Mesotocin and nonapeptide receptors promote estrildid flocking behavior
Open accessAbstract
Proximate neural mechanisms that influence preferences for groups of a given size are almost wholly unknown. In the highly gregarious zebra finch (Estrildidae: Taeniopygia guttata), blockade of nonapeptide receptors by an oxytocin (OT) antagonist significantly reduced time spent with large groups and familiar social partners independent of time spent in social contact. Opposing effects were produced by central infusions of mesotocin (MT, avian homolog of OT). Most drug effects appeared to be female-specific. Across five estrildid finch species, species-typical group size correlates with nonapeptide receptor distributions in the lateral septum, and sociality in female zebra finches was reduced by OT antagonist infusions into the septum but not a control area. We propose that titration of sociality by MT represents a phylogenetically deep framework for the evolution of OT's female-specific roles in pair bonding and maternal functions.
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Oxytocin receptor signaling influences several social behaviors in animals, including maternal care and bonding, social reward and gregariousness, social recognition, and pair bonding in monogamous species.
“OXTR affects a range of social behaviors in animals including maternal nurturing and bonding (1, 2), social reward and gregariousness (3, 4), social recognition (5), and pair bonding in monogamous species (6–8).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [4]
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- Authors
- Goodson, J. L., Schrock, S. E., Klatt, J. D., Kabelik, D., & Kingsbury, M. A.
- Affiliations
- Indiana University Bloomington (US)
- Corresponding author
- Goodson, James L.
- Venue
- Science
- Published
- 2009-08-14
- Volume
- 325
- Issue
- 5942
- Pages
- 862-866
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2862247
- OpenAlex
- W2049578724
- Cited by
- 241
- References
- 30
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 10 · 2021: 16 · 2020: 7 · 2019: 19 · 2018: 9 · 2017: 18 · 2016: 24 · 2015: 14 · 2014: 23 · 2013: 15 · 2012: 18
- FWCI
- 20.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH062656, R01MH062656)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- mesotocin, oxytocin, zebra finch, Estrildidae, flocking, lateral septum, sociality, female social behavior, pair bonding, maternal behavior, evolution of social behavior
- MeSH terms
- Animals, Behavior, Animal, Binding Sites, Female, Male, Ornipressin, Oxytocin, Sex Characteristics, Social Behavior, Species Specificity, Vasotocin, Prosencephalon, Receptors, Neuropeptide, Receptors, Oxytocin, Septum of Brain, Finches
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