The DOI matches its Crossref record; 239 of the 239 references it cites were found in a registry or an index.
Sleep and depression--results from psychobiological studies: an overview
Abstract
Disturbances of sleep are typical for most depressed patients and belong to the core symptoms of the disorder. Polysomnographic sleep research has demonstrated that besides disturbances of sleep continuity, in depression sleep is characterized by a reduction of slow wave sleep and a disinhibition of REM sleep, with a shortening of REM latency, a prolongation of the first REM period and increased REM density. These findings have stimulated many sleep studies in depressive patients and patients with other psychiatric disorders. In the meantime, several theoretical models, originating from basic research, have been developed to explain sleep abnormalities of depression, like the two-process-model of sleep and sleep regulation, the GRF/CRF imbalance model and the reciprocal interaction model of non-REM and REM sleep regulation. Interestingly, most of the effective antidepressant agents suppress REM sleep. Furthermore, manipulations of the sleep-wake cycle, like sleep deprivation or a phase advance of the sleep period, alleviate depressive symptoms. These data indicate a strong bi-directional relationship between sleep, sleep alterations and depression.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Riemann et al., 2001
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Riemann et al., 2001
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Riemann et al., 2001
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Riemann et al., 2001
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Riemann et al., 2001
In the citing paper
“However, exogenously-induced inflammation using both endotoxin and IFN-α also led to a suppression of REM sleep (Mullington et al., 2000; Raison et al., 2010), which is the opposite of changes observed in depressed patients (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Riemann et al., 2001
In the citing paper
“and remediate one of the sleep problems influenced by inflammation (Palagini et al., 2013; Riemann et al., 2001)”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Riemann et al., 2001
In the citing paper
“suggesting shared pathophysiological mechanisms between the two entities (36).”
From ChatGPT is not ready yet for use in providing mental health assessment and interventions (2024) · cites this paper as [36]
Citations
Cites
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
Two-Process Model of Sleep Regulation
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_6166 · Cited by 3,900
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?
Ford, D. E. (1989) · JAMA · doi:10.1001/jama.262.11.1479 · Cited by 2,440
Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders: An Opportunity for Prevention?
Ford, D. E. (1989) · JAMA · doi:10.1001/jama.1989.03430110069030 · Cited by 2,252
Frank, E. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810330075011 · Cited by 1,959
Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young Adults
Breslau, N., Roth, T., Rosenthal, L., & Andreski, P. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00188-3 · Cited by 1,831
Psychopharmacology: The Fourth Generation of Progress
Brophy, J. J. (1995) · JAMA · doi:10.1001/jama.1995.03530220079046 · Cited by 1,582
Sleep and Psychiatric Disorders: A Meta-analysis
Benca, R. M. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080059010 · Cited by 1,468
Sleep Cycle Oscillation: Reciprocal Discharge by Two Brainstem Neuronal Groups
Hobson, J. A., McCarley, R. W., & Wyzinski, P. (1975) · Science · doi:10.1126/science.1094539 · Cited by 1,238
Research works printed but not linked: 9
- Borbély, 1982, Sleep, sleep deprivation and depression, Hum. Neurobiol., 1, 205
- Brunner, 1993, Sleep parameters in SAD: effects of midday light, season, and sleep deprivation, Sleep Res., 22, 396
- Cashman, 1986, Sleep markers for major depressive disorder in adolescent patients, Sleep Res., 15, 91
- Knowles, 1990, Age-related changes in sleep in depressed and healthy subjects, Neuropsychopharmacology, 3, 251
- Pflug, 1971, Therapie endogener Depressionen durch Schlafentzug, Nervenarzt, 42, 117
- Reynolds, 1998, What do antidepressant effects on sleep tell us about pathways to treatment response?, Biol. Psychiatry, 44, 1
- Rosenthal, 1989, Sleep architecture in seasonal affective disorder: the effects of light therapy and changing seasons, Sleep Res., 18, 440
- Schulz, 1979, A comparison of eye-movement density in normal subjects and in depressed patients before and after remission, Sleep Res., 8, 49
- Wu, 1994, PET studies of sleep deprivation in unipolar depression, Neuropsychopharmacology, 10, 876
Cited by
Sorted by citations
Baglioni, C., Battagliese, G., Feige, B., Spiegelhalder, K., Nissen, C., Voderholzer, U., Lombardo, C., & Riemann, D. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.01.011 · Cited by 2,779
Self-citationSleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
The hyperarousal model of insomnia: A review of the concept and its evidence
Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.04.002 · Cited by 1,789
Self-citationDiscovering Endophenotypes for Major Depression
Hasler, G., Drevets, W. C., Manji, H. K., & Charney, D. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300506 · Cited by 1,123
Sleep and emotions: a focus on insomnia
Baglioni, C., Spiegelhalder, K., Lombardo, C., & Riemann, D. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.10.007 · Cited by 873
Self-citationThe genetics of depression: A review
Levinson, D. F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.024 · Cited by 855
Sleep disturbance and psychiatric disorders
Freeman, D., Sheaves, B., Waite, F., Harvey, A. G., & Harrison, P. J. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30136-x · Cited by 843
Jansson-Fröjmark, M., & Lindblom, K. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.10.016 · Cited by 646
Circadian rhythm disturbances in depression
Germain, A., & Kupfer, D. J. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.964 · Cited by 644
Primary insomnia: a risk factor to develop depression?
Riemann, D. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00072-1 · Cited by 641
Self-citationREM sleep dysregulation in depression: state of the art
Palagini, L., Baglioni, C., Ciapparelli, A., Gemignani, A., & Riemann, D. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.11.001 · Cited by 513
Self-citationComorbidity of insomnia and depression
Staner, L. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.09.003 · Cited by 481
Evidence for prospective associations among depression and obesity in population‐based studies
Faith, M. S., Butryn, M., Wadden, T. A., Fabricatore, A., Nguyen, A. M., & Heymsfield, S. B. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00843.x · Cited by 340
Mannan, M., Mamun, A., Doi, S., & Clavarino, A. (2016) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2015.12.008 · Cited by 280
Insomnia and Daytime Sleepiness Are Risk Factors for Depressive Symptoms in the Elderly
Jaussent, I., Bouyer, J., Ancelin, M.-L., Akbaraly, T., Peres, K., Ritchie, K., Besset, A., & Dauvilliers, Y. (2011) · Sleep · doi:10.5665/sleep.1170 · Cited by 291
Srinivasan, V., Smits, M., Spence, W., Lowe, A. D., Kayumov, L., Pandi-Perumal, S. R., Parry, B., & Cardinali, D. P. (2006) · The World Journal of Biological Psychiatry · doi:10.1080/15622970600571822 · Cited by 292
Knutson, K. L. (2013) · Social Science & Medicine · doi:10.1016/j.socscimed.2012.05.002 · Cited by 228
Nocturnal cortisol and melatonin secretion in primary insomnia
Riemann, D., Klein, T., Rodenbeck, A., Feige, B., Horny, A., Hummel, R., Weske, G., Al-Shajlawi, A., & Voderholzer, U. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00249-4 · Cited by 202
Self-citationInsomnia and comorbid psychiatric disorders
Riemann, D. (2007) · Sleep Medicine · doi:10.1016/s1389-9457(08)70004-2 · Cited by 198
Self-citationEvaluation and management of sleep disturbance during the menopause transition
Joffe, H., Massler, A., & Sharkey, K. (2010) · Seminars in Reproductive Medicine · doi:10.1055/s-0030-1262900 · Cited by 195
The circadian basis of mood disorders: Recent developments and treatment implications
Monteleone, P., & Maj, M. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.06.007 · Cited by 185
Glozier, N., Martiniuk, A., Patton, G., Ivers, R., Li, Q., Hickie, I., Senserrick, T., Woodward, M., Norton, R., & Stevenson, M. (2010) · Sleep · doi:10.1093/sleep/33.9.1139 · Cited by 177
Hasler, B. P., Buysse, D. J., Kupfer, D. J., & Germain, A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.04.027 · Cited by 177
Dooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176
Wittmann, L., Schredl, M., & Kramer, M. (2007) · Psychotherapy and Psychosomatics · doi:10.1159/000096362 · Cited by 167
Circadian rhythms and depression: Human psychopathology and animal models
Kronfeld-Schor, N., & Einat, H. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.020 · Cited by 166
Physiological correlates of bereavement and the impact of bereavement interventions
Buckley, T., Sunari, D., Marshall, A., Bartrop, R., McKinley, S., & Tofler, G. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.2/tbuckley · Cited by 160
Glial Dysfunction in the Mouse Habenula Causes Depressive-Like Behaviors and Sleep Disturbance
Cui, W., Mizukami, H., Yanagisawa, M., Aida, T., Nomura, M., Isomura, Y., Takayanagi, R., Ozawa, K., Tanaka, K., & Aizawa, H. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1465-14.2014 · Cited by 139
Insomnia and depression: a multifaceted interplay
Manber, R., & Chambers, A. S. (2009) · Current Psychiatry Reports · doi:10.1007/s11920-009-0066-1 · Cited by 134
Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs
Srinivasan, V., Singh, J., Pandi-Perumal, S. R., Brown, G. M., Spence, D. W., & Cardinali, D. P. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0065-y · Cited by 129
ChatGPT is not ready yet for use in providing mental health assessment and interventions
Dergaa, I., Fekih-Romdhane, F., Hallit, S., Loch, A. A., Glenn, J. M., Fessi, M. S., Ben Aissa, M., Souissi, N., Guelmami, N., Swed, S., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1277756 · Cited by 125
REM Sleep Rebound as an Adaptive Response to Stressful Situations
Suchecki, D., Tiba, P. A., & Machado, R. B. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00041 · Cited by 119
Luik, A. I., Zuurbier, L. A., Direk, N., Hofman, A., Van Someren, E. J. W., & Tiemeier, H. (2015) · Depression and Anxiety · doi:10.1002/da.22355 · Cited by 120
Sleep Duration and Sleep Quality: Associations With Depressive Symptoms Across Adolescence
Raniti, M. B., Allen, N. B., Schwartz, O., Waloszek, J. M., Byrne, M. L., Woods, M. J., Bei, B., Nicholas, C. L., & Trinder, J. (2017) · Behavioral Sleep Medicine · doi:10.1080/15402002.2015.1120198 · Cited by 117
Nofzinger, E. A., Buysse, D. J., Germain, A., Carter, C., Luna, B., Price, J. C., Meltzer, C. C., Miewald, J. M., Reynolds, C. F., & Kupfer, D. J. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.695 · Cited by 113
Kenney, S. R., Lac, A., LaBrie, J. W., Hummer, & Pham, A. (2013) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2013.74.841 · Cited by 110
Sleep disturbance, personality and the onset of depression and anxiety: Prospective cohort study
Batterham, P. J., Glozier, N., & Christensen, H. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412457997 · Cited by 108
Modell, S., Ising, M., Holsboer, F., & Lauer, C. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.004 · Cited by 103
Respiratory sinus arrhythmia reactivity in current and remitted major depressive disorder
Bylsma, L. M., Salomon, K., Taylor-Clift, A., Morris, B. H., & Rottenberg, J. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000019 · Cited by 89
Role of melatonin in mood disorders and the antidepressant effects of agomelatine
Srinivasan, V., De Berardis, D., Shillcutt, S. D., & Brzezinski, A. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2012.711314 · Cited by 84
Sleep and manipulations of the sleep–wake rhythm in depression
Berger, M., Van Calker, D., & Riemann, D. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.108.s418.17.x · Cited by 82
Self-citationThe natural history of insomnia: acute insomnia and first-onset depression.
Ellis, J. G., Perlis, M. L., Bastien, C. H., Gardani, M., & Espie, C. A. (2014) · Sleep · doi:10.5665/sleep.3316 · Cited by 81
Rapid-acting antidepressant strategies: mechanisms of action
Bunney, B. G., & Bunney, W. E. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000927 · Cited by 79
Delta Sleep Response to Metyrapone in Post-Traumatic Stress Disorder
Neylan, T. C., Lenoci, M., Maglione, M. L., Rosenlicht, N. Z., Metzler, T. J., Otte, C., Schoenfeld, F. B., Yehuda, R., & Marmar, C. R. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300215 · Cited by 75
The impact of sleep, stress, and depression on postpartum weight retention: A systematic review
Xiao, R. S., Kroll-Desrosiers, A. R., Goldberg, R. J., Pagoto, S. L., Person, S. D., & Waring, M. E. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.09.016 · Cited by 62
Ng, M.-Y., & Wong, W.-S. (2013) · Journal of Health Psychology · doi:10.1177/1359105312439733 · Cited by 58
Ben-Hamo, M., Larson, T. A., Duge, L. S., Sikkema, C., Wilkinson, C. W., de la Iglesia, H. O., & González, M. M. C. (2016) · eneuro · doi:10.1523/eneuro.0237-16.2016 · Cited by 57
Desai, R. I., Limoli, C. L., Stark, C. E. L., & Stark, S. M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104676 · Cited by 55
Simor, P., Bódizs, R., Horváth, K., & Ferri, R. (2013) · SLEEP · doi:10.5665/sleep.2462 · Cited by 52
Chang, J. J., Salas, J., Habicht, K., Pien, G. W., Stamatakis, K. A., & Brownson, R. C. (2012) · The Journal of Rural Health · doi:10.1111/j.1748-0361.2011.00398.x · Cited by 46
The therapeutic potentials of Ayahuasca in the treatment of depression
Palhano-Fontes, F., Alchieri, J. C., Oliveira, J. P. M., Soares, B. L., Hallak, J. E. C., Galvao-Coelho, N., & de Araujo, D. B. (2014) · The Therapeutic Use of Ayahuasca · doi:10.1007/978-3-642-40426-9_2 · Cited by 36
Tapering antidepressants: is 3 months slow enough?
Phelps, J. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.08.035 · Cited by 16
Casaglia, E., & Luppi, P. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13633 · Cited by 8
Metadata
- Authors
- Riemann, D., Berger, M., & Voderholzer, U.
- Affiliations
- University Medical Center Freiburg (DE)
- Corresponding author
- Riemann, Dieter
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 57
- Issue
- 1-3
- Pages
- 67-103
- ISSN
- 0301-0511 (ISSN-L)
- OpenAlex
- W2013935018
- Cited by
- 653
- References
- 239
- Citations by year
- 2026: 16 · 2025: 26 · 2024: 26 · 2023: 29 · 2022: 31 · 2021: 31 · 2020: 28 · 2019: 25 · 2018: 21 · 2017: 23 · 2016: 33 · 2015: 37 · 2014: 25 · 2013: 38 · 2012: 35
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- sleep disorders, depression, REM sleep, slow-wave sleep, REM latency, REM density, antidepressants, sleep deprivation, sleep phase advance, sleep-wake cycle, polysomnography
- MeSH terms
- Brain, Depressive Disorder, Humans, Sleep Deprivation, Sleep Wake Disorders, Sleep Stages, Sleep, REM, Polysomnography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
