., de Souza, Y. O., Garcia, R. M. G., Otoni, W. C., Chedier, L. M., Viccini, L. F., & de Campos, J. M. S. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.11.038 · Cited by 8
In vitro adjuvant antitumor activity of various classes of semi-synthetic poststerone derivatives
Savchenko, R. G., Nové, M., Spengler, G., Hunyadi, A., & Parfenova, L. V. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104485 · Cited by 8
Ko, D., Medagoda, N., Yun, K., & Lee, K. (2023) · Journal of the World Aquaculture Society · doi:10.1111/jwas.13021 · Cited by 11
Mokua, G. N. (2013) · Kenyatta University Institutional Repository (Kenyatta University) · doi:10.12691/wjoc-1-1-1 · Cited by 8
“Reported experiments [32,33,34,35,36] working on some plant extracts having potential larvicides also note that botanical blends provide better effect in reducing vector population.”
BackgroundMuema, J. M., Bargul, J. L., Mutunga, J. M., Obonyo, M. A., Asudi, G. O., & Njeru, S. N. (2021) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2021.104912 · Cited by 8
Zhang, Y., Tan, Q., Jin, L., & Li, G. (2024) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.22111 · Cited by 8
Nowak, G., Urbańska, M., Nawrot, J., Bernard, M. K., & Dawid-Pać, R. (2013) · Journal of Planar Chromatography – Modern TLC · doi:10.1556/jpc.26.2013.3.15 · Cited by 8
Role of Natural Products as Alternative of Synthetic Steroidal Drugs
Tiwari, P., Pandey, R., Singh, R., & Sharma, B. (2020) · Springer eBooks · doi:10.1007/978-981-15-2195-9_7 · Cited by 8
Ecdysteroid Chemistry and Biochemistry ☆
Lafont, R., Dauphin‐Villemant, C., Warren, J. T., & Rees, H. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.04026-7 · Cited by 8
Sashindran, K., Kariappa, B. K., & Kamble, C. K. (2008) · Journal of Biological Sciences · doi:10.3923/jbs.2008.470.473 · Cited by 8
β-Ecdysterone accumulation and regulation in Ajuga multiflora Bunge suspension culture
Wang, Y.-C., Zhao, J., & Chi, D. (2018) · 3 Biotech · doi:10.1007/s13205-018-1117-2 · Cited by 8
Insect Growth Regulator (IGR) effects of Eucalyptus citriodora Hook (Myrtaceae)
Salazar, J. R., Torres, P., Serrato, B., Domı́nguez, M., Alarcón, J., & Céspedes, C. L. (2015) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 8
Wünschiers, R., Jahn, M., Jahn, D., Schomburg, I., Peifer, S., Heinzle, E., BURTSCHER, H. J., Garbe, J., Steen, A., Schobert, M., et al. (2012) · Wiley eBooks · doi:10.1002/9781118657072.ch3 · Cited by 8
Supercritical fluid extraction of beta-ecdysone from Brazilian ginseng (Pfaffia glomerata) roots
C. N. Debien, I., & Angela A. Meireles, M. (2014) · Food and public health · doi:10.5923/j.fph.20140402.08 · Cited by 7
“Among the phytoecdysteroids, betaecdysone (Figure 1) is recognized as the major biologically active ecdysteroid in most invertebrate systems [3].”
Mamadalieva, N. Z., Hussain, H., Mollica, A., Zengin, G., Mamadalieva, R. Z., Elhady, S. S., Fadil, S. A., Ashour, M. L., & Youssef, F. S. (2022) · Life · doi:10.3390/life12060824 · Cited by 7
“Ecdysteroids exist in ≈5–6% of plant species with higher concentrations than their concentrations in arthropods, where they are believed to contribute to the deterrence of invertebrate predators [9].”
BackgroundTodorova, V., Ivanova, S., Yotov, V., Zaytseva, E., Ardasheva, R., Turiyski, V., Prissadova, N., & Ivanov, K. (2024) · Molecules · doi:10.3390/molecules29215145 · Cited by 7
Kostov, T., Diel, P., & Isenmann, E. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.10.005 · Cited by 7
Савченко, Р. Г., Kostyleva, S. A., Качала, В. В., Khalilov, L. M., & Одиноков, В. Н. (2014) · Steroids · doi:10.1016/j.steroids.2014.06.019 · Cited by 7
“These compound exhibit physiological activities in insects and has been shown in both invertebrates and plant species [1].”
Synthesis of 7,8α-dihydro-14α-deoxyecdysteroids
Савченко, Р. Г., Urasaeva, Y. R., Galyautdinov, I. V., Афонькина, С. Р., Khalilov, L. M., Dolgushin, F. M., & Одиноков, В. Н. (2011) · Steroids · doi:10.1016/j.steroids.2011.02.027 · Cited by 7
Antidiabetic Sterols from Peniocereus greggii Roots
Muñoz-Gómez, R. J., Rivero‐Cruz, I., Ovalle‐Magallanes, B., Linares, E., Bye, R. A., Tovar, A. R., Noriega, L. G., Tovar‐Palacio, C., & Mata, R. (2022) · ACS Omega · doi:10.1021/acsomega.2c00595 · Cited by 7
Navrátilová, B., Ondřej, V., Vrchotová, N., Třı́ska, J., Horník, Š., & Pavela, R. (2022) · Horticulturae · doi:10.3390/horticulturae8070581 · Cited by 7
Poels, J., Martínez, A., Suner, M., LOOF, A. D., Dunbar, S. J., & Broeck, J. V. (2004) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2004.02.005 · Cited by 8
HPLC and TLC characterisation of ecdysteroid alkyl ethers
Lapenna, S., & Dinan, L. N. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.07.014 · Cited by 7
Sun, H., Dinan, L. N., Lafont, R., Suksamrarn, A., Griesinger, C., Reinscheid, U. M., & Lapenna, S. (2010) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201000366 · Cited by 7
A New Conformer of 20-Hydroxyecdysone from Sesuvium Portulacastrum : An X-ray Crystallographic Study
Rele, S. S., Banerji, A., Chintalwar, G. J., Kumar, V., & Yadava, V. S. (2003) · Natural Product Research · doi:10.1080/1478641031000103696 · Cited by 7
Tel‐Çayan, G., Doğan, B., Erol, E., Öztürk, M., Nadeem, S., Ullah, Z., Duru, M. E., & Duran, A. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 7
Rybin, V., BOLTENKOV, E. V., & Новожилова, Е. В. (2007) · Natural Product Communications · doi:10.1177/1934578x0700201110 · Cited by 7
Synthesis and biological activities of turkesterone 11α-acyl derivatives
Dinan, L. N., Bourne, P. C., Whiting, P., Tsitsekli, A., Saatov, Z., Dhadialla, T. S., Hormann, R. E., Lafont, R., & Coll, J. (2003) · Journal of Insect Science · doi:10.1673/031.003.0601 · Cited by 7
“They also occur in certain plant species, where they are known as phytoecdysteroids and are believed to contribute to the deterrence of invertebrate predators (Dinan, 2001).”
Role of Preparative Rotation Planar Chromatography in the Isolation of Ecdysteroids
Kalász, H., Liktor‐Busa, E., Janicsák, G., & Báthori, M. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070600759967 · Cited by 7
“This newly developed purification procedure has led to the isolation of two previously unknown ecdysteroids and several known, biologically important ecdysteroids, such as ajugasterone C, dacrychainansterone, 22deoxy-integristerone A, and 20-hydroxyecdysone.([6,7]) 20-Hydroxyecdysone is the main ecdysteroid of plants…”
BackgroundDenben, B., Sripinyowanich, S., Ruangthai, R., & Phoemsapthawee, J. (2023) · Sports · doi:10.3390/sports11090175 · Cited by 6
“Extensive research on the potential anabolic-promoting effects of ecdys-terone in various animal models and cell cultures has been reported [10,14,17–20].”
BackgroundKaratt, T. K., Sathiq, M. A., Laya, S., Ajeebsanu, M. M., Kal, A. K. K., Subhahar, M. B., & Perwad, Z. (2023) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.9611 · Cited by 6
General Overview of Plant Secondary Metabolism
Viladomat, F., & Bastida, J. (2015) · Springer eBooks · doi:10.1007/978-81-322-2286-6_21 · Cited by 6
Stereoselective synthesis of 9α-hydroxylated ecdysteroids
Drach, S. V., Khripach, V. A., Litvinovskaya, R. P., Lyakhov, A. S., Schneider, B., & Zhylitskaya, H. A. (2009) · Steroids · doi:10.1016/j.steroids.2009.10.011 · Cited by 6
John, R., Shajitha, P. P., Devassy, A., & Mathew, L. (2017) · Acta Physiologiae Plantarum · doi:10.1007/s11738-017-2555-x · Cited by 6
Milano, F., Mussi, F., Fornaciari, S., Altunoz, M., Forti, L., Arru, L., & Buschini, A. (2019) · Biomolecules · doi:10.3390/biom9020053 · Cited by 6
ATR-FTIR Spectral Analysis of Ferns Using as Fingerprint for Identification of Fern Species
Topală, C. M., Păunescu, A., & Soare, L. C. (2019) · Revista de Chimie · doi:10.37358/rc.19.3.7024 · Cited by 6
Ecdysteroid ingestion suppresses carbohydrate hydrolysis in larvae of the silkworm Bombyx mori
Suzuki, T., & Iwami, M. (2020) · Die Naturwissenschaften · doi:10.1007/s00114-020-01684-z · Cited by 6
“Phytoecdysteroids have been proposed to act as antifeedants to protect plants from insect damage (Kubo and Klocke 1983; Dinan 2001; Dinan et al. 2009).”
BackgroundTranscriptome analysis of abscisic acid induced 20E regulation in suspension Ajuga lobata cells
Wang, Y., Yang, Y., & Chi, D. (2018) · 3 Biotech · doi:10.1007/s13205-018-1352-6 · Cited by 6
“However, the full 20E synthesis pathway remains unclear; the pathways from squalene to 20E are not completely described (Adler and Grebenok 1995; Dinan 2001; Báthori and Pongrácz 1 3 2005; Ma et al.”
BackgroundDinan, L. N., Mamadalieva, N. Z., & Lafont, R. (2021) · Springer eBooks · doi:10.1007/978-981-15-4148-3_35 · Cited by 5
Phytoecdysteroid C2‐hydroxylase is microsomal in spinach, Spinacia oleracea L.
Bakrim, A., Crilat, E., Maria, A., de Virville, J. D., Lafont, R., & Takvorian, N. (2009) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.20330 · Cited by 5
Ecofriendly Approach for Steroids, Terpenes, and Alkaloids-based Biosurfactant
(2022) · Biointerface Research in Applied Chemistry · doi:10.33263/briac132.114 · Cited by 5
“In insects, they go about as shedding hormones, directing transformation, and a few other significant life-cycle measures [109].”
BackgroundHermosaningtyas, A. A., Kruszka, D., Juszczyk, K., Rewers, M., Budzianowska, A., Yanti, Y., & Kikowska, M. A. (2024) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-024-02859-6 · Cited by 5
“Plants generate ecdyster - oids in response to environmental stress (e.g., temperature and seasonal variation) and offer protection against phytophagous insects or soil-dwelling nematodes (Dinan 2001 ; Thiem et al. 2017 ; Das et al. 2021).”
Stress- and geroprotective properties of 20-hydroxyecdysone and its derivatives
Савченко, Р. Г., Kostyleva, S. A., Одиноков, В. Н., Akhmetkireeva, T. T., & Васильевна, Б. Г. (2015) · Advances in Gerontology · doi:10.1134/s2079057015040190 · Cited by 5
Boo, K.-H., Seo, J. K., Ahn, J., Riu, K.-Z., & Kim, S. I. (2017) · Journal of Asia-Pacific Entomology · doi:10.1016/j.aspen.2017.11.002 · Cited by 5
Cousins, M. M., Briggs, J. A., & Whitwell, T. (2017) · Journal of Environmental Horticulture · doi:10.24266/jeh-d-17-00008.1 · Cited by 5
“Plants often produce these compounds (Dinan 2001), and ecdysteroids have demonstrated abilities to disrupt insect endocrine function (Adler and Grebenok 1999).”
BackgroundAdvances in Genetic Engineering of Ajuga Species
Kayani, W. K., Hasan, H., & Mirza, B. (2018) · Springer eBooks · doi:10.1007/978-981-13-0535-1_27 · Cited by 5
Fujaya, Y., Trijuno, D. D., Haryati, H., Hasnidar, H., Rusdi, M. S., & Usman, Z. (2019) · TORANI Journal of Fisheries and Marine Science · doi:10.35911/torani.v2i1.5857 · Cited by 5
“Bahkan, lebih dari 1000 struktur yang mungkin muncul secara alami (Dinan, 2001).”
BackgroundSoares, S. F., Louly, C. C. B., Neves, C. A., Marion‐Poll, F., & Borges, L. M. F. (2012) · Physiological Entomology · doi:10.1111/j.1365-3032.2012.00839.x · Cited by 5
“Ecdysteroids are polyhydroxylated sterolic compounds that represent a class of steroid hormones occurring in all classes of arthropods, and probably in other invertebrates as well (Dinan, 2001).”
BackgroundPlant Steroids: Occurrence, Biological Significance, and Their Analysis
Gunaherath, G. M. K. B., & Gunatilaka, A. A. L. (2020) · Wiley eBooks · doi:10.1002/9780470027318.a9931.pub2 · Cited by 5
Metadata
- Authors
- Dinan, L.
- Affiliations
- University of Exeter (GB)
- Corresponding author
- Dinan, Laurence
- ORCID
- Dinan, Laurence
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 57
- Issue
- 3
- Pages
- 325-339
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W2032058270
- Cited by
- 392
- References
- 166
- Citations by year
- 2026: 17 · 2025: 11 · 2024: 11 · 2023: 13 · 2022: 18 · 2021: 27 · 2020: 23 · 2019: 18 · 2018: 18 · 2017: 18 · 2016: 18 · 2015: 13 · 2014: 17 · 2013: 15 · 2012: 19
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- phytoecdysteroids, 20-hydroxyecdysone, plant steroids, steroidogenesis, biological significance
- MeSH terms
- Animals, Ecdysone, Ecdysterone, Invertebrates, Pest Control, Biological, Phytosterols, Plant Physiological Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
