Cited by 369Autism Spectrum Disorder ResearchFunctional Brain Connectivity StudiesGenetics and Neurodevelopmental Disorders

Fractionation of social brain circuits in autism spectrum disorders

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Gotts, Stephen J., Simmons, W. Kyle, Milbury, Lydia A., Wallace, Gregory L., Cox, Robert W., Martin, Alex·2012·Brain

Abstract

Autism spectrum disorders are developmental disorders characterized by impairments in social and communication abilities and repetitive behaviours. Converging neuroscientific evidence has suggested that the neuropathology of autism spectrum disorders is widely distributed, involving impaired connectivity throughout the brain. Here, we evaluate the hypothesis that decreased connectivity in high-functioning adolescents with an autism spectrum disorder relative to typically developing adolescents is concentrated within domain-specific circuits that are specialized for social processing. Using a novel whole-brain connectivity approach in functional magnetic resonance imaging, we found that not only are decreases in connectivity most pronounced between regions of the social brain but also they are selective to connections between limbic-related brain regions involved in affective aspects of social processing from other parts of the social brain that support language and sensorimotor processes. This selective pattern was independently obtained for correlations with measures of social symptom severity, implying a fractionation of the social brain in autism spectrum disorders at the level of whole circuits.

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Crossref · 10.1093/brain/aws160

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  • Disorganization of synaptic connectivity in the temporal lobe may compromise function of a network of brain regions underlying global brain dysfunction and ASD-like social deficits.

    “the disorganization of synaptic connectivity in the temporal lobe, a central node in the social brain network (Gotts et al., 2012), may compromise function of a network of anatomically distinct brain regions that underlie global brain dysfunction and ASD-like social deficits (Normand et al., 2013; Tsai et al., 2012).”

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Authors
Gotts, S. J., Simmons, W. K., Milbury, L. A., Wallace, G. L., Cox, R. W., & Martin, A.
Affiliations
  • National Institutes of Health (US)
  • Laureate Institute for Brain Research (US)
Venue
Brain
Published
2012-07-11
Volume
135
Issue
9
Pages
2711-2725
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
OpenAlex
W2154608643
Cited by
369
References
100
Citations by year
2026: 20 · 2025: 9 · 2024: 25 · 2023: 16 · 2022: 38 · 2021: 18 · 2020: 31 · 2019: 27 · 2018: 30 · 2017: 32 · 2016: 29 · 2015: 31 · 2014: 21 · 2013: 39 · 2012: 3
FWCI
15.38
Type
journal article
Language
en
Open access
Locations
  • Brain (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, functional connectivity, limbic system, whole-brain connectivity
MeSH terms
Adolescent, Brain, Brain Mapping, Child, Child Development Disorders, Pervasive, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Severity of Illness Index, Social Behavior, Young Adult

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