Behavioral epigenetics and the developmental origins of child mental health disorders
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Advances in understanding the molecular basis of behavior through epigenetic mechanisms could help explain the developmental origins of child mental health disorders. However, the application of epigenetic principles to the study of human behavior is a relatively new endeavor. In this paper we discuss the 'Developmental Origins of Health and Disease' including the role of fetal programming. We then review epigenetic principles related to fetal programming and the recent application of epigenetics to behavior. We focus on the neuroendocrine system and develop a simple heuristic stress-related model to illustrate how epigenetic changes in placental genes could predispose the infant to neurobehavioral profiles that interact with postnatal environmental factors potentially leading to mental health disorders. We then discuss from an 'Evo-Devo' perspective how some of these behaviors could also be adaptive. We suggest how elucidation of these mechanisms can help to better define risk and protective factors and populations at risk.
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Mental health disorders are linked in different ways and levels, exerting a dimensional effect between environmental, genetic factors and other biological mechanisms.
“Mental health disorders are linked in different ways and levels, exerting a dimensional effect between environmental, genetic factors and other biological mechanisms [55], [56], [57].”
From Interventions for Adolescent Mental Health: An Overview of Systematic Reviews (2016) · cites this paper as [56]
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Interventions for Adolescent Mental Health: An Overview of Systematic Reviews
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- Authors
- Lester, B. M., Marsit, C. J., Conradt, E., Bromer, C., & Padbury, J. F.
- Affiliations
- Brown University (US)
- Dartmouth College (US)
- Corresponding author
- Lester, B. M.
- Venue
- Journal of Developmental Origins of Health and Disease
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-07-03
- Volume
- 3
- Issue
- 6
- Pages
- 395-408
- ISSN
- 2040-1744 (ISSN-L)
- 2040-1752
- PMC
- PMC12787317
- OpenAlex
- W2039284296
- Cited by
- 48
- References
- 163
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 5 · 2013: 4 · 2012: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Locations
- Journal of Developmental Origins of Health and Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH094609)
- National Institute on Drug Abuse (F32DA032175)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- behavioral epigenetics, developmental origins of health and disease, fetal programming, child psychopathology, neuroendocrine system, stress response, evolutionary developmental biology, risk and protective factors
- MeSH terms
- Mental Disorders, Child, Humans, Neurosecretory Systems, Polymorphism, Single Nucleotide, 11-beta-Hydroxysteroid Dehydrogenase Type 2, Epigenesis, Genetic, Fetal Development
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