Cycles of Aberrant Synaptic Sprouting and Neurodegeneration in Alzheimer's and Dementia with Lewy Bodies

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123

Arzneimittelforschung

Miletzki, B., & Gleiter, C. H. (2005) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-005-1024-7 · Cited by 9,401

α-Synuclein in Lewy bodies

Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop

McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

Srimaroeng, C., Cecile, J. P., Walden, R., & Pritchard, J. B. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350077 · Cited by 2,989

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668

Diagnosis of Alzheimer's Disease

Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376

A Drosophila model of Parkinson's disease

Feany, M. Β., & Bender, W. W. (2000) · Nature · doi:10.1038/35006074 · Cited by 2,157

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975

High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

Masliah, E., Rockenstein, E. M., Veinbergs, I., Mallory, M. E., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., & Mucke, L. (2000) · Science · doi:10.1126/science.287.5456.1265 · Cited by 1,776

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Verdugo, J. M. G., Armanini, M., Ryan, A., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)80886-7 · Cited by 1,722

APP Processing and Synaptic Function

Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644

Purification and cloning of amyloid precursor protein β-secretase from human brain

Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., et al. (1999) · Nature · doi:10.1038/990114 · Cited by 1,612

Apoptosis in neurodegenerative disorders

Mattson, M. P. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35040009 · Cited by 1,605

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

Conway, K. A., Harper, J. D., & Lansbury, P. T. (1998) · Nature Medicine · doi:10.1038/3311 · Cited by 1,519

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

Okamoto, T., Schlegel, A., Scherer, P. E., & Lisanti, M. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5419 · Cited by 1,496

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,486

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

Uéda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A., Kondo, J. D. M., Ihara, Y., & Saitoh, T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11282 · Cited by 1,469

The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., Flanagan, L., Rohan de Silva, H. A., Kittel, A., & Saitoh, T. (1995) · Neuron · doi:10.1016/0896-6273(95)90302-x · Cited by 1,316

Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein

Lotharius, J., & Brundin, P. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn983 · Cited by 1,315

Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein

Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q., & Lee, V. M.-Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00682-7 · Cited by 1,266

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

Chartier-Harlin, M.-C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., Roques, P., Hardy, J., et al. (1991) · Nature · doi:10.1038/353844a0 · Cited by 1,214

Caveolins, Liquid-Ordered Domains, and Signal Transduction

Smart, E. J., Graf, G. A., McNiven, M. A., Sessa, W. C., Engelman, J. A., Scherer, P. E., Okamoto, T., & Lisanti, M. P. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7289 · Cited by 1,005

Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein

Cabin, D. E., Shimazu, K., Murphy, D., Cole, N. B., Gottschalk, W., McIlwain, K. L., Orrison, B., Chen, A., Ellis, C. E., Paylor, R., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-08797.2002 · Cited by 865

Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice

Lee, M. K., Stirling, W., Xu, Y., Xu, X., Qui, D., Mandir, A. S., Dawson, T. M., Copeland, N. G., Jenkins, N. A., & Price, D. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132197599 · Cited by 824

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

Braak, F., Braak, H., & Mandelkow, E. (1994) · Acta Neuropathologica · doi:10.1007/bf00293315 · Cited by 769

Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease

Xu, J., Kao, S., Lee, F. J. S., Song, W., Jin, L., & Yankner, B. A. (2002) · Nature Medicine · doi:10.1038/nm0602-600 · Cited by 767

α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress

Hsu, L. J., Sagara, Y., Arroyo, A., Rockenstein, E. M., Sisk, A., Mallory, M. E., Wong, J., Takenouchi, T., Hashimoto, M., & Masliah, E. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64553-1 · Cited by 737

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

Masliah, E., Mallory, M., Alford, M., DeTeresa, R., Hansen, L. A., McKeel, D. W., & Morris, J. C. (2001) · Neurology · doi:10.1212/wnl.56.1.127 · Cited by 720

Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

Takahashi, R. H., Milner, T. A., Li, F., Nam, E. E., Edgar, M. A., Yamaguchi, H., Beal, M. F., Xu, H., Greengard, P., & Gouras, G. K. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64463-x · Cited by 706

Amyloid diseases: Abnormal protein aggregation in neurodegeneration

Koo, E. H., Lansbury, P. T., & Kelly, J. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.9989 · Cited by 686

Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System

Kirik, D., Rosenblad, C., Burger, C., Lundberg, C., Johansen, T. E., Muzyczka, N., Mandel, R. J., & Björklund, A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02780.2002 · Cited by 649

ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.

Terry, R. D., Gonatas, N. K., & WEISS, M. (1964) · PubMed Central · Cited by 644

α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

Wakabayashi, K., Yoshimoto, M., Tsuji, S., & Takahashi, H. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00407-8 · Cited by 643

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

Davies, C. A., Mann, D. M. A., Sumpter, P. Q., & Yates, P. O. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90057-8 · Cited by 628

Making New Connections

Impey, S., Obrietan, K. H., & Storm, D. R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80747-3 · Cited by 616

β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., & Mucke, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211412398 · Cited by 607

Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease

Hurtig, H. I., Trojanowski, J. Q., Galvin, J. E., Ewbank, D., Schmidt, M. L., Lee, V. M. Y., Clark, C., Glosser, G., Stern, M. B., Gollomp, S. M., et al. (2000) · Neurology · doi:10.1212/wnl.54.10.1916 · Cited by 604

Membrane microdomains and caveolae

Kurzchalia, T. V., & Parton, R. G. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80061-1 · Cited by 579

β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease

Fukumoto, H. (2002) · Archives of Neurology · doi:10.1001/archneur.59.9.1381 · Cited by 575

Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease

Holsinger, R. M. D., McLean, C. A., Beyreuther, K., Masters, C. L., & Evin, G. (2002) · Annals of Neurology · doi:10.1002/ana.10208 · Cited by 562

α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins

Ostrerova, N., Petrucelli, L., Farrer, M. J., Mehta, N., Choi, P., Hardy, J., & Wolozin, B. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05782.1999 · Cited by 560

Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease

Lansbury, P. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3342 · Cited by 557

A Portrait of Alzheimer Secretases--New Features and Familiar Faces

Esler, W. P., & Wolfe, M. S. (2001) · Science · doi:10.1126/science.1064638 · Cited by 493

Synaptic loss in Alzheimer's disease and other dementias

Hamos, J. E., DeGennaro, L. J., & Drachman, D. A. (1989) · Neurology · doi:10.1212/wnl.39.3.355 · Cited by 432

Correlations of synaptic and pathological markers with cognition of the elderly

Dickson, D. W., Crystal, H. A., Bevona, C., Honer, W., Vincent, I., & Davies, P. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00013-5 · Cited by 410

Clinical-Neuropathological Correlations in Alzheimer's Disease and Related Dementias

Galasko, D., Hansen, L. A., Katzman, R., Wiederholt, W. C., Masliah, E., Terry, R. D., Hill, L. R., Lessin, P. J., & Thal, L. J. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540210060013 · Cited by 408

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders.

Takeda, A., Mallory, M. E., Sundsmo, M. P., Honer, W. G., Hansen, L. A., & Masliah, E. (1998) · Europe PMC (PubMed Central) · Cited by 402

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

Palop, J. J., Jones, B., Kekonius, L., Chin, J., Yu, G.-Q., Raber, J., Masliah, E., & Mucke, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133381100 · Cited by 402

Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease?

Kosaka, K., Yoshimura, M., Ikeda, K., & Budka, H. (1984) · PubMed · Cited by 401

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

Masliah, E., Sisk, A., Mallory, M. E., Mucke, L., Schenk, D., & Games, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-18-05795.1996 · Cited by 389

An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts

Matthews, D. A., Cotman, C. W., & LYNCH, G. S. (1976) · Brain Research · doi:10.1016/0006-8993(76)90820-9 · Cited by 384

Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.

Dickson, D. W., Farlo, J., Davies, P., Crystal, H., Fuld, P. A., & Yen, S. H. (1988) · PubMed Central · Cited by 383

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part X. Neuropathology Confirmation of the Clinical Diagnosis of Alzheimer's Disease

Gearing, M., Mirra, S. S., Hedreen, J. C., Sumi, S. M., Hansen, L. A., & Heyman, A. (1995) · Neurology · doi:10.1212/wnl.45.3.461 · Cited by 381

Synaptic and neuritic alterations during the progression of Alzheimer's disease

Masliah, E., Mallory, M., Hansen, L., Richard, D., Alford, M., & Terry, R. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90121-x · Cited by 370

Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

Masliah, E., Terry, R. D., DeTeresa, R. M., & Hansen, L. A. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90582-x · Cited by 363

A quantitative electron microscopic study of synaptogenesis in the dentate gyrus of the rat

Crain, B. J., Cotman, C. W., Taylor, D. A., & LYNCH, G. S. (1973) · Brain Research · doi:10.1016/0006-8993(73)90088-7 · Cited by 349

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease

Wakabayashi, K., Matsumoto, K., Takayama, K., Yoshimoto, M., & Takahashi, H. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00891-4 · Cited by 330

Golgi Fragmentation Occurs in the Cells with Prefibrillar α-Synuclein Aggregates and Precedes the Formation of Fibrillar Inclusion

Gosavi, N., Lee, H.-J., Lee, J. S., Patel, S. S., & Lee, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208194200 · Cited by 300

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

Trojanowski, J. Q., Goedert, M., Iwatsubo, T., & Lee, V. M. ‐. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400432 · Cited by 297

Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.

Masliah, E., Terry, R. D., Alford, M. F., DeTeresa, R. M., & Hansen, L. A. (1991) · PubMed Central · Cited by 296

Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites

SCHUBERT, W. J., Prior, R., Weidemann, A., Dircksen, H., Multhaup, G., Masters, C. L., & Beyreuther, K. T. (1991) · Brain Research · doi:10.1016/0006-8993(91)91532-6 · Cited by 272

Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease

Hashimoto, M., Hsu, L. J., Sisk, A., Xia, Y., Takeda, A., Sundsmo, M. P., & Masliah, E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00514-9 · Cited by 266

Synapse loss in the temporal lobe in Alzheimer's disease

Scheff, S. W., & PRICE, D. A. (1993) · Annals of Neurology · doi:10.1002/ana.410330209 · Cited by 263

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α‐synuclein protein implicated in Parkinson's disease

El‐Agnaf, O. M. A., Jakes, R., Curran, M. D., & Wallace, A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01419-7 · Cited by 258

Alpha‐synuclein in Lewy Body Disease and Alzheimer's Disease

Hashimoto, M., & Masliah, E. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00552.x · Cited by 254

Patterns of aberrant sprouting in alzheimer's disease

Masliah, E., Mallory, M. E., Hansen, L. A., Alford, M. F., Albright, T., DeTeresa, R. M., Terry, R. D., Baudier, J., & Saitoh, T. (1991) · Neuron · doi:10.1016/0896-6273(91)90170-5 · Cited by 245

Research advances in Alzheimer's disease and related disorders

Iqbal, K., & Disorders, R. (1995) · Wiley eBooks · Cited by 228

Circadian rhythm of periodic limb movements and sensory symptoms of restless legs syndrome

Trenkwalder, C., Hening, W. A., Walters, A. S., Campbell, S. S., Rahman, K., & Chokroverty, S. (1999) · Movement Disorders · doi:10.1002/1531-8257(199901)14:1 · Cited by 226

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson’s disease

Meredith, G. E., Totterdell, S., Petroske, E., Cruz, K. S., Callison, R. C., & Lau, Y.-S. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03514-x · Cited by 212

α-Synuclein Protects against Oxidative Stress via Inactivation of the c-Jun N-terminal Kinase Stress-signaling Pathway in Neuronal Cells

Hashimoto, M., Hsu, L. J., Rockenstein, E. M., Takenouchi, T., Mallory, M. E., & Masliah, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111428200 · Cited by 210

Synaptic pathology in Alzheimer's disease: Relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele

Blennow, K., Bogdanović, N., Alafuzoff, I. I., Ekman, R., & Davidsson, P. (1996) · Journal of Neural Transmission · doi:10.1007/bf01273157 · Cited by 207

The Role of APP Processing and Trafficking Pathways in the Formation of Amyloid β‐Proteina

SELKOE, D. J., YAMAZAKI, T., CITRON, M., PODLISNY, M. B., KOO, E. H., TEPLOW, D. B., & HAASS, C. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34401.x · Cited by 205

Defects in expression of genes related to synaptic vesicle traffickingin frontal cortex of Alzheimer’s disease

Yao, P. J., Zhu, M., Pyun, E. I., Brooks, A. I., Therianos, S., Meyers, V. E., & Coleman, P. D. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00009-8 · Cited by 205

Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat

Masliah, E., Fagan, A. M., Terry, R. D., DeTeresa, R. M., Mallory, M. E., & Gage, F. H. (1991) · Experimental Neurology · doi:10.1016/0014-4886(91)90169-d · Cited by 204

Diffuse Lewy body disease

Dickson, D. W., Davies, P., Mayeux, R. P., Crystal, H., Horoupian, D. S., Thompson, A. J., & Goldman, J. E. (1987) · Acta Neuropathologica · doi:10.1007/bf00686786 · Cited by 203

Spine Loss and Regrowth in Hippocampus following Deafferentation

Parnavelas, J. G., LYNCH, G. S., Brecha, N. C., Cotman, C. W., & Globus, A. (1974) · Nature · doi:10.1038/248071a0 · Cited by 198

Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

Tabrizi, S. J. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.18.2683 · Cited by 196

Enhanced vulnerability to oxidative stress by α-synuclein mutations and C-terminal truncation

Kanda, S., Bishop, J. F., Eglitis, M. A., Yang, Y., & Mouradian, M. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00077-4 · Cited by 193

Synaptic Rearrangement in the Dentate Gyrus: Histochemical Evidence of Adjustments after Lesions in Immature and Adult Rats

Cotman, C. W., Matthews, D. A., Taylor, D. A., & LYNCH, G. S. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.12.3473 · Cited by 191

The Contribution of Altered Synapses in the Senile Plaque: An Electron Microscopic Study in Alzheimer's Dementia*†

Gonatas, N. K., Anderson, W., & Evangelista, I. (1967) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196701000-00003 · Cited by 186

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.

Koo, E. H., Park, L., & Selkoe, D. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4748 · Cited by 180

Lewy Body Pathology in Alzheimer's Disease

Kotzbauer, P. T., Tojanowski, J. Q., & Lee, V. M. V. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:225 · Cited by 177

β-Secretase Processing in the Trans-Golgi Network Preferentially Generates Truncated Amyloid Species That Accumulate in Alzheimer’s Disease Brain

Huse, J. T., Liu, K., Pijak, D. S., Carlin, D., Lee, V. M.-Y., & Doms, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111141200 · Cited by 176

Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease

Masliah, E., Hansen, L. A., Albright, T., Mallory, M. E., & Terry, R. D. (1991) · Acta Neuropathologica · doi:10.1007/bf00293464 · Cited by 174

Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex.

(1994) · PubMed Central · Cited by 169

Senile plaques as aberrant sprout-stimulating structures

Geddes, J. W., Anderson, K. J., & Cotman, C. W. (1986) · Experimental Neurology · doi:10.1016/0014-4886(86)90254-2 · Cited by 162

Synaptic pathology in alzheimer's disease: Immunological data for markers of synaptic and large dense-core vesicles

Lassmann, H., Weiler, R., Fischer, P. A., Bancher, C., Jellinger, K. A., Floor, E., Danielczyk, W., SEITELBERGER, F., & Winkler, H. J. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90003-k · Cited by 160

Characterization of neuronal dystrophy induced by fibrillar amyloid β: implications for Alzheimer’s disease

Grace, E. A., Rabiner, C. A., & Busciglio, J. A. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00241-5 · Cited by 153

Neocortical Lewy Body Counts Correlate with Dementia in the Lewy Body Variant of Alzheimerʼs Disease

Samuel, W., Galasko, D., Masliah, E., & Hansen, L. A. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199601000-00005 · Cited by 145

Oxidative Stress, Perturbed Calcium Homeostasis, and Immune Dysfunction in Alzheimer's Disease

Mattson, M. P. (2002) · Journal of NeuroVirology · doi:10.1080/13550280290100978 · Cited by 143

α-Synuclein Affects the MAPK Pathway and Accelerates Cell Death

Iwata, A., Maruyama, M., Kanazawa, I., & Nukina, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103736200 · Cited by 139

α-Synuclein Interacts with Phospholipase D Isozymes and Inhibits Pervanadate-induced Phospholipase D Activation in Human Embryonic Kidney-293 Cells

Ahn, B., Rhim, H., Kim, S. Y., Sung, Y., Lee, M., Choi, J., Wolozin, B. L., Chang, J., Lee, Y. H., Kwon, T. K., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110414200 · Cited by 136

Fibroblast Growth Factor 1 Regulates Signaling via the Glycogen Synthase Kinase-3β Pathway

Hashimoto, M., Sagara, Y., Langford, D., Everall, I., Mallory, M. E., Everson, A., Digicaylioglu, M. H., & Masliah, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202803200 · Cited by 127

An introduction to molecular neurobiology

(1992) · Choice Reviews Online · doi:10.5860/choice.30-1496 · Cited by 124

Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in alzheimer's disease

Cummings, B. J., Su, J. H., Geddes, J. W., Van Nostrand, W. E., Wagner, S. L., Cunningham, D. D., & Cotman, C. W. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90265-4 · Cited by 120

Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits.

Cork, L. C., Masters, C. L., Beyreuther, K. T., & Price, D. L. (1990) · Europe PMC (PubMed Central) · Cited by 112

Quantitative Assessment of the Synaptophysin Immuno-Reactivity of the Cortical Neuropil in Various Neurodegenerative Disorderswith Dementia

Zhan, S., Beyreuther, K. T., & Schmitt, H. P. (1993) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107299 · Cited by 110

Hippocampal connectivity and Alzheimer's dementia

Samuel, W., Masliah, E., Hill, L., Butters, N., & Terry, R. D. (1994) · Neurology · doi:10.1212/wnl.44.11.2081 · Cited by 108

Synaptic plasticity and functional stabilization in the hippocampal formation: possible role in Alzheimer's disease.

Cotman, C. W., & Anderson, K. J. (1988) · PubMed · Cited by 105

Neuronal and glial β‐secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

Roßner, S., Apelt, J., Schliebs, R., Perez-Polo, J. R., & Bigl, V. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1095 · Cited by 102

alpha-Synuclein forms a complex with transcription factor Elk-1

Iwata, A., Miura, S., Kanazawa, I., Sawada, M., & Nukina, N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.t01-1-00232.x · Cited by 98

Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease.

Wakabayashi, K., Honer, W., & Masliah, E. (1994) · Brain Research · doi:10.1016/0006-8993(94)91709-4 · Cited by 98

Localization of amyloid precursor protein in GAP43-immunoreactive aberrant sprouting neurites in Alzheimer's disease

Masliah, E., Mallory, M. E., Hansen, L. A., Alford, M. F., DeTeresa, R. M., Terry, R. D., Baudier, J., & Saitoh, T. (1992) · Brain Research · doi:10.1016/0006-8993(92)90831-s · Cited by 91

A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease

Bellmann‐Weiler, R., Lassmann, H., Fischer, P. A., Jellinger, K. A., & Winkler, H. J. S. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81408-g · Cited by 89

α‐Synuclein up‐regulates expression of caveolin‐1 and down‐regulates extracellular signal‐regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease

Hashimoto, M., Takenouchi, T., Rockenstein, E. M., & Masliah, E. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01791.x · Cited by 83

Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease

Scheff, S. W., Sparks, D. L., & PRICE, D. A. (1993) · Annals of Neurology · doi:10.1002/ana.410340309 · Cited by 82

Amyloid precursor protein is localized in growing neurites of neonatal rat brain

Masliah, E., Mallory, M. E., Ge, N., & Saitoh, T. (1992) · Brain Research · doi:10.1016/0006-8993(92)91329-d · Cited by 79

Reduced Neuritic Outgrowth and Cell Adhesion in Neuronal Cells Transfected with Human α-Synuclein

Takenouchi, T., Hashimoto, M., Hsu, L. J., Mackowski, B., Rockenstein, E. M., Mallory, M. E., & Masliah, E. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0923 · Cited by 77

Synaptophysin and chromogranin A immunoreactivities of Lewy bodies in Parkinson's disease brains

Nishimura, M., Tomimoto, H., Suenaga, T., Nakamura, S., Namba, Y., Ikeda, K., Akiguchi, I., & Kimura, J. (1994) · Brain Research · doi:10.1016/0006-8993(94)91940-2 · Cited by 73

Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia

Hansen, L. A., Daniel, S. E., Wilcock, G., & Love, S. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.5.653 · Cited by 73

A Novel SNAP25–Caveolin Complex Correlates with the Onset of Persistent Synaptic Potentiation

Braun, J. E. A., & Madison, D. V. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-05997.2000 · Cited by 69

Alzheimer's disease-related synapse loss in the cingulate cortex

Scheff, S. W., & PRICE, D. A. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3509 · Cited by 68

APP is required during an early phase of memory formation

Mileusnić, R., Lancashire, C. L., Johnston, A. N. B., & Rose, S. P. R. (2000) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2000.01344.x · Cited by 66

Alzheimer's and Parkinson's disease – overlapping or synergistic pathologies?

Kurosinski, P., Guggisberg, M., & Götz, J. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02246-8 · Cited by 66

Roles for Protein Kinase C and Mitogen‐Activated Protein Kinase in Nicotine‐Induced Secretion from Bovine Adrenal Chromaffin Cells

Cox, M., & Parsons, S. J. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031119.x · Cited by 63

The Lewy body variant of Alzheimer disease

Hansen, L. A. (1997) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6846-2_7 · Cited by 62

An Analysis of Contemporary Morphological Concepts of Synaptic Remodelling in the CNS: Perforated Synapses Revisited

Jones, D. G., & Harris, R. J. (1995) · Reviews in the Neurosciences · doi:10.1515/revneuro.1995.6.3.177 · Cited by 60

Differing patterns of aberrant neuronal sprouting in Alzheimer's disease with and without Lewy bodies

Masliah, E., Mallory, M. E., DeTeresa, R. M., Alford, M. F., & Hansen, L. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)91093-8 · Cited by 58

Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus

Masliah, E., Honer, W. G., Mallory, M. E., Voigt, M., Kushner, P. D., Hansen, L. A., & Terry, R. D. (1994) · Acta Neuropathologica · doi:10.1007/bf00296182 · Cited by 56

Synaptic Proteins in Alzheimer's Disease

Marksteiner, J., Kaufman, W. A., Gurka, P., & Humpel, C. (2002) · Journal of Molecular Neuroscience · doi:10.1385/jmn:18:1-2:53 · Cited by 54

Aβ1–42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD

Masliah, E., Alford, M. F., Adame, A., Rockenstein, E. M., Galasko, D., Salmon, D. P., Hansen, L. A., & Thal, L. J. (2003) · Neurology · doi:10.1212/01.wnl.0000073987.79060.4b · Cited by 53

Amyloid Protein Precursor Stimulates Excitatory Amino Acid Transport

Masliah, E., Raber, J., Alford, M. F., Mallory, M. E., Mattson, M. P., Yang, D., Wong, D. T., & Mucke, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12548 · Cited by 52

Synaptic replacement in the dentate gyrus after unilateral entorhinal lesion: electron microscopic analysis of the extent of replacement of synapses by the remaining entorhinal cortex

Cotman, C. W., Gentry, C. A., & Steward, O. (1977) · Journal of Neurocytology · doi:10.1007/bf01178228 · Cited by 48

Mechanisms of synaptic pathology in Alzheimer’s disease

Masliah, E. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_13 · Cited by 46

Epitope analysis of senile plaque components in the hippocampus of patients with Parkinson's disease

Arai, H., Schmidt, M. L., Lee, V. M.-Y., Hurtig, H. I., Greenberg, B. D., Adler, C. H., & Trojanowski, J. Q. (1992) · Neurology · doi:10.1212/wnl.42.7.1315 · Cited by 46

Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease

Chan, S. L., Furukawa, K., & Mattson, M. P. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:167 · Cited by 45

Abnormal brain spectrin immunoreactivity in sprouting neurons in Alzheimer disease

Masliah, E., Hansen, L. A., Mallory, M. E., Albright, T., & Terry, R. D. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90707-z · Cited by 33

beta-Amyloid, protein processing and Alzheimer's disease.

Haas, C., Hung, A. Y., Citron, M., Teplow, D. B., & Selkoe, D. J. (1995) · PubMed · Cited by 31

The Role of Misdirected Plasticity in Plaque Biogenesis and Alzheimer’s Disease Pathology

Cotman, C. W., Cummings, B. J., & Whitson, J. S. (1991) · Springer eBooks · doi:10.1007/978-3-642-46722-6_19 · Cited by 27

Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release from PC12 Cells

Bloch‐Shilderman, E., Jiang, H., Abu‐Raya, S., Michal Linial, B., & Lazarovici, P. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38806-8 · Cited by 27

Abnormal synaptic regeneration in hAPP transgenic and ApoE knockout mice

San Diego, C. A. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)92498-8 · Cited by 26

Alzheimer's disease is a degenerative disorder

Katzman, R. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90137-1 · Cited by 19

Noradrenaline and dopamine-beta-hydroxylase levels in rat salivary glands after preganglionic nerve stimulation: Evidence for re-use of amine storage granules in transmitter release

H�ggendal, J. (1982) · Journal of Neural Transmission · doi:10.1007/bf01243406 · Cited by 18

The APP and PS1/2 Mutations Linked to Early Onset Familial Alzheimer’s Disease Increase the Extracellular Concentration of Aβ1–42(43)

Younkin, S. G. (1998) · Springer eBooks · doi:10.1007/978-3-642-72103-8_4 · Cited by 16

Chapter 15. Neurodegenerative Dementias

LoBue, C., Cullum, C. M., Didehbani, N., Yeatman, K., Jones, B. H., Kraut, M. A., & Hart, J. A. L. (2018) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615372645.js15 · Cited by 15

The Pathology of the Synapse in Alzheimer's Disease

Gonatas, N. K., & Gambetti, P. L. (1970) · Novartis Foundation symposium · doi:10.1002/9780470719749.ch11 · Cited by 14

Recent Advances in the Understanding of the Processing of APP to Beta Amyloid Peptide

SINHA, S., ANDERSON, J., JOHN, V., McCONLOGUE, L., BASI, G., THORSETT, E., & SCHENK, D. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06923.x · Cited by 12

Deafferentative Synaptopathology in Physiological Aging and Alzheimer's Disease

Bertoni–Freddari, C., Fattoretti, P., DELFINO, A., Solazzi, M., Giorgetti, B., ULRICH, J., & Meier-Ruge, W. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04833.x · Cited by 11

Natural evolution of the neurodegenerative alterations in Alzheimer's disease

Masliah, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00020-f · Cited by 10

Neurite sprouting and cytoskeletal pathology in Alzheimer's disease: a comparative study with monoclonal antibodies to growth associated protein B-50 and paired helical filaments

Six, J., bke, U. L. ⁄., Lenders, M., Vandermeeren, M., Mercken, M. H., Villanova, M., Vandevoorde, A., Gheuens, J., Martin, J.-J., & Cras, P. P. (1992) · Neurodegeneration · Cited by 9

Neuropathological Correlates of Dementia in Alzheimer’s Disease

Masliah, E., & Salmon, D. P. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_15 · Cited by 5

RELATIONSHIPS OF ABNORMAL NEURONAL PROCESSES AND AMYLOID IN PLAQUES IN AGED MONKEYS

Cork, L. C., & Price, D. L. (1990) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199005000-00152 · Cited by 4

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588

Curcumin labels amyloid pathology in vivo , disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model

Garcı́a-Alloza, M., Borrelli, L. A., Rozkalne, A., Hyman, B. T., & Bacskai, B. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04613.x · Cited by 675

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases

Spencer, B., Potkar, R., Trejo, M., Rockenstein, E., Patrick, C., Gindi, R., Adame, A., Wyss-Coray, T., & Masliah, E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4390-09.2009 · Cited by 595

Functional Alterations in Memory Networks in Early Alzheimer’s Disease

Sperling, R. A., Dickerson, B. C., Pihlajamaki, M. M., Vannini, P., LaViolette, P. S., Vitolo, O. V., Hedden, T., Becker, J. A., Rentz, D. M., Selkoe, D. J., et al. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8109-7 · Cited by 617

Medial temporal lobe function and structure in mild cognitive impairment

Dickerson, B. C., Salat, D. H., Bates, J. F., Atiya, M., Killiany, R., Greve, D. N., Dale, A. M., Stern, C. E., Blacker, D., Albert, M., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20163 · Cited by 579

Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: Insights from functional MRI studies

Dickerson, B. C., & Sperling, R. A. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.11.030 · Cited by 389

Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline

O’Brien, J. L., O’Keefe, K., LaViolette, P. S., DeLuca, A. N., Blacker, D., Dickerson, B. C., & Sperling, R. A. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e3966e · Cited by 303

Apolipoproteins in the brain: implications for neurological and psychiatric disorders

Elliott, D. A., Weickert, C. S., & Garner, B. (2010) · Clinical Lipidology · doi:10.2217/clp.10.37 · Cited by 194

Spontaneous Age-Related Neurite Branching in Caenorhabditis elegans

Tank, E. M. H., Rodgers, K. E., & Kenyon, C. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6606-10.2011 · Cited by 175

APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer’s disease

Walton, J. R., & Wang, M.-X. (2009) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2009.07.027 · Cited by 158

Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice

Poon, H. F., Vaishnav, R., Getchell, T. V., Getchell, M. L., & Butterfield, D. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.006 · Cited by 132

iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease

Martin, B., Brenneman, R., Becker, K. G., Guček, M., Cole, R. N., & Maudsley, S. R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002750 · Cited by 113

Neuronal Structure is Altered by Amyloid Plaques

Spires‐Jones, T. L., & Hyman, B. T. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.4.267 · Cited by 108

Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage

Ferrer, I., Kapfhammer, J. P., Hindelang, C., Kemp, S., Troffer-Charlier, N., Broccoli, V., Callyzot, N., Mooyer, P., Selhorst, J., Vreken, P., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi384 · Cited by 106

Early involvement of the cerebral cortex in Parkinson's disease: Convergence of multiple metabolic defects

Ferrer, I. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.02.004 · Cited by 108

Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model

Garcia-Alloza, M., Dodwell, S. A., Meyer-Luehmann, M., Hyman, B. T., & Bacskai, B. J. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240468.12543.af · Cited by 99

Rapid Modulation of Protein Expression in the Rat Hippocampus Following Deep Brain Stimulation of the Fornix

Gondard, E., Chau, H. N., Mann, A., Tierney, T. S., Hamani, C., Kalia, S. K., & Lozano, A. M. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.07.044 · Cited by 94

Neurochemistry and the non-motor aspects of PD

Ferrer, I., López‐González, I., Carmona, M., Dalfó, E., Pujol, A., & Martı́nez, A. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.10.019 · Cited by 92

Signal transduction in Alzheimer disease: p21‐activated kinase signaling requires C‐terminal cleavage of APP at Asp664

Nguyen, T. V., Galván, V., Huang, W., Banwait, S., Tang, H., Zhang, J., & Bredesen, D. E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05031.x · Cited by 76

Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons

Singh, I. N., El‐Hage, N., Campbell, M. E., Lutz, S. E., Knapp, P. E., Nath, A., & Hauser, K. F. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.028 · Cited by 73

Individual differences in associative memory among older adults explained by hippocampal subfield structure and function

Carr, V. A., Bernstein, J. D., Favila, S. E., Rutt, B. K., Kerchner, G. A., & Wagner, A. D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713308114 · Cited by 76

α-Synuclein Aggregates Interfere with Parkin Solubility and Distribution

Kawahara, K., Hashimoto, M., Bar‐On, P., Ho, G. J., Crews, L. A., Mizuno, H., Rockenstein, E. M., Imam, S. Z., & Masliah, E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710418200 · Cited by 64

ROCK, PAK, and Toll of synapses in Alzheimer’s disease

Salminen, A., Suuronen, T., & Kaarniranta, K. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.148 · Cited by 65

α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease

Spencer, B. J., Kim, C., Gonzalez, T., Bisquertt, A., Patrick, C., Rockenstein, E. M., Adame, A., Lee, S., Desplats, P., & Masliah, E. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddv633 · Cited by 59

A role for caveolin‐1 in post‐injury reactive neuronal plasticity

Gaudreault, S. B., Blain, J., Gratton, J., & Poirier, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02917.x · Cited by 58

Regulation of protein phosphatase 2A methylation by LCMT1 and PME‐1 plays a critical role in differentiation of neuroblastoma cells

Sontag, J., Nunbhakdi‐Craig, V., Mitterhuber, M., Ogris, E., & Sontag, E. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07049.x · Cited by 57

Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies

Garcia‐Esparcia, P., Lucena, D. D., Ainciburu, M., Torrejón-Escribano, B., Carmona, M., Llorens, F., & Ferrer, I. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00122 · Cited by 56

Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and α-synuclein pathology

Newman, J., Rissman, R. A., Sarsoza, F. M., Kim, R. C., Dick, M. B., Bennett, D. A., Cotman, C. W., Rohn, T. T., & Head, E. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1027-3 · Cited by 55

Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms

Garcia‐Esparcia, P., López‐González, I., Grau‐Rivera, O., Garrido, M. G., Koneti, A., Llorens, F., Zafar, S., Carmona, M., del Rı́o, J. A., Zerr, I., et al. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00089 · Cited by 52

Genetics of primary open angle glaucoma

Takamoto, M., & Araie, M. (2013) · Japanese Journal of Ophthalmology · doi:10.1007/s10384-013-0286-0 · Cited by 53

Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice

Masliah, E., Xie, F., Dayan, S., Rockenstein, E. M., Mante, M., Adame, A., Patrick, C., Chan, A. F., & Zheng, B. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.045 · Cited by 51

Specific and disease stage-dependent episodic memory-related brain activation patterns in Alzheimer’s disease: a coordinate-based meta-analysis

Nellessen, N. D., Rottschy, C., Eickhoff, S. B., Ketteler, S. T., Kuhn, H., Shah, N. J., Schulz, J. B., Reske, M., & Reetz, K. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0744-6 · Cited by 49

Stereologic analysis of hippocampal Alzheimer's disease pathology in the oldest-old: Evidence for sparing of the entorhinal cortex and CA1 field

von Gunten, A., Kövari, E., Rivara, C., Bouras, C., Hof, P. R., & Giannakopoulos, P. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.12.005 · Cited by 52

Regenerating Islet-derived 1α (Reg-1α) Protein Is New Neuronal Secreted Factor That Stimulates Neurite Outgrowth via Exostosin Tumor-like 3 (EXTL3) Receptor

Ba, I. A.-T. V., Marchal, S., François, F., Silhol, M., Lleres, C., Michel, B. F., Benyamin, Y., Verdier, J., Trousse, F., & Marcilhac, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.260349 · Cited by 48

Chronic cocaine administration causes extensive white matter damage in brain: Diffusion tensor imaging and immunohistochemistry studies

Narayana, P. A., Herrera, J. J., Bockhorst, K. H. J., Esparza‐Coss, E., Xia, Y., Steinberg, J. L., & Moeller, F. G. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.01.005 · Cited by 42

Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments

Hwang, Y. K., Ma, J., Choi, B., Cui, C., Jeon, W. K., Kim, H., Kim, H. Y., Han, S., & Han, J. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.06.025 · Cited by 43

In Vivo Assessment of Vesicular Monoamine Transporter Type 2 in Dementia With Lewy Bodies and Alzheimer Disease

Villemagne, V. L. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.142 · Cited by 43

Expression of caveolin in trabecular meshwork cells and its possible implication in pathogenesis of primary open angle glaucoma.

Surgucheva, I. G., & Surguchov, A. P. (2011) · PubMed Central · Cited by 41

Medial temporal lobe dysfunction during encoding and retrieval of episodic memory in non-demented APOE ε4 carriers

Kukolja, J., Thiel, C. M., Eggermann, T., Zerres, K., & Fink, G. R. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.044 · Cited by 40

Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice

Garcı́a-Alloza, M., Borrelli, L. A., Hyman, B. T., & Bacskai, B. J. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.11.006 · Cited by 44

Associations of Short-Term Exposure to Fine Particulate Matter with Neural Damage Biomarkers: A Panel Study of Healthy Retired Adults

Song, J., Qu, R., Sun, B., Chen, R., Kan, H., An, Z., Jiang, J., Li, J., Zhang, Y., & Wu, W. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c03754 · Cited by 36

Neuritic Pathology as a Correlate of Synaptic Loss in Dementia With Lewy Bodies

Revuelta, G. J., Rosso, A. L., & Lippa, C. F. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507310565 · Cited by 35

Caveolin isoform expression during differentiation of C6 glioma cells

Silva, W. I., Maldonado, H. M., Velazquez, G., Rubio-Dávila, M. M., Miranda, J. D., Aquino, E. E., Mayol, N., Cruz‐Torres, A., Jardón, J., & Salgado, I. K. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.07.007 · Cited by 33

Novel strategies for Alzheimer's disease treatment

Spencer, B. J., Rockenstein, E. M., Crews, L. A., Marr, R. A., & Masliah, E. (2007) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.7.12.1853 · Cited by 31

Using 18 F-AV-133 VMAT2 PET Imaging to Monitor Progressive Nigrostriatal Degeneration in Parkinson Disease

Beauchamp, L. C., Doré, V., Villemagne, V. L., Xu, S., Finkelstein, D. I., Barnham, K. J., & Rowe, C. C. (2023) · Neurology · doi:10.1212/wnl.0000000000207748 · Cited by 30

BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice

Yan, X.-X., Cai, Y., Zhang, X.-M., Luo, X.-G., Cai, H., Rose, G. M., & Patrylo, P. R. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.003 · Cited by 29

Similarities and Differences in the Pattern of Tau Hyperphosphorylation in Physiological and Pathological Conditions: Impacts on the Elaboration of Therapies to Prevent Tau Pathology

Duquette, A., Pernègre, C., Carpentier, A. V., & Leclerc, N. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.607680 · Cited by 38

Noradrenergic Sympathetic Sprouting and Cholinergic Reinnervation Maintains Non-Amyloidogenic Processing of AβPP

Nelson, A. R., Kolasa, K., & McMahon, L. L. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130608 · Cited by 24

Reduced striatal vesicular monoamine transporter 2 in REM sleep behavior disorder: imaging prodromal parkinsonism

Beauchamp, L. C., Villemagne, V. L., Finkelstein, D. I., Doré, V., Bush, A. I., Barnham, K. J., & Rowe, C. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-74495-x · Cited by 23

FMRI: Use in Early Alzheimer‘s Disease and in Clinical Trials

Pihlajamaki, M. M., & Sperling, R. A. (2008) · Future Neurology · doi:10.2217/14796708.3.4.409 · Cited by 22

Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective

Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 24

Should Alzheimer's disease be equated with human brain ageing?: A maladaptive interaction between brain evolution and senescence

Neill, D. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.06.004 · Cited by 22

Lewy Body Disorders

Jellinger, K. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-30377-2_15 · Cited by 22

Alterations of Synaptic Turnover Rate in Aging May Trigger Senile Plaque Formation and Neurodegeneration

Bertoni–Freddari, C., Fattoretti, P., Giorgetti, B., Grossi, Y., Balietti, M., Casoli, T., Stefano, G. D., & Perretta, G. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1397.078 · Cited by 17

Nonsteroidal anti-inflammatory drugs attenuate amyloid-β protein-induced actin cytoskeletal reorganization through Rho signaling modulation

Ferrera, P., Zepeda, A., & Arias, C. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0467-3 · Cited by 16

SV2 frustrating exocytosis at the semi‐diffusor synapse

Vautrin, J. (2009) · Synapse · doi:10.1002/syn.20610 · Cited by 12

Deep brain stimulation of the nucleus basalis of Meynert in an experimental rat model of dementia: Stimulation parameters and mechanisms

Liu, H., Wolters, A., Temel, Y., Alosaimi, F., Jahanshahi, A., & Hescham, S. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105797 · Cited by 11

Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease

Hashimoto, M., Ho, G. J., Takamatsu, Y., Wada, R., Sugama, S., Takenouchi, T., Waragai, M., & Masliah, E. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-191675 · Cited by 12

Pyridoindole antioxidant-induced preservation of rat hippocampal pyramidal cell number linked with reduction of oxidative stress yet without influence on cognitive deterioration in Alzheimer-like neurodegeneration.

Gáspárová, Z., Stara, V., Janega, P., Navarová, J., Sedláčková, N., Mach, M., & Ujházy, E. (2014) · PubMed · Cited by 9

fMRI in Neurodegenerative Diseases: From Scientific Insights to Clinical Applications

Dickerson, B. C., Agosta, F., & Filippi, M. (2016) · Neuromethods · doi:10.1007/978-1-4939-5611-1_23 · Cited by 8

Successful Scene Encoding in Presymptomatic Early-Onset Alzheimer’s Disease

Quiroz, Y. T., Celone, K., Castrillón, G., Muniz, M. C., Lopera, F. J., Budson, A. E., & Stern, C. E. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150214 · Cited by 7

Neural Networks in Autosomal Dominant Alzheimer’s Disease: Insights From Functional Magnetic Resonance Imaging Studies

Qiu, Q. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.903269 · Cited by 6

VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosis

García-García, E., Ramón-Lainez, A., Conde-Berriozabal, S., del Toro, D., Escaramís, G., Giralt, A., Masana, M., Alberch, J., & Rodríguez, M. J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106292 · Cited by 5

Sympathetic sprouting in visual cortex stimulated by cholinergic denervation rescues expression of two forms of long-term depression at layer 2/3 synapses

McCoy, P. A., & McMahon, L. L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.027 · Cited by 3

fMRI in Neurodegenerative Diseases: From Scientific Insights to Clinical Applications

Dickerson, B. C. (2009) · Neuromethods · doi:10.1007/978-1-60327-919-2_22 · Cited by 2

Innate and Adaptive Immunity in Health and Disease

Gendelman, H. E., & Masliah, E. (2008) · Springer eBooks · doi:10.1007/978-0-387-72573-4_2 · Cited by 1

Applications of fMRI to Neurodegenerative Disease

Mahmoud, S. Y., Moon, D., Lee, J. K., & Jones, S. E. (2023) · Springer eBooks · doi:10.1007/978-3-031-10909-6_36 · Cited by 1

REDOX PROTEOMICS IDENTIFICATION OF OXIDATIVELY MODIFIED PROTEINS AND THEIR PHARMACOLOGICAL MODULATION: INSIGHT INTO OXIDATIVE STRESS IN BRAIN AGING, AGE-RELATED COGNITIVE IMPAIRMENT

Poon, H. F. (2005) · UKnowledge (University of Kentucky)

Applications of fMRI to Neurodegenerative Disease

Mahmoud, S. Y., Jones, S. E., & Phillips, M. D. (2011) · Springer eBooks · doi:10.1007/978-1-4419-0345-7_32

Anatomical Networks: Structure and Function of the Nervous System

Masliah, E. (2008) · Springer eBooks · doi:10.1007/978-0-387-72573-4_3

On nogo receptors, plasticity and lasting memories

Karlsson, T. E. (2012) · Figshare

SpontaneousAge-RelatedNeuriteBranchingin Caenorhabditiselegans

Tank, H. (2011)

2and Adaptive Immunity in Health and Disease

Gendelman, H. E., & Masliah, E. (2008)

Applications of fMRI to Neurodegenerative Disease

Mahmoud, S. Y., Jones, S. E., & Phillips, M. D. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1995-6_18

Anatomical Networks: Structure and Function of the Nervous System

Masliah, E. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_7

Innate and Adaptive Immunity in Health and Disease

Gendelman, H. E., & Masliah, E. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_1

fMRI in Neurodegenerative Diseases: From Scientific Insights to Clinical Applications

Dickerson, B. C., Canu, E., Tripodi, C., Agosta, F., & Filippi, M. (2025) · Neuromethods · doi:10.1007/978-1-0716-4438-6_24

Fast Fourier Transform and Dynamic Imaging of Caveolar Complex Arrays in Active Striated Muscle

Smith, K. H. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)

Alpha‐synuclein in Lewy Body Disease and Alzheimer's Disease

Hashimoto, M., & Masliah, E. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00552.x · Cited by 254

Impact of coexistent Alzheimer pathology on the natural history of dementia with Lewy bodies

Ka, J., Boltzmann, L., Seppi, K., Wenning, G. K., Luginger, E., & Poewe, W. H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)82352-0 · Cited by 2

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases

Hashimoto, M., Rockenstein, E. M., Crews, L. A., & Masliah, E. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:4:1-2:21 · Cited by 507

Neuritic Alterations and Neural System Dysfunction in Alzheimer's Disease and Dementia with Lewy Bodies

Klucken, J., McLean, P. J., Gómez‐Tortosa, E., Ingelsson, M., & Hyman, B. T. (2003) · Neurochemical Research · doi:10.1023/a:1026061021946 · Cited by 38

Neurobiology of Disorders with Lewy Bodies

Hansen, L. A., & Masliah, E. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50016-0 · Cited by 4