CoChat
Sign Up
Cited by 1,030Food composition and propertiesPhytochemicals and Antioxidant ActivitiesNutritional Studies and Diet

The DOI matches its Crossref record; 1,019 of the 1,031 references it cites were found in a registry or an index.

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

Open access
Fardet, Anthony·2010·Nutrition Research Reviews
DOI 10.1017/s0954422410000041
Open this paper in CoChat — free accountOpen PDF

Abstract

Epidemiological studies have clearly shown that whole-grain cereals can protect against obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety, reduced transit time and glycaemic response), fibre (improved faecal bulking and satiety, viscosity and SCFA production, and/or reduced glycaemic response) and Mg (better glycaemic homeostasis through increased insulin secretion), together with the antioxidant and anti-carcinogenic properties of numerous bioactive compounds, especially those in the bran and germ (minerals, trace elements, vitamins, carotenoids, polyphenols and alkylresorcinols), are today well-recognised mechanisms in this protection. Recent findings, the exhaustive listing of bioactive compounds found in whole-grain wheat, their content in whole-grain, bran and germ fractions and their estimated bioavailability, have led to new hypotheses. The involvement of polyphenols in cell signalling and gene regulation, and of sulfur compounds, lignin and phytic acid should be considered in antioxidant protection. Whole-grain wheat is also a rich source of methyl donors and lipotropes (methionine, betaine, choline, inositol and folates) that may be involved in cardiovascular and/or hepatic protection, lipid metabolism and DNA methylation. Potential protective effects of bound phenolic acids within the colon, of the B-complex vitamins on the nervous system and mental health, of oligosaccharides as prebiotics, of compounds associated with skeleton health, and of other compounds such as α-linolenic acid, policosanol, melatonin, phytosterols and para-aminobenzoic acid also deserve to be studied in more depth. Finally, benefits of nutrigenomics to study complex physiological effects of the ‘whole-grain package’, and the most promising ways for improving the nutritional quality of cereal products are discussed.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1017/s0954422410000041

Cites

1019 of 1019 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

1 retracted

Items 201–400 of 1,019

Research works printed but not linked: 27

  1. Bagheri, 1982, Bioavailability to rats of calcium, magnesium, phosphorus and zinc in wheat bran diets containing equal amounts of these minerals, Nutr Rep Int, 25, 583
  2. Mühlum, 1989, Precaecal and postileal digestion of sucrose, lactose, stachyose and raffinose, Adv Anim Physiol Anim Nutr, 19, 31
  3. Surget, 2005, Histologie du grain de blé (Histology of the wheat grain), Ind Cér, 145, 3
  4. Fallahi, 2005, Effect of consumption of whole bread baked from cultivated wheat with micronutrient fertilizers on blood indices of iron, J Food Agric Environ, 3, 39
  5. McCallum, 1990, Proanthocyanidins in wheat bran, Cereal Chem, 67, 282
  6. 1998, Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline
  7. Fretzdorff, 2003, Fructan and raffinose contents in cereals and pseudo-cereal grains, Getreide, Mehl und Brot, 57, 3
  8. Souci, 2000, Food Composition and Nutritional Tables
  9. Antoine, 2002, Nutritional interest of the wheat seed aleurone layer, Sci Alim, 22, 545
  10. 2001, Dietary Reference Intake for Vitamin A, Vitamin K, Arsenic, Baron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc
  11. Kies, 1984, Vitamin B6 availability from wheat, rice and corn brans for humans, Nutr Rep Int, 30, 483
  12. 2005, Lutein and zeaxanthin. Monograph, Altern Med Rev, 10, 128
  13. Colonna, 1995, Nutrition des ruminants domestiques. Ingestion et digestion (Nutrition of domestic ruminants. Ingestion and digestion)
  14. 10.1093/ajcn/10.2.158 · DOI
  15. 1998, Development of the Norwegian Diet
  16. 10.1079/BJN2002601 · DOI
  17. 1997, Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride
  18. Beattie, 2003, Evaluation of the in vivo antioxidant activity of wheat bran in human subjects, Proc Nutr Soc, 62, 17A
  19. Linko, 1960, Changes in the soluble carbohydrates during browning of wheat embryos, Cereal Chem, 37, 548
  20. Stringheta, 2006, Lutein: antioxidant properties and health benefits, Alimentos e Nutricao, 17, 229
  21. Lioger, 2006, Intérêt de la fermentation, en milieu très hydraté, des produits céréaliers riches en fibres pour améliorer leur valeur nutritionnelle (Interest of fibre-rich cereal products fermentation in very hydrated environment to improve their nutritional value), Ind Cér, 149, 14
  22. Martin, 2001, Apports nutritionnels conseillés pour la population française (Recommended Dietary Allowances for the French Population)
  23. Rettura, 1983, Dimethylbenz(a)anthracene (DMBA)-induced tumors: prevention by supplemental β-carotene (BC), Fed Proc, 42, 786
  24. Ishihara, 1982, Clinical effect of γ-oryzanol on climacteric disturbance - on serum lipid peroxides (article in Japanese), Nippon Sanka Fujinka Gakkai Zasshi, 34, 243
  25. 10.1016/S0753-3322(97)88045-6 · DOI · Paper page
  26. Keaney, 2002, Obesity as a source of systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study, Circulation, 106, 467
  27. Davis, 1981, Evaluation of the nutrient composition of wheat. 2. Proximate analysis, thiamin, riboflavin, niacin, and pyridoxine, Cereal Chem, 58, 116

Cited by

Sorted by citations

See all 1,030

Related

See all

Metadata

Authors
Fardet, A.
Affiliations
Unité de Nutrition Humaine (FR)
Corresponding author
Fardet, Anthony
ORCID
Fardet, Anthony
Venue
Nutrition Research Reviews
Publisher
Cambridge University Press (CUP)
Published
2010-06
Volume
23
Issue
1
Pages
65-134
ISSN
  • 0954-4224 (ISSN-L)
  • 1475-2700
DOI
10.1017/s0954422410000041
OpenAlex
W2167433110
Cited by
1,030
References
1,031
Citations by year
2026: 34 · 2025: 44 · 2024: 54 · 2023: 63 · 2022: 69 · 2021: 77 · 2020: 77 · 2019: 77 · 2018: 68 · 2017: 78 · 2016: 69 · 2015: 82 · 2014: 87 · 2013: 68 · 2012: 45
FWCI
5.39
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 21 d)
Locations
  • Nutrition Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Lunds Universitet
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
whole grain cereals, whole wheat, dietary fiber, magnesium, bioactive compounds, polyphenols, sulfur compounds, lignin, phytic acid, methyl donors, DNA methylation, prebiotics, oligosaccharides, bound phenolic acids, B vitamins, nutrigenomics, obesity, diabetes mellitus, cardiovascular disease, cancer prevention
MeSH terms
Antioxidants, Blood Glucose, Cardiovascular Diseases, Edible Grain, Diabetes Mellitus, Dietary Fiber, Flavonoids, Gastrointestinal Motility, Health Promotion, Humans, Lignin, Neoplasms, Obesity, Phenols, Phytic Acid, Satiation, Sulfur Compounds, Anticarcinogenic Agents, Butyric Acid, Polyphenols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review