Cited by 1,092Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

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The neuroanatomical and neurochemical basis of conditioned fear

Fendt, M., Fanselow, M.S.·1999·Neuroscience & Biobehavioral Reviews

DOI 10.1016/s0149-7634(99)00016-0

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Abstract

After a few pairings of a threatening stimulus with a formerly neutral cue, animals and humans will experience a state of conditioned fear when only the cue is present. Conditioned fear provides a critical survival-related function in the face of threat by activating a range of protective behaviors. The present review summarizes and compares the results of different laboratories investigating the neuroanatomical and neurochemical basis of conditioned fear, focusing primarily on the behavioral models of freezing and fear-potentiated startle in rats. On the basis of these studies, we describe the pathways mediating and modulating fear. We identify several key unanswered questions and discuss possible implications for the understanding of human anxiety disorders.

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Untitled work
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
The hippocampus as a cognitive map
Passingham, R. E. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90015-0 · Cited by 5,128
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
The Expression of the Emotions in Man and Animals
Crowley, T. (1957) · Philosophical Studies · doi:10.5840/philstudies1957703 · Cited by 3,625
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Self-citation
Emotion, attention, and the startle reflex
Lang, P. J., Bradley, M. M., & Cuthbert, B. N. (1990) · Psychological Review · doi:10.1037/0033-295x.97.3.377 · Cited by 2,205
Preliminary analysis of functions of the temporal lobes in monkeys
KLÜVER, H. (1939) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1939.02270240017001 · Cited by 1,696

Show all 244 references

Research works printed but not linked: 4

Miller, 1941, An experimental study of acquired drives, Psychol Bull, 38, 534
Shi, 1997, Anatomical tracing and lesion studies of pain pathways involved in fear conditioning measured with fear potentiated startle, Soc Neurosci Abstr, 23, 627.12
Fendt, 1997, Stimulation of startle modulating midbrain areas has different effects on the acoustic startle response, Soc Neurosci Abstr, 23, 627.14
Cassella, 1984, Sensitization fear conditioning and pharmacological modulation of acoustic startle following lesions of the dorsal periaqueductal gray, Soc Neurosci Abstr, 10, 1067

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Authors: Fendt, M., & Fanselow, M. S.
Affiliations: University of Tübingen (DE)
University of California, Los Angeles (US)
Corresponding author: Fendt, M.
ORCID: Fendt, M.
Fanselow, M.S.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 1999-05
Volume: 23
Issue: 5
Pages: 743-760
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/s0149-7634(99)00016-0
OpenAlex: W2042847262
Cited by: 1,092
References: 244
Citations by year: 2026: 8 · 2025: 15 · 2024: 21 · 2023: 32 · 2022: 29 · 2021: 28 · 2020: 27 · 2019: 27 · 2018: 26 · 2017: 39 · 2016: 44 · 2015: 35 · 2014: 41 · 2013: 55 · 2012: 54
FWCI: 4.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: fear conditioning, freezing behavior, fear-potentiated startle, anxiety disorders, threat response
MeSH terms: Animals, Brain, Brain Chemistry, Conditioning, Psychological, Fear, Humans

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The neuroanatomical and neurochemical basis of conditioned fear

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