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A critical role for alpha-synuclein in development and function of T lymphocytes

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Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

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α-Synuclein transgenic mice exhibit reduced anxiety-like behaviour

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Alpha-synuclein modulates dopamine neurotransmission

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Subcellular localisation of recombinant α- and γ-synuclein

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Conformation-specific Binding of α-Synuclein to Novel Protein Partners Detected by Phage Display and NMR Spectroscopy

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Pathogenic effects of α-synuclein aggregation

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α‐Synuclein up‐regulates expression of caveolin‐1 and down‐regulates extracellular signal‐regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease

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α-Synuclein and Parkinsonism: Updates and Future Perspectives

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Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death

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Doxycycline Inhibits α-Synuclein-Associated Pathologies in Vitro and in Vivo

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Mitochondrial Dysfunction in Parkinson's Disease: Pathogenesis and Neuroprotection

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The phosphorylation of α‐synuclein: development and implication for the mechanism and therapy of the Parkinson's disease

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Proteomics in animal models of Alzheimer's and Parkinson's diseases

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123I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in α-synucleinopathies

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Intrinsically disordered proteins in synaptic vesicle trafficking and release

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α-Synuclein Budding Yeast Model: Toxicity Enhanced by Impaired Proteasome and Oxidative Stress

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Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

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Synucleins: New Data on Misfolding, Aggregation and Role in Diseases

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A Specific Survival Response in Dopamine Neurons at Most Risk in Parkinson's Disease

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Tyrosine-to-Cysteine Modification of Human α-Synuclein Enhances Protein Aggregation and Cellular Toxicity

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Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization

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The effect of α‐synuclein knockdown on MPP+ toxicity in models of human neurons

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Cycles of Aberrant Synaptic Sprouting and Neurodegeneration in Alzheimer's and Dementia with Lewy Bodies

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Seeding and transgenic overexpression of alpha‐synuclein triggers dendritic spine pathology in the neocortex

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Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of α-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL/6J mice

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Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein

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α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice

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Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra

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α-Synuclein knockout mice have cognitive impairments

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Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease

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Neurons Expressing the Highest Levels of γ-Synuclein Are Unaffected by Targeted Inactivation of the Gene

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Mechanisms of alpha-synuclein toxicity: An update and outlook

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Flexible Nets of Malleable Guardians: Intrinsically Disordered Chaperones in Neurodegenerative Diseases

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GABA transmission via ATP-dependent K + channels regulates α-synuclein secretion in mouse striatum

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The pathology roadmap in Parkinson disease

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Gangliosides, α-Synuclein, and Parkinson's Disease

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Subcellular localization of alpha-synuclein aggregates and their interaction with membranes

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Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo

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Hsp70 molecular chaperones and Parkinson's disease

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Phosphorylation of α-Synuclein Protein at Ser-129 Reduces Neuronal Dysfunction by Lowering Its Membrane Binding Property in Caenorhabditis elegans

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Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity

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Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease

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Interaction Between α-Synuclein and Metal Ions, Still Looking for a Role in the Pathogenesis of Parkinson’s Disease

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Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets

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Parkinson’s disease: a rethink of rodent models

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Parkin is linked to the ubiquitin pathway

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Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models

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Axonal transport of human α‐synuclein slows with aging but is not affected by familial Parkinson's disease‐linked mutations

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Aggregation of α-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis

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Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease

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Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal

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Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease

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Common anti-apoptotic roles of parkin and α-synuclein in human dopaminergic cells

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Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43

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Nervonic acid and its sphingolipids: Biological functions and potential food applications

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Mutations in LRRK2 potentiate age-related impairment of autophagic flux

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Alpha‐synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway

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Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in α‐synuclein knockout and A30P transgenic mice

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Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation

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Genetically engineered mouse models of Parkinson's disease

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α-Synuclein aggregation and neurodegenerative diseases

Ma, Q., Chan, P., Yoshii, M., & Uéda, K. (2003) · Journal of Alzheimer s Disease · doi:10.3233/jad-2003-5208 · Cited by 72

α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration

Fecchio, C., Palazzi, L., & de Laureto, P. P. (2018) · Molecules · doi:10.3390/molecules23071531 · Cited by 74

Alpha-Synuclein Contribution to Neuronal and Glial Damage in Parkinson’s Disease

Saramowicz, K., Siwecka, N., Galita, G., Kucharska-Lusina, A., Rozpędek‐Kamińska, W., & Majsterek, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010360 · Cited by 79

α‐Synuclein mediates alterations in membrane conductance: a potential role for α‐synuclein oligomers in cell vulnerability

Feng, L., Federoff, H. J., Vicini, S., & Maguire‐Zeiss, K. A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07266.x · Cited by 72

α-Synuclein, Parkinson's disease, and Alzheimer's disease

Kim, S., Seo, J., & Suh, Y. (2004) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2003.11.005 · Cited by 70

Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease

SUN, F., KANTHASAMY, A. G., ANANTHARAM, V., & KANTHASAMY, A. G. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.04.001 · Cited by 69

Wild-type α-synuclein interacts with pro-apoptotic proteins PKCδ and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death

Kaul, S., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.05.022 · Cited by 70

Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, α‐synuclein, and tau

Taymans, J., & Cookson, M. (2010) · BioEssays · doi:10.1002/bies.200900163 · Cited by 70

Proteolysis of α‐synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology

Sacino, A. N., Brooks, M., Chakrabarty, P., Saha, K., Khoshbouei, H., Golde, T. E., & Giasson, B. I. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13743 · Cited by 71

Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells

O’Farrell, C., Murphy, D. D., Petrucelli, L., Singleton, A., Hussey, J., Farrer, M. J., Hardy, J., Dickson, D. W., & Cookson, M. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00292-3 · Cited by 69

Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson's disease

Volta, M., Milnerwood, A. J., & Farrer, M. J. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00186-6 · Cited by 69

Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease

Chege, P. M., & McColl, G. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00089 · Cited by 68

Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation

Thomas, B., Mandir, A. S., West, N. C., Liu, Y., Andrabi, S. A., Stirling, W. L. H., Dawson, V. L., Dawson, T. M., & Lee, M. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016706 · Cited by 73

Clues to how alpha‐synuclein damages neurons in Parkinson's disease

Sulzer, D. L. (2010) · Movement Disorders · doi:10.1002/mds.22639 · Cited by 68

Progression of alpha‐synuclein pathology in multiple system atrophy of the cerebellar type

Brettschneider, J., Irwin, D. J., Boluda, S., Byrne, M., Fang, L., Lee, E. B., Robinson, J. L., Suh, E. R., Deerlin, V. M. V., Toledo, J. B., et al. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12362 · Cited by 70

Summary

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Manuel, J., Verdugo, G., Armanini, M. P., et al. (2013)

Increased striatal dopamine release and hyperdopaminergic‐like behaviour in mice lacking both alpha‐synuclein and gamma‐synuclein

Senior, S. L., Ninkina, N. N., Deacon, R. M. J., Bannerman, D. M., Buchman, V. L., Cragg, S. J., & Wade‐Martins, R. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06055.x · Cited by 160

Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein

Chadchankar, H., Ihalainen, J. A., Tanila, H., & Yavich, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.064 · Cited by 66

Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

Ninkina, N. N., Tarasova, T. V., Chaprov, K., Roman, A. Y., Kukharsky, M. S., Колик, Л. Г., Ovchinnikov, R. K., Ustyugov, A. A., Дурнев, А. Д., & Buchman, V. L. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.02.026 · Cited by 35

Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α‐synuclein

Lam, H. A., Wu, N., Cely, I., Kelly, R. L., Hean, S., Richter, F., Magen, I., Cepeda, C., Ackerson, L. C., Walwyn, W., et al. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22611 · Cited by 184