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A whole-grain cereal-rich diet increases plasma betaine, and tends to decrease total and LDL-cholesterol compared with a refined-grain diet in healthy subjects

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Ross, Alastair B., Bruce, Stephen J., Blondel-Lubrano, Anny, Oguey-Araymon, Sylviane, Beaumont, Maurice, Bourgeois, Alexandre, Nielsen-Moennoz, Corine, Vigo, Mario, Fay, Laurent-Bernard, Kochhar, Sunil, Bibiloni, Rodrigo, Pittet, Anne-Cécile, Emady-Azar, Shahram, Grathwohl, Dominik, Rezzi, Serge·2011·British Journal of Nutrition
DOI 10.1017/s0007114510005209
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Abstract

Epidemiological studies have repeatedly found that whole-grain (WG) cereal foods reduce the risk of several lifestyle-related diseases, though consistent clinical outcomes and mechanisms are elusive. To compare the effects of a WG-rich diet with a matched refined-grain (RG) diet on plasma biomarkers and bowel health parameters, seventeen healthy subjects (eleven females and six males) completed an exploratory cross-over study with a 2-week intervention diet based on either WG- or RG-based foods, separated by a washout of at least 5 weeks. Both diets were the same except for the use of WG (150 g/d) or RG foods. Subjects undertook a 4 h postprandial challenge on day 8 of each intervention diet. After 2 weeks, the WG diet tended to decrease plasma total and LDL-cholesterol (both P = 0·09), but did not change plasma HDL-cholesterol, fasting glucose, C-reactive protein or homocysteine compared with the RG diet. Plasma betaine and alkylresorcinol concentrations were elevated after 1 week of the WG diet (P = 0·01 and P < 0·0001, respectively).Clostridium leptum populations in faeces were increased after the WG diet, along with a trend for decreased faecal water pH (P = 0·096) and increased stool frequency (P < 0·0001) compared with the RG diet. A short controlled intervention trial with a variety of commercially available WG-based products tended to improve biomarkers of CVD compared with a RG diet. Changes in faecal microbiota related to increased fibre fermentation and increased plasma betaine concentrations point to both fibre and phytochemical components of WG being important in mediating any potential health effects.

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Research works printed but not linked: 65

  1. 10.1016/0026-0495(93)90198-W · DOI · Paper page
  2. Olthof, 2003, Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women, J Nutr, 133, 4135, 10.1093/jn/133.12.4135 · DOI
  3. 10.1021/jf903930k · DOI
  4. 10.1017/S0029665108007076 · DOI
  5. Behall, 2004, Diets containing barley significantly reduce lipids in mildly hypercholesterolemic men and women, Am J Clin Nutr, 80, 1185, 10.1093/ajcn/80.5.1185 · DOI · Paper page
  6. 10.1111/j.1753-4887.2006.tb00190.x · DOI
  7. 10.3945/jn.109.109470 · DOI
  8. Landberg, 2006, Human plasma kinetics and relative bioavailability of alkylresorcinols after intake of rye bran, J Nutr, 136, 2760, 10.1093/jn/136.11.2760 · DOI
  9. 10.1016/j.numecd.2009.03.025 · DOI
  10. 10.1017/S0007114509990845 · DOI
  11. Detopoulou, 2008, Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study, Am J Clin Nutr, 87, 424, 10.1093/ajcn/87.2.424 · DOI · Paper page
  12. Sahyoun, 2006, Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults, Am J Clin Nutr, 83, 124, 10.1093/ajcn/83.1.124 · DOI · Paper page
  13. 10.1128/AEM.00151-06 · DOI
  14. Craig, 2004, Betaine in human nutrition, Am J Clin Nutr, 80, 539, 10.1093/ajcn/80.3.539 · DOI · Paper page
  15. McIntosh, 2003, Whole-grain rye and wheat foods and markers of bowel health in overweight middle-aged men, Am J Clin Nutr, 77, 967, 10.1093/ajcn/77.4.967 · DOI · Paper page
  16. 10.1016/j.jfca.2008.10.005 · DOI
  17. 10.1038/sj.ejcn.1601985 · DOI
  18. 10.3945/ajcn.2010.29417 · DOI · Paper page
  19. 10.1016/j.jfca.2004.05.004 · DOI
  20. Slow, 2009, Plasma dependent and independent accumulation of betaine in male and female rat tissues, Physiol Res, 58, 403, 10.33549/physiolres.931569 · DOI
  21. 10.1021/jf900239t · DOI
  22. 10.1017/S0007114510000656 · DOI
  23. Waggle, 1967, Extensive analyses of flours and millfeeds made from nine different wheat mixes. II. Amino acids, minerals, vitamins, and gross energy, Cereal Chem, 44, 48
  24. 10.1016/j.tifs.2008.02.005 · DOI · Paper page
  25. Barbé, 2001, Detection of moderate hyperhomocysteinemia: comparison of the Abbott fluorescence polarization immunoassay with the Bio-Rad and SBD-F high-performance liquid chromatographic assays, Amino Acids, 20, 435, 10.1007/s007260170039 · DOI
  26. 10.1016/j.nutres.2003.08.014 · DOI
  27. Landberg, 2008, Alkylresorcinols as biomarkers of whole-grain wheat and rye intake: plasma concentration and intake estimated from dietary records, Am J Clin Nutr, 87, 832, 10.1093/ajcn/87.4.832 · DOI · Paper page
  28. 10.1080/01635580701274848 · DOI
  29. 10.1017/S1368980007001279 · DOI · Paper page
  30. 10.3945/ajcn.2009.28521 · DOI
  31. 10.1007/s11883-004-0081-y · DOI · Paper page
  32. Schwab, 2006, Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans, J Nutr, 136, 34, 10.1093/jn/136.1.34 · DOI
  33. 10.1371/journal.pmed.0020135 · DOI
  34. 10.1016/j.jada.2006.06.010 · DOI
  35. Pereira, 2002, Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults, Am J Clin Nutr, 75, 848, 10.1093/ajcn/75.5.848 · DOI · Paper page
  36. Konstantinova, 2008, Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women, J Nutr, 138, 914, 10.1093/jn/138.5.914 · DOI · Paper page
  37. 10.1038/sj.ejcn.1602725 · DOI · Paper page
  38. 10.1038/sj.bjc.6602543 · DOI · Paper page
  39. Andersson, 2007, Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects, J Nutr, 137, 1401, 10.1093/jn/137.6.1401 · DOI · Paper page
  40. 10.1017/S0007114510000644 · DOI · Paper page
  41. Atkinson, 2008, Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects, Am J Clin Nutr, 87, 577, 10.1093/ajcn/87.3.577 · DOI
  42. 10.1016/j.ab.2008.10.031 · DOI
  43. 10.1079/BJN20051642 · DOI
  44. 10.1515/CCLM.2005.187 · DOI · Paper page
  45. 10.3945/jn.108.103762 · DOI
  46. 10.1017/S0007114510002084 · DOI
  47. 2005, Dietary Guidelines for Americans 2005
  48. Jacobs, 2004, Commercially available whole grain foods reduce body weight compared to equal servings of refined grain foods, FASEB J
  49. 10.1016/0278-6915(85)90187-5 · doi:10.1016/0278-6915(85)90187-5
  50. Juntunen, 2003, High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women, Am J Clin Nutr, 77, 385, 10.1093/ajcn/77.2.385 · DOI · Paper page
  51. Pins, 2002, Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?, J Fam Pract, 51, 353
  52. 10.1016/j.jada.2006.06.003 · DOI
  53. Vos, 2000, Whole grains and coronary heart disease, Am J Clin Nutr, 71, 1009, 10.1093/ajcn/71.4.1009 · DOI
  54. Gråsten, 2000, Rye bread improves bowel function and decreases the concentrations of some compounds that are putative colon cancer risk markers in middle-aged women and men, J Nutr, 130, 2215, 10.1093/jn/130.9.2215 · DOI
  55. 10.1038/sj.ejcn.1600716 · DOI
  56. Linko-Parvinen, 2007, Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins, J Nutr, 137, 1137, 10.1093/jn/137.5.1137 · DOI
  57. 10.1079/PNS2002221 · DOI · Paper page
  58. 10.1111/j.1753-4887.2004.tb00029.x · DOI · Paper page
  59. Leinonen, 2000, Rye bread decreases serum total and LDL cholesterol in men with moderately elevated serum cholesterol, J Nutr, 130, 164, 10.1093/jn/130.2.164 · DOI
  60. 10.1080/07315724.2000.10718969 · DOI · Paper page
  61. 10.3945/jn.109.118570 · DOI
  62. 10.1016/j.jada.2009.10.037 · DOI · Paper page
  63. Refsum, 2006, The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease, J Nutr, 136, 1731S, 10.1093/jn/136.6.1731S · DOI · Paper page
  64. 10.1079/BJN20051511 · DOI
  65. Chiuve, 2007, The association between betaine and choline intakes and the plasma concentrations of homocysteine in women, Am J Clin Nutr, 86, 1073, 10.1093/ajcn/86.4.1073 · DOI

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Metadata

Authors
Ross, A. B., Bruce, S. J., Blondel-Lubrano, A., Oguey-Araymon, S., Beaumont, M., Bourgeois, A., Nielsen-Moennoz, C., Vigo, M., Fay, L.-B., Kochhar, S., Bibiloni, R., Pittet, A.-C., Emady-Azar, S., Grathwohl, D., & Rezzi, S.
Venue
British Journal of Nutrition
Publisher
Cambridge University Press (CUP)
Published
2011-01-28
Volume
105
Issue
10
Pages
1492-1502
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
DOI
10.1017/s0007114510005209
OpenAlex
W2149543057
Cited by
177
References
8
FWCI
13.09
Type
journal article
Language
en
Open access
bronze
Licence
www.cambridge.org/core/terms (unspecified)

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CoChat. (2026). Citation check: A whole-grain cereal-rich diet increases plasma betaine, and tends to decrease total and LDL-cholesterol compared with a refined-grain diet in healthy subjects. https://app.cochat.ai/papers/10.1017/s0007114510005209
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Ross, A. B., Bruce, S. J., Blondel-Lubrano, A., Oguey-Araymon, S., Beaumont, M., Bourgeois, A., Nielsen-Moennoz, C., Vigo, M., Fay, L.-B., Kochhar, S., Bibiloni, R., Pittet, A.-C., Emady-Azar, S., Grathwohl, D., & Rezzi, S. (2011). A whole-grain cereal-rich diet increases plasma betaine, and tends to decrease total and LDL-cholesterol compared with a refined-grain diet in healthy subjects. British Journal of Nutrition. https://doi.org/10.1017/s0007114510005209

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