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Synapsins regulate α-synuclein functions

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The usual suspects, dopamine and alpha‐synuclein, conspire to cause neurodegeneration

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Curvature Dynamics of α-Synuclein Familial Parkinson Disease Mutants

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Mutant and Wild-Type α-Synuclein Interact with Mitochondrial Cytochrome C Oxidase

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RNAi: a potential new class of therapeutic for human genetic disease

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Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

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Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective

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α-Synuclein Populates Both Elongated and Broken Helix States on Small Unilamellar Vesicles

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Acetylcholine‐Triggered Cargo Release from Supramolecular Nanovalves Based on Different Macrocyclic Receptors

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Microbial Infections Are a Risk Factor for Neurodegenerative Diseases

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Role of α-synuclein in synaptic glutamate release

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Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human α-synuclein

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Parkinson's Disease-associated α-Synuclein Is a Calmodulin Substrate

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Loss of Functional Alpha-Synuclein: A Toxic Event in Parkinson's Disease?

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Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

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Structural Determinants of PLD2 Inhibition by α-Synuclein

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Alterations in corticostriatal synaptic plasticity in mice overexpressing human α-synuclein

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Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation

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Abnormal α-Synuclein Interactions with Rab Proteins in α-Synuclein A30P Transgenic Mice

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α-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice

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Multiple System Atrophy

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Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities

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αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease

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New insights into cellular α-synuclein homeostasis in health and disease

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Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of α-Synuclein in a pH-Dependent Manner

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alpha-Synuclein forms a complex with transcription factor Elk-1

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Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes

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Synaptic vesicle trafficking and Parkinson's disease

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Adenosine A2AReceptors Modulate α-Synuclein Aggregation and Toxicity

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Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson’s disease model

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Physiological and Pathological Role of Alpha-synuclein in Parkinson’s Disease Through Iron Mediated Oxidative Stress; The Role of a Putative Iron-responsive Element

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Hypokinesia and Reduced Dopamine Levels in Zebrafish Lacking β- and γ1-Synucleins

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New Developments in Genetic rat models of Parkinson's Disease

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1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of parkinson's disease, with emphasis on mice and nonhuman primates.

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Transcriptional regulation of mesencephalic dopaminergic neurons: The full circle of life and death

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Genes associated with Parkinson syndrome

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α‐Synuclein induces apoptosis by altered expression in human peripheral lymphocytes in Parkinson’s disease

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Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress

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Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD

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Synuclein‐1 is selectively up‐regulated in response to nerve growth factor treatment in PC12 cells

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dl-3-n-Butylphthalide prevents oxidative damage and reduces mitochondrial dysfunction in an MPP+-induced cellular model of Parkinson's disease

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α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons

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Summary

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Manuel, J., Verdugo, G., Armanini, M. P., et al. (2013)

Increased striatal dopamine release and hyperdopaminergic‐like behaviour in mice lacking both alpha‐synuclein and gamma‐synuclein

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Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein

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Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

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Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α‐synuclein

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