Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of mexican population: a preliminary report
Open accessAbstract
Background: Spirulina maxima is a filamentous cyanobacterium used as food supplement because of its high nutrient contents. It has been experimentally proven, in vivo and in vitro that posses several pharmacological properties. The purpose of this study was to evaluate the effects of Spirulina maxima orally supplied (4.5 g/day, for 6 weeks) to a sample of 36 subjects (16 men and 20 women, with ages between 18–65 years) on serum lipids, glucose, aminotransferases and on blood pressure. The volunteers did not modify their dietary habits or lifestyle during the whole experimental period. From each subject, a sample of blood was drawn in fasting state of 12 hours to determi the plasma concentrations of glucose, triacylglycerols (TAG), total cholesterol (TC), cholesterol associated to high density lipoprotein (HDL-C) and aspartate aminotransferase (AST). Anthropometric measurements including systolic (SYST-P) and diastolic (DIAST-P) blood pressure, height, weight and Body Mass Index (BMI) were also recorded. Results: Comparing initial and final data, the results showed that there were no significant changes in the values of glucose and AST, but significant differences in TAG, TC, and HDL-C, were observed: TAG 233.7 ± 177.8 vs. 167.7 ± 100.7 mg/dL (p < 0.001), TC 181.7 ± 37.5 vs. 163.5 ± 34.4 mg/dL (p < 0.001), C-HDL 43.5 ± 14.4 vs. 50 ± 18.8 mg/dL (p < 0.01). The univariated analysis showed that the changes in the HDL-C and TC concentrations were dependent on TAG concentration (p = 0.247 and p = 0.108, respectively); nevertheless the calculated values for cholesterol associated to low density lipoprotein (LDL-C) were significantly reduced by the Spirulina maxima treatment but independently of the TAG changes. In addition, significant differences were found comparing initial and final SYST-P and DIAST-P blood pressure in both male and female: SYST-P male 121 ± 9 vs. 111 ± 8 mm Hg (p < 0.01), DIAST-P male 85 ± 6.5 vs. 77 ± 9 mm Hg (p < 0.01); SYST-P female 120 ± 9.5 vs. 109 ± 11 mm Hg (p < 0.002), DIAST-P female 85 ± 11 vs. 79 ± 7.5 mm Hg (p < 0.03). Conclusion: The Spirulina maxima showed a hypolipemic effect, especially on the TAG and the LDL-C concentrations but indirectly on TC and HDL-C values. It also reduces systolic and diastolic blood pressure.
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Spirulina has antihypertensive properties.
“Spirulina presents hypolipidemic [11], hypoglycemic [12], and antihypertensive [13] properties.”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i> (2017) · cites this paper as [13]
In overweight subjects and in T2D patients with dyslipidemia, the improvement in the lipid profile was accompanied by a reduction of blood pressure.
“In overweight subjects [13] and in T2D patients with dyslipidemia [106] the improvement in the lipid profile was accompanied by a reduction of blood pressure.”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i> (2017) · cites this paper as [13]
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- Authors
- Torres-Duran, P. V., Ferreira-Hermosillo, A., & Juarez-Oropeza, M. A.
- Venue
- Lipids in Health and Disease
- Published
- 2007-11-26
- Volume
- 6
- Issue
- 1
- Pages
- 33-33
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC2211748
- OpenAlex
- W2019647669
- Cited by
- 181
- References
- 57
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 13 · 2021: 8 · 2020: 23 · 2019: 10 · 2018: 14 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 7 · 2013: 10 · 2012: 2
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Greater South Information System
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Keywords
- Spirulina maxima, cyanobacteria, dietary supplementation, hyperlipidemia, hypertension, serum lipids, HDL cholesterol, LDL cholesterol, triglycerides, blood pressure, aspartate aminotransferase, glucose, body mass index, Mexican population, hypolipidemic effect, antihypertensive effect, sex differences, body composition, anthropometry
- MeSH terms
- Adolescent, Adult, Aged, Antihypertensive Agents, Hypolipidemic Agents, Blood Pressure, Female, Humans, Hypertension, Cholesterol, HDL, Cholesterol, LDL, Male, Mexico, Middle Aged, Triglycerides, Prevalence, Dietary Supplements, Dyslipidemias, Spirulina
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