Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study
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Epidemiological studies have shown an inverse association between dietary intake of whole grains and the risk of chronic disease. This may be related to the ability to mediate a prebiotic modulation of gut microbiota. However, no studies have been conducted on the microbiota modulatory capability of whole-grain (WG) cereals. In the present study, the impact of WG wheat on the human intestinal microbiota compared to wheat bran (WB) was determined. A double-blind, randomised, crossover study was carried out in thirty-one volunteers who were randomised into two groups and consumed daily 48 g breakfast cereals, either WG or WB, in two 3-week study periods, separated by a 2-week washout period. Numbers of faecal bifidobacteria and lactobacilli (the target genera for prebiotic intake), were significantly higher upon WG ingestion compared with WB. Ingestion of both breakfast cereals resulted in a significant increase in ferulic acid concentrations in blood but no discernible difference in faeces or urine. No significant differences in faecal SCFA, fasting blood glucose, insulin, total cholesterol (TC), TAG or HDL-cholesterol were observed upon ingestion of WG compared with WB. However, a significant reduction in TC was observed in volunteers in the top quartile of TC concentrations upon ingestion of either cereal. No adverse intestinal symptoms were reported and WB ingestion increased stool frequency. Daily consumption of WG wheat exerted a pronounced prebiotic effect on the human gut microbiota composition. This prebiotic activity may contribute towards the beneficial physiological effects of WG wheat.
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Food sources of fibre, such as whole grains, have been suggested to have a prebiotic-like effect on the gut microbiota.
“Food sources of fibre, such as whole grains, have been suggested to have a prebiotic-like effect on the gut microbiota [60].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [60]
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Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., Moreno-Arribas, M. V., & Bartolomé, B. (2015) · BioMed Research International · doi:10.1155/2015/850902 · Cited by 396 · see citing works
“In two intervention studies with whole grain breakfast cereals from wheat (n = 31) and maize (n = 32) [84, 85], the ingestion of both products resulted in significant increases in fecal bifidobacteria and/or lactobacilli without changing the relative abundance of other dominant members of the gut microbiota.”
Background(2013) · The Journal of Nutrition · doi:10.3945/jn.111.155325 · Cited by 634 · see citing works
Towards microbial fermentation metabolites as markers for health benefits of prebiotics
Verbeke, K. A., Boobis, A. R., Chiodini, A., Edwards, C. A., Franck, A., Kleerebezem, M., Nauta, A., Raes, J., van Tol, E. A. F., & Tuohy, K. M. (2015) · Nutrition Research Reviews · doi:10.1017/s0954422415000037 · Cited by 343 · see citing works
“20; median 23 (IQR 21–24) years Median (IQR) 297 (194–437) mmol/d Cloetens (2010)((108)) 12; median 24 (IQR 21–28) years Median (IQR) 214 (107–315) mmol/d Cloetens (2008)((250)) 20; range 19–41 years Median (IQR) 297 (239–349) mmol/d Windey (2012)((103)) 19; range 21–53 years Mean (SEM) 218 (58) mmol/d Gostner (2006)(…”
Self-citationPolyphenols and Human Health: A Prospectus
Visioli, F., Alarcón‐de‐la‐Lastra, C., Andrés‐Lacueva, C., Aviram, M., Calhau, C., Cassano, A., D’Archivio, M., Faria, A., Favé, G., Fogliano, V., et al. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408391003698677 · Cited by 347 · see citing works
“This process largely explains the delay of absorption of the polyphenol metabolites recorded after cereal or grape dietary fiber consumption (Costabile et al., 2008; Perez-Jimenez et al., 2009).”
BackgroundSelf-citationProbiotics, prebiotics, synbiotics and insulin sensitivity
Kim, Y. A., Keogh, J. B., & Clifton, P. M. (2017) · Nutrition Research Reviews · doi:10.1017/s095442241700018x · Cited by 341 · see citing works
“Costabile et al. (108) suggested that whole-grain wheat could exert a prebiotic effect on gut microbiota composition.”
BackgroundInfluentialBread Affects Clinical Parameters and Induces Gut Microbiome-Associated Personal Glycemic Responses
Korem, T., Zeevi, D., Zmora, N., Weissbrod, O., Bar, N., Lotan-Pompan, M., Avnit-Sagi, T., Kosower, N., Malka, G., Rein, M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.002 · Cited by 318 · see citing works
Vitaglione, P., Mennella, I., Ferracane, R., Rivellese, A. A., Giacco, R., Ercolini, D., Gibbons, S. M., Storia, A. L., Gilbert, J. A., Jonnalagadda, S. S., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.088120 · Cited by 325 · see citing works
“The observation that FA concentration can increase in the blood on WG wheat consumption was conceptually in agreement with a previous study conducted in healthy normal-weight subjects (9), whereas in a recent study in overweight healthy subjects, a 4 wk-consumption of bread and cereals enriched with an aleurone fracti…”
BackgroundResultSelf-citationKellow, N. J., Coughlan, M. T., & Reid, C. M. (2014) · British Journal of Nutrition · doi:10.1017/s0007114513003607 · Cited by 307 · see citing works
“The unique role played by prebiotics and specific bacteria in gut hormone kinetics requires further investigation, as non-prebiotic dietary fibres have also been reported to be associated with increased SCFA, peptide YY and GLP-1 production in human feeding studies((60,61)).”
BackgroundPrebiotics, bone and mineral metabolism
Whisner, C. M., & Castillo, L. F. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0339-3 · Cited by 292 · see citing works
“More recent research with regard to intestinal microbiota effects suggests that arabinoxylan oligosaccharide-rich wheat bran extracts and whole-grain wheat may increase the composition of bifidobacteria and lactobacillus [131, 132], which have been linked to improvements in bone health.”
BackgroundDietary Fiber, Gut Microbiota, and Metabolic Regulation—Current Status in Human Randomized Trials
Myhrstad, M. C. W., Tunsjø, H. S., Charnock, C., & Telle‐Hansen, V. H. (2020) · Nutrients · doi:10.3390/nu12030859 · Cited by 280 · see citing works
“Several SCFA-producers were reported to be significantly increased after intake of dietary fiber, including Lachnospira, Akkermannsia, Bifidobacterium, Lactobacillus, Ruminococcus, Roseburia, Clostridium, Faecalibacterium, and Dorea [33,34,36,37,44,45].”
BackgroundInfluentialZelber‐Sagi, S., Salomone, F., & Mlynarsky, L. (2017) · Liver International · doi:10.1111/liv.13435 · Cited by 273 · see citing works
Up-regulating the Human Intestinal Microbiome Using Whole Plant Foods, Polyphenols, and/or Fiber
Tuohy, K. M., Conterno, L., Gasperotti, M., & Viola, R. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2053959 · Cited by 272 · see citing works
Self-citationJonnalagadda, S. S., Harnack, L., Liu, R. H., McKeown, N. M., Seal, C. J., Liu, S., & Fahey, G. C., Jr. (2011) · Journal of Nutrition · doi:10.3945/jn.110.132944 · Cited by 268 · see citing works
“For example, the presence of oligosaccharides, RS, and other fermentable carbohydrates may increase the number of fecal bifidobacteria and lactobacilli (49), thus potentially increasing the SCFA production and thereby potentially altering the metabolic and physiological responses that affect body weight regulation.”
BackgroundYe, E. Q., Chacko, S. A., Chou, E. L., Kugizaki, M., & Liu, S. (2012) · Journal of Nutrition · doi:10.3945/jn.113.179473 · Cited by 257 · see citing works
Williams, B. A., Grant, L. J., Gidley, M. J., & Mikkelsen, D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102203 · Cited by 255 · see citing works
“reported increased amounts of bacteria considered beneficial for those fed a whole grain supplement compared to a more processed wheat bran counterpart [190].”
BackgroundRole of resistant starch in improving gut health, adiposity, and insulin resistance
Keenan, M. J., Zhou, J., Hegsted, M., Pelkman, C., Durham, H. A., Coulon, D. B., & Martin, R. J. (2015) · Advances in Nutrition · doi:10.3945/an.114.007419 · Cited by 243 · see citing works
Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?
Aron‐Wisnewsky, J., Warmbrunn, M. V., Nieuwdorp, M., & Clément, K. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.049 · Cited by 245 · see citing works
The Development and Evaluation of a Literature-Based Dietary Index for Gut Microbiota
Kase, B. E., Liese, A. D., Zhang, J., Murphy, E. A., Zhao, L., & Steck, S. E. (2024) · Nutrients · doi:10.3390/nu16071045 · Cited by 221 · see citing works
“Whole-grain intake was associated with an increase in Bifidobacterial , Prevetolla , and Roseburia hominis [59,60,62].”
BackgroundAn Evidence-Based Systematic Review on the Management of Irritable Bowel Syndrome
Brandt, L. J., Chey, W. D., Foxx-Orenstein, A. E., Quigley, E. M. M., Schiller, L. R., Schoenfeld, P. S., Spiegel, B. M., Talley, N. J., & Moayyedi, P. (2009) · American Journal of Gastroenterology · doi:10.14309/00000434-200901001-00002 · Cited by 225 · see citing works
Sun, L., Wang, Y., & Miao, M. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.08.003 · Cited by 221 · see citing works
Ganesan, K., Chung, S. K., Vanamala, J., & Xu, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123720 · Cited by 221 · see citing works
“Whole grain wheat [101,102] ↑Bifidobacteria animalis, ↑Roseburia, ↑Bacteroides, ↑Prevotella, ↑Clostridium ↑Lactobacillus/Enterococci”
Impact of Diet on Human Intestinal Microbiota and Health
Salonen, A., & de Vos, W. M. (2014) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030212-182554 · Cited by 215 · see citing works
Gut Microbiota, Host Organism, and Diet Trialogue in Diabetes and Obesity
Lazăr, V., Diţu, L.-M., Pîrcălăbioru, G. G., Picu, A. A., Petcu, L. M., Cucu, N., & Chifiriuc, M. C. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00021 · Cited by 207 · see citing works
“Indeed, diets rich in whole grain and wheat bran promoted an increase in intestinal bifidobacteria and lactobacilli (99, 100).”
BackgroundAune, D. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz042 · Cited by 215 · see citing works
The Benefits of Breakfast Cereal Consumption: A Systematic Review of the Evidence Base
Williams, P. (2014) · Advances in Nutrition · doi:10.3945/an.114.006247 · Cited by 208 · see citing works
Gut microbiota, diet, and obesity-related disorders: the good, the bad, and the future challenges
Portune, K. J., Benítez‐Páez, A., Del Pulgar, E. M. G., Cerrudo, V., & Sanz, Y. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600252 · Cited by 201 · see citing works
Whole cereal grains and potential health effects: Involvement of the gut microbiota
Gong, L., Cao, W., Chi, H., Wang, J., Zhang, H., Liu, J., & Sun, B. (2017) · Food Research International · doi:10.1016/j.foodres.2017.10.025 · Cited by 204 · see citing works
Diet, the Gut Microbiome, and Epigenetics
Hullar, M. A. J., & Fu, B. C. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000053 · Cited by 205 · see citing works
“For example, in a randomized, controlled crossover designed dietary intervention, Costabile et al found that bacterial groups and plasma levels of bacterial phenolic metabolites were altered depending on the type of fiber ingested in two 3-week periods.(18) However, the microbial metabolites only increased in one of t…”
BackgroundMaccaferri, S., Vitali, B., Klinder, A., Kolida, S., Ndagijimana, M., Laghi, L., Calanni, F., Brigidi, P., Gibson, G. R., & Costabile, A. (2010) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq345 · Cited by 186 · see citing works
Self-citationFreeland, K. R., Wilson, C., & Wolever, T. M. S. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991462 · Cited by 187 · see citing works
“However, controlled clinical trials lasting 4–12 weeks showed no significant effect of wheat fibre on glycaemic control or oral glucose tolerance in normal((8,9)) or diabetic subjects((10,11)).”
BackgroundKnudsen, K. E. B. (2015) · Advances in Nutrition · doi:10.3945/an.114.007450 · Cited by 185 · see citing works
Seal, C. J., Courtin, C. M., Venema, K., & de Vries, J. (2021) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12728 · Cited by 190 · see citing works
The gut microbiota as a novel regulator of cardiovascular function and disease
Battson, M. L., Lee, D. M., Weir, T. L., & Gentile, C. L. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.12.010 · Cited by 185 · see citing works
Fei, L., Meredith A. J., H., Yvonne, S., & Johanna W., L. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.108191 · Cited by 181 · see citing works
Ross, A. B., Bruce, S. J., Blondel‐Lubrano, A., Oguey-Araymon, S., Beaumont, M., Bourgeois, A., Nielsen-Moennoz, C., Vigo, M., Fay, L., Kochhar, S., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114510005209 · Cited by 177 · see citing works
“microbiota populations, and found that bifidobacteria and lactobacilli/enterococci populations increased with WG wheat((19)), and a similar study has found that WG maize breakfast cereal increased faecal bifidobacteria populations after 3 weeks((66)).”
BackgroundInfluentialOliver, A., Chase, A. B., Weihe, C., Orchanian, S. B., Riedel, S. F., Hendrickson, C. L., Lay, M., Sewall, J. M., Martiny, J. B. H., & Whiteson, K. (2021) · mSystems · doi:10.1128/msystems.00115-21 · Cited by 171 · see citing works
Analysis of short-chain fatty acids in human feces: A scoping review
Primec, M., Mičetić‐Turk, D., & Langerholc, T. (2017) · Analytical Biochemistry · doi:10.1016/j.ab.2017.03.007 · Cited by 164 · see citing works
Linking dietary patterns with gut microbial composition and function
Sheflin, A. M., Melby, C. L., Carbonero, F., & Weir, T. L. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1270809 · Cited by 162 · see citing works
“However, long chain inulin decreased Bacteroides and also Prevotella after 21 d in the same population type with a similar crossover design.(53) Therefore, when interpret-”
BackgroundGut microbiome-Mediterranean diet interactions in improving host health
Nagpal, R., Shively, C. A., Register, T. C., Craft, S., & Yadav, H. (2019) · F1000Research · doi:10.12688/f1000research.18992.1 · Cited by 162 · see citing works
Gut Microbiome Composition in Non-human Primates Consuming a Western or Mediterranean Diet
Nagpal, R., Shively, C. A., Appt, S. A., Register, T. C., Michalson, K. T., Vitolins, M. Z., & Yadav, H. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00028 · Cited by 158 · see citing works
The impact of pre‐ and/or probiotics on human colonic metabolism: Does it affect human health?
Preter, V. D., Hamer, H. M., Windey, K., & Verbeke, K. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000451 · Cited by 157 · see citing works
Jefferson, A., & Adolphus, K. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00033 · Cited by 149 · see citing works
Eid, N., Enani, S., Walton, G., Corona, G., Costabile, A., Gibson, G., Rowland, I., & Spencer, J. P. E. (2014) · Journal of Nutritional Science · doi:10.1017/jns.2014.16 · Cited by 192 · see citing works
“Indeed, a large number of human intervention studies have indicated that foods rich in fibres and polyphenols and/or rich in both compounds((29)) have an impact on the gut microbiota, including cocoa((26)), pomegranate((14)), wine((28)), blueberries((27)), whole-grain cereal((18)), maize-derived whole grain((22)), art…”
Self-citationMcKeown, N. M., Troy, L. M., Jacques, P. F., Hoffmann, U., O’Donnell, C. J., & Fox, C. S. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29106 · Cited by 151 · see citing works
Hydroxycinnamic acids and human health: recent advances
Coman, V., & Vodnar, D. C. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10010 · Cited by 155 · see citing works
do Nascimento, R. D. P., Machado, A. P. D. F., Gálvez, J., Cazarin, C. B. B., & Maróstica, M. R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118129 · Cited by 146 · see citing works
How probiotics face food stress: They get by with a little help
Fiocco, D., Longo, A., Arena, M. P., Russo, P., Spano, G., & Capozzi, V. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1580673 · Cited by 143 · see citing works
“Food rich in fibers, particularly non-digestible carbohydrates, controls satiety (Gu erin-Deremaux et al. 2011), contrasts hypercholesterolemia (Whitehead et al. 2014) and ameliorates gastrointestinal functions by modulating the gut microbiota (Costabile et al. 2008; Drakoularakou et al. 2010).”
BackgroundCarvalho-Wells, A. L., Helmolz, K., Nodet, C., Mölzer, C., Leonard, C., McKevith, B., Thielecke, F., Jackson, K. G., & Tuohy, K. M. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510002084 · Cited by 141 · see citing works
“Recent findings from our group have shown for the first time that consumption of a minimally processed source of WG in the form of a breakfast cereal had a prebiotic effect compared with a wheat bran cereal within a mixed diet, healthy, normolipaemic cohort((13)).”
BackgroundInfluentialSelf-citationFogliano, V., Corollaro, M. L., Vitaglione, P., Napolitano, A., Ferracane, R., Travaglia, F., Arlorio, M., Costabile, A., Klinder, A., & Gibson, G. R. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000360 · Cited by 143 · see citing works
“Series 200) as previously described [9].”
BackgroundSelf-citationMueller, N. T., Shin, H., Pizoni, A., Werlang, I. C. R., Matte, Ú. D. S., Goldani, M. Z., Goldani, H. A. S., & Domínguez-Bello, M. G. (2016) · Scientific Reports · doi:10.1038/srep23133 · Cited by 141 · see citing works
Dietary fiber sources and human benefits: The case study of cereal and pseudocereals
Ciudad‐Mulero, M., Fernández‐Ruiz, V., González, M. C. M., & Morales, P. (2019) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2019.02.002 · Cited by 144 · see citing works
Maillard reaction products modulate gut microbiota composition in adolescents
Seiquer, I., Rubio, L. A., Peinado, M. J., Delgado‐Andrade, C., & Navarro, M. P. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300847 · Cited by 138 · see citing works
Influence of food matrices on probiotic viability – A review focusing on the fruity bases
Santo, A. P. D. E., Perego, P., Converti, A., & de Oliveira, M. N. (2011) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2011.04.008 · Cited by 134 · see citing works
Vitetta, L., Vitetta, G., & Hall, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02240 · Cited by 134 · see citing works
Phytochemicals in whole grain wheat and their health‐promoting effects
Zhu, Y., & Sang, S. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600852 · Cited by 131 · see citing works
Pushpass, R.-A. G., Alzoufairi, S., Jackson, K. G., & Lovegrove, J. A. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000081 · Cited by 130 · see citing works
“Certain secondary bile acids may be more readily excreted from the body, and bile acid neo-synthesis and LDL clearance may be enhanced (63,64).”
BackgroundThe Impact of Cereal Grain Composition on the Health and Disease Outcomes
Garutti, M., Nevola, G., Mazzeo, R., Cucciniello, L., Totaro, F., Bertuzzi, C. A., Caccialanza, R., Pedrazzoli, P., & Puglisi, F. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.888974 · Cited by 126 · see citing works
Tuohy, K. M., Fava, F., & Viola, R. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003911 · Cited by 124 · see citing works
Self-citationPolyphenols and Their Interactions With Other Dietary Compounds: Implications for Human Health
Kardum, N., & Glibetić, M. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2017.12.001 · Cited by 124 · see citing works
Guglielmetti, S., Fracassetti, D., Taverniti, V., Del Bo’, C., Vendrame, S., Klimis-Zacas, D., Arioli, S., Riso, P., & Porrini, M. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf402495k · Cited by 123 · see citing works
Intestinal Microbiota and its Role in Irritable Bowel Syndrome (IBS)
Öhman, L., & Simrén, M. (2013) · Current Gastroenterology Reports · doi:10.1007/s11894-013-0323-7 · Cited by 123 · see citing works
“in healthy subjects [72].”
Li, T., Huang, Z., Jia, R., Lv, X., Zhao, C., & Liu, B. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110530 · Cited by 122 · see citing works
Ramnani, P., Gaudier, E. A., Bingham, M. O., van Bruggen, P., Tuohy, K. M., & Gibson, G. R. (2010) · British Journal Of Nutrition · doi:10.1017/s000711451000036x · Cited by 121 · see citing works
“Thus, their concentration in the faeces is unlikely to represent their rate of production by the gut microbiota (6,29) .”
BackgroundSelf-citationWhat can feruloyl esterases do for us?
Faulds, C. B. (2009) · Phytochemistry Reviews · doi:10.1007/s11101-009-9156-2 · Cited by 115 · see citing works
Whole grain intake in relation to body weight: From epidemiological evidence to clinical trials
Giacco, R., Pepa, G. D., Luongo, D., & Riccardi, G. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.07.003 · Cited by 115 · see citing works
“It is not known whether the habitual intake of whole grain products is able to influence the composition of gut microbiota in humans; however, available data in humans show that a diet rich in whole wheat cereals compared with a diet based on bran wheat is able to increase the number of fecal bifidobacteria and lactob…”
BackgroundMarventano, S., Vetrani, C., Vitale, M., Godos, J., Riccardi, G., & Grosso, G. (2017) · Nutrients · doi:10.3390/nu9070769 · Cited by 116 · see citing works
“As regards medium/long-term RCT in 12 studies [5,23,35–41,48,50,51,55], participants consumed a diet in which food with refined cereals were substituted with WG foods, while in four studies the intervention groups were invited to consume WG sourdough bread [32], WG biscuits [45], WG breakfast cereals [4] or WG oats [4…”
BackgroundMethodInfluentialDiet Effects in Gut Microbiome and Obesity
Chen, J., He, X., & Huang, J. (2014) · Journal of Food Science · doi:10.1111/1750-3841.12397 · Cited by 116 · see citing works
Rosa‐Sibakov, N., Poutanen, K. S., & Micard, V. (2014) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2014.10.003 · Cited by 113 · see citing works
Motherway, M. O., Fitzgerald, G. F., Neirynck, S., Ryan, S. M., Steidler, L., & van Sinderen, D. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01169-08 · Cited by 112 · see citing works
“Carbohydrates that have been shown to exert prebiotic effects include those from whole-grain wheat, fructooligosaccharides, galactooligosaccharides, and lactulose ( 12 , 17, 20, 33).”
BackgroundGluten-Free Diet: Imprudent Dietary Advice for the General Population?
Gaesser, G. A., & Angadi, S. S. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.06.009 · Cited by 112 · see citing works
Effects of cereal fiber on bowel function: A systematic review of intervention trials
de Vries, J. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i29.8952 · Cited by 110 · see citing works
Bioactive compounds of pigmented wheat (Triticum aestivum): Potential benefits in human health
Gupta, R., Meghwal, M., & Prabhakar, P. K. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.02.003 · Cited by 108 · see citing works
Host and Microbiome Interplay Shapes the Vaginal Microenvironment
Kwon, M. S., & Lee, H. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.919728 · Cited by 112 · see citing works
Oishi, K., Yamamoto, S., Itoh, N., Nakao, R., Yasumoto, Y., Tanaka, K., Kikuchi, Y., Fukudome, S.-I., Okita, K., & Takano‐Ishikawa, Y. (2014) · Journal of Nutrition · doi:10.3945/jn.114.202754 · Cited by 107 · see citing works
Lampe, J. W., Navarro, S. L., Hullar, M. A. J., & Shojaie, A. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113000025 · Cited by 105 · see citing works
“Costabile et al.((58)) n 31; 16 F, 15 M Randomised controlled crossover, 48 g/d breakfast cereal of either 100% WG (11.”
BackgroundLappi, J., Salojärvi, J., Kolehmainen, M., Mykkänen, H. M., Poutanen, K. S., de Vos, W. M., & Salonen, A. (2013) · Journal of Nutrition · doi:10.3945/jn.112.172668 · Cited by 102 · see citing works
Eid, N. M. S., Osmanova, H., Natchez, C., Walton, G., Costabile, A., Gibson, G. R., Rowland, I. R., & Spencer, J. P. E. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002780 · Cited by 103 · see citing works
“In previous human trials of this nature, even though bacterial numbers were significantly changed, SCFA were rarely altered by bacterial fermentation of plant-based foods, as seen previously with whole-grain consumption((36)).”
BackgroundSelf-citationYang, W., Ma, Y., Liu, Y., Smith‐Warner, S. A., Simon, T. G., Chong, D. Q., Qi, Q., Meyerhardt, J. A., Giovannucci, E. L., Chan, A. T., et al. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2018.7159 · Cited by 101 · see citing works
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Kopf, J., Haute, M. J. S. V., Clarke, J., Eyun, S., Riethoven, J.-J. M., Ramer‐Tait, A. E., & Rose, D. J. (2018) · Nutrition Journal · doi:10.1186/s12937-018-0381-7 · Cited by 102 · see citing works
Ampatzoglou, A., Atwal, K., Maidens, C. M., Williams, C. L., Ross, A. B., Thielecke, F., Jonnalagadda, S. S., Kennedy, O. B., & Yaqoob, P. (2014) · Journal of Nutrition · doi:10.3945/jn.114.202176 · Cited by 95 · see citing works
“Soluble fiber and b-glucan content may partly explain the beneficial effects reported after interventions with oats (16, 18, 42, 43) in comparison to wheat (14, 23, 36, 37), although other studies have demonstrated beneficial effects of WG wheat on BP (19) and blood lipids (44, 45) in comparison to RG controls.”
BackgroundResult
- Authors
- Costabile, A., Klinder, A., Fava, F., Napolitano, A., Fogliano, V., Leonard, C., Gibson, G. R., & Tuohy, K. M.
- Affiliations
- University of Reading (GB)
- University of Naples Federico II (IT)
- Corresponding author
- Costabile, Adele
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-08-29
- Volume
- 99
- Issue
- 1
- Pages
- 110-120
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2165083361
- Semantic Scholar
- 762a3ebdd78c6f878c158e51fbe41b625566d9b0
- Cited by
- 444
- References
- 69
- Citations by year
- 2026: 17 · 2025: 15 · 2024: 21 · 2023: 25 · 2022: 23 · 2021: 33 · 2020: 34 · 2019: 40 · 2018: 29 · 2017: 29 · 2016: 19 · 2015: 24 · 2014: 34 · 2013: 29 · 2012: 17
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (acceptedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- University of Reading
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- whole wheat, breakfast cereals, prebiotic activity, gut microbiota, wheat bran, Bifidobacterium, lactobacilli, ferulic acid, short-chain fatty acids, total cholesterol
- MeSH terms
- Adult, Analysis of Variance, Bifidobacterium, Blood Glucose, Cholesterol, Coumaric Acids, Dietary Fiber, DNA Damage, DNA, Bacterial, Double-Blind Method, Fatty Acids, Volatile, Feces, Female, Humans, Insulin, Intestines, Cholesterol, HDL, Male, Triglycerides, Triticum, In Situ Hybridization, Fluorescence, Cross-Over Studies, HT29 Cells, Foods, Specialized, Comet Assay
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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