The DOI matches its Crossref record; 150 of the 166 references it cites were found in a registry or an index.
Phytoecdysteroids: biological aspects
Abstract
Phytoecdysteroids are a family of about 200 plant steroids related in structure to the invertebrate steroid hormone 20-hydroxyecdysone. Typically, they are C27, C28 or C29 compounds possessing a 14alpha-hydroxy-7-en-6-one chromophore and A/B-cis ring fusion (5beta-H). In the present review, the distribution, biosynthesis, biological significance and potential applications of phytoecdysteroids are summarised.
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In the citing paper
“research results suggest that only around 6% of plant species contain detectable levels of PEs [6,8,9,10].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [8]
In the citing paper
“However, variations exist regarding the levels of 20HE in spinach, with some reporting lower amounts, such as 50 μg/g dry mass, 10.3 and 16.8 μg/g in different spinach accessions, and 0.44 mg% dry weight [8,156,160].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [8]
In the citing paper
“The biosynthetic pathway(s) in plants, just like that in arthropods, has not yet been fully elucidated, but the biosynthesis appears to differ mechanistically from that in animals (Figure 7), and maybe also differ within types of plant (e.g., between angiosperms and ferns; [3,35])”
From Ecdysteroids (2021) · cites this paper as [35]
In the citing paper
“The huge diversity of phytoecdysteroid molecular structures indicates that biosynthesis in plants occurs as a combinatorial system of a network of enzymes without strong substrate specificity, which could result in over 1000 possible permutations of structure from a small number of early intermediates (14α-hydroxy-6-oxo-7-ene C 27/28/29sterols [35]).”
From Ecdysteroids (2021) · cites this paper as [35]
In the citing paper
“It has been shown in several ecdysteroid-accumulating species that ecdysteroid levels are additionally influenced by environmental factors (e.g., temperature, nutritional factors, invertebrate predation [35]).”
From Ecdysteroids (2021) · cites this paper as [35]
In the citing paper
“Both E and 20E exist in plants to play roles in the plants or participate in the defense of plants against insects [73].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [73]
In the citing paper
“A series of evidence suggests that PEs do not accumulate in the majority of plant species as the expression of the biosynthetic pathways in plants is downregulated6.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [6]
In the citing paper
“a survey indicates that only ∼6% of all plants contain detectable levels of ecdysteroids6.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [6]
In the citing paper
“PEs have several beneficial effects on mammals: they play roles in anabolic, adaptogenic, antidiabetic, anti-inflammatory, antioxidant, antitumor, antimicrobial, and anti-arthritic activity. They also act as hepatoprotectors and immunomodulators [3,8,12,15,155].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [3]
In the citing paper
“PE treatment negatively affects invertebrate growth, development, and reproduction, but PEs do not exhibit toxicity in mammals [3].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [3]
In the citing paper
“Ecdysteroids exhibit interesting pharmacological effects on mammals, such as the stimulation of protein synthesis, antidiabetic activity, and antirheumatic activity [5,6,7].”
In the citing paper
“Ecdysteroids are a,b-unsaturated 6-ketosteroids that occur in a wide range of plant species; as analogs of the insect molting hormone ecdysone, these compounds possess several biological functions in the flora and the fauna [11,12].”
From Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam (2018) · cites this paper as [11]
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An antimicrobial ecdysone from Asparagus dumosus
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2-dehydro-3-epi-20-hydroxyecdysone from Froelichia florida
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Distribution and identities of phytoecdysteroids in the genus Briza (Gramineae)
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Cell-Specific Ecdysone-Inducible Expression of FLP Recombinase in Mammalian Cells
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Standardized abbreviations for common ecdysteroids
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Sileneoside H, a New Phytoecdysteroid from Silene brahuica
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24(241)[Z]-dehydroamarasterone B, a phytoecdysteroid from seeds of Leuzea carthamoides
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Biosynthesis of ecdysteroids in in vitro prothalli cultures of Polypodium vulgare
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Effect of Ecdysterone on Carbohydrate and Lipid Metabolism
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Chemical Methods for Isolating and Identifying Phytochemicals Biologically Active in Insects
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Ecdysteroids of flowering plants (Angiospermae)
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Structure of calonysterone, an unusually modified phytoecdysone
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Studies on the Constituents of Achyranthis Radix. I.
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1α,20R-dihydroxyecdysone from Axyris amaranthoides
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20-Hydroxyecdysone 2-β-d-glucopyranoside from the seeds of Xerophyllum tenax
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Application of Exogenously Regulatable Promoter Systems to Transgenic Models for the Study of Aging
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Effects of ingested phytoecdysteroids in the female soft tickOrnithodoros moubata
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The rate of ecdysteroid production in suspension cultured cells of the fern Pteridium aquilinum
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Ecdysteroside, a phytoecdysteroid from Silene tatarica
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Isolation of hispidin from a walnut-tree fungus and its antioxidant activity
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“Phytoecdysteroids (Figure 3) represent a group of plant compounds that mimic insect hormones, ecdysteroids (including ecdyson), and interfere with the regulation of the periodical molting process (40).”
BackgroundPlant cholesterol biosynthetic pathway overlaps with phytosterol metabolism
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“It has been suggested that cholesterol serves as a precursor of glycoalkaloids (Bergenstråhle et al., 1996) and ecdysteroids (Dinan, 2001) in these plants.”
BackgroundSteroids in aquatic invertebrates
Lafont, R., & Mathieu, M. (2007) · Ecotoxicology · doi:10.1007/s10646-006-0113-1 · Cited by 284
“This function appears similar to that of phytoecdysteroids used as a plant protection against phytophagous insects (Dinan 2001) and has also been found in an insect, Chrysolina carnifex (Coleoptera: Chrysomelidae) as a protection against spiders (Laurent et al.”
BackgroundArthropod nuclear receptors and their role in molting
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Metadata
- Authors
- Dinan, L.
- Affiliations
- University of Exeter (GB)
- Corresponding author
- Dinan, Laurence
- ORCID
- Dinan, Laurence
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 57
- Issue
- 3
- Pages
- 325-339
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W2032058270
- Cited by
- 392
- References
- 166
- Citations by year
- 2026: 17 · 2025: 11 · 2024: 11 · 2023: 13 · 2022: 18 · 2021: 27 · 2020: 23 · 2019: 18 · 2018: 18 · 2017: 18 · 2016: 18 · 2015: 13 · 2014: 17 · 2013: 15 · 2012: 19
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- phytoecdysteroids, 20-hydroxyecdysone, plant steroids, steroidogenesis, biological significance
- MeSH terms
- Animals, Ecdysone, Ecdysterone, Invertebrates, Pest Control, Biological, Phytosterols, Plant Physiological Phenomena
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