The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
Open accessAbstract
alpha-Synuclein (alpha-Syn) is a 14 kDa protein of unknown function that has been implicated in the pathophysiology of Parkinson's disease (PD). Here, we show that alpha-Syn-/- mice are viable and fertile, exhibit intact brain architecture, and possess a normal complement of dopaminergic cell bodies, fibers, and synapses. Nigrostriatal terminals of alpha-Syn-/- mice display a standard pattern of dopamine (DA) discharge and reuptake in response to simple electrical stimulation. However, they exhibit an increased release with paired stimuli that can be mimicked by elevated Ca2+. Concurrent with the altered DA release, alpha-Syn-/- mice display a reduction in striatal DA and an attenuation of DA-dependent locomotor response to amphetamine. These findings support the hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission.
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“However, αSyn-KO, and α/β-Syn double-KO mice exhibited reduced brain dopamine levels compared to wild-type (wt) animals”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [155]
Citations
Cites
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., & Goedert, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6469 · Cited by 2,868
Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain
DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J. P., & Aronin, N. (1997) · Science · doi:10.1126/science.277.5334.1990 · Cited by 2,439
The synaptic vesicle cycle: a cascade of protein–protein interactions
Südhof, T. C. (1995) · Nature · doi:10.1038/375645a0 · Cited by 1,991
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
Maroteaux, L., Campanelli, J., & Scheller, R. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02804.1988 · Cited by 1,646
Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes
Davidson, W. S., Jonas, A., Clayton, D. F., & George, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9443 · Cited by 1,622
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593
NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded
Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A., & Lansbury, P. T. (1996) · Biochemistry · doi:10.1021/bi961799n · Cited by 1,524
Conway, K. A., Harper, J. D., & Lansbury, P. T. (1998) · Nature Medicine · doi:10.1038/3311 · Cited by 1,520
Research works printed but not linked: 1
- Starke, 1989, Modulation of presynaptic release by presynaptic autoreceptors, J. Neurochem., 2, 449
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Items 1,001–1,003 of 1,003
Manecka, D.-L., Vanderperre, B., Fon, E. A., & Durcan, T. M. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00311 · Cited by 21
Josephs, K. A. (2018) · Brain · doi:10.1093/brain/awx367 · Cited by 17
Chronic stress induces depression-like behaviors and Parkinsonism via upregulating α-synuclein
Xia, D., Xiong, M., Yang, Y., Wang, X., Chen, Q., Li, S., Meng, L., & Zhang, Z. (2025) · npj Parkinson's Disease · doi:10.1038/s41531-025-00998-x · Cited by 15
Metadata
- Authors
- Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Verdugo, J. M. G., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., & Rosenthal, A.
- Affiliations
- University of California, San Francisco (US)
- New York State Psychiatric Institute (US)
- Universitat de València (ES)
- Genentech (US)
- Stanford Medicine (US)
- Corresponding author
- Rosenthal, Arnon
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 25
- Issue
- 1
- Pages
- 239-252
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2171281715
- Cited by
- 1,722
- References
- 51
- Citations by year
- 2026: 39 · 2025: 41 · 2024: 53 · 2023: 50 · 2022: 67 · 2021: 61 · 2020: 65 · 2019: 68 · 2018: 61 · 2017: 70 · 2016: 61 · 2015: 75 · 2014: 82 · 2013: 71 · 2012: 77
- FWCI
- 39.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Figshare (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- alpha-synuclein, Parkinson's disease, nigrostriatal dopamine system, dopamine release, presynaptic modulation, paired-pulse facilitation, calcium-dependent release, striatal dopamine, dopamine reuptake, dopamine signaling
- MeSH terms
- Amphetamine, Animals, Calcium, Corpus Striatum, Dopamine, Female, Hippocampus, Locomotion, Male, Mice, Inbred C57BL, Motor Activity, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Substantia Nigra, Dopamine Agents, Gene Expression, Autoreceptors, Presynaptic Terminals, Long-Term Potentiation, Mice, Knockout, Glutamic Acid, rab3A GTP-Binding Protein, Mice, Synucleins, alpha-Synuclein, Calbindins, S100 Calcium Binding Protein G
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