Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles
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Abstract
Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-aggregation offers a means to transform stable, near-infrared (NIR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that hollow mesoporous silica nanoparticles (HMSNs) can template the J-aggregation of NIR fluorophore IR-140 to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging in vivo with 980 nm excitation.
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IR-140 formed J-aggregates by loading the molecules into 85 nm hollow mesoporous silica nanoparticles.
“NIR cyanine fluorophore IR-140 formed J-aggregates by loading the molecules into 85 nm size hollow mesoporous silica nanoparticles (Figure 4c).114”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [114]
Silica particles contain negatively charged pores that help to associate with the cationic IR-140 molecules.
“Silica particles contain negatively charged pores that help to associate with the cationic IR-140 molecules.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [114]
IR-140 J-aggregates displayed a red shift of the absorption spectra from 826 nm in the monomer form to 1040 nm in the J-aggregates.
“The formed J-aggregates displayed a red shift of the absorption spectra (from 826 nm in the monomer form to 1040 nm in the J-aggregates).”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [114]
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- Authors
- Chen, W., Cheng, C.-A., Cosco, E. D., Ramakrishnan, S., Lingg, J. G. P., Bruns, O. T., Zink, J. I., & Sletten, E. M.
- Affiliations
- California NanoSystems Institute (US)
- University of California, Los Angeles (US)
- Helmholtz Munich (DE)
- Helmholtz Pioneer Campus, Helmholtz Zentrum München, D-85764 Neuherberg, Germany
- Corresponding author
- Zink, Jeffrey I.
- Sletten, Ellen M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-07-27
- Volume
- 141
- Issue
- 32
- Pages
- 12475-12480
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- PMC
- PMC6746239
- OpenAlex
- W2965950773
- Cited by
- 202
- References
- 73
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 31 · 2023: 30 · 2022: 37 · 2021: 28 · 2020: 28 · 2019: 6
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Journal of the American Chemical Society (publishedVersion)
- ChemRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Royal College of Surgeons in Ireland (submittedVersion, cc-by-nc-nd)
- Site cant be reached (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- University of California, Los Angeles
- Division of Graduate Education (DGE-1144087)
- Deutsche Forschungsgemeinschaft (5355/2-1)
- Alfred P. Sloan Foundation (FG-2018-10855)
- National Institute of Biomedical Imaging and Bioengineering (1R01EB027172-01)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- short-wave infrared imaging, J-aggregates, hollow mesoporous silica nanoparticles, near-infrared fluorophores, PEGylation, in vivo imaging, nanomaterial stability
- MeSH terms
- Animals, Contrast Media, Drug Stability, Infrared Rays, Mice, Nude, Polyethylene Glycols, Silicon Dioxide, Benzothiazoles, Nanoparticles, Optical Imaging
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