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A dual role for α-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo

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The ultrastructural distribution of alpha-synuclein-like protein in normal mouse brain

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Transcriptional dysregulation in a transgenic model of Parkinson disease

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Functional Domains in Dorsal Striatum of the Nonhuman Primate Are Defined by the Dynamic Behavior of Dopamine

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Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis

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Molecular Chaperones, Alpha-Synuclein, and Neurodegeneration

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Intrinsically disordered proteins may escape unwanted interactions via functional misfolding

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Age-related changes in dopamine signaling in Nurr1 deficient mice as a model of Parkinson's disease

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Targeting heat shock proteins to modulate α-synuclein toxicity

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α-Synuclein: Its Biological Function and Role in Neurodegenerative Diseases

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Neuroinflammation in Parkinson’s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?

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Acetylcholine waves and dopamine release in the striatum

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Discovery and characterization of three novel synuclein genes in zebrafish

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Transglutaminase 2: Biology, Relevance to Neurodegenerative Diseases and Therapeutic Implications

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Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease

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Oxidative stress and synaptic dysfunction in rodent models of Parkinson's disease

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In Vivo Imaging of α-Synuclein in Mouse Cortex Demonstrates Stable Expression and Differential Subcellular Compartment Mobility

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Inhibitors of α-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson’s disease and related disorders

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Role of Oxidative Damage in Protein Aggregation Associated with Parkinson's Disease and Related Disorders

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Genetic models of Parkinson disease

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Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders

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Are rodent models of Parkinson’s disease behaving as they should?

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Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding

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Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

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Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice

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Proteostasis and Movement Disorders: Parkinson's Disease and Amyotrophic Lateral SclerosisPreprint

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Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology

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More than meets the eye in Parkinson’s disease and other synucleinopathies: from proteinopathy to lipidopathy

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The interaction of α-synuclein and Tau: A molecular conspiracy in neurodegeneration?

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Alpha synuclein in hematopoiesis and immunity

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Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins

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Cross-talk between mitochondria and proteasome in Parkinson’s disease pathogenesis

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CRISPR System: A High-throughput Toolbox for Research and Treatment of Parkinson’s Disease

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α-Synuclein interactions with phospholipid model membranes: Key roles for electrostatic interactions and lipid-bilayer structure

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Distribution of α‐ and γ‐synucleins in the adult rat brain and their modification by high‐dose cocaine treatment

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Role for the Ubiquitin-Proteasome System in Parkinson's Disease and Other Neurodegenerative Brain Amyloidoses

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Alpha‐synuclein protects cerebellar granule neurons against 6‐hydroxydopamine‐induced death

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Mechanisms of Alpha-Synuclein Action on Neurotransmission: Cell-Autonomous and Non-Cell Autonomous Role

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Parkinson's disease genetic mutations increase cell susceptibility to stress: Mutant α-synuclein enhances H2O2- and Sin-1-induced cell death

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Structural and Dynamical Insights into the Membrane-Bound α-Synuclein

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Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease

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The effect of music performance on the transcriptome of professional musicians

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Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes

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Role of RhoA-ROCK signaling in Parkinson's disease

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BDNF is induced by wild-type α-synuclein but not by the two mutants, A30P or A53T, in glioma cell line

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A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies

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Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-Like Behavior

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Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging

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Metal Dyshomeostasis and Their Pathological Role in Prion and Prion-Like Diseases: The Basis for a Nutritional Approach

Toni, M., Massimino, M. L., Mario, A. D., Angiulli, E., & Spisni, E. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00003 · Cited by 56

Synucleins and Gene Expression: Ramblers in a Crowd or Cops Regulating Traffic?

Surguchev, A. A., & Surguchov, A. P. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00224 · Cited by 57

The Membrane Interaction of Alpha-Synuclein

Liu, C., Zhao, Y., Xi, H., Jiang, J., Yu, Y., & Dong, W. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.633727 · Cited by 57

Differences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of ?-synuclein

Siegmund, A., Langnaese, K., & Wotjak, C. T. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.07.007 · Cited by 57

Intermediates of α-synuclein aggregation: Implications in Parkinson's disease pathogenesis

Gadhe, L. G., Sakunthala, A., Mukherjee, S., Gahlot, N., Bera, R., Sawner, A. S., Kadu, P., & Maji, S. K. (2021) · Biophysical Chemistry · doi:10.1016/j.bpc.2021.106736 · Cited by 56

Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism

Connor‐Robson, N., Peters, O. M., Millership, S. J., Ninkina, N. N., & Buchman, V. L. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.06.020 · Cited by 56

Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model

Spencer, B. J., Desplats, P., Overk, C., Valera, E., Rissman, R. A., Wu, C., Mante, M., Adame, A., Florio, J. B., Rockenstein, E. M., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0775-16.2016 · Cited by 56

Yeast as a drug discovery platform in Huntington's and Parkinson's diseases

Outeiro, T. F., & Giorgini, F. (2006) · Biotechnology Journal · doi:10.1002/biot.200500043 · Cited by 57

Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease?

Rajagopalan, S., & Andersen, J. K. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00283-4 · Cited by 56

Effects of metformin on apoptosis and α-synuclein in a rat model of pentylenetetrazole-induced epilepsy

Hussein, A. M., Eldosoky, M., El-Shafey, M., El-Mesery, M., Ali, A. N., Abbas, K. M., & Abulseoud, O. A. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0266 · Cited by 51

Vesicle trafficking and lipid metabolism in synucleinopathy

Fanning, S., Selkoe, D. J., & Dettmer, U. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02177-z · Cited by 56

Familial Parkinson Disease-associated Mutations Alter the Site-specific Microenvironment and Dynamics of α-Synuclein

Sahay, S., Ghosh, D., Dwivedi, S., Arunagiri, A., Mohite, G. M., Kombrabail, M. H., Krishnamoorthy, G., & Maji, S. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.598607 · Cited by 55

Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse

Taylor, T. N., Potgieter, D., Anwar, S., Senior, S. L., Janezic, S., Threlfell, S., Ryan, B. J., Parkkinen, L., Deltheil, T., Cioroch, M., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.005 · Cited by 57

α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cells

Bisaglia, M., Greggio, E., Maric, D., Miller, D. W., Cookson, M., & Bubacco, L. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-41 · Cited by 57

α-Synuclein Expression Levels Do Not Significantly Affect Proteasome Function and Expression in Mice and Stably Transfected PC12 Cell Lines

Martín‐Clemente, B., Alvarez‐Castelao, B., Mayo, I., Sierra, A. B., Dìaz, V., Milán, M., Fariñas, I., Gómez‐Isla, T., Ferrer, I., & Castaño, J. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409028200 · Cited by 55

Summary

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Manuel, J., Verdugo, G., Armanini, M. P., et al. (2013)

Increased striatal dopamine release and hyperdopaminergic‐like behaviour in mice lacking both alpha‐synuclein and gamma‐synuclein

Senior, S. L., Ninkina, N. N., Deacon, R. M. J., Bannerman, D. M., Buchman, V. L., Cragg, S. J., & Wade‐Martins, R. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06055.x · Cited by 160

Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein

Chadchankar, H., Ihalainen, J. A., Tanila, H., & Yavich, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.064 · Cited by 66

Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

Ninkina, N. N., Tarasova, T. V., Chaprov, K., Roman, A. Y., Kukharsky, M. S., Колик, Л. Г., Ovchinnikov, R. K., Ustyugov, A. A., Дурнев, А. Д., & Buchman, V. L. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.02.026 · Cited by 35

Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α‐synuclein

Lam, H. A., Wu, N., Cely, I., Kelly, R. L., Hean, S., Richter, F., Magen, I., Cepeda, C., Ackerson, L. C., Walwyn, W., et al. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22611 · Cited by 184