Fractionation of social brain circuits in autism spectrum disorders
Open accessAbstract
Autism spectrum disorders are developmental disorders characterized by impairments in social and communication abilities and repetitive behaviours. Converging neuroscientific evidence has suggested that the neuropathology of autism spectrum disorders is widely distributed, involving impaired connectivity throughout the brain. Here, we evaluate the hypothesis that decreased connectivity in high-functioning adolescents with an autism spectrum disorder relative to typically developing adolescents is concentrated within domain-specific circuits that are specialized for social processing. Using a novel whole-brain connectivity approach in functional magnetic resonance imaging, we found that not only are decreases in connectivity most pronounced between regions of the social brain but also they are selective to connections between limbic-related brain regions involved in affective aspects of social processing from other parts of the social brain that support language and sensorimotor processes. This selective pattern was independently obtained for correlations with measures of social symptom severity, implying a fractionation of the social brain in autism spectrum disorders at the level of whole circuits.
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Disorganization of synaptic connectivity in the temporal lobe may compromise function of a network of brain regions underlying global brain dysfunction and ASD-like social deficits.
“the disorganization of synaptic connectivity in the temporal lobe, a central node in the social brain network (Gotts et al., 2012), may compromise function of a network of anatomically distinct brain regions that underlie global brain dysfunction and ASD-like social deficits (Normand et al., 2013; Tsai et al., 2012).”
From Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits (2014) · cites this paper as Gotts et al., 2012
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Bolton, T. A. W., Jochaut, D., Giraud, A., & Ville, D. V. D. (2018) · Human Brain Mapping · doi:10.1002/hbm.24009 · Cited by 61 · see citing works
- Authors
- Gotts, S. J., Simmons, W. K., Milbury, L. A., Wallace, G. L., Cox, R. W., & Martin, A.
- Affiliations
- National Institutes of Health (US)
- Laureate Institute for Brain Research (US)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-07-11
- Volume
- 135
- Issue
- 9
- Pages
- 2711-2725
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC3437021
- OpenAlex
- W2154608643
- Cited by
- 369
- References
- 100
- Citations by year
- 2026: 20 · 2025: 9 · 2024: 25 · 2023: 16 · 2022: 38 · 2021: 18 · 2020: 31 · 2019: 27 · 2018: 30 · 2017: 32 · 2016: 29 · 2015: 31 · 2014: 21 · 2013: 39 · 2012: 3
- FWCI
- 15.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, functional connectivity, limbic system, whole-brain connectivity
- MeSH terms
- Adolescent, Brain, Brain Mapping, Child, Child Development Disorders, Pervasive, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Severity of Illness Index, Social Behavior, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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