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Pathogenic mutations in Parkinson disease

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c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

Mahul‐Mellier, A., Fauvet, B., Gysbers, A. M., Dikiy, I., Oueslati, A., Georgeon, S., Lamontanara, A. J., Bisquertt, A., Eliezer, D., Masliah, E., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt674 · Cited by 227

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

Mor, D. E., Tsika, E., Mazzulli, J. R., Gould, N. S., Kim, H., Daniels, M. J., Doshi, S., Gupta, P., Grossman, J., Tan, V. X., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4641 · Cited by 226

Tyrosine and serine phosphorylation of α-synuclein have opposing effects on neurotoxicity and soluble oligomer formation

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Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain

Beatman, E. L., Massey, A. R., Shives, K. D., Burrack, K. S., Chamanian, M., Morrison, T. E., & Beckham, J. D. (2015) · Journal of Virology · doi:10.1128/jvi.02949-15 · Cited by 219

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

Tong, Y., Giaime, E., Yamaguchi, H., Ichimura, T., Liu, Y., Si, H., Cai, H., Bonventre, J. V., & Shen, J. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-2 · Cited by 219

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

Klivènyi, P., Siwek, D. F., Gardian, G., Yang, L., Starkov, A. A., Cléren, C., Ferrante, R. J., Kowall, N. W., Abeliovich, A., & Beal, M. F. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.08.018 · Cited by 216

In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

Gorbatyuk, O. S., Li, S., Nash, K. R., Gorbatyuk, M. S., Lewin, A. S., Sullivan, L. F., Mandel, R. J., Chen, W., Meyers, C., Manfredsson, F. P., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.115 · Cited by 221

Ubiquitin–proteasome system and Parkinson's disease

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APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis

Uddin, M. S., Kabir, M. T., Al Mamun, A., Abdel-Daim, M. M., Barreto, G. E., & Ashraf, G. M. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1237-z · Cited by 212

Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation

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Brain Iron Homeostasis: From Molecular Mechanisms To Clinical Significance and Therapeutic Opportunities

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Summary

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Manuel, J., Verdugo, G., Armanini, M. P., et al. (2013)

Increased striatal dopamine release and hyperdopaminergic‐like behaviour in mice lacking both alpha‐synuclein and gamma‐synuclein

Senior, S. L., Ninkina, N. N., Deacon, R. M. J., Bannerman, D. M., Buchman, V. L., Cragg, S. J., & Wade‐Martins, R. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06055.x · Cited by 160

Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein

Chadchankar, H., Ihalainen, J. A., Tanila, H., & Yavich, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.064 · Cited by 66

Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

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Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α‐synuclein

Lam, H. A., Wu, N., Cely, I., Kelly, R. L., Hean, S., Richter, F., Magen, I., Cepeda, C., Ackerson, L. C., Walwyn, W., et al. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22611 · Cited by 184