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Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect
Abstract
An ideal cancer therapeutic strategy is expected to possess potent ability to not only ablate primary tumors but also prevent distance metastasis and relapse. In this study, human serum albumin was hybridized with hemoglobin by intermolecular disulfide bonds to develop a hybrid protein oxygen nanocarrier with chlorine e6 encapsulated (C@HPOC) for oxygen self-sufficient photodynamic therapy (PDT). C@HPOC realized the tumor-targeted co-delivery of photosensitizer and oxygen, which remarkably relieved tumor hypoxia. C@HPOC was favorable for more efficient PDT and enhanced infiltration of CD8 + T cells in tumors. Moreover, oxygen-boosted PDT of C@HPOC induced immunogenic cell death, with the release of danger-associated molecular patterns to activate dendritic cells, T lymphocytes, and natural killer cells in vivo . Notably, C@HPOC-mediated immunogenic PDT could destroy primary tumors and effectively suppress distant tumors and lung metastasis in a metastatic triple-negative breast cancer model by evoking systemic anti-tumor immunity. This study provides a paradigm of oxygen-augmented immunogenic PDT for metastatic cancer treatment.
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Citations
Cites
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145
Immunogenic Cell Death in Cancer Therapy
Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303
Immunogenic cell death and DAMPs in cancer therapy
Krysko, D. V., Garg, A. D., Kaczmarek, A., Krysko, O., Agostinis, P., & Vandenabeele, P. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3380 · Cited by 3,223
Immunogenic cell death in cancer and infectious disease
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119
Nanoparticles in Photodynamic Therapy
Lucky, S. S., Soo, K. C., & Zhang, Y. (2015) · Chemical Reviews · doi:10.1021/cr5004198 · Cited by 2,980
Cancer immunotherapy: moving beyond current vaccines
Rosenberg, S. A., Yang, J. C., & Restifo, N. P. (2004) · Nature Medicine · doi:10.1038/nm1100 · Cited by 2,972
Photodynamic therapy and anti-tumour immunity
Castano, A. P., Mroz, P., & Hamblin, M. R. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1894 · Cited by 2,676
Tumor metastasis: mechanistic insights and clinical challenges
Steeg, P. S. (2006) · Nature Medicine · doi:10.1038/nm1469 · Cited by 2,134
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
Zhou, Z., Song, J., Nie, L., & Chen, X. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00271d · Cited by 2,098
Overcoming the Achilles' heel of photodynamic therapy
Fan, W., Huang, P., & Chen, X. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00616g · Cited by 1,684
Combining immunotherapy and targeted therapies in cancer treatment
Vanneman, M., & Dranoff, G. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3237 · Cited by 1,586
Yang, G., Xu, L., Chao, Y., Xu, J., Sun, X., Wu, Y., Peng, R., & Liu, Z. (2017) · Nature Communications · doi:10.1038/s41467-017-01050-0 · Cited by 1,477
Gardai, S. J., McPhillips, K. A., Frasch, S. C., Janssen, W. J., Starefeldt, A., Murphy-Ullrich, J. E., Bratton, D. L., Oldenborg, P.-A., Michalak, M., & Henson, P. M. (2005) · Cell · doi:10.1016/j.cell.2005.08.032 · Cited by 1,473
Rankin, E. B., & Giaccia, A. J. (2016) · Science · doi:10.1126/science.aaf4405 · Cited by 1,340
Treating metastatic cancer with nanotechnology
Schroeder, A., Heller, D. A., Winslow, M. M., Dahlman, J. E., Pratt, G. W., Langer, R., Jacks, T., & Anderson, D. G. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3180 · Cited by 1,159
Cheng, Y., Cheng, H., Jiang, C., Qiu, X., Wang, K., Huan, W., Yuan, A., Wu, J., & Hu, Y. (2015) · Nature Communications · doi:10.1038/ncomms9785 · Cited by 941
A STING-activating nanovaccine for cancer immunotherapy
Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., et al. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.52 · Cited by 900
Self-citationZitvogel, L., Galluzzi, L., Smyth, M. J., & Kroemer, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.014 · Cited by 870
Nanozyme Decorated Metal–Organic Frameworks for Enhanced Photodynamic Therapy
Zhang, Y., Wang, F., Liu, C., Wang, Z., Kang, L., Huang, Y., Dong, K., Ren, J., & Qu, X. (2018) · ACS Nano · doi:10.1021/acsnano.7b07746 · Cited by 854
Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer
O'Shaughnessy, J., Osborne, C., Pippen, J. E., Yoffe, M., Patt, D., Rocha, C., Koo, I. C., Sherman, B. M., & Bradley, C. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011418 · Cited by 817
Kim, J., Cho, H. R., Jeon, H., Kim, D., Song, C., Lee, N., Choi, S. H., & Hyeon, T. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b05559 · Cited by 707
Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy
Min, Y., Roche, K. C., Tian, S., Eblan, M. J., McKinnon, K. P., Caster, J. M., Chai, S., Herring, L. E., Zhang, L., Zhang, T., et al. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.113 · Cited by 701
Xu, J., Xu, L., Wang, C., Yang, R., Zhuang, Q., Han, X., Dong, Z., Zhu, W., Peng, R., & Liu, Z. (2017) · ACS Nano · doi:10.1021/acsnano.7b00715 · Cited by 695
Fan, W., Bu, W., Shen, B., He, Q., Cui, Z., Liu, Y., Zheng, X., Zhao, K., & Shi, J. (2015) · Advanced Materials · doi:10.1002/adma.201405141 · Cited by 665
Immunological mechanisms of the antitumor effects of supplemental oxygenation
Hatfield, S. M., Kjaergaard, J., Lukashev, D., Schreiber, T. H., Belikoff, B., Abbott, R., Sethumadhavan, S., Philbrook, P., Ko, K., Cannici, R., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa1260 · Cited by 600
Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines
Melief, C. J. M., & van der Burg, S. H. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2373 · Cited by 594
Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4′-dithiodipyridine
Riener, C. K., Kada, G., & Gruber, H. J. (2002) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-002-1347-2 · Cited by 564
Lin, T., Zhao, P., Jiang, Y., Tang, Y., Jin, H., Pan, Z., He, H., Yang, V. C., & Huang, Y. (2016) · ACS Nano · doi:10.1021/acsnano.6b04268 · Cited by 527
Self-citationLing, D., Park, W., Park, S.-J., Lu, Y., Kim, K. S., Hackett, M. J., Kim, B. H., Yim, H., Jeon, Y. S., Na, K., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4108287 · Cited by 517
Lu, K., He, C., Guo, N., Chan, C., Ni, K., Weichselbaum, R. R., & Lin, W. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b06663 · Cited by 505
In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer
Lizotte, P. H., Wen, A. M., Sheen, M. R., Fields, J., Rojanasopondist, P., Steinmetz, N. F., & Fiering, S. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2015.292 · Cited by 485
Duan, X., Chan, C., Guo, N., Han, W., Weichselbaum, R. R., & Lin, W. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b09538 · Cited by 458
Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer
Chouaib, S., Noman, M. Z., Kosmatopoulos, K., & Curran, M. A. (2017) · Oncogene · doi:10.1038/onc.2016.225 · Cited by 365
An O2 Self‐Sufficient Biomimetic Nanoplatform for Highly Specific and Efficient Photodynamic Therapy
Cheng, H., Zhu, J., Li, S., Zeng, J., Lei, Q., Chen, K., Zhang, C., & Zhang, X. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201603212 · Cited by 335
Albumin Carriers for Cancer Theranostics: A Conventional Platform with New Promise
Chen, Q., & Liu, Z. (2016) · Advanced Materials · doi:10.1002/adma.201600038 · Cited by 290
Song, Q., Yin, Y., Shang, L., Wu, T., Zhang, D., Kong, M., Zhao, Y., He, Y., Tan, S., Guo, Y., et al. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03186 · Cited by 254
Cancer Cell Membrane‐Biomimetic Oxygen Nanocarrier for Breaking Hypoxia‐Induced Chemoresistance
Tian, H., Luo, Z., Liu, L., Zheng, M., Chen, Z., Ma, A., Liang, R., Han, Z., Lu, C., & Cai, L. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201703197 · Cited by 243
Self-citationLiu, L., Zhang, Y., Qiu, W., Zhang, L., Gao, F., Li, B., Xu, L., Fan, J., Li, Z., & Zhang, X. (2017) · Small · doi:10.1002/smll.201701621 · Cited by 240
Self-citationDanger signalling during cancer cell death: origins, plasticity and regulation
Garg, A. D., Martin, S., Golab, J., & Agostinis, P. (2014) · Cell Death & Differentiation · doi:10.1038/cdd.2013.48 · Cited by 226
Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy
Adkins, I., Fucikova, J., Garg, A. D., Agostinis, P., & Špíšek, R. (2014) · OncoImmunology · doi:10.4161/21624011.2014.968434 · Cited by 200
Hemoglobin‐Based Nanoarchitectonic Assemblies as Oxygen Carriers
Jia, Y., Duan, L., & Li, J. (2016) · Advanced Materials · doi:10.1002/adma.201502581 · Cited by 186
Li, F., Park, S.-J., Ling, D., Park, W., Han, J. Y., Na, K., & Char, K. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb00506b · Cited by 173
Hu, D., Sheng, Z., Gao, G., Siu, F., Liu, C., Wan, Q., Gong, P., Zheng, H., Ma, Y., & Cai, L. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.037 · Cited by 161
Self-citationWang, S., Fang, Y., Chen, K., Chen, G., Tu, K., Wang, H., & Wang, L. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00571 · Cited by 139
In vivo albumin labeling and lymphatic imaging
Wang, Y., Lang, L., Huang, P., Wang, Z., Jacobson, O., Kiesewetter, D. O., Ali, I., Teng, G., Niu, G., & Chen, X. S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414821112 · Cited by 100
Protein-based photothermal theranostics for imaging-guided cancer therapy
Rong, P., Huang, P., Liu, Z., Lin, J., Jin, A. J., Ma, Y., Niu, G., Yu, L., Zeng, W., Wang, W., et al. (2015) · Nanoscale · doi:10.1039/c5nr04428f · Cited by 86
Self-citationYang, Y., Hu, Y., & Wang, H. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5274084 · Cited by 79
Nanoparticle-based Strategies for Cancer Immunotherapy and Immunodiagnostics
Grimaldi, A., Incoronato, M., Salvatore, M., & Soricelli, A. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0208 · Cited by 68
Immunochemotherapy mediated by thermosponge nanoparticles for synergistic anti-tumor effects
Zhao, Y., Song, Q., Yin, Y., Wu, T., Hu, X., Gao, X., Gao, L., Tan, S., & Zhang, Z. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.11.037 · Cited by 59
Ling, D., Bae, B.-C., Park, W., & Na, K. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.04.023 · Cited by 50
Liu, L., Yi, H., Wang, C., He, H., Li, P., Pan, H., Sheng, N., Ji, M., Cai, L., & Ma, Y. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600182 · Cited by 45
Self-citationToward Personalized Peptide-Based Cancer Nanovaccines: A Facile and Versatile Synthetic Approach
Kakwere, H., Ingham, E. S., Allen, R. P., Mahakian, L. M., Tam, S. M., Zhang, H., Silvestrini, M. T., Lewis, J. S., & Ferrara, K. W. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00502 · Cited by 44
Zhao, P., Zheng, M., Luo, Z., Fan, X., Sheng, Z., Gong, P., Chen, Z., Zhang, B., Ni, D., Ma, Y., et al. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600121 · Cited by 43
Self-citationLeone, R. D., Horton, M. R., & Powell, J. D. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.03.014 · Cited by 42
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Cancer nanomedicine for combination cancer immunotherapy
Nam, J., Son, S., Park, K. S., Zou, W., Shea, L. D., & Moon, J. J. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0108-1 · Cited by 940
Immunogenic cell death in cancer therapy: Present and emerging inducers
Zhou, J., Wang, G., Chen, Y., Wang, H., Hua, Y., & Cai, Z. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14356 · Cited by 719
Conquering the Hypoxia Limitation for Photodynamic Therapy
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202103978 · Cited by 705
Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future
Alzeibak, R., Mishchenko, T. A., Shilyagina, N. Y., Balalaeva, I. V., Vedunova, M. V., & Krysko, D. V. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001926 · Cited by 565
Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy
Ji, B., Wei, M., & Yang, B. (2022) · Theranostics · doi:10.7150/thno.67300 · Cited by 544
Metadata
- Authors
- Chen, Z., Liu, L., Liang, R., Luo, Z., He, H., Wu, Z., Tian, H., Zheng, M., Ma, Y., & Cai, L.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-07-13
- Volume
- 12
- Issue
- 8
- Pages
- 8633-8645
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2884664246
- Cited by
- 363
- References
- 54
- FWCI
- 16.14
- Type
- journal article
- Language
- en
- Open access
- closed
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