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α-Synuclein Expression Modulates Microglial Activation Phenotype

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Back to the tubule: microtubule dynamics in Parkinson’s disease

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Residual Structure, Backbone Dynamics, and Interactions within the Synuclein Family

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Mice expressing the A53T mutant form of human alpha‐synuclein exhibit hyperactivity and reduced anxiety‐like behavior

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Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies

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Dual Role of Autophagy in Diseases of the Central Nervous System

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α-Synuclein – Regulator of Exocytosis, Endocytosis, or Both?

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Expression of α-synuclein, a presynaptic protein implicated in Parkinson’s disease, in erythropoietic lineage

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Distinct Roles of the N-terminal-binding Domain and the C-terminal-solubilizing Domain of α-Synuclein, a Molecular Chaperone

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RNA interference‐mediated knockdown of α‐synuclein protects human dopaminergic neuroblastoma cells from MPP+ toxicity and reduces dopamine transport

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Amino acid sequence motifs and mechanistic features of the membrane translocation of α‐synuclein

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Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression

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Synphilin-1 Is Developmentally Localized to Synaptic Terminals, and Its Association with Synaptic Vesicles Is Modulated by α-Synuclein

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Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region

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Chapter 6 Molecular and Cellular Biology of Synucleins

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Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration

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Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2A in Vitro and in Vivo

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α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity*

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Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease

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Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson’s disease mice

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Mice Lacking α-Synuclein have an Attenuated Loss of Striatal Dopamine Following Prolonged Chronic MPTP Administration

Drolet, R. E., Behrouz, B., Lookingland, K. J., & Goudreau, J. L. (2004) · NeuroToxicology · doi:10.1016/j.neuro.2004.05.002 · Cited by 116

Single Molecule Characterization of α-Synuclein in Aggregation-Prone States

Trexler, A., & Rhoades, E. R. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.08.056 · Cited by 116

α‐Synuclein sequesters arachidonic acid to modulate SNARE‐mediated exocytosis

Darios, F. D., Ruipérez, V., López‐Font, I., Villanueva, J., Gutiérrez, L. M., & Davletov, B. A. (2010) · EMBO Reports · doi:10.1038/embor.2010.66 · Cited by 115

Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity

Luna, E., Decker, S. C., Riddle, D. M., Caputo, A., Zhang, B., Cole, T. A., Caswell, C., Xie, S. X., Lee, V. M. ‐., & Luk, K. C. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1829-8 · Cited by 116

Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking

Stojkovska, I., Wani, W. Y., Zunke, F., Belur, N. R., Pavlenko, E. A., Mwenda, N., Sharma, K., Francelle, L., & Mazzulli, J. R. (2021) · Neuron · doi:10.1016/j.neuron.2021.10.032 · Cited by 116

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

Guilliams, T., El-Turk, F., Buell, A. K., O’Day, E. M., Aprile, F. A., Esbjörner, E. K., Vendruscolo, M., Cremades, N., Pardon, E., Wyns, L., et al. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.01.040 · Cited by 114

Alpha‐synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells

Tehranian, R., Montoya, S. E., Laar, A. D. V., Hastings, T. G., & Perez, R. G. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04146.x · Cited by 116

Formation of dopamine-mediated α-synuclein-soluble oligomers requires methionine oxidation

Leong, S. L., Pham, C. L. L., Galatis, D., Fodero‐Tavoletti, M. T., Perez, K. A., Hill, A. F., Masters, C. L., Ali, F. E. A., Barnham, K. J., & Cappai, R. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.009 · Cited by 114

Age-dependent synuclein pathology following traumatic brain injury in mice.

Uryu, K., Giasson, B. I., Longhi, L., Martinez, D., Murray, I. V. J., Conte, V., Nakamura, M., Saatman, K., Talbot, K., Horiguchi, T., et al. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00245-0 · Cited by 113

A critical evaluation of the ubiquitin–proteasome system in Parkinson's disease

Cook, C. N., & Petrucelli, L. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.01.012 · Cited by 119

Mouse and fly models of neurodegeneration

Zoghbi, H. Y., & Botas, J. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02729-4 · Cited by 111

Siah-1 Facilitates Ubiquitination and Degradation of Synphilin-1

Nagano, Y., Yamashita, H., Takahashi, T., Kishida, S., Nakamura, T., Iseki, E., Hattori, N., Mizuno, Y., Kikuchi, A., & Matsumoto, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306347200 · Cited by 113

Structural characterization of α‐synuclein in an aggregation prone state

Cho, M., Nodet, G., Kim, H., Jensen, M. R., Bernadó, P., Fernández, C. O., Becker, S., Blackledge, M. J., & Zweckstetter, M. (2009) · Protein Science · doi:10.1002/pro.194 · Cited by 115

α-Synuclein and Its A30P Mutant Affect Actin Cytoskeletal Structure and Dynamics

Sousa, V. L., Bellani, S., Giannandrea, M., Yousuf, M., Valtorta, F., Meldolesi, J., & Chieregatti, E. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0302 · Cited by 119

A Genomewide Functional Network for the Laboratory Mouse

Guan, Y., Myers, C. L., Lu, R., Lemischka, I. R., Bult, C. J., & Troyanskaya, O. G. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000165 · Cited by 108

From α-synuclein to synaptic dysfunctions: New insights into the pathophysiology of Parkinson's disease

Bellucci, A., Zaltieri, M., Navarria, L., Grigoletto, J., Missale, C., & Spano, P. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.014 · Cited by 115

Lipids at the Crossroad of α-Synuclein Function and Dysfunction: Biological and Pathological Implications

Alza, N. P., González, P. A. I., Conde, M. A., Uranga, R. M., & Salvador, G. A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00175 · Cited by 116

α-Synuclein modulates tau spreading in mouse brains

Bassil, F., Meymand, E. S., Brown, H. J., Xu, H. W., Cox, T. O., Pattabhiraman, S., Maghames, C. M., Wu, Q., Zhang, B., Trojanowski, J. Q., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20192193 · Cited by 109

The Role of α‐Synuclein in Both Neuroprotection and Neurodegeneration

Sidhu, A., Wersinger, C., Moussa, C., & Vernier, P. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.016 · Cited by 110

Summary

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Manuel, J., Verdugo, G., Armanini, M. P., et al. (2013)

Increased striatal dopamine release and hyperdopaminergic‐like behaviour in mice lacking both alpha‐synuclein and gamma‐synuclein

Senior, S. L., Ninkina, N. N., Deacon, R. M. J., Bannerman, D. M., Buchman, V. L., Cragg, S. J., & Wade‐Martins, R. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06055.x · Cited by 160

Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein

Chadchankar, H., Ihalainen, J. A., Tanila, H., & Yavich, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.064 · Cited by 66

Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

Ninkina, N. N., Tarasova, T. V., Chaprov, K., Roman, A. Y., Kukharsky, M. S., Колик, Л. Г., Ovchinnikov, R. K., Ustyugov, A. A., Дурнев, А. Д., & Buchman, V. L. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.02.026 · Cited by 35

Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α‐synuclein

Lam, H. A., Wu, N., Cely, I., Kelly, R. L., Hean, S., Richter, F., Magen, I., Cepeda, C., Ackerson, L. C., Walwyn, W., et al. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22611 · Cited by 184