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Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons

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Postsynaptic synucleins mediate endocannabinoid signaling

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Modeling Parkinson’s Disease Using Patient-specific Induced Pluripotent Stem Cells

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Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease

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Alpha-synuclein is a potential biomarker in the serum and CSF of patients with intractable epilepsy

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Dynamics of Subcellular Proteomes During Brain Development

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Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?

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Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

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α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies

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Fish Synucleins: An Update

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Identification and Characterization of a Novel Pyk2/Related Adhesion Focal Tyrosine Kinase-associated Protein That Inhibits α-Synuclein Phosphorylation

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1‐Benzyl‐1,2,3,4‐tetrahydroisoquinoline, a Parkinsonism‐inducing endogenous toxin, increases α‐synuclein expression and causes nuclear damage in human dopaminergic cells

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Association of &agr;-Synuclein Immunoreactivity With Inflammatory Activity in Multiple Sclerosis Lesions

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Deletion of alpha‐synuclein decreases impulsivity in mice

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Lack of involvement of alpha-synuclein in unconditioned anxiety in mice

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SUMOylation in α-Synuclein Homeostasis and Pathology

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Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of α-synuclein

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Direct Interaction of α-Synuclein and AKT Regulates IGF-1 Signaling: Implication of Parkinson Disease

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α-synuclein interacts with SOD1 and promotes its oligomerization

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Impairment of macroautophagy in dopamine neurons has opposing effects on parkinsonian pathology and behavior

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Alpha-Synuclein Pathophysiology in Neurodegenerative Disorders: A Review Focusing on Molecular Mechanisms and Treatment Advances in Parkinson’s Disease

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The Medicinal Chemistry of Natural and Semisynthetic Compounds against Parkinson’s and Huntington’s Diseases

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Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein

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α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies?

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Hypoxia and Alpha-Synuclein: Inextricable Link Underlying the Pathologic Progression of Parkinson's Disease

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Regulation of Weibel-Palade Body Exocytosis by α-Synuclein in Endothelial Cells

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α‐Synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII

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T cells, α-synuclein and Parkinson disease

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Detection of copy number changes in genes associated with Parkinson's disease in Iranian patients

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Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology

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Forebrain overexpression of α-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption

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In Vivo Alterations in Calcium Buffering Capacity in Transgenic Mouse Model of Synucleinopathy

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Regulation of α-Synuclein Expression in Limbic and Motor Brain Regions of Morphine-Treated Mice

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Restoration of intestinal function in an MPTP model of Parkinson’s Disease

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In Vitro Phosphorylation Does not Influence the Aggregation Kinetics of WT α-Synuclein in Contrast to Its Phosphorylation Mutants

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Nicotine prevents alpha-synuclein accumulation in mouse and human iPSC-derived dopaminergic neurons through activation of the dopamine D3- acetylcholine nicotinic receptor heteromer

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Structurally Distinct α‐Synuclein Fibrils Induce Robust Parkinsonian Pathology

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Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures

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α-Synuclein modulates neurite outgrowth by interacting with SPTBN1

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Evidence That α-Synuclein Does Not Inhibit Phospholipase D

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The Cell Biology of α Synuclein

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Synucleins Antagonize Endoplasmic Reticulum Function to Modulate Dopamine Transporter Trafficking

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Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia

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Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide

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Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

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VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration

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A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease

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Non-Alzheimer's Disease Dementias: Anatomic, Clinical, and Molecular Correlates

Hou, C. E., Carlin, D. A., & Miller, B. L. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404900303 · Cited by 35

Neuroprotection in PD—A role for dopamine agonists?

Schapira, A. H. V. (2003) · Neurology · doi:10.1212/wnl.61.6_suppl_3.s34 · Cited by 35

α-Synuclein Strains and Their Relevance to Parkinson’s Disease, Multiple System Atrophy, and Dementia with Lewy Bodies

Graves, N. J., Gambin, Y., & Sierecki, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512134 · Cited by 36

Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies

Chopra, A., & Outeiro, T. F. (2023) · Brain · doi:10.1093/brain/awad260 · Cited by 35

Aquaporin-4 and Parkinson’s Disease

Lapshina, K. V., & Ekimova, I. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031672 · Cited by 34

Multiple system atrophy: an update and emerging directions of biomarkers and clinical trials

Liu, M., Wang, Z., & Shang, H. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12269-5 · Cited by 36

Unaltered Striatal Dopamine Release Levels in Young Parkin Knockout, Pink1 Knockout, DJ-1 Knockout and LRRK2 R1441G Transgenic Mice

Sanchez, G. M., Varaschin, R. K., Büeler, H., Marcogliese, P. C., Park, D. S., & Trudeau, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094826 · Cited by 41

N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice

Crupi, R., Impellizzeri, D., Cordaro, M., Siracusa, R., Casili, G., Evangelista, M., & Cuzzocrea, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0959-2 · Cited by 34

Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau

Bhasne, K., Sebastian, S., Jain, N., & Mukhopadhyay, S. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.04.020 · Cited by 33

Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala

Chen, L., Nagaraja, C., Daniels, S. R., Fisk, Z. A., Dvorak, R., Meyerdirk, L. K., Steiner, J. A., Galvis, M. L. E., Henderson, M. X., Rousseaux, M. W. C., et al. (2022) · eLife · doi:10.7554/elife.78055 · Cited by 33

αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson’s Disease?

Protter, D. S. W., Lang, C., & Cooper, A. A. (2012) · Parkinson s Disease · doi:10.1155/2012/829207 · Cited by 38

Selective loss of dopaminergic neurons and formation of Lewy body‐like aggregations in α‐synuclein transgenic fly neuronal cultures

Park, S. S., & Lee, D. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04844.x · Cited by 34

Differential Calcium Dependence of Axonal Versus Somatodendritic Dopamine Release, with Characteristics of Both in the Ventral Tegmental Area

Chen, B. T., Patel, J. C., Moran, K. A., & Rice, M. E. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00039 · Cited by 34

Alpha‐synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats

Boyer, F., & Dreyer, J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05878.x · Cited by 36

Advances in the genetics of Parkinson's disease

Rosner, S., Giladi, N., & Orr‐Urtreger, A. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00731.x · Cited by 35

Proteomic Approach to Studying Parkinson's Disease

Zhang, J., & Goodlett, D. R. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:3:271 · Cited by 34

? - synuclein and Parkinson's disease: the first roadblock

Chua, C. E. L., & Tang, B. L. (2006) · Journal of Cellular and Molecular Medicine · doi:10.2755/jcmm010.004.04 · Cited by 34

Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease

Kallhoff, V., Peethumnongsin, E., & Zheng, H. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-6 · Cited by 33

Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy

Minakaki, G., Canneva, F., Chevessier, F., Bode, F., Menges, S., Timotius, I. K., Kalinichenko, L. S., Meixner, H., Müller, C. P., Eskofier, B. M., et al. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.035 · Cited by 34

Teratogenicity and neurotoxicity effects induced by methomyl insecticide on the developmental stages of Bufo arabicus

Seleem, A. A. (2019) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2018.12.002 · Cited by 33

Prion-like propagation of α-synuclein in neurodegenerative diseases

Tarutani, A., & Hasegawa, M. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.07.005 · Cited by 33

Summary

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Manuel, J., Verdugo, G., Armanini, M. P., et al. (2013)

Increased striatal dopamine release and hyperdopaminergic‐like behaviour in mice lacking both alpha‐synuclein and gamma‐synuclein

Senior, S. L., Ninkina, N. N., Deacon, R. M. J., Bannerman, D. M., Buchman, V. L., Cragg, S. J., & Wade‐Martins, R. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06055.x · Cited by 160

Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein

Chadchankar, H., Ihalainen, J. A., Tanila, H., & Yavich, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.064 · Cited by 66

Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

Ninkina, N. N., Tarasova, T. V., Chaprov, K., Roman, A. Y., Kukharsky, M. S., Колик, Л. Г., Ovchinnikov, R. K., Ustyugov, A. A., Дурнев, А. Д., & Buchman, V. L. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.02.026 · Cited by 35

Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α‐synuclein

Lam, H. A., Wu, N., Cely, I., Kelly, R. L., Hean, S., Richter, F., Magen, I., Cepeda, C., Ackerson, L. C., Walwyn, W., et al. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22611 · Cited by 184