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Cited by 413

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Effect of Photic Stimulation on Human Visual Cortex Lactate and Phosphates Using 1H and 31P Magnetic Resonance Spectroscopy

Sappey-Marinier, D., Calabrese, G., Fein, G., Hugg, J. W., Biggins, C., Weiner, M. W.·1992·Journal of Cerebral Blood Flow & Metabolism
DOI 10.1038/jcbfm.1992.82
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Abstract

Previous animal and human studies showed that photic stimulation (PS) increased cerebral blood flow and glucose uptake much more than oxygen consumption, suggesting selective activation of anaerobic glycolysis. In the present studies, image-guided 1 H and 31 P magnetic resonance spectroscopy (MRS) was used to monitor the changes in lactate and high-energy phosphate concentrations produced by PS of visual cortex in six normal volunteers. PS initially produced a significant rise (to 250% of control, p < 0.01) in visual cortex lactate during the first 6.4 min of PS, followed by a significant decline ( p = 0.01) as PS continued. The PCr/Pi ratios decreased significantly from control values during the first 12.8 min of PS ( p < 0.05), and the pH was slightly increased. The positive P100 deflection of the visual evoked potential recorded between 100 and 172 ms after the strobe was significantly decreased from control at 12.8 min of PS ( p < 0.05). The finding that PS caused decreased PCr/Pi is consistent with the view that increased brain activity stimulated ATPase, causing a rise in ADP that shifted the creatine kinase reaction in the direction of ATP synthesis. The rise in lactate together with an increase in pH suggest that intracellular alkalosis, caused by the shift of creatine kinase, selectively stimulated glycolysis.

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Crossref · 10.1038/jcbfm.1992.82

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Metadata

Authors
Sappey-Marinier, D., Calabrese, G., Fein, G., Hugg, J. W., Biggins, C., & Weiner, M. W.
Venue
Journal of Cerebral Blood Flow & Metabolism
Publisher
SAGE Publications
Published
1992-07
Volume
12
Issue
4
Pages
584-592
ISSN
  • 0271-678X (ISSN-L)
  • 1559-7016
DOI
10.1038/jcbfm.1992.82
OpenAlex
W2030431065
Cited by
413
References
3
FWCI
10.64
Type
journal article
Language
en
Open access
closed

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