The DOI matches its Crossref record; 150 of the 166 references it cites were found in a registry or an index.
Phytoecdysteroids: biological aspects
Abstract
Phytoecdysteroids are a family of about 200 plant steroids related in structure to the invertebrate steroid hormone 20-hydroxyecdysone. Typically, they are C27, C28 or C29 compounds possessing a 14alpha-hydroxy-7-en-6-one chromophore and A/B-cis ring fusion (5beta-H). In the present review, the distribution, biosynthesis, biological significance and potential applications of phytoecdysteroids are summarised.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“research results suggest that only around 6% of plant species contain detectable levels of PEs [6,8,9,10].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [8]
In the citing paper
“However, variations exist regarding the levels of 20HE in spinach, with some reporting lower amounts, such as 50 μg/g dry mass, 10.3 and 16.8 μg/g in different spinach accessions, and 0.44 mg% dry weight [8,156,160].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [8]
In the citing paper
“The biosynthetic pathway(s) in plants, just like that in arthropods, has not yet been fully elucidated, but the biosynthesis appears to differ mechanistically from that in animals (Figure 7), and maybe also differ within types of plant (e.g., between angiosperms and ferns; [3,35])”
From Ecdysteroids (2021) · cites this paper as [35]
In the citing paper
“The huge diversity of phytoecdysteroid molecular structures indicates that biosynthesis in plants occurs as a combinatorial system of a network of enzymes without strong substrate specificity, which could result in over 1000 possible permutations of structure from a small number of early intermediates (14α-hydroxy-6-oxo-7-ene C 27/28/29sterols [35]).”
From Ecdysteroids (2021) · cites this paper as [35]
In the citing paper
“It has been shown in several ecdysteroid-accumulating species that ecdysteroid levels are additionally influenced by environmental factors (e.g., temperature, nutritional factors, invertebrate predation [35]).”
From Ecdysteroids (2021) · cites this paper as [35]
In the citing paper
“Both E and 20E exist in plants to play roles in the plants or participate in the defense of plants against insects [73].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [73]
In the citing paper
“A series of evidence suggests that PEs do not accumulate in the majority of plant species as the expression of the biosynthetic pathways in plants is downregulated6.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [6]
In the citing paper
“a survey indicates that only ∼6% of all plants contain detectable levels of ecdysteroids6.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [6]
In the citing paper
“PEs have several beneficial effects on mammals: they play roles in anabolic, adaptogenic, antidiabetic, anti-inflammatory, antioxidant, antitumor, antimicrobial, and anti-arthritic activity. They also act as hepatoprotectors and immunomodulators [3,8,12,15,155].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [3]
In the citing paper
“PE treatment negatively affects invertebrate growth, development, and reproduction, but PEs do not exhibit toxicity in mammals [3].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [3]
In the citing paper
“Ecdysteroids exhibit interesting pharmacological effects on mammals, such as the stimulation of protein synthesis, antidiabetic activity, and antirheumatic activity [5,6,7].”
In the citing paper
“Ecdysteroids are a,b-unsaturated 6-ketosteroids that occur in a wide range of plant species; as analogs of the insect molting hormone ecdysone, these compounds possess several biological functions in the flora and the fauna [11,12].”
From Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam (2018) · cites this paper as [11]
Citations
Cites
Comprehensive insect physiology, biochemistry and pharmacology
(1985) · Journal of Insect Physiology · doi:10.1016/0022-1910(85)90117-9 · Cited by 4,819
Progress in the Chemistry of Organic Natural Products 109
(2019) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-030-12858-6 · Cited by 2,052
Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
Yao, T., FORMAN, B. M., Jiang, Z., Cherbas, L., Chen, J.-D., McKeown, M., Cherbas, P. T., & Evans, R. M. (1993) · Nature · doi:10.1038/366476a0 · Cited by 947
New insecticides with ecdysteroidal and juvenile hormone activity
Dhadialla, T. S., Carlson, G. R., & Le, D. P. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.545 · Cited by 912
National Research Council (1969) · National Academies Press eBooks · doi:10.17226/20506 · Cited by 721
Naturally Occurring Insecticides
Jacobson, M., Crosby, D. G., & FORGASH, A. J. (1972) · Soil Science · doi:10.1097/00010694-197205000-00015 · Cited by 543
Ecdysone : from chemistry to mode of action
Koolman, J., Becker, J., & Karlson, P. (1989) · Medical Entomology and Zoology · Cited by 490
Miller, J. R., & Miller, T. A. (1986) · Springer series in experimental entomology · doi:10.1007/978-1-4612-4910-8 · Cited by 448
Über die Isolierung eines Metamorphose-Hormons der Insekten in kristallisierter Form
Butenandt, A., & Karlson, P. (1954) · Zeitschrift für Naturforschung B · doi:10.1515/znb-1954-0601 · Cited by 367
Ecological Chemistry and Biochemistry of Plant Terpenoids.
Meurer‐Grimes, B., Harborne, J. B., & Tomás-Barberán, F. A. (1992) · Brittonia · doi:10.2307/2806846 · Cited by 338
Research works printed but not linked: 20
- Anufrieva, 1998, The content and composition of ecdysteroids in plants and tissue cultures of Serratula coronata, Russian Journal of Plant Physiology, 45, 326
- Baltayev, 1992, Phytoecdysteroids of Rhaponticum carthamoides. III. Rapisterone C, Khimiya Prirodnykh Soedinenii, 231
- Delbecque, 1995, In vitro incorporation of radiolabelled cholesterol and mevalonic acid into ecdysteroids by hairy root cultures of a plant, Serratula tinctoria, European Journal of Entomology, 92, 301
- Dinan, 1995, A strategy for the identification of ecdysteroid receptor agonists and antagonists from plants, European Journal of Entomology, 92, 271
- Dinan, 1998, A strategy towards the elucidation of the contribution made by phytoecdysteroids to the deterrence of invertebrate predators on plants, Russian Journal of Plant Physiology, 45, 296
- Dinan, 1999, Phytoecdysteroids in seeds and plants of Rhagodia baccata (Labill.) Moq. (Chenopodiaceae), Archives of Insect Biochemistry and Physiology, 41, 18, 10.1002/(SICI)1520-6327(1999)41:1<18::AID-ARCH4>3.0.CO;2-T · DOI
- Koudela, 1995, Stimulation of growth and development in Japanese quails after oral administration of ecdysteroid-containing diet, European Journal of Entomology, 92, 349
- Lafont, 1997, Ecdysteroids and related molecules in animals and plants, Archives of Insect Biochemistry and Physiology, 35, 3, 10.1002/(SICI)1520-6327(1997)35:1/2<3::AID-ARCH2>3.0.CO;2-X · DOI
- Lafont, 1998, Phytoecdysteroids in the world flora, Russian Journal of Plant Physiology, 45, 276
- Lev, 1990, Ecdysteroids from tissue and cell cultures of Ajuga turkestanica, Khimiya Prirodnykh Soedinenii, 51
- Mirzaev, 1992, Effect of phytoecdysteroids on the sexual activity of male rats, Doklady Academii Nauk Respublinki Uzbekistan, 3, 47
- Mondy, 1997, Effects of the ingestion of Serratula tinctoria extracts, a plant containing phytoecdysteroids, on the development of the vineyard pest Lobesia botrana (Lepidoptera. Tortricidae), Archives of Insect Biochemistry and Physiology, 35, 227, 10.1002/(SICI)1520-6327(1997)35:1/2<227::AID-ARCH21>3.0.CO;2-C · DOI
- Prakash, 1979, Phytoecdysones, Journal of Scientific and Industrial Research (India), 38, 632
- Prymak, 1996, Effects of the phytoecdysteroid composition BTK-8L on fractionated intact rat liver chromatin, Ukrainskii Biokhimichnii Zhurnal, 68, 84
- Rees, 1995, Ecdysteroid biosynthesis and inactivation in relation to function, European Journal of Entomology, 92, 9
- Sláma, 1995, Insect hormones — ecdysteroids, European Journal of Entomology, 92, 355
- Spindler-Barth, 1997, Biological effects of muristerone A and turkesterone on the epithelial cell line from Chironomus tentans (Diptera, European Journal of Entomology, 94, 161
- Syrov, 1984, Mechanism of anabolic action of phytoecdysteroids in mammals, Biol. Nauki (Moscow), 11, 16
- Trenin, 1999, 20-Hydroxyecdysone as a human lymphocyte and neutrophil modulator, Archives of Insect Biochemistry and Physiology, 41, 156, 10.1002/(SICI)1520-6327(1999)41:3<156::AID-ARCH7>3.0.CO;2-Q · DOI
- Zibareva, 1997, The prognosis of the presence of ecdysteroids among the species Silene L. and Chenopodium L. to their contents in the seeds, Rastitelny Resursy, 33, 89
Cited by
Sorted by citations
Items 101–200 of 393
Muema, J. M., Bargul, J. L., Nyanjom, S. G., Mutunga, J. M., & Njeru, S. N. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1789-6 · Cited by 31
“Commonly known IGRs are insect developmental hormone agonists that mimic the actions of juvenile hormone and ecdysone while others inhibit chitin synthesis [55, 56].”
BackgroundLignan Glucosides and Serotonin Phenylpropanoids from the Seeds of Leuzea carthamoides
Harmatha, J., Buděšı́nský, M., Vokáč, K., Pavlı́k, M., Grüner, K., & Laudová, V. (2007) · Collection of Czechoslovak Chemical Communications · doi:10.1135/cccc20070334 · Cited by 31
Ahmed, B., Mostapha, L., Fouad, S., & Fatiha, C. (2007) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb2007.000-2446 · Cited by 30
“20-hydroxyecdysone (20E) is the most commonly occurring and the most abundant phytoecdysteroids produced by plants (Lafont, 1997; Dinan, 2001).”
BackgroundShuvalov, O., Fedorova, O., Tananykina, E., Gnennaya, Y., Daks, A., Petukhov, A., & Barlev, N. A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.561537 · Cited by 30
Курашов, Е. А., Krylova, J. V., Mitrukova, G. G., & Чернова, А. М. (2014) · Contemporary Problems of Ecology · doi:10.1134/s1995425514040064 · Cited by 30
“At the same time, when arthropods eat plants containing phytoecdysteroids, they can suffer from various disorders (metabolic stress, premature molt, weight loss, etc.) up to their death; i.e., these substances perform an active safety function (Dinan, 2001; Timofeev, 2006).”
BackgroundLim, H.-S., Moon, B. C., Lee, J., Choi, G., & Park, G. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.010 · Cited by 30
Scanlan, J. L., Gledhill-Smith, R. S., Battlay, P., & Robin, C. (2020) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2020.103429 · Cited by 28
Biological functions of active ingredients in quinoa bran: Advance and prospective
Yang, F., Guo, T., Zhou, Y., Han, S., Sun, S., & Luo, F. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2139219 · Cited by 29
“The bases are 20-hydroxyecdysone and have 14 α-hydroxy-7-ene-6-one chromophores fused with a/B-cis ring (5 β-H) in their chemical structures (Dinan 2001).”
Background24-Epibrassinolide and 20-hydroxyecdysone affect photosynthesis differently in maize and spinach
Rothová, O., Hola, D., Kočová, M., Tůmová, L., Hnilička, F., Hniličková, H., Kamlar, M., & Macek, T. (2014) · Steroids · doi:10.1016/j.steroids.2014.04.006 · Cited by 29
C-29 Ecdysteroids from Ajuga reptans var. reptans
Ványolós, A., Simon, A., Tóth, G., Polgár, L., Kele, Z., Ilku, A., Mátyus, P., & Báthori, M. (2009) · Journal of Natural Products · doi:10.1021/np800708g · Cited by 28
Phytoecdysteroids from the Roots of Achyranthes bidentata Blume
Zhang, M., Zhou, Z., Wang, J., Cao, Y., Chen, X., Zhang, W., Lin, L., & Tan, J. (2012) · Molecules · doi:10.3390/molecules17033324 · Cited by 28
“3 and Tables 1 and 2) supported the fact that 1 was an ecdysteroid closely related to inokosterone-20,22-acetonide, a reported [21,22] ecdysteroid compound which was also obtained as compound 3 in the present study.”
BackgroundProapoptotic and proautophagic activity of 20-hydroxyecdysone in breast cancer cells in vitro
Romaniuk-Drapała, A., Lisiak, N., Totoń, E., Matysiak, A., Nawrot, J., Nowak, G., Kaczmarek, M., Rybczyńska, M., & Rubiś, B. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109479 · Cited by 27
Ecdysteroids from Polypodium vulgare L.
Simon, A., Ványolós, A., Béni, Z., Dékány, M., Tóth, G., & Báthori, M. (2011) · Steroids · doi:10.1016/j.steroids.2011.07.007 · Cited by 27
“They can be found in plant families comprising ferns, gymnosperms and angiosperms [1].”
Kapare, V., Satdive, R., Fulzele, D. P., & Malpathak, N. (2017) · Journal of Plant Growth Regulation · doi:10.1007/s00344-017-9697-3 · Cited by 27
“20HE is metabolically stable and found in a variety of plant families and participates in plant defenses against herbivorous insects, rather than as a phytohormonal role (Schmelz and others 2000; Dinan 2001). Gamma rays are ionizing radiation, and high doses are harmful due to the generation of free radicals which cau…”
BackgroundEcdysterone and its Activity on some Degenerative Diseases
Cahlíková, L., Macáková, K., Chlebek, J., Hošťálková, A., Kulhánková, A., & Opletal, L. (2011) · Natural Product Communications · doi:10.1177/1934578x1100600527 · Cited by 26
Rharrabe, K., Bouayad, N., & Sayah, F. (2008) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2008.12.002 · Cited by 26
Genetically transformed root cultures — generation, properties and application in plant sciences
Kuzovkina, I. N., & Schneider, B. (2006) · Springer eBooks · doi:10.1007/3-540-27998-9_13 · Cited by 26
9α,20-Dihydroxyecdysone, a New Natural Ecdysteroid from Silene italica ssp. nemoralis
Pongrácz, Z., Báthori, M., Tóth, G. K., Simon, A., Mák, M., & Máthé, I. (2003) · Journal of Natural Products · doi:10.1021/np0205194 · Cited by 25
Level and distribution of 20-hydroxyecdysone during Pfaffia glomerata development
Festucci-Buselli, R. A., Contim, L. A. S., Barbosa, L. C. A., Stuart, J. J., Vieira, R. F., & Otoni, W. C. (2008) · Brazilian Journal of Plant Physiology · doi:10.1590/s1677-04202008000400006 · Cited by 25
Yamaki, J., Venkata, K. C. N., Mandal, A., Bhattacharyya, P., & Bishayee, A. (2016) · Journal of Chinese Integrative Medicine · doi:10.1016/s2095-4964(16)60247-9 · Cited by 26
Aly, R., Ravid, U., Abu‐Nassar, J., Botnick, I., Lebedev, G., Gal, S., Ziadna, H., Achdari, G., Smirov, E., Meir, A., et al. (2011) · Pest Management Science · doi:10.1002/ps.2203 · Cited by 26
Phytoecdysteroids from the rhizomes of Brainea insignis
Wu, P., Xie, H., Tao, W., Miao, S., & Wei, X. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.03.002 · Cited by 24
The first two ecdysteroids containing a furan ring from Serratula wolffii
Liktor‐Busa, E., Simon, A., Tóth, G., & Báthori, M. (2008) · Tetrahedron Letters · doi:10.1016/j.tetlet.2008.01.074 · Cited by 24
Martucciello, S., Paolella, G., Музашвили, Т. С., Схиртладзе, А. В., Pìzza, C., Caputo, I., & Piacente, S. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.11.002 · Cited by 24
Tel‐Çayan, G., Öztürk, M., Duru, M. E., Doğan, B., & Harmandar, M. (2013) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.5072/zenodo.24596 · Cited by 24
Plant Steroids: Occurrence, Biological Significance and their Analysis
Gunaherath, G. M. K. B., & Gunatilaka, A. A. L. (2014) · Wiley eBooks · doi:10.1002/9780470027318.a9931 · Cited by 24
Low-polarity phytoecdysteroids from the juice of Serratula coronata L. (Asteraceae)
Odinokov, V. N., Kumpun, S., Galyautdinov, I. V., Evrard-Todeschi, N., Veskina, N. A., Khalilov, L. M., Girault, J.-P., Dinan, L., Maria, A., & Lafont, R. (2005) · Collection of Czechoslovak Chemical Communications · doi:10.1135/cccc20052038 · Cited by 23
Self-citationAssessing herbal products with health claims
Lapenna, S., Gemen, R., Wollgast, J., Worth, A., Maragkoudakis, P., & Caldeira, S. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.726661 · Cited by 23
“Plants from the genera Leuzea (Rhaponticum), Serratula, Cyanotis, and Pfaffia are among those known to contain high amounts of PEs (Dinan, 2001; Lafont and Dinan, 2003).”
BackgroundEcdysteroid metabolism in mammals: The fate of ingested 20-hydroxyecdysone in mice and rats
Dinan, L., Balducci, C., Guibout, L., Foucault, A.-S., Bakrim, A., Kumpun, S., Girault, J.-P., Tourette, C., Dioh, W., Dilda, P. J., et al. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105896 · Cited by 23
Self-citationFlores, R., Brondani, D., Cezarotto, V. S., Giacomelli, S. R., & Nicoloso, F. T. (2010) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-010-9286-7 · Cited by 23
“In general, important tissues/organs for plant survival contain a higher concentration of phytoecdysteroids, which is probably due to the protective effect of these compounds against insects (Dinan 2001; Klein 2004). Interestingly, Festucci-Buselli et al. (2008) recently reported that the stem and leaf total of 20-hyd…”
BackgroundInfluentialThree new steroids from the roots of Serratula wolffii
Simon, A., Tóth, G., Liktor‐Busa, E., Kele, Z., Takács, M., Gergely, A., & Báthori, M. (2007) · Steroids · doi:10.1016/j.steroids.2007.06.004 · Cited by 23
Patel, U., Girme, A., Patel, K. G., Ghule, C., Hingorani, L., & Gandhi, T. R. (2021) · Journal of Planar Chromatography – Modern TLC · doi:10.1007/s00764-021-00115-7 · Cited by 23
Edible and Medicinal Pteridophytes of Nepal: A Review
Ojha, R., & Devkota, H. P. (2021) · Ethnobotany Research and Applications · doi:10.32859/era.22.16.1-16 · Cited by 23
Zaid, R., Canela, R., Chacón, N. M. O., & Mouhouche, F. (2021) · Journal of the Saudi Society of Agricultural Sciences · doi:10.1016/j.jssas.2021.10.011 · Cited by 23
“They have various physiological effects: antibacterial (Derwich et al., 2010), antimicrobials (Hussain and Gorsi, 2004), insecticides (Dinan, 2001), inflammatory (Aggarwal and Shishodia, 2006) and cytotoxic (Mijatovic et al., 2007).”
Harada, T., Nakagawa, Y., Akamatsu, M., & Miyagawa, H. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.07.011 · Cited by 23
Protective role of 20-hydroxyecdysone against lead stress in Chlorella vulgaris cultures
Bajguz, A., & Godlewska-Zylkiewicz, B. (2004) · Phytochemistry · doi:10.1016/j.phytochem.2004.01.015 · Cited by 22
Wang, Q. J., Zheng, L. P., Sima, Y. H., Yuan, H. Y., & Wang, J. (2013) · Plant Omics · Cited by 22
Gonsalves, S. E., Neal, S. J., Kehoe, A. S., & Westwood, J. T. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-475 · Cited by 22
“Instead, it is predicted that phytoecdysteroids induce precocious molting and subsequently death in insects providing an effective defense against insect feeding [22].”
InfluentialKumar, R. P., Babu, K. V. D., & Da, E. (2018) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2018.11.018 · Cited by 22
Uawisetwathana, U., Chevallier, O. P., Yun Xu, A., Kamolsukyeunyong, W., Nookaew, I., Somboon, T., Toojinda, T., Vanavichit, A., Goodacre, R., Elliott, C. T., et al. (2019) · Metabolomics · doi:10.1007/s11306-019-1616-0 · Cited by 23
“Secondly, 20-hydroxyecdysone acetate is a phytoecdysteroid synthesized by plants for defense against phytophagous insects (Adler and Grebenok 1999; Dinan 2001).”
BackgroundBiosynthesis of Triterpenoid Natural Products
Hu, D., Gao, H., & Yao, X. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.14678-5 · Cited by 22
Speranza, A. (2010) · Plant Signaling & Behavior · doi:10.4161/psb.5.8.12295 · Cited by 22
“PE biosynthesis and transport in developing spinach had a continuous redistribution within the growing plant between ‘source’ older leaves and young, developing ‘sinks’ leaves.5 Spinach PE synthesis showed direct negative feedback of the major PE, 20E.5 Biomedical applications of PEs.”
BackgroundInfluentialIshola, I. O., Ochieng, C. O., Olayemi, S. O., Jimoh, M. O., & Lawal, S. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.11.005 · Cited by 22
“Interestingly, ecdysteroids stimulate protein synthesis without thymolytic, anti-gonadotropic, or androgenic side effect (Dinan, 2001; Meena et al., 2010).”
Guan, H., Chi, D., Yu, J., & Li, H. (2010) · Chemical Engineering Journal · doi:10.1016/j.cej.2010.12.040 · Cited by 22
Supercritical fluid extraction of cynaropicrin and 20‐hydroxyecdysone from Leuzea carthamoides DC
Sovová, H., Opletal, L., Sajfrtová, M., & Bártlová, M. (2008) · Journal of Separation Science · doi:10.1002/jssc.200700496 · Cited by 21
Phytoecdysteroids and other constituents from the roots of Klaseopsis chinensis
Ling, T.-J., Zhang, Z., Xia, T., Ling, W.-W., & Wan, X. (2008) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2008.11.017 · Cited by 21
Yuan, H., Qiao, H., Fu, Y., Fu, H., Zhang, W., Jin, S., Gong, Y., Jiang, S., Xiong, Y., Hu, Y., et al. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105976 · Cited by 21
A Brief Review of Phytochemical Defenses of Ferns against Herbivores
Castrejón-Varela, A., Pérez‐García, B., Guerrero‐Analco, J. A., & Mehltreter, K. (2022) · American Fern Journal · doi:10.1640/0002-8444-112.4.233 · Cited by 21
“These insects develop normally on diets with up to 400 ppm 20-hydroxyecdysone (Dinan, 2001).”
BackgroundInfluentialDistribution and Biosynthesis of 20-Hydroxyecdysone in Plants ofAchyranthes japonicaNakai
Boo, K.-H., Lee, D., Jeon, G. L., Ko, S. H., Cho, S. K., Kim, J. H., Park, S., Hong, Q. C., Lee, S., Lee, D., et al. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100410 · Cited by 21
Side-chain cleaved phytoecdysteroid metabolites as activators of protein kinase B
Issaadi, H. M., Csábi, J., Hsieh, T., Gáti, T., Tóth, G., & Hunyadi, A. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2018.10.049 · Cited by 22
“The A/B ring junction is normally cis, whereas the B/C and C/D ring junctions are almost always trans [2].”
BackgroundNew Minor Ecdysteroids from Silene viridiflora
Mamadalieva, N. Z., Zibareva, L. N., Evrard‐Todeschi, N., Girault, J., Maria, A., Ramazanov, N. S., Saatov, Z., & Lafont, R. (2004) · Collection of Czechoslovak Chemical Communications · doi:10.1135/cccc20041675 · Cited by 21
Ho, R., Girault, J.-P., Cousteau, P.-Y., Bianchini, J.-P., Raharivelomanana, P., & Lafont, R. (2008) · Journal of Chromatographic Science · doi:10.1093/chromsci/46.2.102 · Cited by 28
Mallek, A., Movassat, J., Ameddah, S., Liu, J., Semiane, N., Khalkhal, A., & Dahmani, Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.03.070 · Cited by 20
Fang, L., Li, J., Zhou, J., Wang, X., & Guo, L. (2017) · Molecules · doi:10.3390/molecules22081310 · Cited by 20
Issaadi, H. M., Tsai, Y.-C., Chang, F.-R., & Hunyadi, A. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.03.043 · Cited by 19
Báthori, M., Kalász, H., Pongrácz, Z., Máthé, I., Kálmán, A., & Argay, G. (2002) · Biomedical Chromatography · doi:10.1002/bmc.168 · Cited by 19
20-Hydroxyecdysone protects wheat seedlings (Triticum aestivum L.) against lead stress
Lamhamdi, M., Lafont, R., Rharrabe, K., Sayah, F., Aarab, A., & Bakrim, A. (2016) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2015.11.006 · Cited by 18
Céspedes, C. L., Lina-García, L. P., Kubo, I., Salazar, J. R., Ariza‐Castolo, A., Alarcón, J., Aqueveque, P. M., Werner, E., & Seigler, D. S. (2016) · Industrial Crops and Products · doi:10.1016/j.indcrop.2016.05.026 · Cited by 18
Effects of ecdysteroids on Chlorella vulgaris
Bajguz, A., & Dinan, L. (2004) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2004.00329.x · Cited by 17
Ecdysteroids from the flowers of Aerva javanica
Saleem, M., Musaddiq, S., Riaz, N., Zubair, M., Ashraf, M., Nasar, R., & Jabbar, A. (2013) · Steroids · doi:10.1016/j.steroids.2013.07.012 · Cited by 17
Li, D., Zhang, Y., Cui, Z., He, L., Chen, W., Meng, Q., & Ren, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153584 · Cited by 17
“The main zoo-ecdysteroid is 20-hydroxyecdysone (20E), which is recognized as the most biologically active ecdysteroid [9].”
BackgroundBatista, D. S., Koehler, A. D., Romanel, E. A. D. C., Souza, V., Silva, T. D., Almeida, M. C., Maciel, T. E. F., Ferreira, P. R. B., Felipe, S. H. S., Saldanha, C. W., et al. (2018) · PROTOPLASMA · doi:10.1007/s00709-018-1322-1 · Cited by 17
Ajaha, A., Bouayad, N., Aarab, A., & Rharrabe, K. (2019) · Journal of Insect Science · doi:10.1093/jisesa/iez097 · Cited by 19
“Phytoecdysteroids were found to have defensive potential against pests’s attacks (Dinan 2001, Schmelz et al.”
BackgroundMethodPhytoecdysteroids: Phytochemistry and Pharmacological Activity
Laekeman, G., & Vlietinck, A. J. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_173 · Cited by 17
Pavela, R., Harmatha, J., Bárnet, M., & Vokáč, K. (2005) · European Journal of Entomology · doi:10.14411/eje.2005.091 · Cited by 17
Innovative and Future Applications for Ecdysteroids
Lafont, R., & Dinan, L. N. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9112-4_23 · Cited by 17
“Although ecdysteroids are present in seeds of ca. 6% of all investigated plant species ( Dinan, 2001 ), significant amounts of them have been detected in only a few food plants (Table 23.3), possibly because cultivated plants have been selected for productivity and have therefore lost their ability to produce secondar…”
BackgroundInfluentialAmbrosio, G., Yuliandra, T., Wuest, B., Mazzarino, M., Torre, X. D. L., Botrè, F., Diel, P., Isenmann, E., & Parr, M. K. (2021) · doi:10.20944/preprints202105.0106.v1 · Cited by 14
“Moreover, growth-promoting and anabolic effects in animals and in humans have been reported [3-19].”
BackgroundBathori, M., Pongracz, Z., Toth, G., Simon, A., Kandra, L., Kele, Z., & Ohmacht, R. (2002) · Journal of Chromatographic Science · doi:10.1093/chromsci/40.7.409 · Cited by 23
John, R., Shajitha, P. P., Devassy, A., & Mathew, L. (2018) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-018-0506-7 · Cited by 16
“The most common phytoecdysteroid is 20-hydroxyecdysone and it has potential therapeutic applications (Dinan 2001) and several agricultural applications.”
Preston-Mafham, J., & Dinan, L. (2002) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2002-1-224 · Cited by 18
“A range of evidence now exists in support of this hypothesis (summarised in Dinan, 1998; 2001).”
BackgroundThe Use of Plant Steroids in Viral Disease Treatments: Current Status and Future Perspectives
Yerlikaya, P. O., Arısan, E. D., Mehdizadehtapeh, L., Onganer, P. U., & Gürkan, A. Ç. (2023) · European Journal of Biology · doi:10.26650/eurjbiol.2023.1130357 · Cited by 16
Meng, Y.-H., Whiting, P., Šik, V., Rees, H. H., & Dinan, L. N. (2001) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2001-11-1214 · Cited by 16
Salazar, J. R., Loza-Mejía, M. A., & Soto-Cabrera, D. (2020) · Molecules · doi:10.3390/molecules25071649 · Cited by 16
“were included in the present review because of the special feature of the configuration 5β in a sterol configuration, an infrequent feature in cacti sterols [52], but common in ecdysteroids and related phytoecdysteroids [53,54].”
BackgroundWatanabe, M., Miyashita, T., & Devkota, H. P. (2020) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2020.104211 · Cited by 16
Yang, S., Zhang, X., Sun, X.-S., Ling, T.-J., Feng, Y., Du, X., Zhao, M., Yang, Y., Xue, D., Wang, L., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100621 · Cited by 16
“However, ECRs exhibit extremely high structural diversity, especially in the number, position, and orientation of hydroxyl groups as well as in the variety of long carbon side chains [13], resulting in different effects on A β aggregation and cytotoxicity.”
InfluentialRagged Robin (Lychnis flos-cuculi) - a plant with potential medicinal value
Maliński, M. P., Michalska‐Falkowska, A., Tomczykowa, M., Tomczyk, M., & Thiem, B. (2014) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2014.11.004 · Cited by 16
Kayani, W. K., Palazón, J., Cusido, R. M., & Mirza, B. (2016) · RSC Advances · doi:10.1039/c6ra00250a · Cited by 15
Neves, C. S., Gomes, S. S. L., dos Santos, T. R., de Almeida, M. M., de Souza, Y. O., Garcia, R. M. G., Otoni, W. C., Chedier, L. M., Raposo, N. R. B., Viccini, L. F., et al. (2016) · South African Journal of Botany · doi:10.1016/j.sajb.2016.07.003 · Cited by 16
Muchate, N. S., Rajurkar, N. S., Suprasanna, P., & Nikam, T. D. (2018) · International Journal of Phytoremediation · doi:10.1080/15226514.2018.1452184 · Cited by 16
“Ecdysteroids which are triterpenoid compounds play significant biological activities (Dinan 2001).”
BackgroundDereplication and Partial Identification of Compounds
Dinan, L. N. (2006) · Humana Press eBooks · doi:10.1385/1-59259-955-9:297 · Cited by 17
Synthesis and biological activities of turkesterone 11α-acyl derivatives
Dinan, L. N., Bourne, P. C., Whiting, P., Tsitsekli, A., Saatov, Z., Dhadialla, T. S., Hormann, R. E., Lafont, R., & Coll, J. (2003) · Journal of Insect Science · doi:10.1093/jis/3.1.6 · Cited by 16
Thussagunpanit, J., Jutamanee, K., Homvisasevongsa, S., Suksamrarn, A., Yamagami, A., Nakano, T., & Asami, T. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.05.003 · Cited by 15
“Ecdysteroids are generally known as compounds that regulate molting and metamorphosis in insects and crustaceans [12, 13], but various plant species also produce these compounds (phytoecdysteroids), which are widely thought to inhibit the feeding of phytophagous insects [12].”
Agoun, H., Semiane, N., Mallek, A., Bellahreche, Z., Hammadi, S., Madjerab, M., Abdlalli, M., Khalkhal, A., & Dahmani, Y. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1621350 · Cited by 15
“Phytoecdysteroids are a large family of polyhydroxylated steroids related to insect moulting hormones, that are produced by many plant species (Dinan 2001), including a few cultivated crops (e.g. spinach, quinoa).”
BackgroundMuchate, N. S., Kadam, N. S., Rajurkar, N. S., & Nikam, T. D. (2017) · Journal of Planar Chromatography – Modern TLC · doi:10.1556/1006.2017.30.3.7 · Cited by 15
Duan, H., Yang, X. L., Bu, Z., Li, X., Zhang, Z., & Sun, W. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00508 · Cited by 15
“Since the isolation of ecdysone from silkworm pupae in 1954, ecdysteroid analogs called phytoecdysteroids were also discovered in plant species (Butenandt and Karlson, 1954; Nakanishi et al., 1966; Lafont and Horn, 1989; Dinan, 2001).”
BackgroundPreclinical evaluation of safety and potential of black hellebore extracts for cancer treatment
Felenda, J. E., Turek, C., Mörbt, N., Herrick, A., Müller, M., & Stintzing, F. C. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2517-5 · Cited by 15
Felipe, S. H. S., Batista, D. S., Chagas, K., Correia, L. N. F., Silva, T. D., Fortini, E. A., Silva, P. O., & Otoni, W. C. (2019) · PROTOPLASMA · doi:10.1007/s00709-019-01400-3 · Cited by 15
“In mammals, they are not biosynthesized but show medicinal effects, especially for humans (Dinan 2001; Báthori and Pongrácz 2005; Dinan and Lafont 2006; Thiem et al. 2017; Dias et al. 2019).”
BackgroundRostagno, M., Debien, I. C. N., Vardanega, R., Nogueira, G. C., Barbero, G., & Meireles, M. (2014) · Analytical Methods · doi:10.1039/c3ay42276c · Cited by 15
Dinan, L., Balducci, C., Guibout, L., & Lafont, R. (2020) · Phytochemical Analysis · doi:10.1002/pca.2930 · Cited by 14
Napierała, M., Nawrot, J., Gornowicz-Porowska, J., Florek, E., Moroch, A., Adamski, Z., Kroma, A., Miechowicz, I., & Nowak, G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186453 · Cited by 14
A new ecdysteroid and other constituents from two Dioscorea species
Sautour, M., Canon, F., Miyamoto, T., Dongmo, A., & Lacaille-Dubois, M.-A. (2008) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2008.03.002 · Cited by 17
Kamada, T., Picoli, E. A. D. T., Vieira, R. F., Barbosa, L. C. A., Cruz, C. D., & Otoni, W. C. (2009) · Revista Brasileira de Plantas Medicinais · doi:10.1590/s1516-05722009000300004 · Cited by 14
Laurent, P., Braekman, J. C., Daloze, D., & Pasteéls, J. M. (2003) · Chemoecology · doi:10.1007/s00049-003-0235-3 · Cited by 14
“They are often present in high concentrations ( Dinan, 2001 ).”
BackgroundPhytoecdysteroids: A Novel, Non-Androgenic Alternative for Muscle Health and Performance
McBride, J. M. (2013) · Journal of Steroids & Hormonal Science · doi:10.4172/2157-7536.s12-e001 · Cited by 15
“In general, PEs are characterized as polyhydroxylated basic carbon ring structures of 27-29 carbon atoms [15].”
BackgroundInfluentialPreparative-Scale Chromatography of Ecdysteroids: A Class of Biologically Active Steroids
Toth, N., & Báthori, M. (2008) · Journal of Chromatographic Science · doi:10.1093/chromsci/46.2.111 · Cited by 14
Harmatha, J., Vokáč, K., Kmonı́čková, E., & Zı́dek, Z. (2008) · Steroids · doi:10.1016/j.steroids.2007.12.014 · Cited by 14
Todorova, V., Ivanov, K., Karcheva-Bahchevanska, D., & Ivanova, S. (2023) · Processes · doi:10.3390/pr11061786 · Cited by 13
Effect of 20-hydroxyecdysone on proteolytic regulation in skeletal muscle atrophy
HIRUNSAI, M., YIMLAMAI, T., & SUKSAMRARN, A. (2016) · In Vivo · doi:10.21873/invivo.11007 · Cited by 13
Marschall, M. J. M., Ringseis, R., Gessner, D. K., Grundmann, S. M., Most, E., Wen, G., Maheshwari, G., Zorn, H., & Eder, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105241 · Cited by 13
“While zooecdysteroids in insects regulate important developmental processes, such as embryogenesis, moulting (ecdysis), metamorphosis, reproduction, and diapause [1], phytoecdysteroids provide protection against invertebrate predators by acting as feeding deterrents and by disrupting critical developmental processes o…”
BackgroundCsábi, J., Martins, A., Sinka, I., Csorba, A., Molnár, J., Zupkó, I., Tóth, G., Tillekeratne, L. M. V., & Hunyadi, A. (2016) · MedChemComm · doi:10.1039/c6md00431h · Cited by 13
Metadata
- Authors
- Dinan, L.
- Affiliations
- University of Exeter (GB)
- Corresponding author
- Dinan, Laurence
- ORCID
- Dinan, Laurence
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 57
- Issue
- 3
- Pages
- 325-339
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W2032058270
- Cited by
- 392
- References
- 166
- Citations by year
- 2026: 17 · 2025: 11 · 2024: 11 · 2023: 13 · 2022: 18 · 2021: 27 · 2020: 23 · 2019: 18 · 2018: 18 · 2017: 18 · 2016: 18 · 2015: 13 · 2014: 17 · 2013: 15 · 2012: 19
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- phytoecdysteroids, 20-hydroxyecdysone, plant steroids, steroidogenesis, biological significance
- MeSH terms
- Animals, Ecdysone, Ecdysterone, Invertebrates, Pest Control, Biological, Phytosterols, Plant Physiological Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
