Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 195

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Chapter 9 The Primary Cilium

Open access
·2008·Current Topics in Developmental Biology
DOI 10.1016/s0070-2153(08)00809-0
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0070-2153(08)00809-0

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 24 references

Research works printed but not linked: 166

  1. Adams, 2007, The retinal ciliopathies, Ophthalmic Genet., 28, 113, 10.1080/13816810701537424 · DOI · Paper page
  2. Ahn, 2004, Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning, Cell, 118, 505, 10.1016/j.cell.2004.07.023 · DOI · Paper page
  3. Ansley, 2003, Basal body dysfunction is a likely cause of pleiotropic Bardet‐Biedl syndrome, Nature, 425, 628, 10.1038/nature02030 · DOI · Paper page
  4. Arima, 1984, A deep‐etching study of the guinea pig tracheal cilium with special reference to the ciliary transitional region, J. Ultrastruct. Res., 89, 34, 10.1016/S0022-5320(84)80021-0 · doi:10.1016/s0022-5320(84)80021-0
  5. Aszterbaum, 1999, Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice, Nat. Med., 5, 1285, 10.1038/15242 · DOI · Paper page
  6. Athar, 2006, Hedgehog signalling in skin development and cancer, Exp. Dermatol., 15, 667, 10.1111/j.1600-0625.2006.00473.x · DOI · Paper page
  7. Aza‐Blanc, 1997, Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor, Cell, 89, 1043, 10.1016/S0092-8674(00)80292-5 · DOI · Paper page
  8. Bai, 2001, Gli1 can rescue the in vivo function of Gli2, Development, 128, 5161, 10.1242/dev.128.24.5161 · DOI · Paper page
  9. Bai, 2004, All mouse ventral spinal cord patterning by Hedgehog is Gli dependent and involves an activator function of Gli3, Dev. Cell, 6, 103, 10.1016/S1534-5807(03)00394-0 · DOI · Paper page
  10. Benzing, 2006, Cilium‐generated signaling: A cellular GPS?, Curr. Opin. Nephrol. Hypertens., 15, 245, 10.1097/01.mnh.0000222690.53970.ca · DOI
  11. Bijlsma, 2006, Repression of Smoothened by Patched‐dependent (pro‐)vitamin D3 secretion, PLoS Biol., 4, 1397, 10.1371/journal.pbio.0040232 · DOI · Paper page
  12. Bitgood, 1996, Sertoli cell signaling by Desert hedgehog regulates the male germline, Curr. Biol., 6, 298, 10.1016/S0960-9822(02)00480-3 · DOI · Paper page
  13. Bonnafe, 2004, The transcription factor RFX3 directs nodal cilium development and left–right asymmetry specification, Mol. Cell. Biol., 24, 4417, 10.1128/MCB.24.10.4417-4427.2004 · DOI · Paper page
  14. Bulgakov, 2004, FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues, Development, 131, 2149, 10.1242/dev.01122 · DOI
  15. Bürglin, 1996, Warthog and groundhog, novel families related to hedgehog, Curr. Biol., 6, 1047, 10.1016/S0960-9822(02)70659-3 · DOI
  16. Carlén, 2005, Primary ciliary dyskinesia: A review, Ultrastruct. Pathol., 29, 217, 10.1080/01913120590951220 · doi:10.1080/01913120590951220
  17. Casali, 2004, Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein, Nature, 431, 76, 10.1038/nature02835 · DOI
  18. Caspary, 2007, The graded response to Sonic Hedgehog depends on cilia architecture, Dev. Cell, 12, 767, 10.1016/j.devcel.2007.03.004 · DOI · Paper page
  19. Chamberlain, 2008, Notochord‐derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning, Development, 135, 1097, 10.1242/dev.013086 · DOI · Paper page
  20. Charron, 2003, The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin‐1 in midline axon guidance, Cell, 113, 11, 10.1016/S0092-8674(03)00199-5 · DOI · Paper page
  21. Chen, 1999, Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression, Cell, 98, 305, 10.1016/S0092-8674(00)81960-1 · DOI · Paper page
  22. Chen, 2004, Activity‐dependent internalization of smoothened mediated by beta‐arrestin 2 and GRK2, Science, 306, 2257, 10.1126/science.1104135 · DOI · Paper page
  23. Chen, 2005, Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development, Mol. Cell. Biol., 25, 7042, 10.1128/MCB.25.16.7042-7053.2005 · DOI
  24. Cheng, 2002, Suppressor of Fused represses Gli‐mediated transcription by recruiting the SAP18–mSin3 corepressor complex, Proc. Natl Acad. Sci. USA, 99, 5442, 10.1073/pnas.082096999 · DOI · Paper page
  25. Chiang, 1996, Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function, Nature, 383, 407, 10.1038/383407a0 · DOI · Paper page
  26. Cho, 2008, FKBP8 cell‐autonomously controls neural tube patterning through a Gli2‐ and Kif3a‐dependent mechanism, Dev. Biol., 321, 27, 10.1016/j.ydbio.2008.05.558 · DOI
  27. Cooper, 2003, A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis, Nat. Genet., 33, 508, 10.1038/ng1134 · DOI · Paper page
  28. Cooper, 2005, Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused, Development, 132, 4407, 10.1242/dev.02021 · DOI · Paper page
  29. Corcoran, 2006, Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells, Proc. Natl Acad. Sci. USA, 103, 8408, 10.1073/pnas.0602852103 · DOI · Paper page
  30. Crowson, 2006, Basal cell carcinoma: Biology, morphology and clinical implications, Mod. Pathol., 19, S127, 10.1038/modpathol.3800512 · DOI · Paper page
  31. Deane, 2001, Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles, Curr. Biol., 11, 1586, 10.1016/S0960-9822(01)00484-5 · DOI · Paper page
  32. Denef, 2000, Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened, Cell, 102, 521, 10.1016/S0092-8674(00)00056-8 · DOI · Paper page
  33. Dessaud, 2007, Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism, Nature, 450, 717, 10.1038/nature06347 · DOI · Paper page
  34. Ding, 1998, Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice, Development, 125, 2533, 10.1242/dev.125.14.2533 · DOI · Paper page
  35. Ding, 1999, Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1, Curr. Biol., 9, 1119, 10.1016/S0960-9822(99)80482-5 · DOI · Paper page
  36. Dussillol‐Godar, 2006, Modulation of the suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs, Dev. Biol., 291, 53, 10.1016/j.ydbio.2005.12.004 · DOI
  37. Dwyer, 2007, Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells, J. Biol. Chem., 282, 8959, 10.1074/jbc.M611741200 · DOI · Paper page
  38. Echelard, 1993, Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity, Cell, 75, 1417, 10.1016/0092-8674(93)90627-3 · DOI · Paper page
  39. Eggenschwiler, 2007, Cilia and developmental signaling, Annu. Rev. Cell Dev. Biol., 23, 345, 10.1146/annurev.cellbio.23.090506.123249 · DOI · Paper page
  40. Eggenschwiler, 2001, Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway, Nature, 412, 194, 10.1038/35084089 · DOI · Paper page
  41. Ericson, 1997, Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube, Cold Spring Harb. Symp. Quant. Biol., 62, 451, 10.1101/SQB.1997.062.01.053 · DOI
  42. Essner, 2005, Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left–right development of the brain, heart and gut, Development, 132, 1247, 10.1242/dev.01663 · DOI · Paper page
  43. Farzan, 2008, Costal2 functions as a kinesin‐like protein in the Hedgehog signal transduction pathway, Curr. Biol., 18, 1215, 10.1016/j.cub.2008.07.026 · DOI
  44. Ferrante, 2006, Oral–facial–digital type I protein is required for primary cilia formation and left–right axis specification, Nat. Genet., 38, 112, 10.1038/ng1684 · DOI · Paper page
  45. Gilula, 1972, The ciliary necklace. A ciliary membrane specialization, J. Cell Biol., 53, 494, 10.1083/jcb.53.2.494 · DOI · Paper page
  46. Goodrich, 1996, Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog, Genes Dev., 10, 301, 10.1101/gad.10.3.301 · DOI · Paper page
  47. Hahn, 1998, Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome, Nat. Med., 4, 619, 10.1038/nm0598-619 · DOI · Paper page
  48. Han, 2003, Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm, Curr. Biol., 13, 1679, 10.1016/j.cub.2003.08.034 · DOI · Paper page
  49. Xie, 1998, Activating Smoothened mutations in sporadic basal‐cell carcinoma, Nature, 391, 90, 10.1038/34201 · DOI · Paper page
  50. Harfe, 2004, Evidence for an expansion‐based temporal Shh gradient in specifying vertebrate digit identities, Cell, 118, 517, 10.1016/j.cell.2004.07.024 · DOI · Paper page
  51. Hepker, 1997, Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes, Development, 124, 549, 10.1242/dev.124.2.549 · DOI
  52. Hong, 2001, Retinitis pigmentosa GTPase regulator (RPGR)‐interacting protein is stably associated with the photoreceptor ciliary axoneme and anchors RPGR to the connecting cilium, J. Biol. Chem., 276, 12091, 10.1074/jbc.M009351200 · DOI · Paper page
  53. Hooper, 2005, Communicating with Hedgehogs, Nat. Rev. Mol. Cell Biol., 6, 306, 10.1038/nrm1622 · DOI · Paper page
  54. Huangfu, 2006, Signaling from Smo to Ci/Gli: Conservation and divergence of Hedgehog pathways from Drosophila to vertebrates, Development, 133, 3, 10.1242/dev.02169 · DOI · Paper page
  55. Huangfu, 2003, Hedgehog signalling in the mouse requires intraflagellar transport proteins, Nature, 426, 83, 10.1038/nature02061 · DOI · Paper page
  56. Hui, 1993, A mouse model of greig cephalopolysyndactyly syndrome: The extra‐toesJ mutation contains an intragenic deletion of the Gli3 gene, Nat. Genet., 3, 241, 10.1038/ng0393-241 · DOI · Paper page
  57. Izraeli, 2001, Genetic evidence that Sil is required for the Sonic Hedgehog response pathway, Genesis, 31, 72, 10.1002/gene.10004 · DOI
  58. Jeong, 2005, Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1, Development, 132, 143, 10.1242/dev.01566 · DOI · Paper page
  59. Jia, 2004, Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I, Nature, 432, 1045, 10.1038/nature03179 · DOI · Paper page
  60. Jiang, 1998, Regulation of the Hedgehog and Wingless signalling pathways by the F‐box/WD40‐repeat protein Slimb, Nature, 391, 493, 10.1038/35154 · DOI · Paper page
  61. Kaesler, 2000, Transcriptional activity of GLI1 is negatively regulated by protein kinase A, Biol. Chem., 381, 545, 10.1515/BC.2000.070 · DOI
  62. Kelley, 1996, Holoprosencephaly in RSH/Smith–Lemli–Opitz syndrome: Does abnormal cholesterol metabolism affect the function of Sonic Hedgehog?, Am. J. Med. Genet., 66, 478, 10.1002/(SICI)1096-8628(19961230)66:4<478::AID-AJMG22>3.0.CO;2-Q · DOI · Paper page
  63. Kent, 2006, Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus, Development, 133, 2001, 10.1242/dev.02370 · DOI
  64. Koudijs, 2005, The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway, PLoS Genet., 1, e19, 10.1371/journal.pgen.0010019 · DOI
  65. Kovacs, 2008, Beta‐arrestin‐mediated localization of Smoothened to the primary cilium, Science, 320, 1777, 10.1126/science.1157983 · DOI · Paper page
  66. Krakowiak, 2003, Lathosterolosis: An inborn error of human and murine cholesterol synthesis due to lathosterol 5‐desaturase deficiency, Hum. Mol. Genet., 12, 1631, 10.1093/hmg/ddg172 · DOI · Paper page
  67. Lai, 2003, Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo, Nat. Neurosci., 6, 21, 10.1038/nn983 · DOI · Paper page
  68. Lam, 1999, A frequent activated smoothened mutation in sporadic basal cell carcinomas, Oncogene, 18, 833, 10.1038/sj.onc.1202360 · DOI · Paper page
  69. Lei, 2004, Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord, Development, 131, 3593, 10.1242/dev.01230 · DOI
  70. Levy, 2005, Distinct stem cell populations regenerate the follicle and interfollicular epidermis, Dev. Cell, 9, 855, 10.1016/j.devcel.2005.11.003 · DOI · Paper page
  71. Lin, 2003, Kidney‐specific inactivation of the KIF3A subunit of kinesin‐II inhibits renal ciliogenesis and produces polycystic kidney disease, Proc. Natl Acad. Sci. USA, 100, 5286, 10.1073/pnas.0836980100 · DOI · Paper page
  72. Litingtung, 2002, Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity, Nature, 418, 979, 10.1038/nature01033 · DOI · Paper page
  73. Liu, 2005, Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors, Development, 132, 3103, 10.1242/dev.01894 · DOI · Paper page
  74. Liu, 2007, Fused–Costal2 protein complex regulates Hedgehog‐induced Smo phosphorylation and cell‐surface accumulation, Genes Dev., 21, 1949, 10.1101/gad.1557407 · DOI
  75. Lum, 2004, The Hedgehog response network: Sensors, switches, and routers, Science, 304, 1755, 10.1126/science.1098020 · DOI · Paper page
  76. Lum, 2003, Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal‐2, Mol. Cell, 12, 1261, 10.1016/S1097-2765(03)00426-X · DOI · Paper page
  77. Mans, 2008, All along the watchtower: Is the cilium a tumor suppressor organelle?, Biochim. Biophys. Acta.
  78. Marcotullio, 2006, Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch‐dependent ubiquitination, Nat. Cell Biol., 8, 1415, 10.1038/ncb1510 · DOI · Paper page
  79. Marigo, 1996, Regulation of patched by sonic hedgehog in the developing neural tube, Proc. Natl Acad. Sci. USA, 93, 9346, 10.1073/pnas.93.18.9346 · DOI · Paper page
  80. Marshall, 2006, Cilia: Tuning in to the cell's antenna, Curr. Biol., 16, R604, 10.1016/j.cub.2006.07.012 · DOI · Paper page
  81. Marszalek, 1999, Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin‐II, Proc. Natl Acad. Sci. USA, 96, 5043, 10.1073/pnas.96.9.5043 · DOI · Paper page
  82. Martí, 1995, Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants, Nature, 375, 322, 10.1038/375322a0 · DOI · Paper page
  83. Matise, 1998, Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system, Development, 125, 2759, 10.1242/dev.125.15.2759 · DOI · Paper page
  84. May, 2005, Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli, Dev. Biol., 287, 378, 10.1016/j.ydbio.2005.08.050 · DOI · Paper page
  85. McMahon, 2003, Developmental roles and clinical significance of hedgehog signaling, Curr. Top. Dev. Biol., 53, 1, 10.1016/S0070-2153(03)53002-2 · DOI · Paper page
  86. Meloni, 2006, Smoothened signal transduction is promoted by G protein‐coupled receptor kinase 2, Mol. Cell. Biol., 26, 7550, 10.1128/MCB.00546-06 · DOI
  87. Merchant, 2005, Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus, Mol. Cell. Biol., 25, 7054, 10.1128/MCB.25.16.7054-7068.2005 · DOI
  88. Meyer, 2003, The amino‐terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord, Dev. Biol., 257, 343, 10.1016/S0012-1606(03)00065-4 · DOI
  89. Milenkovic, 1999, Mouse patched1 controls body size determination and limb patterning, Development, 126, 4431, 10.1242/dev.126.20.4431 · DOI
  90. Motoyama, 2003, Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification, Dev. Biol., 259, 150, 10.1016/S0012-1606(03)00159-3 · DOI
  91. Nonaka, 1998, Randomization of left–right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein, Cell, 95, 829, 10.1016/S0092-8674(00)81705-5 · DOI · Paper page
  92. Nonaka, 2002, Determination of left–right patterning of the mouse embryo by artificial nodal flow, Nature, 418, 96, 10.1038/nature00849 · DOI · Paper page
  93. Nüsslein‐Volhard, 1980, Mutations affecting segment number and polarity in Drosophila, Nature, 287, 795, 10.1038/287795a0 · DOI · Paper page
  94. Ocbina, 2008, Intraflagellar transport, cilia, and mammalian Hedgehog signaling: Analysis in mouse embryonic fibroblasts, Dev. Dyn., 237, 2030, 10.1002/dvdy.21551 · DOI · Paper page
  95. Ohlmeyer, 1998, Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator, Nature, 396, 749, 10.1038/25533 · DOI · Paper page
  96. Okada, 2006, Boc is a receptor for sonic hedgehog in the guidance of commissural axons, Nature, 444, 369, 10.1038/nature05246 · DOI · Paper page
  97. Orozco, 1999, Movement of motor and cargo along cilia, Nature, 398, 674, 10.1038/19448 · DOI · Paper page
  98. Ou, 2005, Functional coordination of intraflagellar transport motors, Nature, 436, 583, 10.1038/nature03818 · DOI · Paper page
  99. Paces‐Fessy, 2004, The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins, Biochem. J., 378, 353, 10.1042/bj20030786 · DOI
  100. Pan, 2005, Cilium‐generated signaling and cilia‐related disorders, Lab. Invest., 85, 452, 10.1038/labinvest.3700253 · DOI · Paper page
  101. Pan, 2006, Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation, Mol. Cell. Biol., 26, 3365, 10.1128/MCB.26.9.3365-3377.2006 · DOI · Paper page
  102. Park, 2000, Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation, Development, 127, 1593, 10.1242/dev.127.8.1593 · DOI · Paper page
  103. Pasca di Magliano, 2003, Hedgehog signalling in cancer formation and maintenance, Nat. Rev. Cancer, 3, 903, 10.1038/nrc1229 · DOI · Paper page
  104. Pazour, 1998, A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT), J. Cell Biol., 141, 979, 10.1083/jcb.141.4.979 · DOI · Paper page
  105. Pearse, 1999, Vertebrate homologs of Drosophila suppressor of fused interact with the Gli family of transcriptional regulators, Dev. Biol., 212, 323, 10.1006/dbio.1999.9335 · DOI
  106. Perler, 1998, Protein splicing of inteins and hedgehog autoproteolysis: Structure, function, and evolution, Cell, 92, 1, 10.1016/S0092-8674(00)80892-2 · DOI · Paper page
  107. Persson, 2002, Dorsal–ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity, Genes Dev., 16, 2865, 10.1101/gad.243402 · DOI · Paper page
  108. Piperno, 1998, Distinct mutants of retrograde intraflagellar transport (IFT) share similar morphological and molecular defects, J. Cell Biol., 143, 1591, 10.1083/jcb.143.6.1591 · DOI · Paper page
  109. Préat, 1992, Characterization of suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster, Genetics, 132, 725, 10.1093/genetics/132.3.725 · DOI
  110. Price, 1999, Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A, Development, 126, 4331, 10.1242/dev.126.19.4331 · DOI
  111. Price, 2002, Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1, Cell, 108, 823, 10.1016/S0092-8674(02)00664-5 · DOI · Paper page
  112. Quarmby, 2005, Cilia and the cell cycle?, J. Cell Biol., 169, 707, 10.1083/jcb.200503053 · DOI · Paper page
  113. Rana, 2004, Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates, Development, 131, 4999, 10.1242/dev.01389 · DOI
  114. Reiter, 2006, Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition, Genes Dev., 20, 22, 10.1101/gad.1363606 · DOI
  115. Riddle, 1993, Sonic hedgehog mediates the polarizing activity of the ZPA, Cell, 75, 1401, 10.1016/0092-8674(93)90626-2 · DOI · Paper page
  116. Robbins, 1997, Hedgehog elicits signal transduction by means of a large complex containing the kinesin‐related protein costal2, Cell, 90, 225, 10.1016/S0092-8674(00)80331-1 · DOI · Paper page
  117. Roelink, 1994, Floor plate and motor neuron induction by vhh‐1, a vertebrate homolog of hedgehog expressed by the notochord, Cell, 76, 761, 10.1016/0092-8674(94)90514-2 · DOI · Paper page
  118. Roelink, 1995, Floor plate and motor neuron induction by different concentrations of the amino‐terminal cleavage product of sonic hedgehog autoproteolysis, Cell, 81, 445, 10.1016/0092-8674(95)90397-6 · DOI · Paper page
  119. Romio, 2004, OFD1 is a centrosomal/basal body protein expressed during mesenchymal–epithelial transition in human nephrogenesis, J. Am. Soc. Nephrol., 15, 2556, 10.1097/01.ASN.0000140220.46477.5C · DOI · Paper page
  120. Rosenbaum, 2002, Intraflagellar transport, Nat. Rev. Mol. Cell Biol., 3, 813, 10.1038/nrm952 · DOI · Paper page
  121. Rubin, 2006, Targeting the Hedgehog pathway in cancer, Nat. Rev. Drug Discov., 5, 1026, 10.1038/nrd2086 · DOI · Paper page
  122. Ruel, 2003, Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog, Nat. Cell Biol., 5, 907, 10.1038/ncb1052 · DOI · Paper page
  123. Ruel, 2007, Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened–Fused–Costal2–Cubitus interruptus complex in Hedgehog signalling, Development, 134, 3677, 10.1242/dev.011577 · DOI
  124. Ruiz i Altaba, 1999, Gli proteins encode context‐dependent positive and negative functions: Implications for development and disease, Development, 126, 3205, 10.1242/dev.126.14.3205 · DOI · Paper page
  125. Ruiz i Altaba, 2002, Gli and Hedgehog in cancer: Tumours, embryos and stem cells, Nat. Rev. Cancer, 2, 361, 10.1038/nrc796 · DOI · Paper page
  126. Ruiz‐Perez, 2007, Evc is a positive mediator of Ihh‐regulated bone growth that localises at the base of chondrocyte cilia, Development, 134, 2903, 10.1242/dev.007542 · DOI · Paper page
  127. Salisbury, 2004, Primary cilia: Putting sensors together, Curr. Biol., 14, R765, 10.1016/j.cub.2004.09.016 · DOI
  128. Sarpal, 2003, Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails, Curr. Biol., 13, 1687, 10.1016/j.cub.2003.09.025 · DOI · Paper page
  129. Schafer, 2003, XBX‐1 encodes a dynein light intermediate chain required for retrograde intraflagellar transport and cilia assembly in Caenorhabditis elegans, Mol. Biol. Cell, 14, 2057, 10.1091/mbc.e02-10-0677 · DOI
  130. Scherz, 2007, Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb, Dev. Biol., 308, 343, 10.1016/j.ydbio.2007.05.030 · DOI
  131. Schneider, 2005, PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts, Curr. Biol., 15, 1861, 10.1016/j.cub.2005.09.012 · DOI · Paper page
  132. Sheng, 2002, Dissecting the oncogenic potential of Gli2: Deletion of an NH2‐terminal fragment alters skin tumor phenotype, Cancer Res., 62, 5308
  133. Simons, 2006, Polycystic kidney disease: Cell division without a c(l)ue?, Kidney Int., 70, 854, 10.1038/sj.ki.5001534 · DOI
  134. Singla, 2006, The primary cilium as the cell's antenna: Signaling at a sensory organelle, Science, 313, 629, 10.1126/science.1124534 · DOI · Paper page
  135. Sisson, 1997, Costal2, a novel kinesin‐related protein in the Hedgehog signaling pathway, Cell, 90, 235, 10.1016/S0092-8674(00)80332-3 · DOI · Paper page
  136. Smelkinson, 2006, Processing of the Drosophila hedgehog signaling effector Ci‐155 to the repressor Ci‐75 is mediated by direct binding to the SCF component Slimb, Curr. Biol., 16, 110, 10.1016/j.cub.2005.12.012 · DOI
  137. Snell, 2006, An unusual choanoflagellate protein released by Hedgehog autocatalytic processing, Proc. Biol. Sci., 273, 401
  138. Snow, 2004, Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons, Nat. Cell Biol., 6, 1109, 10.1038/ncb1186 · DOI · Paper page
  139. St‐Jacques, 1999, Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation, Genes Dev., 13, 2072, 10.1101/gad.13.16.2072 · DOI · Paper page
  140. Stone, 1999, Characterization of the human suppressor of fused, a negative regulator of the zinc‐finger transcription factor Gli, J. Cell Sci., 112, 4437, 10.1242/jcs.112.23.4437 · DOI · Paper page
  141. Storm van's Gravesande, 2005, Primary ciliary dyskinesia: Clinical presentation, diagnosis and genetics, Ann. Med., 37, 439, 10.1080/07853890510011985 · DOI
  142. Sun, 2004, A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney, Development, 131, 4085, 10.1242/dev.01240 · DOI · Paper page
  143. Tang, 2007, Novel Hedgehog pathway targets against basal cell carcinoma, Toxicol. Appl. Pharmacol., 224, 257, 10.1016/j.taap.2006.12.011 · DOI
  144. Tay, 2005, A homologue of the Drosophila kinesin‐like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo, Development, 132, 625, 10.1242/dev.01606 · DOI
  145. Tempé, 2006, Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP, Mol. Cell. Biol., 26, 4316, 10.1128/MCB.02183-05 · DOI · Paper page
  146. te Welscher, 2002, Progression of vertebrate limb development through Shh‐mediated counteraction of Gli3, Science, 298, 827, 10.1126/science.1075620 · DOI · Paper page
  147. Tobin, 2007, Bardet‐Biedl syndrome: Beyond the cilium, Pediatr. Nephrol., 22, 926, 10.1007/s00467-007-0435-0 · DOI · Paper page
  148. Town, 2008, The stumpy gene is required for mammalian ciliogenesis, Proc. Natl Acad. Sci. USA, 105, 2853, 10.1073/pnas.0712385105 · DOI · Paper page
  149. Tran, 2008, THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia, Nat. Genet., 40, 403, 10.1038/ng.105 · DOI · Paper page
  150. Tsujikawa, 2004, Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons, Neuron, 42, 703, 10.1016/S0896-6273(04)00268-5 · DOI · Paper page
  151. Varjosalo, 2006, Divergence of hedgehog signal transduction mechanism between Drosophila and mammals, Dev. Cell, 10, 177, 10.1016/j.devcel.2005.12.014 · DOI · Paper page
  152. Vieira, 2006, FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin‐Darby canine kidney (MDCK) cells, Proc. Natl Acad. Sci. USA, 103, 18556, 10.1073/pnas.0608291103 · DOI · Paper page
  153. Vortkamp, 1996, Regulation of rate of cartilage differentiation by Indian hedgehog and PTH‐related protein, Nature, 273, 613
  154. Wang, 1999, The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels, Development, 126, 5097, 10.1242/dev.126.22.5097 · DOI
  155. Wang, 2006, Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing, Proc. Natl Acad. Sci. USA, 103, 33, 10.1073/pnas.0509927103 · DOI · Paper page
  156. Wang, 2008, A unique protection signal in Cubitus interruptus prevents its complete proteasomal degradation, Mol. Cell. Biol., 28, 5555, 10.1128/MCB.00524-08 · DOI
  157. Wang, 2007, The Shh‐independent activator function of the full‐length Gli3 protein and its role in vertebrate limb digit patterning, Dev. Biol., 305, 460, 10.1016/j.ydbio.2007.02.029 · DOI
  158. Wang, 2007, Shifting paradigms in Hedgehog signaling, Curr. Opin. Cell Biol., 19, 159, 10.1016/j.ceb.2007.02.005 · DOI · Paper page
  159. Wigley, 1999, Dynamic association of proteasomal machinery with the centrosome, J. Cell Biol., 145, 481, 10.1083/jcb.145.3.481 · DOI · Paper page
  160. Wolff, 2003, Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo, Curr. Biol., 13, 1169, 10.1016/S0960-9822(03)00461-5 · DOI · Paper page
  161. Yoder, 2002, Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium, Am. J. Physiol. Renal Physiol., 282, F541, 10.1152/ajprenal.00273.2001 · DOI · Paper page
  162. Zhang, 2004, Extensive phosphorylation of Smoothened in Hedgehog pathway activation, Proc. Natl Acad. Sci. USA, 101, 17900, 10.1073/pnas.0408093101 · DOI · Paper page
  163. Zhang, 2005, Hedgehog‐regulated Costal2–kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus, Dev. Cell, 8, 267, 10.1016/j.devcel.2005.01.001 · DOI · Paper page
  164. Zhang, 2006, A hedgehog‐induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor, Dev. Cell, 10, 719, 10.1016/j.devcel.2006.05.004 · DOI · Paper page
  165. Zhou, 2006, The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster, Genetics, 173, 2049, 10.1534/genetics.106.061036 · DOI
  166. Zimmerman, 1898, Beitrage zur kenntniss einiger drusen und epithelien, Arch. Mikr. Anat., 52, 552, 10.1007/BF02975837 · DOI · Paper page

Cited by

See all 195

Metadata

Venue
Current Topics in Developmental Biology
Publisher
Elsevier
Published
2008
Volume
85
Pages
225-260
ISSN
0070-2153 (ISSN-L)
DOI
10.1016/s0070-2153(08)00809-0
OpenAlex
W1577007211
Cited by
195
References
24
FWCI
34.10
Type
book chapter
Language
en
Open access
green
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Chapter 9 The Primary Cilium. https://app.cochat.ai/papers/10.1016/s0070-2153(08)00809-0
The paper
Chapter 9 The Primary Cilium. (2008). Current Topics in Developmental Biology. https://doi.org/10.1016/s0070-2153(08)00809-0

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.