The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Metabolic consequences of sleep and sleep loss
Open accessAbstract
Reduced sleep duration and quality appear to be endemic in modern society. Curtailment of the bedtime period to minimum tolerability is thought to be efficient and harmless by many. It has been known for several decades that sleep is a major modulator of hormonal release, glucose regulation and cardiovascular function. In particular, slow wave sleep (SWS), thought to be the most restorative sleep stage, is associated with decreased heart rate, blood pressure, sympathetic nervous activity and cerebral glucose utilization, compared with wakefulness. During SWS, the anabolic growth hormone is released while the stress hormone cortisol is inhibited. In recent years, laboratory and epidemiologic evidence have converged to indicate that sleep loss may be a novel risk factor for obesity and type 2 diabetes. The increased risk of obesity is possibly linked to the effect of sleep loss on hormones that play a major role in the central control of appetite and energy expenditure, such as leptin and ghrelin. Reduced leptin and increased ghrelin levels correlate with increases in subjective hunger when individuals are sleep restricted rather than well rested. Given the evidence, sleep curtailment appears to be an important, yet modifiable, risk factor for the metabolic syndrome, diabetes and obesity. The marked decrease in average sleep duration in the last 50 years coinciding with the increased prevalence of obesity, together with the observed adverse effects of recurrent partial sleep deprivation on metabolism and hormonal processes, may have important implications for public health.
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In the citing paper
“In addition, the duration of television viewing and of sleep may influence energy consumption, energy expenditure, or both.15–19”
From Changes in diet and lifestyle and long-term weight gain in women and men (2011) · cites this paper as [19]
In the citing paper
“In short-term trials, reduced sleep alters leptin, ghrelin, subjective hunger, and preferences for calorie-dense, refined-carbohydrate foods.19”
From Changes in diet and lifestyle and long-term weight gain in women and men (2011) · cites this paper as [19]
In the citing paper
“Decreases in sleep duration are concordant with the U.S. obesity epidemic.18,19,53”
From Changes in diet and lifestyle and long-term weight gain in women and men (2011) · cites this paper as [19]
In the citing paper
“short sleep duration (6 hours or less), and especially very short sleep duration (less than 5 hours) is associated with increased cardiometabolic morbidity and mortality, including weight gain and obesity, hypertension, hyperlipidemia, and diabetes.”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [28]
In the citing paper
“insufficient sleep has been linked to lower energy expenditure, altered glucose homeostasis and alterations in hormones that mediate hunger(24, 25, 27-31).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [28]
In the citing paper
“Physiologic studies also show that sleep loss can influence metabolism through changes in metabolic hormones,60,61 adipocyte function,62 and beta-cell function.63”
From Sleep, Health, and Society (2017) · cites this paper as [60]
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Citations
Cites
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668
Self-citationTaheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477 · cited 3×
“008) was observed with 5 hours versus 8 hours sleep duration [22].”
BackgroundResultSpiegel, K., Tasali, E., Penev, P., & Cauter, E. V. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00008 · Cited by 2,459
Self-citationMeta-Analysis of Short Sleep Duration and Obesity in Children and Adults
Cappuccio, F. P., Taggart, F. M., Kandala, N.-B., Currie, A., Peile, E., Stranges, S., & Miller, M. A. (2008) · Sleep · doi:10.1093/sleep/31.5.619 · Cited by 2,076
Early life risk factors for obesity in childhood: cohort study
Reilly, J. J., Armstrong, J., Dorosty, A. R., Emmett, P. M., Ness, A., Rogers, I., Steer, C., & Sherriff, A. (2005) · BMJ · doi:10.1136/bmj.38470.670903.e0 · Cited by 1,675
Mortality Associated With Sleep Duration and Insomnia
Kripke, D. F., Garfinkel, L., Wingard, D. L., Klauber, M. R., & Marler, M. R. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.2.131 · Cited by 1,614
Sympathetic-Nerve Activity during Sleep in Normal Subjects
Somers, V. K., Dyken, M. E., Mark, A. L., & Abboud, F. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302043280502 · Cited by 1,574
Short Sleep Duration and Weight Gain: A Systematic Review
Patel, S. R., & Hu, F. B. (2008) · Obesity · doi:10.1038/oby.2007.118 · Cited by 1,505
The metabolic consequences of sleep deprivation
Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365
Self-citationSpiegel, K., Leproult, R., L’Hermite-Balériaux, M., Copinschi, G., Penev, P. D., & Van Cauter, E. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1003 · Cited by 1,006
Self-citationAssociation of sleep time with diabetes mellitus and impaired glucose tolerance
Gottlieb, D. J., Punjabi, N. M., Newman, A. B., Resnick, H. E., Redline, S., Baldwin, C. M., & Nieto, F. J. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.8.863 · Cited by 927
Slow-wave sleep and the risk of type 2 diabetes in humans
Tasali, E., Leproult, R., Ehrmann, D. A., & Van Cauter, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706446105 · Cited by 921
Self-citationInadequate Sleep as a Risk Factor for Obesity: Analyses of the NHANES I
Gangwisch, J. E., Malaspina, D., Boden-Albala, B., & Heymsfield, S. B. (2005) · Sleep · doi:10.1093/sleep/28.10.1289 · Cited by 905
A prospective study of self-reported sleep duration and incident diabetes in women
Ayas, N. T., White, D. P., Al-Delaimy, W. K., Manson, J. E., Stampfer, M. J., Speizer, F. E., Patel, S., & Hu, F. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.380 · Cited by 883
Sleep duration as a risk factor for the development of type 2 diabetes
Yaggi, H. K., Araujo, A. B., & McKinlay, J. B. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-0879 · Cited by 790
Van Cauter, E. (2000) · JAMA · doi:10.1001/jama.284.7.861 · Cited by 773
Hasler, G., Buysse, D. J., Klaghofer, R., Gamma, A., Ajdacic, V., Eich, D., Rössler, W., & Angst, J. (2004) · Sleep · doi:10.1093/sleep/27.4.661 · Cited by 672
Association between Reduced Sleep and Weight Gain in Women
Patel, S. R., Malhotra, A., White, D. P., Gottlieb, D. J., & Hu, F. B. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj280 · Cited by 617
Risk factors for childhood overweight: A prospective study from birth to 9.5 years
Agras, W. S., Hammer, L. D., McNicholas, F., & KRAEMER, H. C. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.03.023 · Cited by 582
Accurate Assessment of β-Cell Function
Bergman, R. N., Ader, M., Hücking, K., & Citters, G. V. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s212 · Cited by 517
Chaput, J., Després, J., Bouchard, C., & Tremblay, A. (2007) · Obesity · doi:10.1038/oby.2007.512 · Cited by 498
We are Chronically Sleep Deprived
Bonnet, M. H., & Arand, D. L. (1995) · SLEEP · doi:10.1093/sleep/18.10.908 · Cited by 478
Sekine, M., Yamagami, T., Handa, K., Saito, T., Nanri, S., Kawaminami, K., Tokui, N., Yoshida, K., & Kagamimori, S. (2002) · Child Care Health and Development · doi:10.1046/j.1365-2214.2002.00260.x · Cited by 418
Vorona, R. D., Winn, M. P., Babineau, T. W., Eng, B. P., Feldman, H. R., & Ware, J. C. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.1.25 · Cited by 405
High Incidence of Diabetes in Men With Sleep Complaints or Short Sleep Duration
Mallon, L., Broman, J.-E., & Hetta, J. (2005) · Diabetes Care · doi:10.2337/diacare.28.11.2762 · Cited by 391
Chaput, J., Brunet, M., & Tremblay, A. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803291 · Cited by 379
Time spent watching television, sleep duration and obesity in adults living in Valencia, Spain
Vioqué, J., Torres-Cantero, A. M., & Izquierdo, J. Q. I. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801434 · Cited by 358
Impact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function
van Cauter, E., Holmbäck, U., Knutson, K., Leproult, R., Miller, A., Nedeltcheva, A., Pannain, S., Penev, P., Tasali, E., & Spiegel, K. (2007) · Hormone Research in Paediatrics · doi:10.1159/000097543 · Cited by 353
Self-citationHeslop, P., Smith, G. D., Metcalfe, C., Macleod, J., & Hart, C. (2002) · Sleep Medicine · doi:10.1016/s1389-9457(02)00016-3 · Cited by 335
von Kries, R., Toschke, A. M., Wurmser, H., Sauerwald, T. U., & Koletzko, B. V. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801980 · Cited by 303
Ohayon, M. M., & Vecchierini, M. (2005) · SLEEP · doi:10.1093/sleep/28.8.981 · Cited by 301
Risk factors of obesity in a five year old population. Parental versus environmental factors.
Locard, E., MAMELLE, N., Billette, A., Miginiac, M., Munoz, F., & Rey, S. (1992) · PubMed · Cited by 271
Sleep Duration and Body Mass Index in a Rural Population
Kohatsu, N. D. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.16.1701 · Cited by 207
Prevalence and risk factors for overweight and obesity in Portuguese children
Padez, C. M. P., Mourão, I., Moreira, P. A. M., & Rosado‐Marques, V. (2005) · Acta Paediatrica · doi:10.1080/08035250510042924 · Cited by 198
The Association Between Obesity and Short Sleep Duration: A Population-Based Study
Singh, M., Drake, C. L., Roehrs, T., Hudgel, D. W., & Roth, A. T. (2005) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26361 · Cited by 184
on behalf of the BHBHK Research Committee, T. H. I. O. H. K. H. A., Ko, G. T. C., Chan, J. C. N., Chan, A. W. Y., Wong, P. T. S., Hui, S. S. C., Tong, S. D. Y., Ng, S.-M., Chow, F., & Chan, C. L. W. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803389 · Cited by 176
Schwartz, M. W., & Morton, G. J. (2002) · Nature · doi:10.1038/418595a · Cited by 165
Ghrelin-leptin tango in body-weight regulation
Cummings, D. E., & Foster, K. E. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00350-0 · Cited by 159
Sleep Disturbances in Midlife Unrelated to 32-Year Diabetes Incidence
Björkelund, C., Bondyr-Carlsson, D., Lapidus, L., Lissner, L., Månsson, J., Skoog, I., & Bengtsson, C. (2005) · Diabetes Care · doi:10.2337/diacare.28.11.2739 · Cited by 158
Short Sleep Is Associated with Obesity among Truck Drivers
Moreno, C. R. D. C., Louzada, F. M., Teixeira, L. R., Borges, F., & Lorenzi‐Filho, G. (2006) · Chronobiology International · doi:10.1080/07420520601089521 · Cited by 132
Sleep and Sleep Disorders in Older Adults
Prinz, P. N. (1995) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199503000-00004 · Cited by 115
Lifestyle, Obesity, and Insulin Resistance
Shigeta, H., Shigeta, M., Nakazawa, A., Nakamura, N., & Yoshikawa, T. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.608 · Cited by 106
The hypothalamic-pituitary-adrenocortical system and sleep in man
Frieß, E., Wiedemann, K., Steiger, A., & Holsboer, F. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(95)00003-k · Cited by 104
Environmental factors associated with body mass index in a population of Southern France
Cournot, M., Ruidavets, J., Marquié, J.-C., Esquirol, Y., Baracat, B., & Ferrièeres, J. (2004) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000129738.22970.62 · Cited by 83
Chin-Chance, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2685 · Cited by 69
The cerebral circulation during sleep: regulation mechanisms and functional implications
Zoccoli, G., WALKER, A. M., Lenzi, P., & Franzini, C. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2001.0194 · Cited by 49
The Impact of Sleep Deprivation on Hormones and Metabolism
Cauter, E. V., Knutson, K. L., Leproult, R., & Spiegel, K. (2005) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) · Cited by 48
Self-citationGenetic Mapping of Disposition Index and Acute Insulin Response Loci on Chromosome 11q
Palmer, N. D., Langefeld, C. D., Campbell, J. K., Williams, A. H., Saad, M. F., Norris, J. M., Haffner, S. M., Rotter, J. I., Wagenknecht, L. E., Bergman, R. N., et al. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-0813 · Cited by 36
Research works printed but not linked: 1
- National Health Interview Survey, 2005, QuickStats: Percentage of Adults Who Reported an Average of <6 Hours of Sleep per 24-Hour Period, by Sex and Age Group – United States, 1985 and 2004, MMWR Morb Mortal Wkly Rep, 54, 933
Cited by
Sorted by citations
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
Changes in diet and lifestyle and long-term weight gain in women and men
Mozaffarian, D., Hao, T., Rimm, E. B., Willett, W. C., & Hu, F. B. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1014296 · Cited by 2,527
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Insufficient Sleep in Adolescents and Young Adults: An Update on Causes and Consequences
Owens, J., ADOLESCENT SLEEP WORKING GROUP, COMMITTEE ON ADOLESCENCE, Au, R., Carskadon, M., Millman, R., Wolfson, A., Braverman, P. K., Adelman, W. P., Breuner, C. C., et al. (2014) · Pediatrics · doi:10.1542/peds.2014-1696 · Cited by 1,413
Roenneberg, T., Allebrandt, K. V., Merrow, M., & Vetter, C. (2012) · Current Biology · doi:10.1016/j.cub.2012.03.038 · Cited by 1,407
Metadata
- Authors
- Van Cauter, E., Spiegel, K., Tasali, E., & Leproult, R.
- Affiliations
- Lyon 1 Université (FR)
- University of Chicago (US)
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 9
- Pages
- S23-S28
- ISSN
- 1389-9457 (ISSN-L)
- PMC
- PMC4444051
- OpenAlex
- W2013252791
- Cited by
- 812
- References
- 48
- Citations by year
- 2026: 37 · 2025: 53 · 2024: 54 · 2023: 54 · 2022: 62 · 2021: 56 · 2020: 56 · 2019: 49 · 2018: 52 · 2017: 46 · 2016: 39 · 2015: 46 · 2014: 51 · 2013: 48 · 2012: 42
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P01-AG11412., P01AG011412)
- National Heart, Lung, and Blood Institute (R01HL075079)
- National Institute of Diabetes and Digestive and Kidney Diseases (P60DK20595, P60DK020595)
- National Center for Research Resources (P41RR013642)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep deprivation, sleep duration, metabolic effects, slow-wave sleep, growth hormone, cortisol, leptin, ghrelin, appetite regulation, energy expenditure, obesity, type 2 diabetes, metabolic syndrome, glucose regulation, cardiovascular function, sleep restriction
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Sleep Initiation and Maintenance Disorders, Obesity, Pituitary-Adrenal System, Risk Factors, Sleep, REM, Human Growth Hormone, Carbohydrate Metabolism
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