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Therapeutic RNA interference for neurodegenerative diseases: From promise to progress

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From genetics to pathology: tau and a–synuclein assemblies in neurodegenerative diseases

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Localization of Alpha-synuclein to identified fibers and synapses in the normal mouse brain

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Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway

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Analysis of exon dosage using MLPA in South African Parkinson's disease patients

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Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles

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Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice

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α-Synuclein levels modulate Huntington's disease in mice

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Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy

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Overexpression of Human E46K Mutant α-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway

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Effect of Pseudorepeat Rearrangement on α-Synuclein Misfolding, Vesicle Binding, and Micelle Binding

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The Membrane Interactions of Synuclein: Physiology and Pathology

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α-Synuclein Expression in Rat Substantia Nigra Suppresses Phospholipase D2 Toxicity and Nigral Neurodegeneration

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Potential Future Neuroprotective Therapies for Neurodegenerative Disorders and Stroke

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Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model

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Synapsin III is a key component of α‐synuclein fibrils in Lewy bodies of PD brains

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A Novel Mechanism of Interaction between α-Synuclein and Biological Membranes

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Neurodegeneration and cell replacement

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Prominent Perikaryal Expression of α- and β-Synuclein in Neurons of Dorsal Root Ganglion and in Medullary Neurons

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Synucleinopathy-associated pathogenesis in Parkinson’s disease and the potential for brain-derived neurotrophic factor

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The Role of DNA Damage in Neural Plasticity in Physiology and Neurodegeneration

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Parkinson’s Disease: Exploring Different Animal Model Systems

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α-Synuclein Elevation in Human Neurodegenerative Diseases: Experimental, Pathogenetic, and Therapeutic Implications

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Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes

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Novel subcellular localization for α-synuclein: possible functional consequences

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Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells1

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Interaction between Neuromelanin and Alpha-Synuclein in Parkinson’s Disease

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Interactions between metals and α‐synuclein − function or artefact?

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α-Synuclein aggregation in neurodegenerative diseases and its inhibition as a potential therapeutic strategy

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Different sub-cellular localization of alpha-synuclein in the C57BL\6J mouse's central nervous system by two novel monoclonal antibodies

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6-Hydroxydopamine but Not 1-Methyl-4-phenylpyridinium Abolishes α-Synuclein Anti-apoptotic Phenotype by Inhibiting Its Proteasomal Degradation and by Promoting Its Aggregation

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The Parkinsonian Models: Invertebrates to Mammals

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α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease

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Linking α-synuclein-induced synaptopathy and neural network dysfunction in early Parkinson’s disease

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Proteomic Profiling of the Epileptic Dentate Gyrus

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Behavioral genetic contributions to the study of addiction-related amphetamine effects

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Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1

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An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain

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Secondary structure and dynamics of micelle bound β‐ and γ‐synuclein

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Alpha-synuclein synaptic pathology and its implications in the development of novel therapeutic approaches to cure Parkinson's disease

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Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration

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Role of Alpha-Synuclein Protein Levels in Mitochondrial Morphology and Cell Survival in Cell Lines

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Lipid dysfunction and pathogenesis of multiple system atrophy

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Functional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats

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Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core

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α-Synuclein Aggregation: A Link Between Mitochondrial Defects and Parkinson's Disease?

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Expression of α-synuclein is increased in the hippocampus of rats with high levels of innate anxiety

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Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils

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Prime Time for α-Synuclein: Figure 1.

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Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress

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Distinct polyadenylation landscapes of diverse human tissues revealed by a modified PA-seq strategy

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The behavior of α‐synuclein in neurons

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Membranes as modulators of amyloid protein misfolding and target of toxicity

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Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy

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Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease

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Prionoid Proteins in the Pathogenesis of Neurodegenerative Diseases

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Expanding spectrum of prion diseases

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Parkin Disrupts the α-Synuclein/Dopamine Transporter Interaction: Consequences Toward Dopamine-induced Toxicity

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Alpha- and Gamma-Synuclein Proteins Are Present in Cerebrospinal Fluid and Are Increased in Aged Subjects with Neurodegenerative and Vascular Changes

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α-Synuclein, Lrrk2 and Their Interplay In Parkinson‘s Disease

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Regulation of α‐synuclein by bFGF in cultured ventral midbrain dopaminergic neurons

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Membrane‐bound structure and energetics of α‐synuclein

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Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese

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α-Synuclein in Parkinson's Disease: Pathogenic Function and Translation into Animal Models

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Decreased α-synuclein expression in the aging mouse substantia nigra

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Alpha-Synuclein, a Novel Viral Restriction Factor Hiding in Plain Sight

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Dampened Amphetamine-Stimulated Behavior and Altered Dopamine Transporter Function in the Absence of Brain GDNF

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Genetic Mouse Models of Neurodegenerative Diseases

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Aggregates Assembled From Overexpression of Wild-Type α-Synuclein are not Toxic to Human Neuronal Cells

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Upregulation of α-synuclein in neurons and glia in inflammatory demyelinating disease

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Alpha-Synuclein Expression in the Developing Human Brain

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Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male MicePreprint

Bondar, N. P., Boyarskikh, U. A., Kovalenko, I. L., Филипенко, М. Л., & Kudryavtseva, N. N. (2008) · Nature Precedings · doi:10.1371/journal.pone.0004190 · Cited by 44

A microRNA embedded AAV alpha-synuclein gene silencing vector for dopaminergic neurons

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Altered short-term hippocampal synaptic plasticity in mutant α-synuclein transgenic mice

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Phosphorylated α‐synuclein in normal mouse brain

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α-Synuclein Conformational Strains as Drivers of Phenotypic Heterogeneity in Neurodegenerative Diseases

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Viral Vector Mediated Overexpression of Human α-Synuclein in the Nigrostriatal Dopaminergic Neurons: A New Model for Parkinson's Disease

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Neuroimaging for Lewy body disease: Is the in vivo molecular imaging of α-synuclein neuropathology required and feasible?

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Determining nuclear localization of alpha-synuclein in mouse brains

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Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease

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Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue

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Mouse models of α-synucleinopathy and Lewy pathology

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Spatial learning is unimpaired in mice containing a deletion of the alpha‐synuclein locus

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Summary

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Manuel, J., Verdugo, G., Armanini, M. P., et al. (2013)

Increased striatal dopamine release and hyperdopaminergic‐like behaviour in mice lacking both alpha‐synuclein and gamma‐synuclein

Senior, S. L., Ninkina, N. N., Deacon, R. M. J., Bannerman, D. M., Buchman, V. L., Cragg, S. J., & Wade‐Martins, R. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06055.x · Cited by 160

Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein

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Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

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Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α‐synuclein

Lam, H. A., Wu, N., Cely, I., Kelly, R. L., Hean, S., Richter, F., Magen, I., Cepeda, C., Ackerson, L. C., Walwyn, W., et al. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22611 · Cited by 184