NF-κB: Ten Years After

Function and Activation of NF-kappaB in the Immune System

Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

THE UBIQUITIN SYSTEM

Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

Nidai Ozes, O., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M., & Donner, D. B. (1999) · Nature · doi:10.1038/43466 · Cited by 1,832

IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice

Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367

Multiple control of interleukin-8 gene expression

Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., & Kracht, M. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.5.847 · Cited by 1,058

NF-kB: a crucial transcription factor for glial and neuronal cell function

O'Neill, L. A. J., & Kaltschmidt, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01035-1 · Cited by 1,013

The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression

De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898

NF-κB in neuronal plasticity and neurodegenerative disorders

Mattson, M. P., & Camandola, S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11916 · Cited by 877

TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor.

Wong, B. R., Josien, R., Lee, S. Y., Sauter, B., Li, H.-L., Steinman, R. M., & Choi, Y. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.12.2075 · Cited by 853

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways

McKay, L. I., & Cidlowski, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0375 · Cited by 805

Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide

Kirschning, C. J., Wesche, H., Merrill Ayres, T., & Rothe, M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.11.2091 · Cited by 753

Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B

Wahl, C., Liptay, S., Adler, G., & Schmid, R. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci992 · Cited by 742

Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.14560 · Cited by 742

Redox signaling: hydrogen peroxide as intracellular messenger

Rhee, S. G. (1999) · Experimental & Molecular Medicine · doi:10.1038/emm.1999.9 · Cited by 701

Signal Transduction and the Control of Gene Expression

Brivanlou, A. H., & Darnell, J. E. (2002) · Science · doi:10.1126/science.1066355 · Cited by 699

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

Janssen-Heininger, Y. M. W., Poynter, M. E., & Baeuerle, P. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00218-5 · Cited by 666

Nuclear Factor (NF)-κB–regulated X-chromosome–linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

Stehlik, C., de Martin, R., Kumabashiri, I., Schmid, J. A., Binder, B. R., & Lipp, J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.1.211 · Cited by 635

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554

Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer

Catz, S. D., & Johnson, J. L. (2001) · Oncogene · doi:10.1038/sj.onc.1204926 · Cited by 538

The molecular inflammatory process in aging

Chung, H. Y., Sung, B., Jung, K. J., Zou, Y., & Yu, B. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.572 · Cited by 437

NF-κB Activation Represses Tumor Necrosis Factor-α-induced Autophagy

Djavaheri-Mergny, M., Amelotti, M., Mathieu, J., Besançon, F., Bauvy, C., Souquère, S., Pierron, G., & Codogno, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602097200 · Cited by 407

Nedd8 Modification of Cul-1 Activates SCFβTrCP-Dependent Ubiquitination of IκBα

Read, M. A., Brownell, J. E., Gladysheva, T. B., Hottelet, M., Parent, L. A., Coggins, M. B., Pierce, J. W., Podust, V. N., Luo, R.-S., Chau, V., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.7.2326-2333.2000 · Cited by 363

Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction

Schwandner, R., Yamaguchi, K., & Cao, Z. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.7.1233 · Cited by 349

Efferent Vagal Fibre Stimulation Blunts Nuclear Factor-κB Activation and Protects Against Hypovolemic Hemorrhagic Shock

Guarini, S., Altavilla, D., Cainazzo, M.-M., Giuliani, D., Bigiani, A., Marini, H., Squadrito, G., Minutoli, L., Bertolini, A., Marini, R., et al. (2003) · Circulation · doi:10.1161/01.cir.0000050627.90734.ed · Cited by 315

Nuclear Integration of Glucocorticoid Receptor and Nuclear Factor-κB Signaling by CREB-binding Protein and Steroid Receptor Coactivator-1

Sheppard, K.-A., Phelps, K. M., Williams, A. J., Thanos, D., Glass, C. K., Rosenfeld, M. G., Gerritsen, M. E., & Collins, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29291 · Cited by 305

Prolonged Methylprednisolone Treatment Suppresses Systemic Inflammation in Patients with Unresolving Acute Respiratory Distress Syndrome: Evidence for Inadequate Endogenous Glucocorticoid Secretion and Inflammation-induced Immune Cell Resistance to Glucocorticoids

Meduri, G. U., Tolley, E. A., Chrousos, G. P., & Stentz, F. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.7.2106014 · Cited by 265

Candida albicans Phospholipomannan Is Sensed through Toll‐Like Receptors

Jouault, T., Ibata‐Ombetta, S., Takeuchi, O., Trinel, P., Sacchetti, P., Lefebvre, P., Akira, S., & Poulain, D. (2003) · The Journal of Infectious Diseases · doi:10.1086/375784 · Cited by 274

Inhibitory action of novel aromatic diamine compound on lipopolysaccharide‐induced nuclear translocation of NF‐κB without affecting IκB degradation

Shin, H.-M., Kim, M.-H., Kim, B. H., Jung, S.-H., Kim, Y. S., Park, H. J., Hong, J. T., Min, K. R., & Kim, Y. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.056 · Cited by 269

Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of IκBα in NF-κB activation by an oxidative stress

Schoonbroodt, S., Ferreira, V., Best-Belpomme, M., Boelaert, J. R., Legrand-Poels, S., Korner, M., & Piette, J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.8.4292 · Cited by 263

p38 MAPK-induced Nuclear Factor-κB Activity Is Required for Skeletal Muscle Differentiation: Role of Interleukin-6

Baeza-Raja, B., & Muñoz-Cánoves, P. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-08-0585 · Cited by 247

Melatonin as an anti-inflammatory agent modulating inflammasome activation

Favero, G., Franceschetti, L., Bonomini, F., Rodella, L. F., & Rezzani, R. (2017) · International Journal of Endocrinology · doi:10.1155/2017/1835195 · Cited by 233

The nuclear factor-kappa B pathway in atherosclerosis: a potential therapeutic target for atherothrombotic vascular disease

Pamukcu, B., Lip, G. Y. H., & Shantsila, E. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.03.025 · Cited by 218

Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-κB signaling in in vivo SKH-1 hairless mice

Sharma, S. D., Meeran, S. M., & Katiyar, S. K. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0661 · Cited by 219

An Age-Related Decline in Interleukin-10 May Contribute to the Increased Expression of Interleukin-6 in Brain of Aged Mice

Ye, S.-M., & Johnson, R. W. (2001) · Neuroimmunomodulation · doi:10.1159/000049025 · Cited by 203

Disruption of Nrf2 Enhances Upregulation of Nuclear Factor‐ κ B Activity, Proinflammatory Cytokines, and Intercellular Adhesion Molecule‐1 in the Brain after Traumatic Brain Injury

Jin, W., Wang, H., Yan, W., Xu, L., Wang, X., Zhao, X., Yang, X., Chen, G., & Ji, Y. (2008) · Mediators of Inflammation · doi:10.1155/2008/725174 · Cited by 172

Nuclear Factor-ĸB- and Glucocorticoid Receptor α- Mediated Mechanisms in the Regulation of Systemic and Pulmonary Inflammation during Sepsis and Acute Respiratory Distress Syndrome

Meduri, G. U., Muthiah, M. P., Carratù, P., Eltorky, M., & Chrousos, G. P. (2005) · Neuroimmunomodulation · doi:10.1159/000091126 · Cited by 167

NF-κB p50 and p52 Expression Is Not Required for RANK-Expressing Osteoclast Progenitor Formation but Is Essential for RANK- and Cytokine-Mediated Osteoclastogenesis

Xing, L., Bushnell, T. P., Carlson, L., Tai, Z., Tondravi, M., Siebenlist, U., Young, F., & Boyce, B. F. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.7.1200 · Cited by 165

A role for NF-κB–dependent gene transactivation in sunburn

Abeyama, K., Eng, W., Jester, J. V., Vink, A. A., Edelbaum, D., Cockerell, C. J., Bergstresser, P. R., & Takashima, A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9745 · Cited by 160

The Eye, Oxidative Damage and Polyunsaturated Fatty Acids

Saccà, S. C., Cutolo, C. A., Ferrari, D., Corazza, P., & Traverso, C. E. (2018) · Nutrients · doi:10.3390/nu10060668 · Cited by 150

Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis

Wu, W.-F., Tan, X.-J., Dai, Y.-B., Krishnan, V., Warner, M., & Gustafsson, J.-Å. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300313110 · Cited by 149

A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis

Arvelo, M. B., Cooper, J. T., Longo, C., Daniel, S., Grey, S. T., Mahiou, J., Czismadia, E., Abu-Jawdeh, G., & Ferran, C. (2002) · Hepatology · doi:10.1053/jhep.2002.31309 · Cited by 147

Protein phosphatase 2A interacts with and directly dephosphorylates RelA

Yang, J., Fan, G.-H., Wadzinski, B. E., Sakurai, H., & Richmond, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106103200 · Cited by 130

The role of NF-κB/IκB proteins in cancer: implications for novel treatment strategies

Schwartz, S. A., Hernandez, A., & Mark Evers, B. (1999) · Surgical Oncology · doi:10.1016/s0960-7404(00)00012-8 · Cited by 132

Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-κB and the glucocorticoid receptor

Doucas, V., Shi, Y., Miyamoto, S., West, A., Verma, I., & Evans, R. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220413297 · Cited by 125

Ubiquitin, TAK1 and IKK: is there a connection?

Chen, Z. J., Bhoj, V, & Seth, R. B. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401869 · Cited by 115

Oxidant-Mediated Activation of Mitogen- Activated Protein Kinases and Nuclear Transcription Factors in the Cardiovascular System

Chakraborti, S., & Chakraborti, T. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(98)00014-x · Cited by 110

Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes

Ku, C. S., Pham, T. X., Park, Y., Kim, B., Shin, M. S., Kang, I., & Lee, J. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.01.018 · Cited by 109

ACTIVATION OF THE CHOLINERGIC ANTI-INFLAMMATORY PATHWAY REDUCES NF-κB ACTIVATION, BLUNTS TNF-α PRODUCTION, AND PROTECTS AGAINTS SPLANCHIC ARTERY OCCLUSION SHOCK

Altavilla, D., Guarini, S., Bitto, A., Mioni, C., Giuliani, D., Bigiani, A., Squadrito, G., Minutoli, L., Venuti, F. S., Messineo, F., et al. (2006) · Shock · doi:10.1097/01.shk.0000209539.91553.82 · Cited by 98

The Antioxidant Effects of Isorhamnetin Contribute to Inhibit COX-2 Expression in Response to Inflammation: A Potential Role of HO-1

Seo, K., Yang, J. H., Kim, S. C., Ku, S. K., Ki, S. H., & Shin, S. M. (2014) · Inflammation · doi:10.1007/s10753-013-9789-6 · Cited by 90

NEMO Trimerizes through Its Coiled-coil C-terminal Domain

Agou, F., Ye, F., Goffinont, S., Courtois, G., Yamaoka, S., Israël, A., & Véron, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201964200 · Cited by 79

Impacts of transcriptional regulation on aging and senescence

Roy, A. K., Oh, T., Rivera, O., Mubiru, J., Song, C. S., & Chatterjee, B. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00006-5 · Cited by 72

Plasma Membrane-Targeted Raf Kinase Activates NF-κB and Human Immunodeficiency Virus Type 1 Replication in T Lymphocytes

Flory, E., Weber, C. K., Chen, P., Hoffmeyer, A., Jassoy, C., & Rapp, U. R. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.2788-2794.1998 · Cited by 55

AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain

Rieske, P., & Pongubala, J. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007482200 · Cited by 54

Neuropeptides as neuroprotective agents: oxytocin a forefront developmental player in the mammalian brain

Vargas-Martínez, F., Uvnäs-Moberg, K., Petersson, M., Olausson, H. A., & Jiménez-Estrada, I. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.10.001 · Cited by 51

The flavonoid, fisetin, inhibits UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells.

(2008) · PubMed Central · Cited by 46

γδT-cell function in sepsis is modulated by C5a receptor signalling

Han, G., Geng, S., Li, Y., Chen, G., Wang, R., Li, X., Ma, Y., Shen, B., & Li, Y. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03445.x · Cited by 32

EGF‐R is Expressed and AP‐1 and NF‐κ:B Are Activated in Stromal Myofibroblasts Surrounding Colon Adenocarcinomas Paralleling Expression of COX‐2 and VEGF

Konstantinopoulos, P. A., Vandoros, G. P., Karamouzis, M. V., Gkermpesi, M., Sotiropoulou-Bonikou, G., & Papavassiliou, A. G. (2007) · Analytical Cellular Pathology · doi:10.1155/2007/831416 · Cited by 32

Role of Redox Imbalance in the Molecular Mechanisms Responsible for Immunosenescence

Daynes, R. A., Enioutina, E. Y., & Jones, D. C. (2003) · Antioxidants & Redox Signaling · doi:10.1089/152308603770310185 · Cited by 27

Solution Study of the NF-κB p50-DNA Complex by UV Laser Protein-DNA Cross-linking¶

Angelov, D., Charra, M., Müller, C. W., Cadet, J., & Dimitrov, S. (2007) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2003)0770592ssotnp2.0.co2 · Cited by 18

Intake of high-fat diet stimulates the risk of ultraviolet radiation-induced skin tumors and malignant progression of papillomas to carcinoma in skh-1 hairless mice

Vaid, M., Singh, T., Prasad, R., & Katiyar, S. K. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.10.030 · Cited by 18

Isolation and neuronal apoptosis inhibitory property of bacoside-A3 via downregulation of β-amyloid induced inflammatory response

Bai, Q., & Zhao, Z. (2022) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2147 · Cited by 12

Molecular modeling of the oxidized form of nuclear factor-κB suggests a mechanism for redox regulation of DNA binding and transcriptional activation

Chandrasekaran, V., & Taylor, E. W. (2008) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2007.05.007 · Cited by 11