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Cited by 319

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The Footprints of Gut Microbial–Mammalian Co-Metabolism

Zheng, Xiaojiao, Xie, Guoxiang, Zhao, Aihua, Zhao, Linjing, Yao, Chun, Chiu, Norman H. L., Zhou, Zhanxiang, Bao, Yuqian, Jia, Weiping, Nicholson, Jeremy K., Jia, Wei·2011·Journal of Proteome Research
DOI 10.1021/pr2007945
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Abstract

Gut microbiota are associated with essential various biological functions in humans through a "network" of microbial-host co-metabolism to process nutrients and drugs and modulate the activities of multiple pathways in organ systems that are linked to different diseases. The microbiome impacts strongly on the metabolic phenotypes of the host, and hence, metabolic readouts can give insights into functional metagenomic activity. We applied an untargeted mass spectrometry (MS) based metabonomics approach to profile normal Wistar rats exposed to a broad spectrum β-lactam antibiotic imipenem/cilastatin sodium, at 50 mg/kg/daily for 4 days followed by a 14-day recovery period. In-depth metabolic phenotyping allowed identification of a panel of 202 urinary and 223 fecal metabolites significantly related to end points of a functional metagenome (p < 0.05 in at least one day), many of which have not been previously reported such as oligopeptides and carbohydrates. This study shows extensive gut microbiota modulation of host systemic metabolism involving short-chain fatty acids, tryptophan, tyrosine metabolism, and possibly a compensatory mechanism of indole-melatonin production. Given the integral nature of the mammalian genome and metagenome, this panel of metabolites will provide a new platform for potential therapeutic markers and mechanistic solutions to complex problems commonly encountered in pathology, toxicology, or drug metabolism studies.

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Cited by

Metadata

Authors
Zheng, X., Xie, G., Zhao, A., Zhao, L., Yao, C., Chiu, N. H. L., Zhou, Z., Bao, Y., Jia, W., Nicholson, J. K., & Jia, W.
Venue
Journal of Proteome Research
Publisher
American Chemical Society (ACS)
Published
2011-10-24
Volume
10
Issue
12
Pages
5512-5522
ISSN
  • 1535-3893 (ISSN-L)
  • 1535-3907
DOI
10.1021/pr2007945
OpenAlex
W1978337734
Cited by
319
References
3
FWCI
7.76
Type
journal article
Language
en
Open access
closed

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