Coupling Capillary Zone Electrophoresis with Electron Transfer Dissociation and Activated Ion Electron Transfer Dissociation for Top-Down Proteomics

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Top Down proteomics: Facts and perspectives

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Performance Characteristics of Electron Transfer Dissociation Mass Spectrometry

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Protein identification using sequential ion/ion reactions and tandem mass spectrometry

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Supplemental Activation Method for High-Efficiency Electron-Transfer Dissociation of Doubly Protonated Peptide Precursors

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Iron, mycobacteria and tuberculosis

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Activated Ion Electron Capture Dissociation for Mass Spectral Sequencing of Larger (42 kDa) Proteins

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Extending Top-Down Mass Spectrometry to Proteins with Masses Greater Than 200 Kilodaltons

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Simplified capillary electrophoresis nanospray sheath‐flow interface for high efficiency and sensitive peptide analysis

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C-Terminal Signal Sequence Promotes Virulence Factor Secretion in Mycobacterium tuberculosis

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Top‐down proteomics in health and disease: Challenges and opportunities

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Ultrasensitive and Fast Bottom‐up Analysis of Femtogram Amounts of Complex Proteome Digests

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Capillary electrophoresis–mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: An update of recent developments

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Probing proteomes using capillary isoelectric focusing-electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.

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The Matrix Suppression Effect and Ionization Mechanisms in Matrix-assisted Laser Desorption/Ionization

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Implementation of Electron-Transfer Dissociation on a Hybrid Linear Ion Trap−Orbitrap Mass Spectrometer

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Deconvolution and Database Search of Complex Tandem Mass Spectra of Intact Proteins

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Protein Identification Using Top-Down Spectra

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ESX‐1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria

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Low-Flow Sheathless Capillary Electrophoresis–Mass Spectrometry for Sensitive Glycoform Profiling of Intact Pharmaceutical Proteins

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Capillary Zone Electrophoresis-Electrospray Ionization-Tandem Mass Spectrometry as an Alternative Proteomics Platform to Ultraperformance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry for Samples of Intermediate Complexity

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Infrared Photoactivation Reduces Peptide Folding and Hydrogen‐Atom Migration following ETD Tandem Mass Spectrometry

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Optimizing capillary electrophoresis for top‐down proteomics of 30–80 kDa proteins

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Sequence analysis of polypeptides by collision activated dissociation on a triple quadrupole mass spectrometer

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Mycobacterium tuberculosis Lsr2 Is a Global Transcriptional Regulator Required for Adaptation to Changing Oxygen Levels and Virulence

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Over 10 000 Peptide Identifications from the HeLa Proteome by Using Single‐Shot Capillary Zone Electrophoresis Combined with Tandem Mass Spectrometry

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Structural characterization of holo- and apo-myoglobin in the gas phase by ultraviolet photodissociation mass spectrometry

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Activated Ion Electron Transfer Dissociation for Improved Fragmentation of Intact Proteins

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Sheathless Capillary Electrophoresis-Tandem Mass Spectrometry for Top-Down Characterization of <i>Pyrococcus furiosus</i> Proteins on a Proteome Scale

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Activated-Ion Electron Transfer Dissociation Improves the Ability of Electron Transfer Dissociation to Identify Peptides in a Complex Mixture

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Analyzing Protein Micro-Heterogeneity in Chicken Ovalbumin by High-Resolution Native Mass Spectrometry Exposes Qualitatively and Semi-Quantitatively 59 Proteoforms

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Fast Top-Down Intact Protein Characterization with Capillary Zone Electrophoresis–Electrospray Ionization Tandem Mass Spectrometry

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Activation of Intact Electron-Transfer Products of Polypeptides and Proteins in Cation Transmission Mode Ion/Ion Reactions

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Capillary Zone Electrophoresis–Electrospray Ionization-Tandem Mass Spectrometry for Top-Down Characterization of the <i>Mycobacterium marinum</i> Secretome

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Quantitative Multiple Reaction Monitoring of Peptide Abundance Introduced via a Capillary Zone Electrophoresis–Electrospray Interface

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Activated ion electron capture dissociation (AI ECD) of proteins: Synchronization of infrared and electron irradiation with ion magnetron motion

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Electron capture and transfer dissociation: Peptide structure analysis at different ion internal energy levels

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A Novel ESX-1 Locus Reveals that Surface-Associated ESX-1 Substrates Mediate Virulence in Mycobacterium marinum

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Characterization of proteins from Spirulina platensis microalga using capillary electrophoresis‐ion trap‐mass spectrometry and capillary electrophoresis‐time of flight‐mass spectrometry

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Capillary zone electrophoresis for analysis of complex proteomes using an electrokinetically pumped sheath flow nanospray interface

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Bottom‐up proteome analysis of E . coli using capillary zone electrophoresis‐tandem mass spectrometry with an electrokinetic sheath‐flow electrospray interface

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CZE ‐ ESI ‐ MS / MS system for analysis of subnanogram amounts of tryptic digests of a cellular homogenate

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A Variety of Activation Methods Employed in “Activated-Ion” Electron Capture Dissociation Mass Spectrometry: A Test against Bovine Ubiquitin 7+ Ions

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Activated Ion ETD Performed in a Modified Collision Cell on a Hybrid QLT-Oribtrap Mass Spectrometer

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Accurate Determination of Peptide Phosphorylation Stoichiometry Via Automated Diagonal Capillary Electrophoresis Coupled with Mass Spectrometry: Proof of Principle

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Beam‐type collisional activation of polypeptide cations that survive ion/ion electron transfer

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Coupling immobilized alkaline phosphatase-based automated diagonal capillary electrophoresis to tandem mass spectrometry for phosphopeptide analysis

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Progress in Top-Down Proteomics and the Analysis of Proteoforms

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Ion Activation Methods for Peptides and Proteins

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Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis

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Top-Down Proteomics: Ready for Prime Time?

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The Role of Electron Transfer Dissociation in Modern Proteomics

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Recent developments in capillary and microchip electroseparations of peptides (2011–2013)

Kašička, V. (2013) · Electrophoresis · doi:10.1002/elps.201300331 · Cited by 130 · see citing works

Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research

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Recent advances in CE‐MS coupling: Instrumentation, methodology, and applications

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Capillary zone electrophoresis-mass spectrometry for top-down proteomics

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Middle-down approach: a choice to sequence and characterize proteins/proteomes by mass spectrometry

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Activated Ion Electron Transfer Dissociation for Improved Fragmentation of Intact Proteins

Riley, N. M., Westphall, M. S., & Coon, J. J. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00881 · Cited by 80 · see citing works

Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics

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Recent developments and applications of capillary and microchip electrophoresis in proteomic and peptidomic analyses

Štěpánová, S., & Kašička, V. (2015) · Journal of Separation Science · doi:10.1002/jssc.201500973 · Cited by 70 · see citing works

Sequencing Larger Intact Proteins (30–70 kDa) with Activated Ion Electron Transfer Dissociation

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Recent developments in capillary and microchip electroseparations of peptides (2013–middle 2015)

Kašička, V. (2015) · Electrophoresis · doi:10.1002/elps.201500329 · Cited by 68 · see citing works

Coupling Capillary Zone Electrophoresis to a Q Exactive HF Mass Spectrometer for Top-down Proteomics: 580 Proteoform Identifications from Yeast

Zhao, Y., Sun, L., Zhu, G., & Dovichi, N. J. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00493 · Cited by 61 · see citing works

The Negative Mode Proteome with Activated Ion Negative Electron Transfer Dissociation (AI-NETD)

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Enhanced Dissociation of Intact Proteins with High Capacity Electron Transfer Dissociation

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Applications of capillary electrophoresis for biopharmaceutical product characterization

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Tapered-Tip Capillary Electrophoresis Nano-Electrospray Ionization Mass Spectrometry for Ultrasensitive Proteomics: the Mouse Cortex

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Phosphoproteomics with Activated Ion Electron Transfer Dissociation

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Recent developments and applications of capillary and microchip electrophoresis in proteomics and peptidomics (2015–mid 2018)

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Characterization of cetuximab Fc/2 dimers by off-line CZE-MS

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Dynamic pH junction preconcentration in capillary electrophoresis- electrospray ionization-mass spectrometry for proteomics analysis

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Recent developments in capillary and microchip electroseparations of peptides (2015–mid 2017)

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Fast separation and analysis of reduced monoclonal antibodies with capillary zone electrophoresis coupled to mass spectrometry

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Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis

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The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins

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Top-down and middle-down approach by fraction collection enrichment using off-line capillary electrophoresis – mass spectrometry coupling: Application to monoclonal antibody F c/2 charge variants

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Evaluation of a commercial electro-kinetically pumped sheath-flow nanospray interface coupled to an automated capillary zone electrophoresis system

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Capillary Zone Electrophoresis-Tandem Mass Spectrometry with Activated Ion Electron Transfer Dissociation for Large-scale Top-down Proteomics

McCool, E. N., Lodge, J. M., Basharat, A. R., Liu, X., Coon, J. J., & Sun, L. (2019) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-019-02206-6 · Cited by 28 · see citing works

Pressure‐assisted capillary electrophoresis frontal analysis for faster binding constant determination

Qian, C., Wang, S., Fu, H., Turner, R. F. B., Li, H., & Chen, D. D. Y. (2018) · Electrophoresis · doi:10.1002/elps.201800049 · Cited by 19 · see citing works

High-Throughput Mass Spectrometry Screening Platform for Discovering New Chemical Reactions under Uncatalyzed, Solvent-Free Experimental Conditions

Kulyk, D. S., Amoah, E., & Badu-Tawiah, A. K. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c02960 · Cited by 17 · see citing works

An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in Mycobacterium marinum

Collars, O. A., Jones, B. S., Hu, D. D., Weaver, S. D., Sherman, T. A., Champion, M. M., & Champion, P. A. D. (2023) · mBio · doi:10.1128/mbio.00987-23 · Cited by 18 · see citing works

Capillary Zone Electrophoresis as A Tool for Bottom-Up Protein Analysis

Wojcik, R., Zhu, G., Zhang, Z., Yan, X., Zhao, Y., Sun, L., Champion, M. M., & Dovic̀hi, N. J. (2015) · Bioanalysis · doi:10.4155/bio.15.227 · Cited by 16 · see citing works

CE-MS for Proteomics and Intact Protein Analysis

Kuzyk, V., Somsen, G. W., & Haselberg, R. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-77252-9_4 · Cited by 15 · see citing works

Probing protein higher-order structures by native capillary electrophoresis-mass spectrometry

Zhang, W., Xiang, Y., & Xu, W. L. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116739 · Cited by 14 · see citing works

Analytical strategies used to identify the readers of histone modifications: A review

Wang, Y., Han, Y., Fan, E., & Zhang, K. (2015) · Analytica Chimica Acta · doi:10.1016/j.aca.2015.06.049 · Cited by 14 · see citing works

Ultraviolet Photodissociation of ESI- and MALDI-Generated Protein Ions on a Q-Exactive Mass Spectrometer

Dilillo, M., de Graaf, E. L., Yadav, A., Belov, M. E., & McDonnell, L. A. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00896 · Cited by 13 · see citing works

Oncoproteomics: Trials and tribulations

Zhou, L., Li, Q., Wang, J., Huang, C., & Nice, E. C. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500081 · Cited by 13 · see citing works

Top‐down and bottom‐up characterization of nitrated birch pollen allergen Bet v 1a with CZE hyphenated to an Orbitrap mass spectrometer

Gusenkov, S., & Stutz, H. (2018) · Electrophoresis · doi:10.1002/elps.201700413 · Cited by 12 · see citing works

Top-down proteomic analysis of monoclonal antibodies by capillary zone electrophoresis-mass spectrometry

Nagy, C., Andrási, M., Hamidli, N., Gyémánt, G., & Gáspár, A. (2021) · Journal of Chromatography Open · doi:10.1016/j.jcoa.2021.100024 · Cited by 12 · see citing works

Capillary Isoelectric Focusing of Proteins and Peptides Using an In-Line cIEF-ESI Interface with Improved MS Characteristics

Kerr, C. M., Schneider, O. L., Tichy, S. E., Huge, B. J., & Champion, M. M. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c05010 · Cited by 10 · see citing works

CE-MS for the analysis of intact proteins

Haselberg, R., & Somsen, G. W. (2016) · Wiley-VCH eBooks · doi:10.1002/9783527693801.ch7 · Cited by 10 · see citing works

Enhanced Separation of Intact Proteins and Proteoforms by CZE‐MS Using Sulfobetaine‐Modified Poly(α‐L‐lysine)‐Based Multilayer Coatings for EOF Adjustment

Höchsmann, A., Frick, H., Dhellemmes, L., Leclercq, L., Kaulich, P. T., Tholey, A., Cottet, H., Schaschke, N., & Neusüß, C. (2025) · PROTEOMICS · doi:10.1002/pmic.70012 · Cited by 8 · see citing works

Broadband ion mobility deconvolution for rapid analysis of complex mixtures

Pettit, M. E., Brantley, M. R., Donnarumma, F., Murray, K. K., & Solouki, T. (2018) · The Analyst · doi:10.1039/c8an00193f · Cited by 9 · see citing works

Coupling of Capillary Electromigration Techniques to Mass Spectrometry

Neusüß, C., Römer, J., Höcker, O., & Jooß, K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809375-7.00012-5 · Cited by 9 · see citing works

Electrospray Ionization Interface Development for Capillary Electrophoresis-Mass Spectrometry

Risley, J. M., Jong, C. A. G. D., & Chen, D. D. Y. (2016) · Wiley-VCH eBooks · doi:10.1002/9783527693801.ch2 · Cited by 6 · see citing works

Online protein digestion in membranes between capillary electrophoresis and mass spectrometry

Ryan, K. A., & Bruening, M. L. (2023) · The Analyst · doi:10.1039/d3an00106g · Cited by 6 · see citing works

An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.Preprint

Collars, O. A., Jones, B. S., Hu, D. D., Weaver, S. D., Champion, M. M., & Champion, P. A. D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.14.532585 · Cited by 5 · see citing works

Capillary Electrophoresis–Mass Spectrometry (CE-MS) by Sheath–Flow Nanospray Interface and Its Use in Biopharmaceutical Applications

Han, M., Smith, R., & Rock, D. A. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2493-7_2 · Cited by 2 · see citing works

Identity verification of monoclonal antibodies by triple injection capillary zone electrophoresis

Carlsson, J., Löfgren, M., & Amini, A. (2024) · Journal of Separation Science · doi:10.1002/jssc.202400092 · Cited by 2 · see citing works

Characterization of Intact Therapeutics and Protein Subunits Using CE-MS Platform

Wang, W. (2016) · Springer eBooks · doi:10.1007/978-3-319-46240-0_7

Capillary Zone Electrophoresis–Mass Spectrometry for Top‐Down Proteomics: Technological Development and Biological Applications

Sun, L. (2022) · Capillary Electrophoresis‐Mass Spectrometry for Proteomics and Metabolomics · doi:10.1002/9783527833092.ch10

Characterization of therapeutic proteins by capillary electrophoresis (CE) coupled to mass spectrometry (MS)

Saïd, N. (2017) · doi:10.70675/a41cd9b1z5c4dz4d60z84fdz2821afe2e277

Capillary Zone Electrophoresis-Tandem Mass Spectrometry with Activated Ion Electron Transfer Dissociation for Large-scale Top-down Proteomics

McCool, E. N., Lodge, J. M., Basharat, A. R., Liu, X., Coon, J. J., & Sun, L. (2019) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-019-02206-6 · Cited by 28 · see citing works

Capillary Zone Electrophoresis-Electron-Capture Collision-Induced Dissociation on a Quadrupole Time-of-Flight Mass Spectrometer for Top-Down Characterization of Intact Proteins

Shen, X., Xu, T., Hakkila, B., Hare, M. G., Wang, Q., Wang, Q., Beckman, J. S., & Sun, L. (2021) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.0c00484 · Cited by 22 · see citing works

Top-Down Proteomics Using Sheath-Flow Capillary Electrophoresis Coupled to Mass Spectrometry

Zhao, Y. (2022) · Figshare · doi:10.7274/3r074t66h2p

The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins

Riley, N. M., Sikora, J. W., Seckler, H. S., Greer, J. B., Fellers, R. T., LeDuc, R. D., Westphall, M. S., Thomas, P. M., Kelleher, N. L., & Coon, J. J. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01638 · Cited by 43 · see citing works

Top-Down Proteomics by Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Characterization of Proteoforms in Complex Samples

McCool, E. N., Lubeckyj, R. A., Chen, D., & Sun, L. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2493-7_8 · Cited by 5 · see citing works