Mechanisms of intracellular protein transport

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443

Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF

Helms, J. B., & Rothman, J. E. (1992) · Nature · doi:10.1038/360352a0 · Cited by 746

Rab proteins as membrane organizers

Zerial, M., & McBride, H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052055 · Cited by 3,381

AMPA Receptor Trafficking and Synaptic Plasticity

Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588

The cell biology of neurogenesis

Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130

Understanding the mechanism of IL-1β secretion

Lopez-Castejon, G., & Brough, D. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.10.001 · Cited by 1,519

Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons

Shi, S.-H., Hayashi, Y., Esteban, J. A., & Malinow, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00321-x · Cited by 1,094

Rabs and their effectors: achieving specificity in membrane traffic

Grosshans, B. L., Ortiz, D., & Novick, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601617103 · Cited by 1,005

The cell biology of synaptic plasticity: AMPA receptor trafficking

Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978

Secretory Granule Exocytosis

Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934

The Rab5 effector EEA1 is a core component of endosome docking

Christoforidis, S., McBride, H. M., Burgoyne, R. D., & Zerial, M. (1999) · Nature · doi:10.1038/17618 · Cited by 854

Synapsins as Regulators of Neurotransmitter Release

Hilfiker, S., Pieribone, V. A., Czernik, A. J., Kao, H.-T., Augustine, G. J., & Greengard, P. (1999) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1999.0378 · Cited by 537

Snares and Munc18 in synaptic vesicle fusion

Rizo, J., & Südhof, T. C. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn898 · Cited by 539

Coordinated protein sorting, targeting and distribution in polarized cells

Mellman, I., & Nelson, W. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2525 · Cited by 521

Oligomeric Complexes Link Rab5 Effectors with NSF and Drive Membrane Fusion via Interactions between EEA1 and Syntaxin 13

McBride, H. M., Rybin, V., Murphy, C., Giner, A., Teasdale, R., & Zerial, M. (1999) · Cell · doi:10.1016/s0092-8674(00)81966-2 · Cited by 520

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

Ozaki, N., Shibasaki, T., Kashima, Y., Miki, T., Takahashi, K., Ueno, H., Sunaga, Y., Yano, H., Matsuura, Y., Iwanaga, T., et al. (2000) · Nature Cell Biology · doi:10.1038/35041046 · Cited by 481

An HMM model for coiled-coil domains and a comparison with PSSM-based predictions

Delorenzi, M., & Speed, T. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.4.617 · Cited by 479

Synaptic Vesicle Endocytosis

Saheki, Y., & De Camilli, P. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005645 · Cited by 457

Role of ampa receptor endocytosis in synaptic plasticity

Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072500 · Cited by 448

Postsynaptic Membrane Fusion and Long-Term Potentiation

Lledo, P.-M., Zhang, X., Südhof, T. C., Malenka, R. C., & Nicoll, R. A. (1998) · Science · doi:10.1126/science.279.5349.399 · Cited by 413

Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products

Seaman, M. N. J., Marcusson, E. G., Cereghino, J. L., & Emr, S. D. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.79 · Cited by 378

Functional genomics reveals genes involved in protein secretion and Golgi organization

Bard, F., Casano, L., Mallabiabarrena, A., Wallace, E., Saito, K., Kitayama, H., Guizzunti, G., Hu, Y., Wendler, F., DasGupta, R., et al. (2006) · Nature · doi:10.1038/nature04377 · Cited by 372

Identification of a Novel Syntaxin- and Synaptobrevin/VAMP-binding Protein, SNAP-23, Expressed in Non-neuronal Tissues

Ravichandran, V., Chawla, A., & Roche, P. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13300 · Cited by 354

The Role of Intraorganellar Ca2+In Late Endosome–Lysosome Heterotypic Fusion and in the Reformation of Lysosomes from Hybrid Organelles

Pryor, P. R., Mullock, B. M., Bright, N. A., Gray, S. R., & Luzio, J. P. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.5.1053 · Cited by 347

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion

Lang, J. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00043.x · Cited by 347

Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles

Trinczek, B., Ebneth, A., Mandelkow, E.-M., & Mandelkow, E. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.14.2355 · Cited by 344

Identification of SNAREs Involved in Synaptotagmin VII-regulated Lysosomal Exocytosis

Rao, S. K., Huynh, C., Proux-Gillardeaux, V., Galli, T., & Andrews, N. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400798200 · Cited by 320

Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors

Nakashima, S., Morinaka, K., Koyama, S., Ikeda, M., Kishida, M., Okawa, K., Iwamatsu, A., Kishida, S., & Kikuchi, A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.13.3629 · Cited by 231

GOLM1 modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasis

Ye, Q.-H., Zhu, W.-W., Zhang, J.-B., Qin, Y., Lu, M., Lin, G.-L., Guo, L., Zhang, B., Lin, Z.-H., Roessler, S., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.07.017 · Cited by 228

Retrograde transport of Golgi-localized proteins to the ER

Cole, N. B., Ellenberg, J., Song, J., DiEuliis, D., & Lippincott-Schwartz, J. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.1.1 · Cited by 226

Rapid ATP‐Dependent Priming of Secretory Granules Precedes Ca 2+ ‐Induced Exocytosis in Mouse Pancreatic B‐Cells

Eliasson, L., Renström, E., Ding, W., Proks, P., & Rorsman, P. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.399bh.x · Cited by 223

Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal Acidification

Hackam, D. J., Rotstein, O. D., Zhang, W.-J., Gruenheid, S., Gros, P., & Grinstein, S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.351 · Cited by 202

Mutations in the Exocyst Component Sec5 Disrupt Neuronal Membrane Traffic, but Neurotransmitter Release Persists

Murthy, M., Garza, D., Scheller, R. H., & Schwarz, T. L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00031-x · Cited by 202

Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis

Ann, K., Kowalchyk, J. A., Loyet, K. M., & Martin, T. F. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19637 · Cited by 182

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

Diao, J., Grob, P., Cipriano, D. J., Kyoung, M., Zhang, Y., Shah, S., Nguyen, A., Padolina, M., Srivastava, A., Vrljic, M., et al. (2012) · eLife · doi:10.7554/elife.00109 · Cited by 170

The R-SNARE Endobrevin/VAMP-8 Mediates Homotypic Fusion of Early Endosomes and Late Endosomes

Antonin, W., Holroyd, C., Tikkanen, R., Höning, S., & Jahn, R. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.10.3289 · Cited by 156

In vitro system capable of differentiating fast Ca 2+ -triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

Kyoung, M., Srivastava, A., Zhang, Y., Diao, J., Vrljic, M., Grob, P., Nogales, E., Chu, S., & Brunger, A. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107900108 · Cited by 154

Rab4 affects both recycling and degradative endosomal trafficking

McCaffrey, M. W., Bielli, A., Cantalupo, G., Mora, S., Roberti, V., Santillo, M., Drummond, F., & Bucci, C. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02359-6 · Cited by 154

Distinct Initial SNARE Configurations Underlying the Diversity of Exocytosis

Kasai, H., Takahashi, N., & Tokumaru, H. (2012) · Physiological Reviews · doi:10.1152/physrev.00007.2012 · Cited by 150

A Selective Transport Route from Golgi to Late Endosomes That Requires the Yeast Gga Proteins

Black, M. W., & Pelham, H. R. B. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.587 · Cited by 140

Intracellular Assembly of VLDL

Olofsson, S.-O., Stillemark-Billton, P., & Asp, L. (2000) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00071-8 · Cited by 132

Pancreatic β-Cell Protein Granuphilin Binds Rab3 and Munc-18 and Controls Exocytosis

Coppola, T., Frantz, C., Perret-Menoud, V., Gattesco, S., Hirling, H., & Regazzi, R. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0025 · Cited by 127

Dynamic Ca 2+ -Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1

Lee, H.-K., Yang, Y., Su, Z., Hyeon, C., Lee, T.-S., Lee, H.-W., Kweon, D.-H., Shin, Y.-K., & Yoon, T.-Y. (2010) · Science · doi:10.1126/science.1187722 · Cited by 123

Single-Molecule Studies of the Neuronal SNARE Fusion Machinery

Brunger, A. T., Weninger, K., Bowen, M., & Chu, S. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.070306.103621 · Cited by 107

Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation

Okazaki, N., Yan, J., Yuasa, S., Ueno, T., Kominami, E., Masuho, Y., Koga, H., & Muramatsu, M.-A. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00218-7 · Cited by 106

Plasma membrane insertion of the AMPA receptor GluA2 subunit is regulated by NSF binding and Q/R editing of the ion pore

Araki, Y., Lin, D.-T., & Huganir, R. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006584107 · Cited by 92

Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex

Conchon, S., Cao, X., Barlowe, C., & Pelham, H. R. B. (1999) · The EMBO Journal · doi:10.1093/emboj/18.14.3934 · Cited by 85

Synaptotagmin C2B Domain Regulates Ca2+-triggered Fusion in Vitro

Gaffaney, J. D., Dunning, F. M., Wang, Z., Hui, E., & Chapman, E. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803355200 · Cited by 75

Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking

Hirling, H., Steiner, P., Chaperon, C., Marsault, R., Regazzi, R., & Catsicas, S. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00076.x · Cited by 69

ADP-ribosylation Factor-1 Stimulates Formation of Nascent Secretory Vesicles from the trans-Golgi Network of Endocrine Cells

Chen, Y.-G., & Shields, D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5297 · Cited by 68

AAGAB Controls AP2 Adaptor Assembly in Clathrin-Mediated Endocytosis

Gulbranson, D. R., Crisman, L., Lee, M., Ouyang, Y., Menasche, B. L., Demmitt, B. A., Wan, C., Nomura, T., Ye, Y., Yu, H., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.06.013 · Cited by 57

Dendritic SNAREs add a new twist to the old neuron theory

Ovsepian, S. V., & Dolly, J. O. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017235108 · Cited by 50

Functional roles of protein interactions with AMPA and kainate receptors

Collingridge, G. L., & Isaac, J. T. R. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(03)00160-3 · Cited by 45

Reconstitution of membrane fusion between pancreatic islet secretory granules and plasma membranes: Catalysis by a protein constituent recognized by monoclonal antibodies directed against glyceraldehyde-3-phosphate dehydrogenase

Han, X., Ramanadham, S., Turk, J., & Gross, R. W. (1998) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00154-0 · Cited by 31

Synaptotagmin II could confer Ca2+ sensitivity to phagocytosis in human neutrophils

Lindmark, I. M., Karlsson, A., Serrander, L., Francois, P., Lew, D., Rasmusson, B., Stendahl, O., & Nüße, O. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00209-4 · Cited by 28

Localization of mRNAs for six ARFs (ADP-ribosylation factors) in the brain of developing and adult rats and changes in the expression in the hypoglossal nucleus after its axotomy

Suzuki, I., Owada, Y., Suzuki, R., Yoshimoto, T., & Kondo, H. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00036-5 · Cited by 21

Ca2+-independent syntaxin binding to the C2B effector region of synaptotagmin

Masumoto, T., Suzuki, K., Ohmori, I., Michiue, H., Tomizawa, K., Fujimura, A., Nishiki, T.-I., & Matsui, H. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.09.007 · Cited by 14