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Cited by 473

The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.

Extracellularly Activated Nanocarriers: A New Paradigm of Tumor Targeted Drug Delivery

Open access
Gullotti, Emily, Yeo, Yoon·2009·Molecular Pharmaceutics
DOI 10.1021/mp900090z
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Abstract

One of the main goals of nanomedicine is to develop a nanocarrier that can selectively deliver anticancer drugs to the targeted tumors. Extensive efforts have resulted in several tumor-targeted nanocarriers, some of which are approved for clinical use. Most nanocarriers achieve tumor-selective accumulation through the enhanced permeability and retention effect. Targeting molecules such as antibodies, peptides, ligands, or nucleic acids attached to the nanocarriers further enhance their recognition and internalization by the target tissues. While both the stealth and targeting features are important for effective and selective drug delivery to the tumors, achieving both features simultaneously is often found to be difficult. Some of the recent targeting strategies have the potential to overcome this challenge. These strategies utilize the unique extracellular environment of tumors to change the long-circulating nanocarriers to release the drug or interact with cells in a tumor-specific manner. This review discusses the new targeting strategies with recent examples, which utilize the environmental stimuli to activate the nanocarriers. Traditional strategies for tumor-targeted nanocarriers are briefly discussed with an emphasis on their achievements and challenges.

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Metadata

Authors
Gullotti, E., & Yeo, Y.
Venue
Molecular Pharmaceutics
Publisher
American Chemical Society (ACS)
Published
2009-05-01
Volume
6
Issue
4
Pages
1041-1051
ISSN
  • 1543-8384 (ISSN-L)
  • 1543-8392
DOI
10.1021/mp900090z
OpenAlex
W1978267970
Cited by
473
References
109
FWCI
14.77
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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