Experimental sleep restriction causes endothelial dysfunction in healthy humans
Open accessAbstract
BACKGROUND: Epidemiologic evidence suggests a link between short sleep duration and cardiovascular risk, although the nature of any relationship and mechanisms remain unclear. Short sleep duration has also been linked to an increase in cardiovascular events. Endothelial dysfunction has itself been implicated as a mediator of heightened cardiovascular risk. We sought to determine the effect of 8 days/8 nights of partial sleep restriction on endothelial function in healthy humans. METHODS AND RESULTS: Sixteen healthy volunteers underwent a randomized study of usual sleep versus sleep restriction of two-thirds normal sleep time for 8 days/8 nights in a hospital-based clinical research unit. The main outcome was endothelial function measured by flow-mediated brachial artery vasodilatation (FMD). Those randomized to sleep restriction slept 5.1 hours/night during the experimental period compared with 6.9 hours/night in the control group. Sleep restriction was associated with significant impairment in FMD (8.6±4.6% during the initial pre-randomization acclimation phase versus 5.2±3.4% during the randomized experimental phase, P=0.01) whereas no change was seen in the control group (5.0±3.0 during the acclimation phase versus 6.73±2.9% during the experimental phase, P=0.10) for a between-groups difference of -4.40% (95% CI -7.00 to -1.81%, P=0.003). No change was seen in non-flow mediated vasodilatation (NFMD) in either group. CONCLUSION: In healthy individuals, moderate sleep restriction causes endothelial dysfunction. CLINICAL TRIAL REGISTRATION URL: ClinicalTrials.gov. Unique identifier: NCT01334788.
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In a randomized controlled study of 15 healthy lean participants, partial sleep deprivation (two thirds of regular sleep duration) for 8 days significantly impaired arterial endothelial function (−4.4%, p<0.01) compared to the control group.
“In a randomized controlled study of 15 healthy lean participants (10 men, 5 women), partial sleep deprivation (two thirds of regular sleep duration) for 8 days showed a significant impairment in arterial endothelial function (−4.4%, p<0.01) when compared to the control group [75].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [75]
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- Authors
- Calvin, A. D., Covassin, N., Kremers, W. K., Adachi, T., Macedo, P., Albuquerque, F. N., Bukartyk, J., Davison, D. E., Levine, J. A., Singh, P., Wang, S., & Somers, V. K.
- Affiliations
- Mayo Clinic (US)
- SHOWA Medical University (JP)
- University Brazilia, Brazil
- Albert Einstein College of Medicine (US)
- ORCID
- Venue
- Journal of the American Heart Association
- Published
- 2014-12-17
- Volume
- 3
- Issue
- 6
- Pages
- e001143-e001143
- ISSN
- 2047-9980 (ISSN-L)
- PMC
- PMC4338700
- OpenAlex
- W2135405891
- Cited by
- 123
- References
- 41
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 11 · 2023: 9 · 2022: 12 · 2021: 12 · 2020: 11 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 12 · 2015: 5
- FWCI
- 11.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of the American Heart Association (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000135)
- U.S. Public Health Service (1ULIRR024150)
- National Heart, Lung, and Blood Institute (R01HL114024, R21HL096071, R01HL114676)
- National Center for Research Resources (UL1RR024150)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep restriction, endothelial dysfunction, flow-mediated dilation, short sleep duration, cardiovascular risk, sleep deprivation, healthy adults
- MeSH terms
- Adult, Brachial Artery, Endothelium, Vascular, Female, Humans, Male, Minnesota, Regional Blood Flow, Risk Factors, Sleep, Sleep Deprivation, Time Factors, Ultrasonography, Vascular Diseases, Vasodilation, Polysomnography, Young Adult, Healthy Volunteers
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